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PMC:7195088 / 65816-67201 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1895 553-561 Species denotes patients Tax:9606
1900 567-575 Disease denotes COVID-19 MESH:C000657245
1922 112-122 Species denotes SARS-CoV-2 Tax:2697049
1923 189-199 Species denotes SARS-CoV-2 Tax:2697049
1924 221-229 Species denotes SARS-CoV Tax:694009
1925 400-410 Species denotes SARS-CoV-2 Tax:2697049
1927 236-245 Species denotes influenza Tax:11520
1928 471-478 Chemical denotes LPV/RTV MESH:C558899
1929 542-549 Chemical denotes LPV/RTV MESH:C558899
1930 867-874 Chemical denotes LPV/RTV MESH:C558899
1931 1068-1075 Chemical denotes LPV/RTV MESH:C558899
1932 1270-1277 Chemical denotes LPV/RTV MESH:C558899
1933 285-294 Disease denotes mortality MESH:D003643
1935 1315-1323 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T376 112-120 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T377 189-197 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T378 221-229 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T379 236-245 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T380 400-408 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T381 567-575 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 1315-1323 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T365 93-100 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T366 253-254 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 691-693 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T368 784-786 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T11348 36-45 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T12438 318-327 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T94861 726-730 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14598 1090-1100 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T18588 1291-1301 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T467 0-200 Sentence denotes Most clinical data on the timing of antiviral therapy initiation are derived from studies on viruses other than SARS-CoV-2, and it remains unclear whether these data can be extrapolated to SARS-CoV-2.
T468 201-384 Sentence denotes Previous studies in SARS-CoV-1 and influenza showed a possible favourable impact on mortality of early initiation of antiviral treatment after symptoms onset [[79], [80], [81], [82]].
T469 385-788 Sentence denotes With regard to SARS-CoV-2, although the results of the previously cited RCT comparing LPV/RTV versus standard of care eventually does not support the use of LPV/RTV in patients with COVID-19, it is also of note that the median time between symptom onset and randomization was 13 days (interquartile range, 11–16 days), so in most cases, the drug was initiated late during the course of the disease [22].
T470 789-917 Sentence denotes Consequently, we cannot exclude the possibility that an earlier initiation of LPV/RTV may be associated with improved prognosis.
T471 918-1137 Sentence denotes In this regard, we think the results of this RCT may be hypothesis generating and may help guide the design of further RCT evaluating the efficacy of LPV/RTV (and/or other antivirals) in an earlier phase of the disease.
T472 1138-1385 Sentence denotes However, until such RCT will be available, we think the currently available clinical evidence is insufficient to support the use of LPV/RTV and/or other antivirals for treating COVID-19 outside the framework of RCT or compassionate-use programmes.

2_test

Id Subject Object Predicate Lexical cue
32360444-14660806-22369819 361-363 14660806 denotes 79
32360444-30304487-22369820 367-369 30304487 denotes 80
32360444-22843781-22369821 373-375 22843781 denotes 81
32360444-24815805-22369822 379-381 24815805 denotes 82
32360444-32187464-22369823 784-786 32187464 denotes 22