PMC:7195088 / 48518-48851 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1461","span":{"begin":117,"end":125},"obj":"Species"},{"id":"1462","span":{"begin":132,"end":142},"obj":"Species"},{"id":"1463","span":{"begin":248,"end":251},"obj":"Species"},{"id":"1467","span":{"begin":35,"end":46},"obj":"Chemical"}],"attributes":[{"id":"A1461","pred":"tao:has_database_id","subj":"1461","obj":"Tax:694009"},{"id":"A1462","pred":"tao:has_database_id","subj":"1462","obj":"Tax:2697049"},{"id":"A1463","pred":"tao:has_database_id","subj":"1463","obj":"Tax:11118"},{"id":"A1467","pred":"tao:has_database_id","subj":"1467","obj":"MESH:D002738"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T85","span":{"begin":92,"end":96},"obj":"Body_part"},{"id":"T86","span":{"begin":190,"end":198},"obj":"Body_part"},{"id":"T87","span":{"begin":252,"end":260},"obj":"Body_part"}],"attributes":[{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67180"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T269","span":{"begin":117,"end":125},"obj":"Disease"},{"id":"T270","span":{"begin":132,"end":140},"obj":"Disease"}],"attributes":[{"id":"A269","pred":"mondo_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A270","pred":"mondo_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T278","span":{"begin":25,"end":33},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T279","span":{"begin":47,"end":50},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T280","span":{"begin":81,"end":88},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T281","span":{"begin":92,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T282","span":{"begin":184,"end":189},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T283","span":{"begin":322,"end":324},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T284","span":{"begin":328,"end":330},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T586","span":{"begin":15,"end":24},"obj":"Chemical"},{"id":"T587","span":{"begin":35,"end":46},"obj":"Chemical"},{"id":"T588","span":{"begin":252,"end":260},"obj":"Chemical"}],"attributes":[{"id":"A586","pred":"chebi_id","subj":"T586","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A587","pred":"chebi_id","subj":"T587","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A588","pred":"chebi_id","subj":"T588","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T15","span":{"begin":213,"end":244},"obj":"http://purl.obolibrary.org/obo/GO_0043687"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T377","span":{"begin":0,"end":333},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}

{"project":"2_test","denotations":[{"id":"32360444-15351731-22369771","span":{"begin":310,"end":312},"obj":"15351731"},{"id":"32360444-32203437-22369772","span":{"begin":328,"end":330},"obj":"32203437"}],"text":"With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]]."}