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PMC:7195088 / 1811-75015 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
30 13-60 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
31 62-72 Species denotes SARS-CoV-2 Tax:2697049
32 635-643 Species denotes patients Tax:9606
33 100-124 Disease denotes coronavirus disease 2019 MESH:C000657245
34 126-134 Disease denotes COVID-19 MESH:C000657245
35 314-333 Disease denotes respiratory failure MESH:D012131
39 1041-1049 Species denotes patients Tax:9606
40 1072-1078 Chemical denotes oxygen MESH:D010100
41 1276-1284 Disease denotes COVID-19 MESH:C000657245
44 1654-1662 Species denotes patients Tax:9606
45 1645-1653 Disease denotes COVID-19 MESH:C000657245
152 3134-3142 Species denotes patients Tax:9606
153 3442-3449 Species denotes patient Tax:9606
154 3710-3718 Species denotes patients Tax:9606
155 4080-4088 Species denotes patients Tax:9606
156 4330-4338 Species denotes patients Tax:9606
157 4913-4921 Species denotes patients Tax:9606
158 5115-5125 Species denotes SARS-CoV-2 Tax:2697049
159 5841-5849 Species denotes patients Tax:9606
160 6064-6072 Species denotes patients Tax:9606
161 6233-6241 Species denotes patients Tax:9606
162 6557-6565 Species denotes patients Tax:9606
163 6715-6723 Species denotes patients Tax:9606
164 7216-7224 Species denotes patients Tax:9606
165 7370-7378 Species denotes patients Tax:9606
166 7384-7394 Species denotes SARS-Cov-2 Tax:2697049
167 7575-7583 Species denotes patients Tax:9606
168 7691-7699 Species denotes patients Tax:9606
169 8066-8074 Species denotes patients Tax:9606
170 8245-8253 Species denotes patients Tax:9606
171 8432-8440 Species denotes patients Tax:9606
172 8781-8789 Species denotes patients Tax:9606
173 9460-9468 Species denotes patients Tax:9606
174 9842-9849 Species denotes patient Tax:9606
175 10096-10104 Species denotes patients Tax:9606
176 10230-10238 Species denotes patients Tax:9606
177 10349-10357 Species denotes patients Tax:9606
178 10359-10367 Species denotes patients Tax:9606
179 10516-10524 Species denotes patients Tax:9606
180 10698-10706 Species denotes patients Tax:9606
181 10927-10935 Species denotes patients Tax:9606
182 11253-11261 Species denotes patients Tax:9606
183 11820-11827 Species denotes patient Tax:9606
184 4740-4749 Species denotes influenza Tax:11520
185 10266-10275 Species denotes influenza Tax:11520
186 3006-3012 Chemical denotes oxygen MESH:D010100
187 3101-3107 Chemical denotes oxygen MESH:D010100
188 3428-3433 Chemical denotes water MESH:D014867
189 3484-3490 Chemical denotes oxygen MESH:D010100
190 4060-4067 Chemical denotes LPV/RTV MESH:C558899
191 4168-4177 Chemical denotes darunavir MESH:D000069454
192 4278-4288 Chemical denotes remdesivir MESH:C000606551
193 4498-4509 Chemical denotes favipiravir MESH:C462182
194 4514-4524 Chemical denotes umifenovir MESH:C086979
195 4643-4654 Chemical denotes Oseltamivir MESH:D053139
196 4658-4667 Chemical denotes zanamivir MESH:D053243
197 4770-4800 Chemical denotes chloroquine/hydroxychloroquine
198 4853-4871 Chemical denotes hydroxychloroquine MESH:D006886
199 5470-5488 Chemical denotes hydroxychloroquine MESH:D006886
200 5768-5786 Chemical denotes hydroxychloroquine MESH:D006886
201 7072-7080 Chemical denotes steroids MESH:D013256
202 7935-7942 Chemical denotes steroid MESH:D013256
203 8012-8019 Chemical denotes steroid MESH:D013256
204 8230-8241 Chemical denotes tocilizumab MESH:C502936
205 8712-8723 Chemical denotes tocilizumab MESH:C502936
206 9768-9774 Chemical denotes oxygen MESH:D010100
207 10204-10215 Chemical denotes oseltamivir MESH:D053139
208 10634-10652 Chemical denotes hydroxychloroquine MESH:D006886
209 10869-10887 Chemical denotes hydroxychloroquine MESH:D006886
210 10989-11019 Chemical denotes Chloroquine/hydroxychloroquine
211 11442-11452 Chemical denotes remdesivir MESH:C000606551
212 11904-11911 Chemical denotes steroid MESH:D013256
213 3148-3175 Disease denotes hypoxic respiratory failure MESH:D012131
214 3724-3732 Disease denotes COVID-19 MESH:C000657245
215 4071-4079 Disease denotes COVID-19 MESH:C000657245
216 4321-4329 Disease denotes COVID-19 MESH:C000657245
217 4927-4935 Disease denotes COVID-19 MESH:C000657245
218 5051-5066 Disease denotes QT prolongation MESH:D008133
219 5440-5449 Disease denotes mortality MESH:D003643
220 6049-6063 Disease denotes critically ill MESH:D016638
221 6078-6087 Disease denotes pneumonia MESH:D011014
222 6095-6103 Disease denotes COVID-19 MESH:C000657245
223 6112-6131 Disease denotes bacterial infection MESH:D001424
224 6204-6215 Disease denotes coinfection MESH:D060085
225 6247-6262 Disease denotes viral pneumonia
226 6379-6388 Disease denotes mortality MESH:D003643
227 6548-6556 Disease denotes COVID-19 MESH:C000657245
228 6706-6714 Disease denotes COVID-19 MESH:C000657245
229 6786-6795 Disease denotes pneumonia MESH:D011014
230 6815-6824 Disease denotes pneumonia MESH:D011014
231 7230-7250 Disease denotes SARS-CoV-2 infection MESH:C000657245
232 7435-7447 Disease denotes inflammation MESH:D007249
233 7469-7480 Disease denotes lung injury MESH:D055370
234 7526-7535 Disease denotes pneumonia MESH:D011014
235 7566-7574 Disease denotes COVID-19 MESH:C000657245
236 7667-7681 Disease denotes critically ill MESH:D016638
237 7682-7690 Disease denotes COVID-19 MESH:C000657245
238 7705-7709 Disease denotes ARDS MESH:D012128
239 7735-7759 Disease denotes ARDS respiratory failure MESH:D012131
240 8038-8056 Disease denotes non–critically ill MESH:D016638
241 8057-8065 Disease denotes COVID-19 MESH:C000657245
242 8259-8267 Disease denotes COVID-19 MESH:C000657245
243 8423-8431 Disease denotes COVID-19 MESH:C000657245
244 8639-8649 Disease denotes infections MESH:D007239
245 8753-8761 Disease denotes COVID-19 MESH:C000657245
246 9605-9613 Disease denotes COVID-19 MESH:C000657245
247 9911-9919 Disease denotes asthenia MESH:D001247
248 9926-9931 Disease denotes fever MESH:D005334
249 9944-9949 Disease denotes cough MESH:D003371
250 10110-10130 Disease denotes SARS-CoV-2 infection MESH:C000657245
251 10373-10377 Disease denotes ARDS MESH:D012128
252 10403-10427 Disease denotes ARDS respiratory failure MESH:D012131
253 10507-10515 Disease denotes COVID-19 MESH:C000657245
254 10689-10697 Disease denotes COVID-19 MESH:C000657245
255 10857-10865 Disease denotes toxicity MESH:D064420
256 11244-11252 Disease denotes COVID-19 MESH:C000657245
257 11373-11414 Disease denotes QT prolongation or hepatic/renal toxicity MESH:D056486
265 12367-12377 Species denotes SARS-CoV-2 Tax:2697049
266 12379-12426 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
267 12263-12270 Chemical denotes LPV/RTV MESH:C558899
268 12272-12291 Chemical denotes lopinavir/ritonavir MESH:C558899
269 12084-12088 Disease denotes ARDS MESH:D012128
270 12090-12125 Disease denotes acute respiratory distress syndrome MESH:D012128
271 12137-12161 Disease denotes coronavirus disease 2019 MESH:C000657245
643 12870-12876 Gene denotes CYP3A4 Gene:1576
644 20742-20748 Gene denotes CYP3A4 Gene:1576
653 12975-12983 Species denotes patients Tax:9606
654 13015-13023 Species denotes patients Tax:9606
655 13893-13901 Species denotes patients Tax:9606
656 14083-14091 Species denotes patients Tax:9606
657 14427-14435 Species denotes patients Tax:9606
658 14672-14680 Species denotes patients Tax:9606
659 14921-14929 Species denotes patients Tax:9606
660 15626-15634 Species denotes patients Tax:9606
661 16052-16060 Species denotes patients Tax:9606
662 16334-16342 Species denotes patients Tax:9606
663 16626-16634 Species denotes patients Tax:9606
664 16942-16950 Species denotes patients Tax:9606
665 17210-17218 Species denotes patients Tax:9606
666 17519-17527 Species denotes patients Tax:9606
667 17945-17953 Species denotes patients Tax:9606
668 18310-18318 Species denotes patients Tax:9606
669 18551-18559 Species denotes patients Tax:9606
670 18824-18832 Species denotes patients Tax:9606
671 18935-18945 Species denotes SARS-CoV-2 Tax:2697049
672 19151-19159 Species denotes patients Tax:9606
673 19358-19366 Species denotes patients Tax:9606
674 19574-19582 Species denotes patients Tax:9606
675 19812-19820 Species denotes patients Tax:9606
676 19976-19984 Species denotes patients Tax:9606
677 20208-20216 Species denotes patients Tax:9606
678 20508-20516 Species denotes patients Tax:9606
679 20873-20881 Species denotes patients Tax:9606
680 21206-21214 Species denotes patients Tax:9606
681 21257-21265 Species denotes patients Tax:9606
682 21339-21347 Species denotes patients Tax:9606
683 62497-62505 Species denotes patients Tax:9606
728 12788-12807 Chemical denotes Lopinavir/ritonavir MESH:C558899
729 12808-12817 Chemical denotes Lopinavir MESH:D061466
730 12855-12864 Chemical denotes Ritonavir MESH:D019438
731 12899-12908 Chemical denotes lopinavir MESH:D061466
732 12951-12970 Chemical denotes lopinavir/ritonavir MESH:C558899
733 13048-13067 Chemical denotes Lopinavir/ritonavir MESH:C558899
734 13619-13638 Chemical denotes lopinavir/ritonavir MESH:C558899
735 13847-13866 Chemical denotes lopinavir/ritonavir MESH:C558899
736 13871-13889 Chemical denotes hydroxychloroquine MESH:D006886
737 14040-14045 Chemical denotes ASC09
738 14046-14055 Chemical denotes ritonavir MESH:D019438
739 14060-14079 Chemical denotes lopinavir/ritonavir MESH:C558899
740 14256-14262 Chemical denotes oxygen MESH:D010100
741 14285-14289 Chemical denotes FiO2
742 14364-14383 Chemical denotes lopinavir/ritonavir MESH:C558899
743 14388-14407 Chemical denotes lopinavir/ritonavir MESH:C558899
744 14413-14423 Chemical denotes umifenovir MESH:C086979
745 14586-14605 Chemical denotes lopinavir/ritonavir MESH:C558899
746 14610-14629 Chemical denotes lopinavir/ritonavir MESH:C558899
747 14635-14644 Chemical denotes ribavirin MESH:D012254
748 14867-14886 Chemical denotes lopinavir/ritonavir MESH:C558899
749 14891-14902 Chemical denotes oseltamivir MESH:D053139
750 14907-14917 Chemical denotes umifenovir MESH:C086979
751 15321-15340 Chemical denotes lopinavir/ritonavir MESH:C558899
752 15559-15569 Chemical denotes carrimycin
753 15574-15593 Chemical denotes lopinavir/ritonavir MESH:C558899
754 15597-15607 Chemical denotes umifenovir MESH:C086979
755 15611-15622 Chemical denotes chloroquine MESH:D002738
756 15909-15928 Chemical denotes lopinavir/ritonavir MESH:C558899
757 15933-15952 Chemical denotes lopinavir/ritonavir MESH:C558899
758 16204-16223 Chemical denotes lopinavir/ritonavir MESH:C558899
759 16257-16276 Chemical denotes lopinavir/ritonavir MESH:C558899
760 16311-16320 Chemical denotes xiyanping
761 16486-16505 Chemical denotes lopinavir/ritonavir MESH:C558899
762 16539-16558 Chemical denotes lopinavir/ritonavir MESH:C558899
763 16786-16805 Chemical denotes lopinavir/ritonavir MESH:C558899
764 16811-16829 Chemical denotes hydroxychloroquine MESH:D006886
765 16834-16853 Chemical denotes lopinavir/ritonavir MESH:C558899
766 16859-16877 Chemical denotes hydroxychloroquine MESH:D006886
767 16883-16893 Chemical denotes levamisole MESH:D007978
768 16904-16914 Chemical denotes budesonide MESH:D019819
769 16920-16930 Chemical denotes formoterol MESH:D000068759
770 17138-17157 Chemical denotes lopinavir/ritonavir MESH:C558899
771 17162-17180 Chemical denotes hydroxychloroquine MESH:D006886
772 17185-17193 Chemical denotes losartan MESH:D019808
773 17389-17408 Chemical denotes lopinavir/ritonavir MESH:C558899
774 17413-17431 Chemical denotes hydroxychloroquine MESH:D006886
775 17436-17455 Chemical denotes lopinavir/ritonavir MESH:C558899
776 17484-17494 Chemical denotes remdesivir MESH:C000606551
777 17685-17704 Chemical denotes lopinavir/ritonavir MESH:C558899
778 17708-17718 Chemical denotes umifenovir MESH:C086979
779 17722-17733 Chemical denotes chloroquine MESH:D002738
780 17737-17755 Chemical denotes hydroxychloroquine MESH:D006886
781 17759-17770 Chemical denotes oseltamivir MESH:D053139
782 17788-17800 Chemical denotes azithromycin MESH:D017963
783 17825-17844 Chemical denotes lopinavir/ritonavir MESH:C558899
784 17848-17858 Chemical denotes umifenovir MESH:C086979
785 17862-17873 Chemical denotes chloroquine MESH:D002738
786 17877-17895 Chemical denotes hydroxychloroquine MESH:D006886
787 17899-17910 Chemical denotes oseltamivir MESH:D053139
788 17928-17940 Chemical denotes azithromycin MESH:D017963
789 18231-18241 Chemical denotes colchicine MESH:D003078
790 18259-18278 Chemical denotes lopinavir/ritonavir MESH:C558899
791 18528-18547 Chemical denotes lopinavir/ritonavir MESH:C558899
792 18586-18605 Chemical denotes lopinavir/ritonavir MESH:C558899
793 18685-18704 Chemical denotes lopinavir/ritonavir MESH:C558899
794 18985-18995 Chemical denotes Remdesivir MESH:C000606551
795 18996-19005 Chemical denotes Adenosine MESH:D000241
796 19125-19135 Chemical denotes remdesivir MESH:C000606551
797 19332-19342 Chemical denotes remdesivir MESH:C000606551
798 19533-19543 Chemical denotes remdesivir MESH:C000606551
799 19702-19708 Chemical denotes oxygen MESH:D010100
800 19771-19781 Chemical denotes remdesivir MESH:C000606551
801 19950-19960 Chemical denotes remdesivir MESH:C000606551
802 20132-20142 Chemical denotes remdesivir MESH:C000606551
803 20147-20165 Chemical denotes hydroxychloroquine MESH:D006886
804 20170-20180 Chemical denotes remdesivir MESH:C000606551
805 20186-20204 Chemical denotes hydroxychloroquine MESH:D006886
806 20378-20397 Chemical denotes lopinavir/ritonavir MESH:C558899
807 20402-20420 Chemical denotes hydroxychloroquine MESH:D006886
808 20425-20444 Chemical denotes lopinavir/ritonavir MESH:C558899
809 20473-20483 Chemical denotes remdesivir MESH:C000606551
810 20658-20667 Chemical denotes Darunavir MESH:D000069454
811 20668-20688 Chemical denotes cobicistat Darunavir
812 20771-20780 Chemical denotes darunavir MESH:D000069454
813 21064-21075 Chemical denotes Favipiravir MESH:C462182
814 21228-21239 Chemical denotes favipiravir MESH:C462182
815 21276-21286 Chemical denotes umifenovir MESH:C086979
816 21358-21369 Chemical denotes favipiravir MESH:C462182
822 67580-67598 Chemical denotes hydroxychloroquine MESH:D006886
905 12711-12719 Disease denotes COVID-19 MESH:C000657245
906 13029-13037 Disease denotes COVID-19 MESH:C000657245
907 13463-13472 Disease denotes mortality MESH:D003643
908 13912-13920 Disease denotes COVID-19 MESH:C000657245
909 14107-14115 Disease denotes COVID-19 MESH:C000657245
910 14441-14449 Disease denotes COVID-19 MESH:C000657245
911 14686-14694 Disease denotes COVID-19 MESH:C000657245
912 14945-14963 Disease denotes COVID-19 pneumonia MESH:C000657245
913 15071-15076 Disease denotes fever MESH:D005334
914 15078-15083 Disease denotes cough MESH:D003371
915 15151-15156 Disease denotes fever MESH:D005334
916 15158-15163 Disease denotes cough MESH:D003371
917 15386-15394 Disease denotes COVID-19 MESH:C000657245
918 15510-15518 Disease denotes COVID-19 MESH:C000657245
919 15640-15658 Disease denotes COVID-19 pneumonia MESH:C000657245
920 15733-15738 Disease denotes fever MESH:D005334
921 15779-15801 Disease denotes pulmonary inflammation MESH:D011014
922 16066-16074 Disease denotes COVID-19 MESH:C000657245
923 16348-16356 Disease denotes COVID-19 MESH:C000657245
924 16640-16648 Disease denotes COVID-19 MESH:C000657245
925 16966-16984 Disease denotes COVID-19 pneumonia MESH:C000657245
926 17224-17232 Disease denotes COVID-19 MESH:C000657245
927 17320-17328 Disease denotes COVID-19 MESH:C000657245
928 17533-17541 Disease denotes COVID-19 MESH:C000657245
929 17959-17967 Disease denotes COVID-19 MESH:C000657245
930 18086-18091 Disease denotes fever MESH:D005334
931 18161-18178 Disease denotes lung inflammation MESH:D011014
932 18343-18351 Disease denotes COVID-19 MESH:C000657245
933 18431-18440 Disease denotes mortality MESH:D003643
934 18570-18578 Disease denotes COVID-19 MESH:C000657245
935 18777-18808 Disease denotes ritonavir plus favipiravir plus MESH:D007625
936 18857-18865 Disease denotes COVID-19 MESH:C000657245
937 19172-19180 Disease denotes COVID-19 MESH:C000657245
938 19389-19397 Disease denotes COVID-19 MESH:C000657245
939 19595-19603 Disease denotes COVID-19 MESH:C000657245
940 19678-19683 Disease denotes fever MESH:D005334
941 19835-19843 Disease denotes COVID-19 MESH:C000657245
942 19990-19998 Disease denotes COVID-19 MESH:C000657245
943 20222-20230 Disease denotes COVID-19 MESH:C000657245
944 20331-20340 Disease denotes mortality MESH:D003643
945 20522-20530 Disease denotes COVID-19 MESH:C000657245
946 20887-20905 Disease denotes COVID-19 pneumonia MESH:C000657245
947 21197-21205 Disease denotes COVID-19 MESH:C000657245
948 21248-21256 Disease denotes COVID-19 MESH:C000657245
950 62511-62519 Disease denotes COVID-19 MESH:C000657245
1015 12618-12626 Disease denotes COVID-19 MESH:C000657245
1022 32733-32741 Species denotes patients Tax:9606
1023 32797-32808 Chemical denotes ruxolitinib MESH:C540383
1024 32810-32821 Chemical denotes baricitinib MESH:C000596027
1025 32826-32837 Chemical denotes tofacitinib MESH:C479163
1026 32593-32601 Disease denotes COVID-19 MESH:C000657245
1027 32747-32755 Disease denotes COVID-19 MESH:C000657245
1035 33031-33035 Gene denotes IL-1 Gene:3552
1036 33037-33050 Gene denotes interleukin 1 Gene:3552
1037 33267-33277 Species denotes SARS-CoV-2 Tax:2697049
1038 33279-33326 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
1039 32840-32844 Disease denotes ARDS MESH:D012128
1040 32847-32882 Disease denotes acute respiratory distress syndrome MESH:D012128
1041 32919-32943 Disease denotes coronavirus disease 2019 MESH:C000657245
1047 2671-2679 Species denotes patients Tax:9606
1048 2044-2063 Disease denotes infectious diseases MESH:D003141
1049 2662-2670 Disease denotes COVID-19 MESH:C000657245
1050 2811-2819 Disease denotes COVID-19 MESH:C000657245
1051 2828-2864 Disease denotes cardiovascular/coagulative disorders MESH:D002318
1053 33392-33398 Chemical denotes oxygen MESH:D010100
1064 33726-33734 Species denotes patients Tax:9606
1065 33843-33851 Species denotes patients Tax:9606
1066 33661-33667 Chemical denotes oxygen MESH:D010100
1067 33502-33510 Disease denotes COVID-19 MESH:C000657245
1068 33533-33545 Disease denotes lung disease MESH:D008171
1069 33592-33601 Disease denotes pneumonia MESH:D011014
1070 33611-33638 Disease denotes hypoxic respiratory failure MESH:D012131
1071 33695-33722 Disease denotes hypoxic respiratory failure MESH:D012131
1072 33740-33748 Disease denotes COVID-19 MESH:C000657245
1073 33834-33842 Disease denotes COVID-19 MESH:C000657245
1080 34030-34038 Species denotes patients Tax:9606
1081 34260-34265 Species denotes women Tax:9606
1082 33991-33997 Chemical denotes oxygen MESH:D010100
1083 34173-34179 Chemical denotes oxygen MESH:D010100
1084 34275-34281 Chemical denotes oxygen MESH:D010100
1085 34044-34077 Disease denotes shortness of breath or hypoxaemia MESH:D004417
1113 34969-34977 Species denotes patients Tax:9606
1114 35738-35745 Species denotes patient Tax:9606
1115 36420-36428 Species denotes patients Tax:9606
1116 36604-36612 Species denotes patients Tax:9606
1117 36980-36988 Species denotes patients Tax:9606
