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PMC:7195088 / 42447-44984 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1203 1150-1153 Gene denotes AST Gene:26503
1204 735-743 Species denotes patients Tax:9606
1205 1273-1281 Species denotes patients Tax:9606
1206 1456-1482 Species denotes Mycobacterium tuberculosis Tax:1773
1207 1682-1690 Species denotes patients Tax:9606
1208 252-265 Chemical denotes triglycerides MESH:D014280
1209 1529-1540 Chemical denotes tocilizumab MESH:C502936
1210 198-231 Disease denotes ritonavir • Hypercholesterolaemia MESH:C564286
1211 320-329 Disease denotes Diarrhoea MESH:D003967
1212 413-419 Disease denotes Nausea MESH:D009325
1213 430-463 Disease denotes Upper respiratory tract infection MESH:D012141
1214 472-486 Disease denotes Abdominal pain MESH:D015746
1215 515-522 Disease denotes Fatigue MESH:D005221
1216 577-585 Disease denotes Headache MESH:D006261
1217 595-604 Disease denotes Skin rash MESH:D005076
1218 613-624 Disease denotes Neutropenia MESH:D009503
1219 645-652 Disease denotes Anxiety MESH:D001007
1220 660-668 Disease denotes Insomnia MESH:D007319
1221 708-719 Disease denotes Retinopathy MESH:D012164
1222 802-826 Disease denotes Stevens-Johnson syndrome MESH:D013262
1223 828-842 Disease denotes abdominal pain MESH:D015746
1224 844-853 Disease denotes diarrhoea MESH:D003967
1225 855-861 Disease denotes nausea MESH:D009325
1226 863-871 Disease denotes vomiting MESH:D014839
1227 873-888 Disease denotes agranulocytosis MESH:D000380
1228 890-900 Disease denotes leukopenia MESH:D007970
1229 902-918 Disease denotes thrombocytopenia MESH:D013921
1230 975-983 Disease denotes myopathy MESH:D009135
1231 985-997 Disease denotes bronchospasm MESH:D001986
1232 1233-1244 Disease denotes Neutropenia MESH:D009503
1233 1285-1293 Disease denotes Headache MESH:D006261
1234 1303-1315 Disease denotes Hypertension MESH:D006973
1235 1325-1334 Disease denotes Dizziness MESH:D004244
1236 1342-1356 Disease denotes Hypothyroidism MESH:D007037
1237 1365-1379 Disease denotes Abdominal pain MESH:D015746
1238 1402-1416 Disease denotes gastric ulcers MESH:D013276
1239 1424-1434 Disease denotes Infections MESH:D007239
1240 1442-1454 Disease denotes Pneumocystis MESH:D011020
1241 1757-1765 Disease denotes Headache MESH:D006261
1242 1770-1778 Disease denotes vomiting MESH:D014839
1243 1790-1800 Disease denotes Arthralgia MESH:D018771
1244 1812-1817 Disease denotes Fever MESH:D005334
1245 1829-1850 Disease denotes Haematologic disorder MESH:D006402
1246 1861-1873 Disease denotes eosinophilia MESH:D004802
1247 1875-1885 Disease denotes leukopenia MESH:D007970
1248 1924-1930 Disease denotes Nausea MESH:D009325
1249 1935-1944 Disease denotes diarrhoea MESH:D003967
1251 150-158 Disease denotes COVID-19 MESH:C000657245
1253 2051-2059 Disease denotes COVID-19 MESH:C000657245
1257 2119-2143 Gene denotes alanine aminotransferase Gene:2875
1258 2145-2148 Gene denotes AST Gene:26503
1259 2188-2212 Disease denotes coronavirus disease 2019 MESH:C000657245
1264 2464-2474 Disease denotes infections MESH:D007239
1265 2484-2494 Disease denotes cellulitis MESH:D002481
1266 2496-2505 Disease denotes pneumonia MESH:D011014
1267 2511-2536 Disease denotes bone and joint infections MESH:D007239

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T65 246-251 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T66 382-387 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T67 430-453 Body_part denotes Upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T68 540-545 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T69 595-599 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T70 1129-1134 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T71 1173-1176 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T72 1387-1398 Body_part denotes Oral mucosa http://purl.org/sig/ont/fma/fma59660
T73 1392-1398 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T74 1643-1651 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T75 1713-1721 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T76 1900-1908 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T77 2119-2126 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T78 2214-2217 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T79 2219-2242 Body_part denotes low-density lipoprotein http://purl.org/sig/ont/fma/fma63170
