PMC:7195088 / 57052-57710 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1693","span":{"begin":15,"end":23},"obj":"Species"},{"id":"1694","span":{"begin":95,"end":103},"obj":"Species"},{"id":"1695","span":{"begin":109,"end":117},"obj":"Species"},{"id":"1696","span":{"begin":456,"end":464},"obj":"Species"},{"id":"1697","span":{"begin":470,"end":478},"obj":"Species"},{"id":"1698","span":{"begin":158,"end":172},"obj":"Chemical"},{"id":"1699","span":{"begin":280,"end":294},"obj":"Chemical"},{"id":"1700","span":{"begin":80,"end":94},"obj":"Disease"},{"id":"1701","span":{"begin":205,"end":213},"obj":"Disease"},{"id":"1702","span":{"begin":263,"end":272},"obj":"Disease"},{"id":"1703","span":{"begin":585,"end":603},"obj":"Disease"},{"id":"1704","span":{"begin":605,"end":614},"obj":"Disease"},{"id":"1705","span":{"begin":616,"end":624},"obj":"Disease"}],"attributes":[{"id":"A1693","pred":"tao:has_database_id","subj":"1693","obj":"Tax:9606"},{"id":"A1694","pred":"tao:has_database_id","subj":"1694","obj":"Tax:9606"},{"id":"A1695","pred":"tao:has_database_id","subj":"1695","obj":"Tax:694009"},{"id":"A1696","pred":"tao:has_database_id","subj":"1696","obj":"Tax:9606"},{"id":"A1697","pred":"tao:has_database_id","subj":"1697","obj":"Tax:694009"},{"id":"A1698","pred":"tao:has_database_id","subj":"1698","obj":"MESH:D006854"},{"id":"A1699","pred":"tao:has_database_id","subj":"1699","obj":"MESH:D006854"},{"id":"A1700","pred":"tao:has_database_id","subj":"1700","obj":"MESH:D016638"},{"id":"A1702","pred":"tao:has_database_id","subj":"1702","obj":"MESH:D007239"},{"id":"A1703","pred":"tao:has_database_id","subj":"1703","obj":"MESH:D010020"},{"id":"A1704","pred":"tao:has_database_id","subj":"1704","obj":"MESH:D011605"},{"id":"A1705","pred":"tao:has_database_id","subj":"1705","obj":"MESH:D003920"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T97","span":{"begin":585,"end":603},"obj":"Phenotype"},{"id":"T98","span":{"begin":605,"end":614},"obj":"Phenotype"}],"attributes":[{"id":"A97","pred":"hp_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/HP_0010885"},{"id":"A98","pred":"hp_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/HP_0000709"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T321","span":{"begin":109,"end":117},"obj":"Disease"},{"id":"T322","span":{"begin":263,"end":272},"obj":"Disease"},{"id":"T323","span":{"begin":470,"end":478},"obj":"Disease"},{"id":"T324","span":{"begin":585,"end":603},"obj":"Disease"},{"id":"T326","span":{"begin":605,"end":614},"obj":"Disease"},{"id":"T327","span":{"begin":616,"end":624},"obj":"Disease"}],"attributes":[{"id":"A321","pred":"mondo_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A322","pred":"mondo_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A323","pred":"mondo_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A324","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0005380"},{"id":"A325","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0018373"},{"id":"A326","pred":"mondo_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/MONDO_0005485"},{"id":"A327","pred":"mondo_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T314","span":{"begin":57,"end":58},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T315","span":{"begin":135,"end":136},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T316","span":{"begin":362,"end":363},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T317","span":{"begin":637,"end":642},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T83355","span":{"begin":158,"end":172},"obj":"Chemical"},{"id":"T63290","span":{"begin":280,"end":294},"obj":"Chemical"},{"id":"T34671","span":{"begin":295,"end":300},"obj":"Chemical"},{"id":"T72854","span":{"begin":325,"end":330},"obj":"Chemical"},{"id":"T88411","span":{"begin":428,"end":443},"obj":"Chemical"}],"attributes":[{"id":"A81824","pred":"chebi_id","subj":"T83355","obj":"http://purl.obolibrary.org/obo/CHEBI_17650"},{"id":"A40681","pred":"chebi_id","subj":"T63290","obj":"http://purl.obolibrary.org/obo/CHEBI_17650"},{"id":"A11644","pred":"chebi_id","subj":"T34671","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A38546","pred":"chebi_id","subj":"T72854","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A25089","pred":"chebi_id","subj":"T88411","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":595,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T22","span":{"begin":595,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T23","span":{"begin":595,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T24","span":{"begin":595,"end":603},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T422","span":{"begin":0,"end":188},"obj":"Sentence"},{"id":"T423","span":{"begin":189,"end":336},"obj":"Sentence"},{"id":"T424","span":{"begin":337,"end":658},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}

{"project":"2_test","denotations":[{"id":"32360444-15494274-22369796","span":{"begin":332,"end":334},"obj":"15494274"},{"id":"32360444-16968120-22369797","span":{"begin":654,"end":656},"obj":"16968120"}],"text":"With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration. Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56]. Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57]."}