PMC:7195088 / 4786-5716 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"152","span":{"begin":159,"end":167},"obj":"Species"},{"id":"153","span":{"begin":467,"end":474},"obj":"Species"},{"id":"154","span":{"begin":735,"end":743},"obj":"Species"},{"id":"186","span":{"begin":31,"end":37},"obj":"Chemical"},{"id":"187","span":{"begin":126,"end":132},"obj":"Chemical"},{"id":"188","span":{"begin":453,"end":458},"obj":"Chemical"},{"id":"189","span":{"begin":509,"end":515},"obj":"Chemical"},{"id":"213","span":{"begin":173,"end":200},"obj":"Disease"},{"id":"214","span":{"begin":749,"end":757},"obj":"Disease"}],"attributes":[{"id":"A152","pred":"tao:has_database_id","subj":"152","obj":"Tax:9606"},{"id":"A153","pred":"tao:has_database_id","subj":"153","obj":"Tax:9606"},{"id":"A154","pred":"tao:has_database_id","subj":"154","obj":"Tax:9606"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"MESH:D010100"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"MESH:D010100"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"MESH:D014867"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"MESH:D010100"},{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"MESH:D012131"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":181,"end":200},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T22","span":{"begin":181,"end":200},"obj":"Disease"},{"id":"T23","span":{"begin":749,"end":757},"obj":"Disease"}],"attributes":[{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T19","span":{"begin":418,"end":419},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T20","span":{"begin":775,"end":776},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":31,"end":37},"obj":"Chemical"},{"id":"T10","span":{"begin":126,"end":132},"obj":"Chemical"},{"id":"T11","span":{"begin":420,"end":424},"obj":"Chemical"},{"id":"T13","span":{"begin":453,"end":458},"obj":"Chemical"},{"id":"T14","span":{"begin":509,"end":515},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A12","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T33","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T34","span":{"begin":12,"end":111},"obj":"Sentence"},{"id":"T35","span":{"begin":112,"end":306},"obj":"Sentence"},{"id":"T36","span":{"begin":307,"end":611},"obj":"Sentence"},{"id":"T37","span":{"begin":612,"end":694},"obj":"Sentence"},{"id":"T38","span":{"begin":695,"end":930},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Question 1. How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation? Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation."}