PMC:7195088 / 6629-7731
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 157 | 95-103 | Species | denotes | patients | Tax:9606 |
| 158 | 297-307 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 159 | 1023-1031 | Species | denotes | patients | Tax:9606 |
| 198 | 35-53 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 199 | 652-670 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 200 | 950-968 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 217 | 109-117 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 218 | 233-248 | Disease | denotes | QT prolongation | MESH:D008133 |
| 219 | 622-631 | Disease | denotes | mortality | MESH:D003643 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T27 | 109-117 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T28 | 297-305 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T22 | 271-279 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T23 | 398-403 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T24 | 419-420 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T25 | 787-792 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T28 | 35-53 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T29 | 139-143 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T30 | 652-670 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T31 | 787-792 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T32 | 950-968 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T48 | 0-249 | Sentence | denotes | Pending results of RCT, the use of hydroxychloroquine may be considered for treating worsening patients with COVID-19 only if no important drug interactions can be anticipated and with close monitoring of hepatic, renal function and QT prolongation. |
| T49 | 250-459 | Sentence | denotes | This is based on its activity in vitro against SARS-CoV-2 (although weak) and on the availability of low-level clinical evidence of anticipation of virus clearance from a small controlled, nonrandomized study. |
| T50 | 460-632 | Sentence | denotes | However, it should also be kept in mind that the study was highly susceptible to bias and there are still no data regarding hard clinical endpoints such as crude mortality. |
| T51 | 633-757 | Sentence | denotes | For these reasons, hydroxychloroquine should be preferentially administered within the framework of investigational studies. |
| T52 | 758-867 | Sentence | denotes | When this is unfeasible, off-label use may be considered according to local protocols and consent procedures. |
| T53 | 868-1064 | Sentence | denotes | In view of the absence of evidence, we are currently unable to support the use of hydroxychloroquine in asymptomatic or mildly symptomatic nonhospitalized patients outside investigational studies. |
| T54 | 1065-1102 | Sentence | denotes | The same applies to prophylactic use. |