1118 34365-34371 Chemical denotes oxygen MESH:D010100
1119 34458-34464 Chemical denotes oxygen MESH:D010100
1120 34514-34520 Chemical denotes oxygen MESH:D010100
1121 34597-34603 Chemical denotes oxygen MESH:D010100
1122 34698-34712 Chemical denotes carbon dioxide MESH:D002245
1123 34788-34794 Chemical denotes oxygen MESH:D010100
1124 35054-35060 Chemical denotes oxygen MESH:D010100
1125 35783-35789 Chemical denotes oxygen MESH:D010100
1126 35837-35843 Chemical denotes oxygen MESH:D010100
1127 35884-35890 Chemical denotes oxygen MESH:D010100
1128 36730-36735 Chemical denotes water MESH:D014867
1129 34983-34991 Disease denotes COVID-19 MESH:C000657245
1130 35373-35382 Disease denotes infection MESH:D007239
1131 36107-36126 Disease denotes respiratory failure MESH:D012131
1132 36275-36287 Disease denotes lung failure MESH:D012131
1133 36351-36359 Disease denotes COVID-19 MESH:C000657245
1134 36396-36410 Disease denotes critically ill MESH:D016638
1135 36411-36419 Disease denotes COVID-19 MESH:C000657245
1136 36589-36600 Disease denotes lung injury MESH:D055370
1137 36618-36626 Disease denotes COVID-19 MESH:C000657245
1138 36994-37002 Disease denotes COVID-19 MESH:C000657245
1139 37229-37259 Disease denotes decreased respiratory distress MESH:D012128
1148 37374-37382 Species denotes patients Tax:9606
1149 37684-37691 Species denotes patient Tax:9606
1150 37952-37960 Species denotes patients Tax:9606
1151 37341-37347 Chemical denotes oxygen MESH:D010100
1152 37670-37675 Chemical denotes water MESH:D014867
1153 37726-37732 Chemical denotes oxygen MESH:D010100
1154 37388-37415 Disease denotes hypoxic respiratory failure MESH:D012131
1155 37966-37974 Disease denotes COVID-19 MESH:C000657245
1203 41786-41789 Gene denotes AST Gene:26503
1204 41371-41379 Species denotes patients Tax:9606
1205 41909-41917 Species denotes patients Tax:9606
1206 42092-42118 Species denotes Mycobacterium tuberculosis Tax:1773
1207 42318-42326 Species denotes patients Tax:9606
1208 40888-40901 Chemical denotes triglycerides MESH:D014280
1209 42165-42176 Chemical denotes tocilizumab MESH:C502936
1210 40834-40867 Disease denotes ritonavir • Hypercholesterolaemia MESH:C564286
1211 40956-40965 Disease denotes Diarrhoea MESH:D003967
1212 41049-41055 Disease denotes Nausea MESH:D009325
1213 41066-41099 Disease denotes Upper respiratory tract infection MESH:D012141
1214 41108-41122 Disease denotes Abdominal pain MESH:D015746
1215 41151-41158 Disease denotes Fatigue MESH:D005221
1216 41213-41221 Disease denotes Headache MESH:D006261
1217 41231-41240 Disease denotes Skin rash MESH:D005076
1218 41249-41260 Disease denotes Neutropenia MESH:D009503
1219 41281-41288 Disease denotes Anxiety MESH:D001007
1220 41296-41304 Disease denotes Insomnia MESH:D007319
1221 41344-41355 Disease denotes Retinopathy MESH:D012164
1222 41438-41462 Disease denotes Stevens-Johnson syndrome MESH:D013262
1223 41464-41478 Disease denotes abdominal pain MESH:D015746
1224 41480-41489 Disease denotes diarrhoea MESH:D003967
1225 41491-41497 Disease denotes nausea MESH:D009325
1226 41499-41507 Disease denotes vomiting MESH:D014839
1227 41509-41524 Disease denotes agranulocytosis MESH:D000380
1228 41526-41536 Disease denotes leukopenia MESH:D007970
1229 41538-41554 Disease denotes thrombocytopenia MESH:D013921
1230 41611-41619 Disease denotes myopathy MESH:D009135
1231 41621-41633 Disease denotes bronchospasm MESH:D001986
1232 41869-41880 Disease denotes Neutropenia MESH:D009503
1233 41921-41929 Disease denotes Headache MESH:D006261
1234 41939-41951 Disease denotes Hypertension MESH:D006973
1235 41961-41970 Disease denotes Dizziness MESH:D004244
1236 41978-41992 Disease denotes Hypothyroidism MESH:D007037
1237 42001-42015 Disease denotes Abdominal pain MESH:D015746
1238 42038-42052 Disease denotes gastric ulcers MESH:D013276
1239 42060-42070 Disease denotes Infections MESH:D007239
1240 42078-42090 Disease denotes Pneumocystis MESH:D011020
1241 42393-42401 Disease denotes Headache MESH:D006261
1242 42406-42414 Disease denotes vomiting MESH:D014839
1243 42426-42436 Disease denotes Arthralgia MESH:D018771
1244 42448-42453 Disease denotes Fever MESH:D005334
1245 42465-42486 Disease denotes Haematologic disorder MESH:D006402
1246 42497-42509 Disease denotes eosinophilia MESH:D004802
1247 42511-42521 Disease denotes leukopenia MESH:D007970
1248 42560-42566 Disease denotes Nausea MESH:D009325
1249 42571-42580 Disease denotes diarrhoea MESH:D003967
1251 40786-40794 Disease denotes COVID-19 MESH:C000657245
1253 42687-42695 Disease denotes COVID-19 MESH:C000657245
1257 42755-42779 Gene denotes alanine aminotransferase Gene:2875
1258 42781-42784 Gene denotes AST Gene:26503
1259 42824-42848 Disease denotes coronavirus disease 2019 MESH:C000657245
1264 43100-43110 Disease denotes infections MESH:D007239
1265 43120-43130 Disease denotes cellulitis MESH:D002481
1266 43132-43141 Disease denotes pneumonia MESH:D011014
1267 43147-43172 Disease denotes bone and joint infections MESH:D007239
1294 38290-38300 Species denotes SARS-CoV-2 Tax:2697049
1295 38310-38323 Species denotes coronaviruses Tax:11118
1296 38382-38393 Species denotes coronavirus Tax:11118
1297 38567-38575 Species denotes patients Tax:9606
1298 38689-38697 Species denotes SARS-CoV Tax:694009
1299 38741-38750 Species denotes MERS)-CoV Tax:1335626
1300 38909-38917 Species denotes patients Tax:9606
1301 39216-39224 Species denotes patients Tax:9606
1302 40247-40255 Species denotes patients Tax:9606
1303 40387-40395 Species denotes patients Tax:9606
1304 38503-38512 Chemical denotes Lopinavir MESH:D061466
1305 38610-38619 Chemical denotes ritonavir MESH:D019438
1306 38811-38830 Chemical denotes lopinavir/ritonavir MESH:C558899
1307 38832-38839 Chemical denotes LPV/RTV MESH:C558899
1308 39258-39265 Chemical denotes LPV/RTV MESH:C558899
1309 39640-39647 Chemical denotes LPV/RTV MESH:C558899
1310 39871-39878 Chemical denotes LPV/RTV MESH:C558899
1311 39965-39972 Chemical denotes LPV/RTV MESH:C558899
1312 40175-40182 Chemical denotes LPV/RTV MESH:C558899
1313 40500-40518 Chemical denotes hydroxychloroquine MESH:D006886
1314 38707-38739 Disease denotes Middle East respiratory syndrome MESH:D018352
1315 38900-38908 Disease denotes COVID-19 MESH:C000657245
1316 39195-39200 Disease denotes death MESH:D003643
1317 39570-39579 Disease denotes mortality MESH:D003643
1318 39610-39616 Disease denotes deaths MESH:D003643
1319 40238-40246 Disease denotes COVID-19 MESH:C000657245
1329 43263-43268 Species denotes Ebola Tax:1570291
1330 43307-43320 Species denotes coronaviruses Tax:11118
1331 43322-43332 Species denotes SARS-CoV-2 Tax:2697049
1332 43334-43342 Species denotes SARS-CoV Tax:694009
1333 43349-43357 Species denotes MERS-CoV Tax:1335626
1334 43494-43502 Species denotes patients Tax:9606
1335 43174-43184 Chemical denotes Remdesivir MESH:C000606551
1336 43632-43642 Chemical denotes remdesivir MESH:C000606551
1337 43485-43493 Disease denotes COVID-19 MESH:C000657245
1357 43796-43809 Gene denotes neuraminidase Gene:4758
1358 43906-43914 Species denotes patients Tax:9606
1359 44022-44030 Species denotes SARS-CoV Tax:694009
1360 44104-44112 Species denotes patients Tax:9606
1361 44339-44347 Species denotes patients Tax:9606
1362 43839-43848 Species denotes influenza Tax:11520
1363 44220-44229 Species denotes influenza Tax:11520
1364 44403-44412 Species denotes influenza Tax:11520
1365 43766-43777 Chemical denotes Oseltamivir MESH:D053139
1366 43782-43791 Chemical denotes zanamivir MESH:D053243
1367 43959-43970 Chemical denotes oseltamivir MESH:D053139
1368 43975-43984 Chemical denotes zanamivir MESH:D053243
1369 44136-44147 Chemical denotes oseltamivir MESH:D053139
1370 43897-43905 Disease denotes COVID-19 MESH:C000657245
1371 44089-44103 Disease denotes critically ill MESH:D016638
1372 44118-44126 Disease denotes COVID-19 MESH:C000657245
1373 44188-44197 Disease denotes infection MESH:D007239
1374 44202-44213 Disease denotes coinfection MESH:D060085
1375 44330-44338 Disease denotes COVID-19 MESH:C000657245
1395 44503-44511 Species denotes patients Tax:9606
1396 45083-45091 Species denotes patients Tax:9606
1397 45137-45145 Species denotes patients Tax:9606
1398 45219-45227 Species denotes patients Tax:9606
1399 45533-45543 Species denotes SARS-CoV-2 Tax:2697049
1400 44581-44590 Species denotes influenza Tax:11520
1401 44626-44635 Species denotes influenza Tax:11520
1402 45482-45490 Species denotes patients Tax:9606
1403 44605-44615 Chemical denotes umifenovir MESH:C086979
1404 44836-44847 Chemical denotes favipiravir MESH:C462182
1405 45105-45116 Chemical denotes favipiravir MESH:C462182
1406 45156-45166 Chemical denotes umifenovir MESH:C086979
1407 45238-45249 Chemical denotes favipiravir MESH:C462182
1408 44494-44502 Disease denotes COVID-19 MESH:C000657245
1409 45074-45082 Disease denotes COVID-19 MESH:C000657245
1410 45128-45136 Disease denotes COVID-19 MESH:C000657245
1411 45288-45297 Disease denotes mortality MESH:D003643
1412 45458-45472 Disease denotes critically ill MESH:D016638
1413 45473-45481 Disease denotes COVID-19 MESH:C000657245
1426 45781-45789 Species denotes patients Tax:9606
1427 46041-46049 Species denotes patients Tax:9606
1428 46448-46457 Species denotes influenza Tax:11520
1429 45761-45768 Chemical denotes LPV/RTV MESH:C558899
1430 45869-45878 Chemical denotes darunavir MESH:D000069454
1431 45979-45989 Chemical denotes remdesivir MESH:C000606551
1432 46209-46220 Chemical denotes favipiravir MESH:C462182
1433 46225-46235 Chemical denotes umifenovir MESH:C086979
1434 46351-46362 Chemical denotes Oseltamivir MESH:D053139
1435 46366-46375 Chemical denotes zanamivir MESH:D053243
1436 45772-45780 Disease denotes COVID-19 MESH:C000657245
1437 46032-46040 Disease denotes COVID-19 MESH:C000657245
1440 46479-46490 Chemical denotes chloroquine MESH:D002738
1441 46491-46509 Chemical denotes hydroxychloroquine MESH:D006886
1458 47115-47142 Gene denotes tumor necrosis factor alpha Gene:7124
1459 47144-47162 Gene denotes interleukin (IL)-6 Gene:3569
1460 46584-46592 Species denotes patients Tax:9606
1461 46824-46832 Species denotes SARS-CoV Tax:694009
1462 46839-46849 Species denotes SARS-CoV-2 Tax:2697049
1463 46955-46958 Species denotes CoV Tax:11118
1464 47372-47380 Species denotes patients Tax:9606
1465 47752-47762 Species denotes SARS-CoV-2 Tax:2697049
1466 46550-46561 Chemical denotes chloroquine MESH:D002738
1467 46742-46753 Chemical denotes chloroquine MESH:D002738
1468 47214-47225 Chemical denotes chloroquine MESH:D002738
1469 47562-47580 Chemical denotes hydroxychloroquine MESH:D006886
1470 47606-47617 Chemical denotes chloroquine MESH:D002738
1471 46575-46583 Disease denotes COVID-19 MESH:C000657245
1472 47352-47371 Disease denotes SARS-CoV-2–infected MESH:C000657245
1473 47668-47676 Disease denotes toxicity MESH:D064420
1480 47962-47970 Species denotes patients Tax:9606
1481 47925-47936 Chemical denotes chloroquine MESH:D002738
1482 47940-47958 Chemical denotes hydroxychloroquine MESH:D006886
1483 48363-48374 Chemical denotes chloroquine MESH:D002738
1484 48375-48393 Chemical denotes hydroxychloroquine MESH:D006886
1485 47976-47984 Disease denotes COVID-19 MESH:C000657245
1508 48621-48629 Species denotes patients Tax:9606
1509 48747-48755 Species denotes patients Tax:9606
1510 48845-48853 Species denotes patients Tax:9606
1511 48894-48902 Species denotes patients Tax:9606
1512 48963-48971 Species denotes patients Tax:9606
1513 49219-49227 Species denotes patients Tax:9606
1514 49692-49700 Species denotes patients Tax:9606
1515 49826-49834 Species denotes patients Tax:9606
1516 49971-49979 Species denotes patients Tax:9606
1517 48643-48661 Chemical denotes hydroxychloroquine MESH:D006886
1518 48777-48795 Chemical denotes hydroxychloroquine MESH:D006886
1519 48985-49003 Chemical denotes hydroxychloroquine MESH:D006886
1520 49018-49030 Chemical denotes azithromycin MESH:D017963
1521 49192-49210 Chemical denotes hydroxychloroquine MESH:D006886
1522 49483-49501 Chemical denotes hydroxychloroquine MESH:D006886
1523 49711-49729 Chemical denotes hydroxychloroquine MESH:D006886
1524 49735-49747 Chemical denotes azithromycin MESH:D017963
1525 49845-49857 Chemical denotes azithromycin MESH:D017963
1526 49873-49891 Chemical denotes hydroxychloroquine MESH:D006886
1527 48612-48620 Disease denotes COVID-19 MESH:C000657245
1528 48738-48746 Disease denotes COVID-19 MESH:C000657245
1529 50050-50065 Disease denotes QT prolongation MESH:D008133
1539 50221-50229 Species denotes patients Tax:9606
1540 50432-50442 Species denotes SARS-CoV-2 Tax:2697049
1541 51157-51165 Species denotes patients Tax:9606
1542 50161-50179 Chemical denotes hydroxychloroquine MESH:D006886
1543 50786-50804 Chemical denotes hydroxychloroquine MESH:D006886
1544 51084-51102 Chemical denotes hydroxychloroquine MESH:D006886
1545 50235-50243 Disease denotes COVID-19 MESH:C000657245
1546 50368-50383 Disease denotes QT prolongation MESH:D008133
1547 50756-50765 Disease denotes mortality MESH:D003643
1561 51430-51438 Species denotes patients Tax:9606
1562 51664-51672 Species denotes patients Tax:9606
1563 51899-51907 Species denotes patients Tax:9606
1564 51296-51306 Disease denotes infections MESH:D007239
1565 51339-51347 Disease denotes COVID-19 MESH:C000657245
1566 51472-51487 Disease denotes viral pneumonia
1567 51539-51550 Disease denotes coinfection MESH:D060085
1568 51640-51660 Disease denotes bacterial infections MESH:D001424
1569 51678-51686 Disease denotes COVID-19 MESH:C000657245
1570 51753-51763 Disease denotes infections MESH:D007239
1571 51890-51898 Disease denotes COVID-19 MESH:C000657245
1572 52086-52097 Disease denotes coinfection MESH:D060085
1573 52147-52155 Disease denotes COVID-19 MESH:C000657245
1590 52390-52398 Species denotes patients Tax:9606
1591 52471-52479 Species denotes patients Tax:9606
1592 52556-52564 Species denotes patients Tax:9606
1593 52763-52784 Species denotes Staphylococcus aureus Tax:1280
1594 52832-52856 Species denotes Streptococcus pneumoniae Tax:1313
1595 52858-52880 Species denotes Haemophilus influenzae Tax:727
1596 52885-52905 Species denotes group A streptococci Tax:36470
1597 52664-52673 Species denotes influenza Tax:11520
1598 52796-52807 Chemical denotes methicillin MESH:D008712
1599 52310-52319 Disease denotes pneumonia MESH:D011014
1600 52375-52389 Disease denotes critically ill MESH:D016638
1601 52426-52445 Disease denotes bacterial infection MESH:D001424
1602 52511-52530 Disease denotes bacterial pneumonia MESH:D016920
1603 52600-52615 Disease denotes virus infection MESH:D001102
1604 52643-52652 Disease denotes mortality MESH:D003643
1605 52712-52721 Disease denotes pneumonia MESH:D011014
1612 53006-53014 Species denotes patients Tax:9606
1613 53175-53183 Species denotes patients Tax:9606
1614 53076-53088 Chemical denotes azithromycin MESH:D017963
1615 53150-53162 Chemical denotes azithromycin MESH:D017963
1616 52997-53005 Disease denotes COVID-19 MESH:C000657245
1617 53166-53174 Disease denotes COVID-19 MESH:C000657245
1633 53336-53344 Species denotes patients Tax:9606
1634 53502-53510 Species denotes patients Tax:9606
1635 53830-53838 Species denotes patients Tax:9606
1636 53988-53996 Species denotes patients Tax:9606
1637 53321-53335 Disease denotes critically ill MESH:D016638
1638 53350-53359 Disease denotes pneumonia MESH:D011014
1639 53367-53375 Disease denotes COVID-19 MESH:C000657245
1640 53384-53403 Disease denotes bacterial infection MESH:D001424
1641 53477-53488 Disease denotes coinfection MESH:D060085
1642 53516-53531 Disease denotes viral pneumonia
1643 53652-53661 Disease denotes mortality MESH:D003643
1644 53821-53829 Disease denotes COVID-19 MESH:C000657245
1645 53979-53987 Disease denotes COVID-19 MESH:C000657245
1646 54059-54068 Disease denotes pneumonia MESH:D011014
1647 54088-54097 Disease denotes pneumonia MESH:D011014
1649 54346-54354 Chemical denotes steroids MESH:D013256
1655 54443-54451 Species denotes patients Tax:9606
1656 54570-54578 Species denotes SARS-CoV Tax:694009
1657 54585-54593 Species denotes MERS-CoV Tax:1335626
1658 54594-54602 Species denotes patients Tax:9606
1659 54457-54465 Disease denotes COVID-19 MESH:C000657245
1670 54666-54674 Species denotes patients Tax:9606
1671 55179-55187 Species denotes patients Tax:9606
1672 55193-55201 Species denotes MERS-CoV Tax:1335626
1673 55203-55211 Species denotes SARS-CoV Tax:694009
1674 54751-54769 Chemical denotes methylprednisolone MESH:D008775
1675 54657-54665 Disease denotes COVID-19 MESH:C000657245
1676 54680-54715 Disease denotes acute respiratory distress syndrome MESH:D012128
1677 54717-54721 Disease denotes ARDS MESH:D012128
1678 54813-54818 Disease denotes death MESH:D003643
1679 55223-55239 Disease denotes viral infections MESH:D001102
1693 55256-55264 Species denotes patients Tax:9606
1694 55336-55344 Species denotes patients Tax:9606
1695 55350-55358 Species denotes SARS-CoV Tax:694009
1696 55697-55705 Species denotes patients Tax:9606
1697 55711-55719 Species denotes SARS-CoV Tax:694009
1698 55399-55413 Chemical denotes hydrocortisone MESH:D006854
1699 55521-55535 Chemical denotes hydrocortisone MESH:D006854
1700 55321-55335 Disease denotes critically ill MESH:D016638
1701 55446-55454 Disease denotes viraemia
1702 55504-55513 Disease denotes infection MESH:D007239
1703 55826-55844 Disease denotes avascular necrosis MESH:D010020
1704 55846-55855 Disease denotes psychosis MESH:D011605
1705 55857-55865 Disease denotes diabetes MESH:D003920
1721 55918-55926 Species denotes patients Tax:9606
1722 56413-56421 Species denotes patients Tax:9606
1723 56482-56490 Species denotes Patients Tax:9606
1724 56457-56470 Chemical denotes dexamethasone MESH:D003907
1725 56517-56530 Chemical denotes dexamethasone MESH:D003907
1726 56718-56731 Chemical denotes dexamethasone MESH:D003907
1727 56983-56996 Chemical denotes dexamethasone MESH:D003907
1728 55903-55917 Disease denotes critically ill MESH:D016638
1729 55976-56000 Disease denotes inflammation–coagulation MESH:D001778
1730 56036-56071 Disease denotes acute respiratory distress syndrome MESH:D012128
1731 56073-56077 Disease denotes ARDS MESH:D012128
1732 56146-56150 Disease denotes ARDS MESH:D012128
1733 56242-56254 Disease denotes inflammation MESH:D007249
1734 56427-56431 Disease denotes ARDS MESH:D012128
1735 56843-56852 Disease denotes mortality MESH:D003643
1752 57084-57092 Species denotes patients Tax:9606
1753 57098-57106 Species denotes SARS-CoV Tax:694009
1754 57262-57270 Species denotes patients Tax:9606
1755 57622-57630 Species denotes patients Tax:9606
1756 57636-57644 Species denotes MERS-CoV Tax:1335626
1757 57868-57876 Species denotes MERS-CoV Tax:1335626
1758 57890-57898 Species denotes patients Tax:9606
1759 57677-57691 Chemical denotes hydrocortisone MESH:D006854
1760 57069-57083 Disease denotes critically ill MESH:D016638
1761 57113-57131 Disease denotes MERS-CoV infection MESH:D018352
1762 57231-57245 Disease denotes CoV-1–infected MESH:D018352
1763 57247-57261 Disease denotes critically ill MESH:D016638
