PMC:7195088 / 39138-39977 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"1148","span":{"begin":47,"end":55},"obj":"Species"},{"id":"1149","span":{"begin":357,"end":364},"obj":"Species"},{"id":"1150","span":{"begin":625,"end":633},"obj":"Species"},{"id":"1151","span":{"begin":14,"end":20},"obj":"Chemical"},{"id":"1152","span":{"begin":343,"end":348},"obj":"Chemical"},{"id":"1153","span":{"begin":399,"end":405},"obj":"Chemical"},{"id":"1154","span":{"begin":61,"end":88},"obj":"Disease"},{"id":"1155","span":{"begin":639,"end":647},"obj":"Disease"}],"attributes":[{"id":"A1148","pred":"tao:has_database_id","subj":"1148","obj":"Tax:9606"},{"id":"A1149","pred":"tao:has_database_id","subj":"1149","obj":"Tax:9606"},{"id":"A1150","pred":"tao:has_database_id","subj":"1150","obj":"Tax:9606"},{"id":"A1151","pred":"tao:has_database_id","subj":"1151","obj":"MESH:D010100"},{"id":"A1152","pred":"tao:has_database_id","subj":"1152","obj":"MESH:D014867"},{"id":"A1153","pred":"tao:has_database_id","subj":"1153","obj":"MESH:D010100"},{"id":"A1154","pred":"tao:has_database_id","subj":"1154","obj":"MESH:D012131"},{"id":"A1155","pred":"tao:has_database_id","subj":"1155","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T44","span":{"begin":69,"end":88},"obj":"Phenotype"}],"attributes":[{"id":"A44","pred":"hp_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/HP_0002878"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T203","span":{"begin":69,"end":88},"obj":"Disease"},{"id":"T204","span":{"begin":639,"end":647},"obj":"Disease"}],"attributes":[{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T221","span":{"begin":308,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T222","span":{"begin":665,"end":666},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T499","span":{"begin":14,"end":20},"obj":"Chemical"},{"id":"T500","span":{"begin":310,"end":314},"obj":"Chemical"},{"id":"T502","span":{"begin":343,"end":348},"obj":"Chemical"},{"id":"T503","span":{"begin":399,"end":405},"obj":"Chemical"}],"attributes":[{"id":"A499","pred":"chebi_id","subj":"T499","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"},{"id":"A500","pred":"chebi_id","subj":"T500","obj":"http://purl.obolibrary.org/obo/CHEBI_53359"},{"id":"A501","pred":"chebi_id","subj":"T500","obj":"http://purl.obolibrary.org/obo/CHEBI_60683"},{"id":"A502","pred":"chebi_id","subj":"T502","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A503","pred":"chebi_id","subj":"T503","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}

{"project":"LitCovid-sentences","denotations":[{"id":"T298","span":{"begin":0,"end":196},"obj":"Sentence"},{"id":"T299","span":{"begin":197,"end":501},"obj":"Sentence"},{"id":"T300","span":{"begin":502,"end":584},"obj":"Sentence"},{"id":"T301","span":{"begin":585,"end":839},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%. Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion). However, no clear indications/criteria can be provided pending further experience. Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed."}