T80 2246-2251 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T81 2520-2525 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T36 246-251 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T37 382-387 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T38 430-453 Body_part denotes Upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T39 436-453 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T40 540-545 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T41 595-599 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T42 1129-1134 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T43 1392-1398 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T44 2246-2251 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T45 236-265 Phenotype denotes increased serum triglycerides http://purl.obolibrary.org/obo/HP_0002155
T46 320-329 Phenotype denotes Diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T47 413-419 Phenotype denotes Nausea http://purl.obolibrary.org/obo/HP_0002018
T48 430-463 Phenotype denotes Upper respiratory tract infection http://purl.obolibrary.org/obo/HP_0002788
T49 472-486 Phenotype denotes Abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T50 497-505 Phenotype denotes Vomiting http://purl.obolibrary.org/obo/HP_0002013
T51 515-522 Phenotype denotes Fatigue http://purl.obolibrary.org/obo/HP_0012378
T52 577-585 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T53 595-604 Phenotype denotes Skin rash http://purl.obolibrary.org/obo/HP_0000988
T54 613-624 Phenotype denotes Neutropenia http://purl.obolibrary.org/obo/HP_0001875
T55 645-652 Phenotype denotes Anxiety http://purl.obolibrary.org/obo/HP_0000739
T56 660-668 Phenotype denotes Insomnia http://purl.obolibrary.org/obo/HP_0100785
T57 708-719 Phenotype denotes Retinopathy http://purl.obolibrary.org/obo/HP_0000488
T58 828-842 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T59 844-853 Phenotype denotes diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T60 855-871 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T61 873-888 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T62 890-900 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T63 902-918 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T64 953-966 Phenotype denotes acute hepatic http://purl.obolibrary.org/obo/HP_0200119
T65 975-983 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T66 985-997 Phenotype denotes bronchospasm http://purl.obolibrary.org/obo/HP_0025428
T67 1008-1029 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T68 1163-1188 Phenotype denotes Increased LDL cholesterol http://purl.obolibrary.org/obo/HP_0003141
T69 1233-1244 Phenotype denotes Neutropenia http://purl.obolibrary.org/obo/HP_0001875
T70 1285-1293 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T71 1303-1315 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T72 1325-1334 Phenotype denotes Dizziness http://purl.obolibrary.org/obo/HP_0002321
T73 1342-1356 Phenotype denotes Hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T74 1365-1379 Phenotype denotes Abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T75 1402-1416 Phenotype denotes gastric ulcers http://purl.obolibrary.org/obo/HP_0002592
T76 1757-1765 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T77 1770-1778 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T78 1790-1800 Phenotype denotes Arthralgia http://purl.obolibrary.org/obo/HP_0002829
T79 1812-1817 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T80 1861-1873 Phenotype denotes eosinophilia http://purl.obolibrary.org/obo/HP_0001880
T81 1875-1885 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T82 1924-1930 Phenotype denotes Nausea http://purl.obolibrary.org/obo/HP_0002018
T83 1935-1944 Phenotype denotes diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T84 2484-2494 Phenotype denotes cellulitis http://purl.obolibrary.org/obo/HP_0100658
T85 2496-2505 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T209 150-158 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T210 320-329 Disease denotes Diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T211 436-463 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T212 454-463 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T213 595-604 Disease denotes Skin rash http://purl.obolibrary.org/obo/MONDO_0006547
T214 613-624 Disease denotes Neutropenia http://purl.obolibrary.org/obo/MONDO_0001475
T215 645-652 Disease denotes Anxiety http://purl.obolibrary.org/obo/MONDO_0005618|http://purl.obolibrary.org/obo/MONDO_0011918
T217 660-668 Disease denotes Insomnia http://purl.obolibrary.org/obo/MONDO_0013600
T218 708-719 Disease denotes Retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T219 802-826 Disease denotes Stevens-Johnson syndrome http://purl.obolibrary.org/obo/MONDO_0018229
T220 810-826 Disease denotes Johnson syndrome http://purl.obolibrary.org/obo/MONDO_0019419