1764 57315-57324 Disease denotes mortality MESH:D003643
1765 57464-57484 Disease denotes secondary infections MESH:D060085
1766 57607-57621 Disease denotes critically ill MESH:D016638
1767 57773-57782 Disease denotes mortality MESH:D003643
1776 58013-58021 Species denotes patients Tax:9606
1777 58114-58122 Species denotes patients Tax:9606
1778 58386-58394 Species denotes patients Tax:9606
1779 58027-58036 Species denotes influenza Tax:11520
1780 57945-57961 Disease denotes viral infections MESH:D001102
1781 58037-58046 Disease denotes pneumonia MESH:D011014
1782 58143-58152 Disease denotes mortality MESH:D003643
1783 58311-58340 Disease denotes bacterial or fungal infection MESH:D001424
1803 58570-58578 Species denotes patients Tax:9606
1804 58747-58755 Species denotes patients Tax:9606
1805 58761-58771 Species denotes SARS-CoV-2 Tax:2697049
1806 58956-58964 Species denotes patients Tax:9606
1807 59083-59091 Species denotes patients Tax:9606
1808 59454-59462 Species denotes patients Tax:9606
1809 59328-59335 Chemical denotes steroid MESH:D013256
1810 59400-59407 Chemical denotes steroid MESH:D013256
1811 58584-58604 Disease denotes SARS-CoV-2 infection MESH:C000657245
1812 58812-58824 Disease denotes inflammation MESH:D007249
1813 58846-58857 Disease denotes lung injury MESH:D055370
1814 58907-58916 Disease denotes pneumonia MESH:D011014
1815 58947-58955 Disease denotes COVID-19 MESH:C000657245
1816 59059-59073 Disease denotes critically ill MESH:D016638
1817 59074-59082 Disease denotes COVID-19 MESH:C000657245
1818 59097-59101 Disease denotes ARDS MESH:D012128
1819 59127-59151 Disease denotes ARDS respiratory failure MESH:D012131
1820 59426-59444 Disease denotes non–critically ill MESH:D016638
1821 59445-59453 Disease denotes COVID-19 MESH:C000657245
1830 59599-59607 Species denotes patients Tax:9606
1831 59613-59621 Disease denotes COVID-19 MESH:C000657245
1832 59634-59679 Disease denotes secondary haemophagocytic lymphohistiocytosis MESH:D060085
1833 59700-59726 Disease denotes hyperinflammatory syndrome MESH:D061325
1834 59766-59783 Disease denotes hypercytokinaemia
1835 59805-59809 Disease denotes ARDS MESH:D012128
1836 59814-59832 Disease denotes multiorgan failure MESH:D009102
1837 59942-59950 Disease denotes COVID-19 MESH:C000657245
1859 60911-60929 Gene denotes C-reactive protein Gene:1401
1860 61296-61300 Gene denotes IL-6 Gene:3569
1861 61626-61630 Gene denotes IL-6 Gene:3569
1862 60145-60153 Species denotes patients Tax:9606
1863 60237-60245 Species denotes patients Tax:9606
1864 60603-60611 Species denotes patients Tax:9606
1865 61252-61260 Species denotes patients Tax:9606
1866 61811-61819 Species denotes patients Tax:9606
1867 59981-59992 Chemical denotes Tocilizumab MESH:C502936
1868 60370-60381 Chemical denotes tocilizumab MESH:C502936
1869 60617-60628 Chemical denotes tocilizumab MESH:C502936
1870 61077-61088 Chemical denotes tocilizumab MESH:C502936
1871 61148-61159 Chemical denotes Tocilizumab MESH:C502936
1872 61558-61569 Chemical denotes tocilizumab MESH:C502936
1873 61787-61798 Chemical denotes tocilizumab MESH:C502936
1874 60159-60179 Disease denotes rheumatoid arthritis MESH:D001172
1875 60181-60201 Disease denotes giant-cell arteritis MESH:D013700
1876 60203-60232 Disease denotes juvenile idiopathic arthritis MESH:D001171
1877 60594-60602 Disease denotes COVID-19 MESH:C000657245
1878 61273-61281 Disease denotes COVID-19 MESH:C000657245
1879 61802-61810 Disease denotes COVID-19 MESH:C000657245
1883 61881-61914 Gene denotes interleukin 1 receptor antagonist Gene:3557
1884 62018-62026 Species denotes patients Tax:9606
1885 61998-62017 Disease denotes SARS-CoV-2–infected MESH:C000657245
1895 64558-64566 Species denotes patients Tax:9606
1900 64572-64580 Disease denotes COVID-19 MESH:C000657245
1903 69797-69805 Disease denotes COVID-19 MESH:C000657245
1906 63733-63741 Species denotes patients Tax:9606
1907 63921-63929 Disease denotes COVID-19 MESH:C000657245
1922 64117-64127 Species denotes SARS-CoV-2 Tax:2697049
1923 64194-64204 Species denotes SARS-CoV-2 Tax:2697049
1924 64226-64234 Species denotes SARS-CoV Tax:694009
1925 64405-64415 Species denotes SARS-CoV-2 Tax:2697049
1927 64241-64250 Species denotes influenza Tax:11520
1928 64476-64483 Chemical denotes LPV/RTV MESH:C558899
1929 64547-64554 Chemical denotes LPV/RTV MESH:C558899
1930 64872-64879 Chemical denotes LPV/RTV MESH:C558899
1931 65073-65080 Chemical denotes LPV/RTV MESH:C558899
1932 65275-65282 Chemical denotes LPV/RTV MESH:C558899
1933 64290-64299 Disease denotes mortality MESH:D003643
1935 65320-65328 Disease denotes COVID-19 MESH:C000657245
1952 65646-65654 Species denotes patients Tax:9606
1953 65702-65710 Species denotes patients Tax:9606
1954 66131-66139 Species denotes patients Tax:9606
1955 66326-66334 Species denotes patients Tax:9606
1956 66347-66355 Species denotes patients Tax:9606
1957 65411-65422 Chemical denotes chloroquine MESH:D002738
1958 65423-65441 Chemical denotes hydroxychloroquine MESH:D006886
1959 65829-65847 Chemical denotes hydroxychloroquine MESH:D006886
1960 66008-66015 Chemical denotes steroid MESH:D013256
1961 66219-66226 Chemical denotes steroid MESH:D013256
1962 65666-65692 Disease denotes respiratory tract symptoms MESH:D012140
1963 65722-65748 Disease denotes respiratory tract symptoms MESH:D012140
1964 66106-66120 Disease denotes critically ill MESH:D016638
1965 66126-66130 Disease denotes ARDS MESH:D012128
1966 66321-66325 Disease denotes ARDS MESH:D012128
1967 66342-66346 Disease denotes ARDS MESH:D012128
1990 66551-66558 Species denotes patient Tax:9606
1991 66809-66817 Species denotes patients Tax:9606
1992 66943-66951 Species denotes patients Tax:9606
1993 67063-67071 Species denotes patients Tax:9606
1994 67073-67081 Species denotes patients Tax:9606
1995 67230-67238 Species denotes patients Tax:9606
1996 67412-67420 Species denotes patients Tax:9606
1997 67638-67646 Species denotes patients Tax:9606
1998 66979-66988 Species denotes influenza Tax:11520
1999 66479-66485 Chemical denotes oxygen MESH:D010100
2000 66917-66928 Chemical denotes oseltamivir MESH:D053139
2001 67348-67366 Chemical denotes hydroxychloroquine MESH:D006886
2003 66623-66631 Disease denotes asthenia MESH:D001247
2004 66638-66643 Disease denotes fever MESH:D005334
2005 66656-66661 Disease denotes cough MESH:D003371
2006 66823-66843 Disease denotes SARS-CoV-2 infection MESH:C000657245
2007 67087-67091 Disease denotes ARDS MESH:D012128
2008 67117-67141 Disease denotes ARDS respiratory failure MESH:D012131
2009 67221-67229 Disease denotes COVID-19 MESH:C000657245
2010 67403-67411 Disease denotes COVID-19 MESH:C000657245
2011 67568-67576 Disease denotes toxicity MESH:D064420
2017 68082-68093 Chemical denotes chloroquine MESH:D002738
2018 68094-68112 Chemical denotes hydroxychloroquine MESH:D006886
2019 68480-68487 Chemical denotes steroid MESH:D013256
2020 68557-68564 Chemical denotes steroid MESH:D013256
2021 68393-68402 Disease denotes mortality MESH:D003643
2030 68915-68923 Species denotes patients Tax:9606
2031 69498-69505 Species denotes patient Tax:9606
2032 68643-68654 Chemical denotes Chloroquine MESH:D002738
2033 68655-68673 Chemical denotes hydroxychloroquine MESH:D006886
2034 69113-69123 Chemical denotes remdesivir MESH:C000606551
2035 69567-69574 Chemical denotes steroid MESH:D013256
2036 68906-68914 Disease denotes COVID-19 MESH:C000657245
2037 69035-69076 Disease denotes QT prolongation or hepatic/renal toxicity MESH:D056486
2046 73065-73073 Species denotes patients Tax:9606
2051 72626-72634 Disease denotes COVID-19 MESH:C000657245
2052 73056-73064 Disease denotes COVID-19 MESH:C000657245
2061 72150-72163 Species denotes coronaviruses Tax:11118
2062 72169-72177 Species denotes patients Tax:9606
2063 72328-72336 Species denotes patients Tax:9606
2064 72500-72508 Species denotes patients Tax:9606
2065 72093-72100 Chemical denotes LPV/RTV MESH:C558899
2066 72480-72487 Chemical denotes LPV/RTV MESH:C558899
2067 72491-72499 Disease denotes COVID-19 MESH:C000657245
2072 72815-72823 Species denotes patients Tax:9606

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 7452-7460 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T2 7469-7473 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T3 9416-9431 Body_part denotes immunoglobulins http://purl.org/sig/ont/fma/fma62871
T4 9435-9441 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T5 9989-9993 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T6 11868-11872 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T7 12824-12827 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T8 15126-15130 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T9 15206-15210 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T10 15268-15272 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T11 15866-15872 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T12 18161-18165 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T13 19028-19031 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T14 19042-19045 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T15 19072-19075 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T16 20695-20698 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T17 20995-21001 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T18 21009-21015 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T19 21019-21042 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662
T20 21091-21094 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T21 21105-21108 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T22 22716-22722 Body_part denotes sputum http://purl.org/sig/ont/fma/fma312401
T23 24174-24183 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T24 24216-24220 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 24268-24272 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T26 27258-27264 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T27 27524-27527 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T28 27586-27589 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T29 27993-28001 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T30 28154-28162 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T31 28350-28354 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T32 29129-29131 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T33 29145-29153 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T34 29345-29353 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T35 29408-29410 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T36 29424-29426 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T37 29524-29532 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T38 30887-30900 Body_part denotes interleukin 6 http://purl.org/sig/ont/fma/fma264829
T39 30887-30898 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T40 30923-30931 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T41 31194-31198 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T42 31194-31196 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T43 31783-31789 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T44 31833-31837 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T45 31833-31835 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T46 31848-31852 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T47 31848-31850 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T48 31934-31942 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T49 32047-32055 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T50 32256-32260 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T51 32256-32258 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T52 33015-33029 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T53 33031-33035 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T54 33031-33033 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T55 33037-33050 Body_part denotes interleukin 1 http://purl.org/sig/ont/fma/fma86583
T56 33037-33048 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T57 33533-33537 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T58 34163-34172 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T59 36275-36279 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T60 36589-36593 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T61 37282-37286 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T62 38563-38566 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T63 38635-38640 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T64 39648-39651 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T65 40882-40887 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T66 41018-41023 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T67 41066-41089 Body_part denotes Upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T68 41176-41181 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T69 41231-41235 Body_part denotes Skin http://purl.org/sig/ont/fma/fma7163
T70 41765-41770 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T71 41809-41812 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T72 42023-42034 Body_part denotes Oral mucosa http://purl.org/sig/ont/fma/fma59660
T73 42028-42034 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T74 42279-42287 Body_part denotes Antibody http://purl.org/sig/ont/fma/fma62871
T75 42349-42357 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T76 42536-42544 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T77 42755-42762 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T78 42850-42853 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T79 42855-42878 Body_part denotes low-density lipoprotein http://purl.org/sig/ont/fma/fma63170
T80 42882-42887 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T81 43156-43161 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T82 43207-43217 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T83 44532-44535 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T84 44546-44549 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T85 46799-46803 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T86 46897-46905 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T87 46959-46967 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T88 47144-47155 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T89 47157-47159 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T90 47327-47332 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T91 56285-56290 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T92 56504-56507 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T93 57877-57880 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T94 57900-57917 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T95 58829-58837 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T96 58846-58850 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T97 60031-60039 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T98 60078-60080 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T99 60187-60191 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T100 60279-60283 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T101 60319-60327 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T102 60404-60412 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T103 60444-60452 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T104 60757-60761 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T105 60802-60807 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T106 60857-60867 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T107 60922-60929 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T108 61296-61298 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T109 61626-61628 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T110 61881-61894 Body_part denotes interleukin 1 http://purl.org/sig/ont/fma/fma86583
T111 61881-61892 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T112 62222-62236 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T113 62253-62259 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T114 63689-63704 Body_part denotes immunoglobulins http://purl.org/sig/ont/fma/fma62871
T115 63708-63714 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T116 65660-65683 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T117 65716-65739 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662
T118 66701-66705 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T119 69534-69538 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 7469-7473 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 9860-9883 Body_part denotes respiratory or systemic http://purl.obolibrary.org/obo/UBERON_0001004
T3 9989-9993 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 11868-11872 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T5 15126-15130 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 15206-15210 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 15268-15272 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 15866-15872 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T9 17346-17351 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T10 17652-17657 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T11 18161-18165 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T12 19284-19289 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T13 20099-20104 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T14 20641-20646 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T15 20995-21001 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T16 21009-21015 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T17 21019-21042 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T18 21025-21042 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T19 22716-22722 Body_part denotes sputum http://purl.obolibrary.org/obo/UBERON_0007311
T20 26715-26720 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T21 27202-27207 Body_part denotes Scale http://purl.obolibrary.org/obo/UBERON_0002542
T22 27897-27902 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T23 28350-28354 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 29759-29764 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T25 29820-29825 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T26 30215-30220 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T27 31783-31789 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T28 33533-33537 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T29 34163-34172 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T30 36275-36279 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T31 36589-36593 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T32 37282-37286 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 38635-38640 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T34 39145-39150 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T35 39648-39651 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T36 40882-40887 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T37 41018-41023 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T38 41066-41089 Body_part denotes Upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T39 41072-41089 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T40 41176-41181 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T41 41231-41235 Body_part denotes Skin http://purl.obolibrary.org/obo/UBERON_0000014
