PMC:7195088 / 74322-74919 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2046","span":{"begin":554,"end":562},"obj":"Species"},{"id":"2051","span":{"begin":115,"end":123},"obj":"Disease"},{"id":"2052","span":{"begin":545,"end":553},"obj":"Disease"},{"id":"2072","span":{"begin":304,"end":312},"obj":"Species"}],"attributes":[{"id":"A2046","pred":"tao:has_database_id","subj":"2046","obj":"Tax:9606"},{"id":"A2051","pred":"tao:has_database_id","subj":"2051","obj":"MESH:C000657245"},{"id":"A2052","pred":"tao:has_database_id","subj":"2052","obj":"MESH:C000657245"},{"id":"A2072","pred":"tao:has_database_id","subj":"2072","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Conclusions\nMany off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic. While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT. Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T398","span":{"begin":115,"end":123},"obj":"Disease"},{"id":"T399","span":{"begin":545,"end":553},"obj":"Disease"}],"attributes":[{"id":"A398","pred":"mondo_id","subj":"T398","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A399","pred":"mondo_id","subj":"T399","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Conclusions\nMany off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic. While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT. Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T396","span":{"begin":21,"end":26},"obj":"http://purl.obolibrary.org/obo/CLO_0007225"}],"text":"Conclusions\nMany off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic. While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT. Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T125","span":{"begin":21,"end":26},"obj":"Chemical"},{"id":"T27070","span":{"begin":27,"end":36},"obj":"Chemical"},{"id":"T16804","span":{"begin":41,"end":64},"obj":"Chemical"},{"id":"T98752","span":{"begin":59,"end":64},"obj":"Chemical"}],"attributes":[{"id":"A44943","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_35209"},{"id":"A69059","pred":"chebi_id","subj":"T27070","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A23282","pred":"chebi_id","subj":"T16804","obj":"http://purl.obolibrary.org/obo/CHEBI_35472"},{"id":"A89007","pred":"chebi_id","subj":"T98752","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Conclusions\nMany off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic. While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT. Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions."}

{"project":"LitCovid-sentences","denotations":[{"id":"T503","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T504","span":{"begin":12,"end":133},"obj":"Sentence"},{"id":"T505","span":{"begin":134,"end":395},"obj":"Sentence"},{"id":"T506","span":{"begin":396,"end":597},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Conclusions\nMany off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic. While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT. Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions."}