T221 844-853 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T222 873-888 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T223 890-900 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T224 902-918 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T225 975-983 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T226 985-997 Disease denotes bronchospasm http://purl.obolibrary.org/obo/MONDO_0001358
T227 1233-1244 Disease denotes Neutropenia http://purl.obolibrary.org/obo/MONDO_0001475
T228 1303-1315 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T229 1342-1356 Disease denotes Hypothyroidism http://purl.obolibrary.org/obo/MONDO_0005420
T230 1402-1416 Disease denotes gastric ulcers http://purl.obolibrary.org/obo/MONDO_0001126
T231 1410-1416 Disease denotes ulcers http://purl.obolibrary.org/obo/MONDO_0043839
T232 1442-1454 Disease denotes Pneumocystis http://purl.obolibrary.org/obo/MONDO_0019121
T233 1470-1482 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T234 1487-1496 Disease denotes varicella http://purl.obolibrary.org/obo/MONDO_0005700
T235 1497-1503 Disease denotes zoster http://purl.obolibrary.org/obo/MONDO_0005609
T236 1861-1873 Disease denotes eosinophilia http://purl.obolibrary.org/obo/MONDO_0015691
T237 1875-1885 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T238 1935-1944 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T239 2051-2059 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T240 2178-2186 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T241 2188-2212 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T242 2464-2474 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T243 2484-2494 Disease denotes cellulitis http://purl.obolibrary.org/obo/MONDO_0005230
T244 2496-2505 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T245 2526-2536 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T238 107-112 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T239 399-402 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3/4
T240 406-408 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T241 490-492 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T242 507-510 http://purl.obolibrary.org/obo/CLO_0050509 denotes 2–7
T243 595-599 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T244 595-599 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T245 595-599 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T246 595-599 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T247 595-599 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T248 632-635 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3/4
T249 744-745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 946-951 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T251 1141-1143 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T252 1156-1158 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T253 1255-1258 http://purl.obolibrary.org/obo/CLO_0050509 denotes 2–7
T254 1392-1398 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T255 1563-1566 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 1636-1638 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T257 1984-1989 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T258 2244-2245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T259 2385-2386 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T260 2511-2515 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T261 2520-2525 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T262 2520-2525 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T525 60-83 Chemical denotes anti-inflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35472
T526 78-83 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T527 107-112 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T528 188-197 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T529 198-207 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T530 252-265 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T531 288-296 Chemical denotes glutamyl http://purl.obolibrary.org/obo/CHEBI_32483
T532 675-686 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T533 687-705 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T534 1092-1104 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T535 1150-1153 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T536 1173-1188 Chemical denotes LDL cholesterol http://purl.obolibrary.org/obo/CHEBI_47774