T42 41765-41770 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T43 42028-42034 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T44 42882-42887 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T45 47327-47332 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T46 56285-56290 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T47 56504-56507 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T48 57900-57917 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T49 58846-58850 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T50 60802-60807 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T51 65660-65683 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T52 65666-65683 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T53 65716-65739 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T54 65722-65739 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T55 66573-66596 Body_part denotes respiratory or systemic http://purl.obolibrary.org/obo/UBERON_0001004
T56 66701-66705 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T57 69534-69538 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T2 314-333 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T3 3156-3175 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T4 6078-6087 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 6253-6262 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T6 6786-6795 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T7 6815-6824 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T8 7526-7535 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T9 7740-7759 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T10 9911-9919 Phenotype denotes asthenia http://purl.obolibrary.org/obo/HP_0025406
T11 9926-9931 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T12 9944-9949 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T13 10408-10427 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T14 12096-12116 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T15 14116-14126 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T16 14954-14963 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T17 15071-15076 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T18 15078-15083 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T19 15151-15156 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T20 15158-15163 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T21 15649-15658 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T22 15733-15738 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T23 16975-16984 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T24 18086-18091 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T25 19678-19683 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T26 20896-20905 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T27 23952-23961 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T28 27993-28007 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T29 28050-28059 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T30 30688-30694 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T31 31566-31575 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T32 31650-31655 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T33 31934-31959 Phenotype denotes cytokine-release syndrome http://purl.obolibrary.org/obo/HP_0033041
T34 32853-32873 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T35 33533-33545 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T36 33592-33601 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 33619-33638 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T38 33703-33722 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T39 34044-34063 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T40 34091-34096 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T41 36107-36126 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T42 36583-36600 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T43 37239-37259 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T44 37396-37415 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T45 40872-40901 Phenotype denotes increased serum triglycerides http://purl.obolibrary.org/obo/HP_0002155
T46 40956-40965 Phenotype denotes Diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T47 41049-41055 Phenotype denotes Nausea http://purl.obolibrary.org/obo/HP_0002018
T48 41066-41099 Phenotype denotes Upper respiratory tract infection http://purl.obolibrary.org/obo/HP_0002788
T49 41108-41122 Phenotype denotes Abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T50 41133-41141 Phenotype denotes Vomiting http://purl.obolibrary.org/obo/HP_0002013
T51 41151-41158 Phenotype denotes Fatigue http://purl.obolibrary.org/obo/HP_0012378
T52 41213-41221 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T53 41231-41240 Phenotype denotes Skin rash http://purl.obolibrary.org/obo/HP_0000988
T54 41249-41260 Phenotype denotes Neutropenia http://purl.obolibrary.org/obo/HP_0001875
T55 41281-41288 Phenotype denotes Anxiety http://purl.obolibrary.org/obo/HP_0000739
T56 41296-41304 Phenotype denotes Insomnia http://purl.obolibrary.org/obo/HP_0100785
T57 41344-41355 Phenotype denotes Retinopathy http://purl.obolibrary.org/obo/HP_0000488
T58 41464-41478 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T59 41480-41489 Phenotype denotes diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T60 41491-41507 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T61 41509-41524 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T62 41526-41536 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T63 41538-41554 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T64 41589-41602 Phenotype denotes acute hepatic http://purl.obolibrary.org/obo/HP_0200119
T65 41611-41619 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T66 41621-41633 Phenotype denotes bronchospasm http://purl.obolibrary.org/obo/HP_0025428
T67 41644-41665 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657
T68 41799-41824 Phenotype denotes Increased LDL cholesterol http://purl.obolibrary.org/obo/HP_0003141
T69 41869-41880 Phenotype denotes Neutropenia http://purl.obolibrary.org/obo/HP_0001875
T70 41921-41929 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T71 41939-41951 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T72 41961-41970 Phenotype denotes Dizziness http://purl.obolibrary.org/obo/HP_0002321
T73 41978-41992 Phenotype denotes Hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T74 42001-42015 Phenotype denotes Abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T75 42038-42052 Phenotype denotes gastric ulcers http://purl.obolibrary.org/obo/HP_0002592
T76 42393-42401 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T77 42406-42414 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T78 42426-42436 Phenotype denotes Arthralgia http://purl.obolibrary.org/obo/HP_0002829
T79 42448-42453 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T80 42497-42509 Phenotype denotes eosinophilia http://purl.obolibrary.org/obo/HP_0001880
T81 42511-42521 Phenotype denotes leukopenia http://purl.obolibrary.org/obo/HP_0001882
T82 42560-42566 Phenotype denotes Nausea http://purl.obolibrary.org/obo/HP_0002018
T83 42571-42580 Phenotype denotes diarrhoea http://purl.obolibrary.org/obo/HP_0002014
T84 43120-43130 Phenotype denotes cellulitis http://purl.obolibrary.org/obo/HP_0100658
T85 43132-43141 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T86 47115-47120 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T87 51478-51487 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T88 52310-52319 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T89 52521-52530 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T90 52712-52721 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T91 52846-52856 Phenotype denotes pneumoniae http://purl.obolibrary.org/obo/HP_0002090
T92 53350-53359 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T93 53522-53531 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T94 54059-54068 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T95 54088-54097 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T96 54686-54706 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T97 55826-55844 Phenotype denotes avascular necrosis http://purl.obolibrary.org/obo/HP_0010885
T98 55846-55855 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T99 56042-56062 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T100 58037-58046 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T101 58907-58916 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T102 59132-59151 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T103 60159-60179 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T104 60192-60201 Phenotype denotes arteritis http://purl.obolibrary.org/obo/HP_0012089
T105 60203-60232 Phenotype denotes juvenile idiopathic arthritis http://purl.obolibrary.org/obo/HP_0005681
T106 60319-60344 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T107 60404-60429 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T108 66623-66631 Phenotype denotes asthenia http://purl.obolibrary.org/obo/HP_0025406
T109 66638-66643 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T110 66656-66661 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T111 67122-67141 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 13-60 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T12 62-70 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 100-124 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T14 126-134 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 308-333 Disease denotes acute respiratory failure http://purl.obolibrary.org/obo/MONDO_0001208|http://purl.obolibrary.org/obo/MONDO_0021113
T17 1276-1284 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 1645-1653 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 2044-2054 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T20 2662-2670 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 2811-2819 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 3156-3175 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T23 3724-3732 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 4071-4079 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 4321-4329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 4740-4749 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T27 4927-4935 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T28 5115-5123 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 6078-6087 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T30 6095-6103 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 6112-6131 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T32 6122-6131 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T33 6247-6262 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T34 6253-6262 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T35 6548-6556 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 6706-6714 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 6786-6795 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T38 6815-6824 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T39 7230-7238 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 7241-7250 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41 7384-7388 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T42 7435-7447 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T43 7474-7480 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T44 7526-7535 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T45 7566-7574 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T46 7682-7690 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T47 7705-7709 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T48 7735-7739 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T49 7740-7759 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T50 8057-8065 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 8259-8267 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T52 8423-8431 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T53 8639-8649 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T54 8753-8761 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 9605-9613 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 10110-10118 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T57 10121-10130 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 10266-10275 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T59 10373-10377 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T60 10403-10407 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T61 10408-10427 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T62 10507-10515 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T63 10689-10697 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T64 11244-11252 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T65 12084-12088 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T66 12090-12125 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T67 12096-12125 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T68 12127-12135 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 12137-12161 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T70 12367-12375 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T71 12379-12426 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T72 12379-12412 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T73 12618-12626 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T74 12711-12719 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T75 13029-13037 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T76 13912-13920 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 14107-14115 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T78 14116-14126 Disease denotes pneumoniae http://purl.obolibrary.org/obo/MONDO_0005249
T79 14441-14449 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T80 14686-14694 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T81 14945-14953 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T82 14954-14963 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T83 15386-15394 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T84 15510-15518 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T85 15640-15648 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 15649-15658 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T87 15789-15801 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T88 16066-16074 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 16348-16356 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T90 16640-16648 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 16966-16974 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 16975-16984 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T93 17224-17232 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T94 17320-17328 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 17533-17541 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 17959-17967 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T97 18166-18178 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T98 18343-18351 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T99 18570-18578 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 18857-18865 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T101 18935-18943 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 19172-19180 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 19389-19397 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 19595-19603 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T105 19835-19843 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T106 19990-19998 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T107 20222-20230 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 20522-20530 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T109 20887-20895 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T110 20896-20905 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T111 21081-21090 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T112 21197-21205 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 21248-21256 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 21537-21545 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T115 21751-21759 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 22038-22046 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 22116-22124 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T118 22265-22273 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 22525-22533 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 22817-22825 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 23098-23106 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 23385-23393 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T123 23463-23471 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 23529-23538 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T125 23632-23640 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 23683-23691 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 23943-23951 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 23952-23961 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T129 24734-24742 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T130 24853-24861 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T131 24963-24971 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T132 25120-25128 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T133 25398-25406 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T134 25476-25484 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 25596-25604 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T136 25752-25760 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 25801-25809 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T138 25991-25999 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T139 26115-26123 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T140 26249-26257 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T141 26373-26381 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 26384-26393 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T143 26480-26488 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T144 26632-26640 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 26838-26846 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 27080-27088 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T147 27176-27184 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 27378-27386 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 27528-27536 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T150 27778-27786 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T151 27968-27976 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T152 28002-28016 Disease denotes storm syndrome http://purl.obolibrary.org/obo/MONDO_0008496
