PMC:7195088 / 56426-57051 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1670","span":{"begin":51,"end":59},"obj":"Species"},{"id":"1671","span":{"begin":564,"end":572},"obj":"Species"},{"id":"1672","span":{"begin":578,"end":586},"obj":"Species"},{"id":"1673","span":{"begin":588,"end":596},"obj":"Species"},{"id":"1674","span":{"begin":136,"end":154},"obj":"Chemical"},{"id":"1675","span":{"begin":42,"end":50},"obj":"Disease"},{"id":"1676","span":{"begin":65,"end":100},"obj":"Disease"},{"id":"1677","span":{"begin":102,"end":106},"obj":"Disease"},{"id":"1678","span":{"begin":198,"end":203},"obj":"Disease"},{"id":"1679","span":{"begin":608,"end":624},"obj":"Disease"}],"attributes":[{"id":"A1670","pred":"tao:has_database_id","subj":"1670","obj":"Tax:9606"},{"id":"A1671","pred":"tao:has_database_id","subj":"1671","obj":"Tax:9606"},{"id":"A1672","pred":"tao:has_database_id","subj":"1672","obj":"Tax:1335626"},{"id":"A1673","pred":"tao:has_database_id","subj":"1673","obj":"Tax:694009"},{"id":"A1674","pred":"tao:has_database_id","subj":"1674","obj":"MESH:D008775"},{"id":"A1675","pred":"tao:has_database_id","subj":"1675","obj":"MESH:C000657245"},{"id":"A1676","pred":"tao:has_database_id","subj":"1676","obj":"MESH:D012128"},{"id":"A1677","pred":"tao:has_database_id","subj":"1677","obj":"MESH:D012128"},{"id":"A1678","pred":"tao:has_database_id","subj":"1678","obj":"MESH:D003643"},{"id":"A1679","pred":"tao:has_database_id","subj":"1679","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T96","span":{"begin":71,"end":91},"obj":"Phenotype"}],"attributes":[{"id":"A96","pred":"hp_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T315","span":{"begin":42,"end":50},"obj":"Disease"},{"id":"T316","span":{"begin":65,"end":100},"obj":"Disease"},{"id":"T317","span":{"begin":71,"end":100},"obj":"Disease"},{"id":"T318","span":{"begin":102,"end":106},"obj":"Disease"},{"id":"T319","span":{"begin":588,"end":596},"obj":"Disease"},{"id":"T320","span":{"begin":608,"end":624},"obj":"Disease"}],"attributes":[{"id":"A315","pred":"mondo_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A316","pred":"mondo_id","subj":"T316","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A317","pred":"mondo_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A318","pred":"mondo_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A319","pred":"mondo_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A320","pred":"mondo_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T10348","span":{"begin":136,"end":154},"obj":"Chemical"},{"id":"T76382","span":{"begin":510,"end":524},"obj":"Chemical"}],"attributes":[{"id":"A83984","pred":"chebi_id","subj":"T10348","obj":"http://purl.obolibrary.org/obo/CHEBI_6888"},{"id":"A49403","pred":"chebi_id","subj":"T76382","obj":"http://purl.obolibrary.org/obo/CHEBI_50858"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T20","span":{"begin":608,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}

{"project":"LitCovid-sentences","denotations":[{"id":"T420","span":{"begin":0,"end":408},"obj":"Sentence"},{"id":"T421","span":{"begin":409,"end":625},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47]. Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections."}