T537 1173-1176 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T538 1177-1188 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T539 1529-1540 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T540 1984-1989 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T541 1990-1995 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T542 2119-2126 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T543 2145-2148 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T544 2150-2159 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T547 2214-2217 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T548 2219-2242 Chemical denotes low-density lipoprotein http://purl.obolibrary.org/obo/CHEBI_39026
T549 2231-2242 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T312 0-167 Sentence denotes Table 3 Known adverse events of marketed anti-infective and anti-inflammatory drugs mostly provided as off-label treatments in the first phase of the COVID-19 pandemic
T313 168-187 Sentence denotes Drug Adverse events
T314 188-273 Sentence denotes Lopinavir/ritonavir • Hypercholesterolaemia and increased serum triglycerides (3–39%)
T315 274-317 Sentence denotes • Increased γ-glutamyl transferase (10–29%)
T316 318-369 Sentence denotes • Diarrhoea (7–28%; greater with once-daily dosing)
T317 370-403 Sentence denotes • Increased serum ALT (grade 3/4:
T318 404-410 Sentence denotes 1–11%)
T319 411-427 Sentence denotes • Nausea (5–16%)
T320 428-469 Sentence denotes • Upper respiratory tract infection (14%)
T321 470-494 Sentence denotes • Abdominal pain (1–11%)
T322 495-512 Sentence denotes • Vomiting (2–7%)
T323 513-527 Sentence denotes • Fatigue (8%)
T324 528-574 Sentence denotes • Increased serum amylase and/or lipase (3–8%)
T325 575-592 Sentence denotes • Headache (2–6%)
T326 593-610 Sentence denotes • Skin rash (≤5%)
T327 611-636 Sentence denotes • Neutropenia (grade 3/4:
T328 637-642 Sentence denotes 1–5%)
T329 643-657 Sentence denotes • Anxiety (4%)
T330 658-674 Sentence denotes • Insomnia (≤4%)
T331 675-745 Sentence denotes Chloroquine/hydroxychloroquine • Retinopathy (4% of treated patients)a
T332 746-997 Sentence denotes • Other adverse effects with unknown frequency included Stevens-Johnson syndrome, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, leukopenia, thrombocytopenia, abnormal hepatic function tests, acute hepatic ailure, myopathy, bronchospasm
T333 998-1104 Sentence denotes • Risk of prolonged QT interval, further increased when administered with fluoroquinolones or azithromycin
T334 1105-1160 Sentence denotes Tocilizumab • Increased serum ALT (≤36%) and AST (≤22%)
T335 1161-1196 Sentence denotes • Increased LDL cholesterol (9–10%)
T336 1197-1230 Sentence denotes • Injection site reaction (4–10%)
T337 1231-1254 Sentence denotes • Neutropenia (grade 3:
T338 1255-1282 Sentence denotes 2–7% of all adult patients)
T339 1283-1300 Sentence denotes • Headache (1–7%)
T340 1301-1322 Sentence denotes • Hypertension (1–6%)
T341 1323-1339 Sentence denotes • Dizziness (3%)
T342 1340-1362 Sentence denotes • Hypothyroidism (<2%)
T343 1363-1384 Sentence denotes • Abdominal pain (2%)
T344 1385-1421 Sentence denotes • Oral mucosa or gastric ulcers (2%)
T345 1422-1595 Sentence denotes • Infections due to Pneumocystis, Mycobacterium tuberculosis and varicella zoster have been reported after tocilizumab, but their prevalence has not been clearly established
T346 1596-1640 Sentence denotes Anakinra • Injection site reactionb (24–71%)
T347 1641-1754 Sentence denotes • Antibody development (up to 50% of the patients but no correlation of antibody development and adverse effects)
T348 1755-1787 Sentence denotes • Headache and vomiting (12–14%)
T349 1788-1809 Sentence denotes • Arthralgia (10–12%)
T350 1810-1826 Sentence denotes • Fever (10–12%)
T351 1827-1921 Sentence denotes • Haematologic disorder including eosinophilia, leukopenia and change in platelet count (2–9%)
T352 1922-1951 Sentence denotes • Nausea and diarrhoea (7–8%)
T353 1952-1979 Sentence denotes • Serious infectionc (2–3%)
T354 1980-2113 Sentence denotes Off-label drugs mostly provided in Italy during the first phase of the COVID-19 pandemic according to the authors' direct experience.
T355 2114-2243 Sentence denotes ALT, alanine aminotransferase; AST, aspartate aminotransferase; COVID-19, coronavirus disease 2019; LDL, low-density lipoprotein.
T356 2244-2384 Sentence denotes a Serum concentration dependent adverse effect; early changes are generally reversible but may progress despite discontinuation if advanced.
T357 2385-2453 Sentence denotes b Injection site reactions were considered serious in 2–3% of cases.
T358 2454-2537 Sentence denotes c Serious infections included cellulitis, pneumonia, and bone and joint infections.