T153 28050-28059 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T154 28061-28065 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T155 28267-28275 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T156 28355-28361 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T157 28459-28467 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T158 28759-28767 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T159 28962-28970 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T160 29195-29203 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T161 29574-29582 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 29665-29673 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T163 29922-29930 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T164 30098-30106 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T165 30359-30367 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T166 30677-30694 Disease denotes metastatic cancer http://purl.obolibrary.org/obo/MONDO_0024880
T167 30688-30694 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T168 30699-30707 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T169 30986-30994 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 31332-31340 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T171 31557-31565 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T172 31566-31575 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T173 31706-31718 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T174 32095-32103 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T175 32394-32402 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 32593-32601 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T177 32747-32755 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T178 32840-32844 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T179 32847-32882 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T180 32853-32882 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T181 32909-32917 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T182 32919-32943 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T183 33267-33275 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 33279-33326 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T185 33279-33312 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T186 33502-33510 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T187 33533-33545 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T188 33592-33601 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T189 33619-33638 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T190 33703-33722 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T191 33740-33748 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T192 33834-33842 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T193 34983-34991 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T194 35373-35382 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T195 36107-36126 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T196 36351-36359 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T197 36411-36419 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T198 36583-36600 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T200 36594-36600 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T201 36618-36626 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T202 36994-37002 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T203 37396-37415 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T204 37966-37974 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T205 38290-38298 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 38689-38697 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T207 38900-38908 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T208 40238-40246 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T209 40786-40794 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T210 40956-40965 Disease denotes Diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T211 41072-41099 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T212 41090-41099 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T213 41231-41240 Disease denotes Skin rash http://purl.obolibrary.org/obo/MONDO_0006547
T214 41249-41260 Disease denotes Neutropenia http://purl.obolibrary.org/obo/MONDO_0001475
T215 41281-41288 Disease denotes Anxiety http://purl.obolibrary.org/obo/MONDO_0005618|http://purl.obolibrary.org/obo/MONDO_0011918
T217 41296-41304 Disease denotes Insomnia http://purl.obolibrary.org/obo/MONDO_0013600
T218 41344-41355 Disease denotes Retinopathy http://purl.obolibrary.org/obo/MONDO_0005283
T219 41438-41462 Disease denotes Stevens-Johnson syndrome http://purl.obolibrary.org/obo/MONDO_0018229
T220 41446-41462 Disease denotes Johnson syndrome http://purl.obolibrary.org/obo/MONDO_0019419
T221 41480-41489 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T222 41509-41524 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T223 41526-41536 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T224 41538-41554 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T225 41611-41619 Disease denotes myopathy http://purl.obolibrary.org/obo/MONDO_0005336
T226 41621-41633 Disease denotes bronchospasm http://purl.obolibrary.org/obo/MONDO_0001358
T227 41869-41880 Disease denotes Neutropenia http://purl.obolibrary.org/obo/MONDO_0001475
T228 41939-41951 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T229 41978-41992 Disease denotes Hypothyroidism http://purl.obolibrary.org/obo/MONDO_0005420
T230 42038-42052 Disease denotes gastric ulcers http://purl.obolibrary.org/obo/MONDO_0001126
T231 42046-42052 Disease denotes ulcers http://purl.obolibrary.org/obo/MONDO_0043839
T232 42078-42090 Disease denotes Pneumocystis http://purl.obolibrary.org/obo/MONDO_0019121
T233 42106-42118 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076
T234 42123-42132 Disease denotes varicella http://purl.obolibrary.org/obo/MONDO_0005700
T235 42133-42139 Disease denotes zoster http://purl.obolibrary.org/obo/MONDO_0005609
T236 42497-42509 Disease denotes eosinophilia http://purl.obolibrary.org/obo/MONDO_0015691
T237 42511-42521 Disease denotes leukopenia http://purl.obolibrary.org/obo/MONDO_0003785
T238 42571-42580 Disease denotes diarrhoea http://purl.obolibrary.org/obo/MONDO_0001673
T239 42687-42695 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T240 42814-42822 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T241 42824-42848 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T242 43100-43110 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T243 43120-43130 Disease denotes cellulitis http://purl.obolibrary.org/obo/MONDO_0005230
T244 43132-43141 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T245 43162-43172 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T246 43263-43268 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T247 43322-43330 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T248 43334-43342 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T249 43485-43493 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T250 43839-43848 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T251 43897-43905 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T252 44022-44030 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 44118-44126 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T254 44188-44197 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T255 44220-44229 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T256 44330-44338 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T257 44403-44412 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T258 44494-44502 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T259 44581-44590 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T260 44626-44635 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T261 45074-45082 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T262 45128-45136 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T263 45473-45481 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T264 45533-45541 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T265 45772-45780 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T266 46032-46040 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T267 46448-46457 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T268 46575-46583 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T269 46824-46832 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T270 46839-46847 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T271 47115-47120 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T272 47352-47360 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T273 47752-47760 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T274 47976-47984 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T275 48612-48620 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T276 48738-48746 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T277 50235-50243 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T278 50432-50440 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T279 51286-51306 Disease denotes Bacterial infections http://purl.obolibrary.org/obo/MONDO_0005113
T280 51339-51347 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T281 51472-51487 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T282 51478-51487 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T283 51640-51663 Disease denotes bacterial infections in http://purl.obolibrary.org/obo/MONDO_0005113
T284 51678-51686 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T285 51743-51763 Disease denotes bacterial infections http://purl.obolibrary.org/obo/MONDO_0005113
T286 51890-51898 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T287 52147-52155 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T288 52310-52319 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T289 52426-52445 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T290 52436-52445 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T291 52511-52530 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T292 52521-52530 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T293 52590-52599 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T294 52600-52615 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T295 52606-52615 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T296 52664-52673 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T297 52702-52721 Disease denotes bacterial pneumonia http://purl.obolibrary.org/obo/MONDO_0004652
T298 52712-52721 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T299 52832-52856 Disease denotes Streptococcus pneumoniae http://purl.obolibrary.org/obo/MONDO_0005972
T300 52870-52880 Disease denotes influenzae http://purl.obolibrary.org/obo/MONDO_0005812
T301 52997-53005 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T302 53166-53174 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T303 53350-53359 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T304 53367-53375 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T305 53384-53403 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T306 53394-53403 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T307 53516-53531 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T308 53522-53531 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T309 53821-53829 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T310 53979-53987 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T311 54059-54068 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T312 54088-54097 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T313 54457-54465 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T314 54570-54578 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T315 54657-54665 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T316 54680-54715 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T317 54686-54715 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T318 54717-54721 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T319 55203-55211 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T320 55223-55239 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T321 55350-55358 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T322 55504-55513 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T323 55711-55719 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T324 55826-55844 Disease denotes avascular necrosis http://purl.obolibrary.org/obo/MONDO_0005380|http://purl.obolibrary.org/obo/MONDO_0018373
T326 55846-55855 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T327 55857-55865 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T328 55976-55988 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T329 56036-56071 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T330 56042-56071 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T331 56073-56077 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T332 56146-56150 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T333 56242-56254 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T334 56427-56431 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T335 57098-57106 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T336 57122-57131 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 57226-57234 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T338 57474-57484 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T339 57945-57961 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T340 58027-58036 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T341 58037-58046 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T342 58324-58340 Disease denotes fungal infection http://purl.obolibrary.org/obo/MONDO_0002041
T343 58331-58340 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T344 58584-58592 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T345 58595-58604 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T346 58761-58769 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T347 58812-58824 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T348 58851-58857 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T349 58907-58916 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T350 58947-58955 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T351 59074-59082 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T352 59097-59101 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T353 59127-59131 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T354 59132-59151 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T355 59445-59453 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T356 59613-59621 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T357 59634-59679 Disease denotes secondary haemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015542
T358 59805-59809 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T359 59814-59832 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T360 59942-59950 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T361 60159-60179 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T362 60170-60179 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T363 60181-60201 Disease denotes giant-cell arteritis http://purl.obolibrary.org/obo/MONDO_0008538
T364 60192-60201 Disease denotes arteritis http://purl.obolibrary.org/obo/MONDO_0043494
T365 60203-60232 Disease denotes juvenile idiopathic arthritis http://purl.obolibrary.org/obo/MONDO_0011429
T366 60223-60232 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T367 60594-60602 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T368 61273-61281 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 61802-61810 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T370 61998-62006 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T371 62511-62519 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T372 62675-62683 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T373 62891-62901 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T374 63005-63013 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T375 63921-63929 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T376 64117-64125 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T377 64194-64202 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T378 64226-64234 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T379 64241-64250 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T380 64405-64413 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T381 64572-64580 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T382 65320-65328 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T383 66126-66130 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T384 66321-66325 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T385 66342-66346 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T386 66823-66831 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T387 66834-66843 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T388 66979-66988 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T389 67087-67091 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T390 67117-67121 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T391 67122-67141 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T392 67221-67229 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T393 67403-67411 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T394 68906-68914 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T395 69797-69805 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T396 70085-70093 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T397 72491-72499 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T398 72626-72634 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T399 73056-73064 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5 143-146 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 410-411 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 452-453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1286-1289 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T9 1363-1364 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1613-1619 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
