PMC:7195088 / 69512-70431 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"2017","span":{"begin":381,"end":392},"obj":"Chemical"},{"id":"2018","span":{"begin":393,"end":411},"obj":"Chemical"},{"id":"2019","span":{"begin":779,"end":786},"obj":"Chemical"},{"id":"2020","span":{"begin":856,"end":863},"obj":"Chemical"},{"id":"2021","span":{"begin":692,"end":701},"obj":"Disease"}],"attributes":[{"id":"A2017","pred":"tao:has_database_id","subj":"2017","obj":"MESH:D002738"},{"id":"A2018","pred":"tao:has_database_id","subj":"2018","obj":"MESH:D006886"},{"id":"A2019","pred":"tao:has_database_id","subj":"2019","obj":"MESH:D013256"},{"id":"A2020","pred":"tao:has_database_id","subj":"2020","obj":"MESH:D013256"},{"id":"A2021","pred":"tao:has_database_id","subj":"2021","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects. Nonetheless, suggested durations vary markedly. For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]]. There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T379","span":{"begin":231,"end":232},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T380","span":{"begin":259,"end":267},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T381","span":{"begin":365,"end":366},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects. Nonetheless, suggested durations vary markedly. For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]]. There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T57203","span":{"begin":203,"end":208},"obj":"Chemical"},{"id":"T40359","span":{"begin":381,"end":392},"obj":"Chemical"},{"id":"T32607","span":{"begin":393,"end":411},"obj":"Chemical"},{"id":"T12702","span":{"begin":779,"end":786},"obj":"Chemical"},{"id":"T60327","span":{"begin":856,"end":863},"obj":"Chemical"}],"attributes":[{"id":"A87325","pred":"chebi_id","subj":"T57203","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A6436","pred":"chebi_id","subj":"T40359","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A35112","pred":"chebi_id","subj":"T32607","obj":"http://purl.obolibrary.org/obo/CHEBI_5801"},{"id":"A19551","pred":"chebi_id","subj":"T12702","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"},{"id":"A8449","pred":"chebi_id","subj":"T60327","obj":"http://purl.obolibrary.org/obo/CHEBI_35341"}],"text":"In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects. Nonetheless, suggested durations vary markedly. For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]]. There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T483","span":{"begin":0,"end":303},"obj":"Sentence"},{"id":"T484","span":{"begin":304,"end":351},"obj":"Sentence"},{"id":"T485","span":{"begin":352,"end":757},"obj":"Sentence"},{"id":"T486","span":{"begin":758,"end":919},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects. Nonetheless, suggested durations vary markedly. For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]]. There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85]."}

{"project":"2_test","denotations":[{"id":"32360444-32164085-22369824","span":{"begin":746,"end":748},"obj":"32164085"},{"id":"32360444-32122468-22369825","span":{"begin":912,"end":914},"obj":"32122468"}],"text":"In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects. Nonetheless, suggested durations vary markedly. For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]]. There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85]."}