PMC:7195088 / 51937-53047
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1539 | 95-103 | Species | denotes | patients | Tax:9606 |
| 1540 | 306-316 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1541 | 1031-1039 | Species | denotes | patients | Tax:9606 |
| 1542 | 35-53 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 1543 | 660-678 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 1544 | 958-976 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 1545 | 109-117 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1546 | 242-257 | Disease | denotes | QT prolongation | MESH:D008133 |
| 1547 | 630-639 | Disease | denotes | mortality | MESH:D003643 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T277 | 109-117 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T278 | 306-314 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T300 | 280-288 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T301 | 407-412 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T302 | 428-429 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T303 | 795-800 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T18 | 35-53 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T4278 | 139-143 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T90933 | 660-678 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T85881 | 795-800 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T42152 | 958-976 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T393 | 0-258 | Sentence | denotes | Pending results of RCT, the use of hydroxychloroquine may be considered for treating worsening patients with COVID-19 only if no important drug interactions can be anticipated and with close monitoring of hepatic function, renal function and QT prolongation. |
| T394 | 259-467 | Sentence | denotes | This is based on its activity in vitro against SARS-CoV-2 (although weak) and on the availability of low-level clinical evidence of anticipation of virus clearance from a small controlled nonrandomized study. |
| T395 | 468-640 | Sentence | denotes | However, it should also be kept in mind that the study was highly susceptible to bias and there are still no data regarding hard clinical endpoints such as crude mortality. |
| T396 | 641-765 | Sentence | denotes | For these reasons, hydroxychloroquine should be preferentially administered within the framework of investigational studies. |
| T397 | 766-875 | Sentence | denotes | When this is unfeasible, off-label use may be considered according to local protocols and consent procedures. |
| T398 | 876-1072 | Sentence | denotes | In view of the absence of evidence, we are currently unable to support the use of hydroxychloroquine in asymptomatic or mildly symptomatic nonhospitalized patients outside investigational studies. |
| T399 | 1073-1110 | Sentence | denotes | The same applies to prophylactic use. |