T11 1688-1689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1787-1788 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1942-1943 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 2263-2264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 2399-2400 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 2424-2425 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T17 2599-2604 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T18 2693-2700 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T19 3393-3394 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 3750-3751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 4039-4044 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T22 5089-5097 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T23 5216-5221 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T24 5237-5238 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 5605-5610 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T26 6217-6218 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 6268-6269 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T28 6294-6295 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 7469-7473 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T30 7469-7473 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T31 8009-8010 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T32 8329-8334 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T33 8682-8683 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 8699-8704 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T35 8850-8851 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 8856-8860 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T37 8856-8860 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T38 8990-8991 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 9435-9441 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T40 9860-9883 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory or systemic
T41 9989-9993 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T42 9989-9993 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T43 11739-11740 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44 11868-11872 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T45 11868-11872 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T46 11976-11977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 12189-12195 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T48 12446-12458 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T49 12561-12566 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T50 12868-12869 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 12931-12936 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T52 13524-13528 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T53 13646-13647 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 13819-13821 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T55 13827-13829 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T56 13927-13932 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T57 13982-13987 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 14000-14004 http://purl.obolibrary.org/obo/CLO_0001000 denotes 3, 5
T59 14020-14022 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T60 14133-14138 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T61 14240-14246 http://purl.obolibrary.org/obo/CLO_0001230 denotes 2 ≤ 93
T62 14240-14246 http://purl.obolibrary.org/obo/CLO_0037237 denotes 2 ≤ 93
T63 14240-14246 http://purl.obolibrary.org/obo/CLO_0050903 denotes 2 ≤ 93
T64 14240-14246 http://purl.obolibrary.org/obo/CLO_0054249 denotes 2 ≤ 93
T65 14240-14246 http://purl.obolibrary.org/obo/CLO_0054250 denotes 2 ≤ 93
T66 14240-14246 http://purl.obolibrary.org/obo/CLO_0054251 denotes 2 ≤ 93
T67 14240-14246 http://purl.obolibrary.org/obo/CLO_0054252 denotes 2 ≤ 93
T68 14456-14461 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T69 14519-14524 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T70 14701-14706 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T71 14970-14975 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T72 15027-15028 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 15126-15130 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T74 15126-15130 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T75 15206-15210 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T76 15206-15210 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T77 15219-15225 http://purl.obolibrary.org/obo/CLO_0001230 denotes 2 > 93
T78 15219-15225 http://purl.obolibrary.org/obo/CLO_0037237 denotes 2 > 93
T79 15219-15225 http://purl.obolibrary.org/obo/CLO_0050903 denotes 2 > 93
T80 15219-15225 http://purl.obolibrary.org/obo/CLO_0054249 denotes 2 > 93
T81 15219-15225 http://purl.obolibrary.org/obo/CLO_0054250 denotes 2 > 93
T82 15219-15225 http://purl.obolibrary.org/obo/CLO_0054251 denotes 2 > 93
T83 15219-15225 http://purl.obolibrary.org/obo/CLO_0054252 denotes 2 > 93
T84 15257-15258 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T85 15268-15272 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T86 15268-15272 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T87 15480-15481 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 15665-15670 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T89 15730-15731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 15776-15777 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T91 16003-16004 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 16081-16086 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T93 16363-16368 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T94 16655-16660 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T95 17059-17060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 17090-17091 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T97 17634-17637 http://purl.obolibrary.org/obo/CLO_0001608 denotes a 7
T98 18041-18042 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 18083-18084 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T100 18161-18165 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T101 18161-18165 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T102 18358-18363 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T103 18872-18877 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T104 19610-19615 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T105 19850-19855 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T106 20081-20084 http://purl.obolibrary.org/obo/CLO_0050154 denotes a 8
T107 20237-20242 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T108 20623-20626 http://purl.obolibrary.org/obo/CLO_0001608 denotes a 7
T109 20740-20741 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T110 20912-20917 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T111 21019-21042 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract
T112 21135-21136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T113 21161-21162 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 21424-21428 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T115 21424-21428 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T116 21552-21557 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T117 22053-22058 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T118 22280-22285 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T119 22382-22383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 22599-22600 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T121 22691-22692 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T122 22832-22837 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T123 22914-22918 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T124 23400-23405 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T125 23539-23547 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T126 23570-23571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T127 23596-23597 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 23859-23863 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T129 23859-23863 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T130 23968-23973 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T131 24031-24036 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T132 24205-24210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 24216-24220 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T134 24268-24272 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T135 24301-24309 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T136 24453-24454 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 24527-24532 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T138 24607-24608 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T139 24669-24670 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T140 25135-25140 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T141 25200-25201 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T142 25247-25248 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T143 25413-25418 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T144 25509-25514 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T145 25731-25732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 25772-25774 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T147 25784-25785 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T148 25821-25823 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T149 25866-25868 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T150 25911-25913 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T151 26343-26344 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 26604-26605 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T153 26675-26676 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T154 26697-26700 http://purl.obolibrary.org/obo/CLO_0001577 denotes a 3
T155 26853-26858 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T156 27258-27264 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T157 27393-27398 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T158 27458-27459 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T159 27471-27476 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T160 27511-27512 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T161 27879-27882 http://purl.obolibrary.org/obo/CLO_0001608 denotes a 7
T162 27933-27934 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T163 27991-27992 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 28282-28287 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T165 28350-28354 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T166 28350-28354 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T167 28474-28479 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T168 28977-28982 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T169 29034-29035 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T170 29068-29069 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T171 29210-29215 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T172 29319-29328 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Humanized
T173 29381-29389 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T174 29546-29549 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T175 29680-29685 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T176 29801-29805 http://purl.obolibrary.org/obo/CLO_0001550 denotes a 10
T177 29937-29942 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T178 30197-30200 http://purl.obolibrary.org/obo/CLO_0001608 denotes a 7
T179 30374-30379 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T180 30439-30440 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T181 30486-30487 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T182 30714-30719 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T183 30887-30900 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin 6
T184 31001-31006 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T185 31347-31352 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T186 31582-31587 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T187 31647-31648 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 31693-31694 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T189 32110-32115 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T190 32409-32414 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T191 32526-32531 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T192 33037-33050 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin 1
T193 33146-33154 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T194 33146-33154 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T195 33346-33358 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T196 33531-33532 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T197 33533-33537 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T198 33533-33537 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T199 34329-34331 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T200 34493-34494 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T201 34526-34527 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 35191-35192 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 35323-35324 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T204 35411-35412 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 35588-35594 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T206 35828-35836 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T207 35828-35836 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T208 35905-35908 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T209 35909-35910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 36217-36220 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T211 36275-36279 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T212 36275-36279 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T213 36463-36464 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 36589-36593 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T215 36589-36593 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T216 36657-36658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 36750-36751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 37282-37286 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T219 37282-37286 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T220 37300-37302 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T221 37635-37636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T222 37992-37993 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T223 38273-38281 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T224 38516-38517 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T225 38672-38680 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T226 38776-38782 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T227 38929-38934 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T228 38949-38951 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T229 39045-39046 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 39120-39121 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 39286-39290 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T232 39590-39591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 39648-39651 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T234 39703-39707 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T235 39822-39823 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 39921-39926 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T237 40539-40540 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 40743-40748 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T239 41035-41038 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3/4
T240 41042-41044 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T241 41126-41128 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T242 41143-41146 http://purl.obolibrary.org/obo/CLO_0050509 denotes 2–7
T243 41231-41235 http://purl.obolibrary.org/obo/UBERON_0000014 denotes Skin
T244 41231-41235 http://purl.obolibrary.org/obo/UBERON_0001003 denotes Skin
T245 41231-41235 http://purl.obolibrary.org/obo/UBERON_0002097 denotes Skin
T246 41231-41235 http://purl.obolibrary.org/obo/UBERON_0002199 denotes Skin
T247 41231-41235 http://www.ebi.ac.uk/efo/EFO_0000962 denotes Skin
T248 41268-41271 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3/4
T249 41380-41381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 41582-41587 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T251 41777-41779 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T252 41792-41794 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T253 41891-41894 http://purl.obolibrary.org/obo/CLO_0050509 denotes 2–7
T254 42028-42034 http://purl.obolibrary.org/obo/UBERON_0000344 denotes mucosa
T255 42199-42202 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T256 42272-42274 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T257 42620-42625 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T258 42880-42881 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T259 43021-43022 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T260 43147-43151 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T261 43156-43161 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T262 43156-43161 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T263 43290-43298 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T264 43385-43391 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T265 43870-43876 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T266 43947-43955 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T267 43985-43988 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T268 44043-44045 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T269 44591-44599 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T270 44636-44644 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T271 44979-44983 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T272 44979-44983 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T273 45047-45048 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 45516-45524 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T275 45553-45556 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T276 45740-45745 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T277 46668-46676 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T278 46732-46740 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T279 46754-46757 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T280 46788-46795 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T281 46799-46803 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T282 46891-46896 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T283 47029-47031 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T284 47035-47037 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T285 47115-47142 http://purl.obolibrary.org/obo/PR_000000134 denotes tumor necrosis factor alpha
T286 47327-47332 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T287 47503-47504 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T288 47735-47743 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T289 48246-48249 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T290 48570-48571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T291 48662-48665 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T292 48691-48693 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T293 48831-48832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T294 49369-49374 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 49387-49388 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T296 49460-49461 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T297 49591-49596 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 49667-49668 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T299 49689-49691 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T300 50406-50414 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T301 50533-50538 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T302 50554-50555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 50921-50926 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T304 51790-51798 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T305 52333-52340 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T306 52344-52345 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T307 52464-52466 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T308 52481-52483 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T309 52600-52605 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T310 52738-52746 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T311 52891-52892 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T312 53567-53568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T313 54387-54390 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T314 55298-55299 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T315 55376-55377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T316 55603-55604 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T317 55878-55883 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T318 56105-56106 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T319 56195-56196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T320 56285-56290 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T321 56375-56376 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T322 56504-56507 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T323 56649-56650 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T324 56816-56817 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T325 57183-57184 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T326 57564-57565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T327 57668-57669 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T328 57750-57751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T329 57987-57988 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T330 58058-58061 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T331 58089-58090 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T332 58626-58638 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T333 58846-58850 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T334 58846-58850 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T335 59744-59745 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T336 59996-59997 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T337 60010-60019 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humanized
T338 60051-60059 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T339 60187-60191 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T340 60277-60283 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T341 60513-60514 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T342 60549-60551 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T343 60651-60655 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T344 60651-60655 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T345 60741-60742 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T346 60790-60791 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T347 60802-60807 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T348 60802-60807 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T349 61160-61163 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T350 61220-61221 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T351 61423-61424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T352 61465-61466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T353 61570-61573 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T354 61618-61619 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T355 61881-61894 http://purl.obolibrary.org/obo/PR_000001091 denotes interleukin 1
T356 62253-62259 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T357 62581-62586 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T358 62934-62935 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T359 62951-62956 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T360 63108-63109 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T361 63114-63118 http://purl.obolibrary.org/obo/CLO_0008416 denotes peer
T362 63114-63118 http://purl.obolibrary.org/obo/CLO_0050081 denotes peer
T363 63249-63250 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T364 63708-63714 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T365 64098-64105 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T366 64258-64259 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T367 64696-64698 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T368 64789-64791 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T369 65557-65562 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T370 65601-65603 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T371 65621-65622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 65716-65739 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract
T373 65802-65803 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T374 66061-66062 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 66174-66175 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T376 66573-66596 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory or systemic
T377 66701-66705 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T378 66701-66705 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T379 67932-67933 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T380 67960-67968 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T381 68066-68067 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T382 69414-69415 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T383 69534-69538 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T384 69534-69538 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T385 69639-69640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T386 70065-70071 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T387 71014-71019 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T388 71419-71424 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T389 71883-71888 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T390 72103-72104 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T391 72133-72141 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T392 72166-72167 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T393 72256-72261 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T394 72445-72446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T395 72461-72466 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T396 72532-72537 http://purl.obolibrary.org/obo/CLO_0007225 denotes label

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 1072-1078 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T7 2599-2604 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T8 2623-2628 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T9 3006-3012 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T10 3101-3107 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T11 3395-3399 Chemical denotes PEEP http://purl.obolibrary.org/obo/CHEBI_53359|http://purl.obolibrary.org/obo/CHEBI_60683
T13 3428-3433 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T14 3484-3490 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T15 3925-3941 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T16 4039-4044 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T17 4142-4161 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T19 4151-4161 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T20 4168-4177 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T21 4278-4288 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T22 4498-4509 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T23 4514-4524 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T24 4643-4654 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T25 4658-4667 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T26 4770-4781 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T27 4782-4800 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T28 4853-4871 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T29 4957-4961 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T30 5470-5488 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T31 5605-5610 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T32 5768-5786 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T33 5940-5951 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T34 6025-6035 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T35 6490-6503 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T36 6845-6864 Chemical denotes antimicrobial agent http://purl.obolibrary.org/obo/CHEBI_33281
T37 6918-6928 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T38 7072-7080 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T39 7183-7197 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T40 7344-7358 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T41 7648-7663 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T42 7935-7942 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T43 8012-8019 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T44 8230-8241 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T45 8329-8334 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T46 8699-8704 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T47 8712-8723 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T48 9297-9314 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T49 9304-9314 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T50 9768-9774 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T51 10049-10058 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T52 10204-10215 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T53 10634-10652 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T54 10869-10887 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T55 10989-11000 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T56 11001-11019 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T57 11442-11452 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T58 11698-11713 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T59 11904-11911 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T60 11995-12009 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T61 12272-12291 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T62 12272-12281 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T63 12282-12291 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T64 12293-12297 Chemical denotes PEEP http://purl.obolibrary.org/obo/CHEBI_53359|http://purl.obolibrary.org/obo/CHEBI_60683
T66 12516-12539 Chemical denotes anti-inflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35472
T67 12534-12539 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T68 12561-12566 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T69 12788-12797 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T70 12798-12807 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T71 12808-12817 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T72 12835-12853 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T74 12844-12853 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T75 12870-12886 Chemical denotes CYP3A4 inhibitor http://purl.obolibrary.org/obo/CHEBI_86501
T76 12877-12886 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T77 12899-12908 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T78 12931-12936 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T79 12951-12970 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T80 12951-12960 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T81 12961-12970 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T82 13048-13057 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T83 13058-13067 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T84 13619-13638 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T85 13619-13628 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T86 13629-13638 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T87 13847-13866 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T88 13847-13856 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T89 13857-13866 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T90 13871-13889 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T91 13927-13932 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T92 14046-14055 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T93 14060-14079 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T94 14060-14069 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T95 14070-14079 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T96 14133-14138 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T97 14256-14262 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T98 14299-14301 Chemical denotes Hg http://purl.obolibrary.org/obo/CHEBI_16170|http://purl.obolibrary.org/obo/CHEBI_25195
T100 14364-14383 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T101 14364-14373 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T102 14374-14383 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T103 14388-14407 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T104 14388-14397 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T105 14398-14407 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T106 14413-14423 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T107 14456-14461 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T108 14586-14605 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T109 14586-14595 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T110 14596-14605 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T111 14610-14629 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T112 14610-14619 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T113 14620-14629 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T114 14635-14644 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T115 14650-14660 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T116 14661-14665 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T117 14701-14706 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T118 14867-14886 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T119 14867-14876 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T120 14877-14886 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T121 14891-14902 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T122 14907-14917 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T123 14970-14975 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T124 15251-15253 Chemical denotes Hg http://purl.obolibrary.org/obo/CHEBI_16170|http://purl.obolibrary.org/obo/CHEBI_25195
T126 15321-15340 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T127 15321-15330 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T128 15331-15340 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T129 15574-15593 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T130 15574-15583 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T131 15584-15593 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T132 15597-15607 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T133 15611-15622 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T134 15665-15670 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T135 15909-15928 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T136 15909-15918 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T137 15919-15928 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T138 15933-15952 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T139 15933-15942 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T140 15943-15952 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T141 16039-16047 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T142 16081-16086 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T143 16204-16223 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T144 16204-16213 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T145 16214-16223 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T146 16237-16247 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T147 16257-16276 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T148 16257-16266 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T149 16267-16276 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T150 16290-16300 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T151 16363-16368 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T152 16486-16505 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T153 16486-16495 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T154 16496-16505 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T155 16519-16529 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T156 16539-16558 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T157 16539-16548 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T158 16549-16558 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T159 16572-16582 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T160 16655-16660 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T161 16786-16805 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T162 16786-16795 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T163 16796-16805 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T164 16811-16829 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T165 16834-16853 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T166 16834-16843 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T167 16844-16853 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T168 16859-16877 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T169 16883-16893 Chemical denotes levamisole http://purl.obolibrary.org/obo/CHEBI_6432
T170 16904-16914 Chemical denotes budesonide http://purl.obolibrary.org/obo/CHEBI_3207
T171 16920-16930 Chemical denotes formoterol http://purl.obolibrary.org/obo/CHEBI_5147
T172 17138-17157 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T173 17138-17147 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T174 17148-17157 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T175 17162-17180 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T176 17185-17193 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T177 17389-17408 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T178 17389-17398 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T179 17399-17408 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T180 17413-17431 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T181 17436-17455 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T182 17436-17445 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T183 17446-17455 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T184 17461-17471 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T185 17472-17476 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T186 17484-17494 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T187 17685-17704 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T188 17685-17694 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T189 17695-17704 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T190 17708-17718 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T191 17722-17733 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T192 17737-17755 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T193 17759-17770 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T194 17788-17800 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T195 17825-17844 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T196 17825-17834 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T197 17835-17844 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T198 17848-17858 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T199 17862-17873 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T200 17877-17895 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T201 17899-17910 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T202 17928-17940 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T203 18231-18241 Chemical denotes colchicine http://purl.obolibrary.org/obo/CHEBI_23359
T204 18259-18278 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T205 18259-18268 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T206 18269-18278 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T207 18358-18363 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T208 18478-18489 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T209 18495-18506 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T210 18511-18522 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T211 18528-18547 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T212 18528-18537 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T213 18538-18547 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T214 18586-18605 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T215 18586-18595 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T216 18596-18605 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T217 18611-18622 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T218 18627-18636 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T219 18637-18646 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T220 18652-18663 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T221 18668-18679 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T222 18685-18704 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T223 18685-18694 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T224 18695-18704 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T225 18709-18718 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T226 18719-18728 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T227 18734-18745 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T228 18751-18762 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T229 18767-18776 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T230 18777-18786 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T231 18792-18803 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T232 18809-18820 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T233 18872-18877 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T234 18996-19005 Chemical denotes Adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T235 19125-19135 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T236 19332-19342 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T237 19533-19543 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T238 19610-19615 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T239 19702-19708 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T240 19771-19781 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T241 19850-19855 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T242 19950-19960 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T243 20132-20142 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T244 20147-20165 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T245 20170-20180 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T246 20186-20204 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T247 20237-20242 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T248 20378-20397 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T249 20378-20387 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T250 20388-20397 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T251 20402-20420 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T252 20425-20444 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T253 20425-20434 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T254 20435-20444 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T255 20450-20460 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T256 20461-20465 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T257 20473-20483 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T258 20658-20667 Chemical denotes Darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T259 20668-20678 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T260 20679-20688 Chemical denotes Darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T261 20706-20724 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T263 20715-20724 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T264 20742-20758 Chemical denotes CYP3A4 inhibitor http://purl.obolibrary.org/obo/CHEBI_86501
T265 20749-20758 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T266 20771-20780 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T267 20828-20837 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T268 20838-20848 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T269 20912-20917 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T270 21105-21129 Chemical denotes RNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_37416
T271 21120-21129 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T272 21228-21239 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T273 21276-21286 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T274 21358-21369 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T275 21459-21470 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T276 21475-21486 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T277 21491-21502 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T278 21508-21519 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T279 21552-21557 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T280 21659-21670 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T281 21676-21687 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T282 21692-21703 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T283 21709-21728 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T284 21709-21718 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T285 21719-21728 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T286 21767-21786 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T287 21767-21776 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T288 21777-21786 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T289 21792-21803 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T290 21808-21817 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T291 21818-21827 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T292 21833-21844 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T293 21849-21860 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T294 21866-21885 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T295 21866-21875 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T296 21876-21885 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T297 21890-21899 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T298 21900-21909 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T299 21915-21926 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T300 21932-21943 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T301 21948-21957 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T302 21958-21967 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T303 21973-21984 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T304 21990-22001 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T305 22053-22058 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T306 22182-22200 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T307 22206-22215 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T308 22216-22226 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T309 22280-22285 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T310 22451-22462 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T311 22468-22479 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T312 22484-22495 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T313 22767-22778 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T314 22832-22837 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T315 22901-22913 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T316 22909-22913 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T317 23006-23017 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T318 23023-23034 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T319 23039-23050 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T320 23056-23075 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T321 23056-23065 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T322 23066-23075 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T323 23114-23133 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T324 23114-23123 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T325 23124-23133 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T326 23139-23150 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T327 23155-23164 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T328 23165-23174 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T329 23180-23191 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T330 23196-23207 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T331 23213-23232 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T332 23213-23222 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T333 23223-23232 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T334 23237-23246 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T335 23247-23256 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T336 23262-23273 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T337 23279-23290 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T338 23295-23304 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T339 23305-23314 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T340 23320-23331 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T341 23337-23348 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T342 23400-23405 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T343 23555-23564 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T344 23663-23674 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T345 23711-23721 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T346 23793-23804 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T347 23894-23904 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T348 23968-23973 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T349 24082-24093 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T350 24095-24113 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T351 24184-24186 Chemical denotes Ph http://purl.obolibrary.org/obo/CHEBI_30396
T352 24352-24370 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T353 24527-24532 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T354 24801-24819 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T355 24824-24837 Chemical denotes ascorbic acid http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073
T357 24833-24837 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T358 25009-25020 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T359 25026-25044 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T360 25050-25062 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T361 25067-25078 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T362 25084-25102 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T363 25135-25140 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T364 25346-25364 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T365 25413-25418 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T366 25548-25566 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T367 25647-25657 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T368 25938-25956 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T369 26184-26203 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T370 26184-26193 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T371 26194-26203 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T372 26434-26452 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T373 26748-26758 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T374 26763-26781 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T375 26786-26796 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T376 26802-26820 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T377 26853-26858 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T378 26994-27013 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T379 26994-27003 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T380 27004-27013 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T381 27018-27036 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T382 27041-27049 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T383 27270-27288 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T384 27294-27306 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T385 27311-27329 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T386 27335-27347 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T387 27393-27398 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T388 27634-27653 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T389 27634-27643 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T390 27644-27653 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T391 27658-27676 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T392 27681-27700 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T393 27681-27690 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T394 27691-27700 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T395 27706-27716 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T396 27717-27721 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T397 27729-27739 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T398 28097-28112 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T399 28203-28221 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T400 28282-28287 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T401 28402-28420 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T402 28474-28479 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T403 28592-28597 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T404 28598-28608 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T405 28614-28632 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T406 28638-28648 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T407 28653-28664 Chemical denotes thalidomide http://purl.obolibrary.org/obo/CHEBI_9513
T408 28678-28683 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T409 28684-28694 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T410 28700-28718 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T411 28724-28734 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T412 28926-28944 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T413 28977-28982 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T414 29129-29131 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T416 29159-29177 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T417 29210-29215 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T418 29355-29366 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T419 29408-29410 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T421 29424-29426 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T423 29615-29626 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T424 29680-29685 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T425 29844-29855 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T426 29860-29871 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T427 29876-29887 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T428 29893-29904 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T429 29937-29942 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T430 30044-30055 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T431 30248-30259 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T432 30265-30283 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T433 30289-30301 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T434 30306-30317 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T435 30323-30341 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T436 30374-30379 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T437 30569-30580 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T438 30601-30612 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T439 30714-30719 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T440 30810-30821 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T441 30840-30851 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T442 31001-31006 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T443 31104-31110 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T444 31156-31167 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T445 31194-31196 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T447 31208-31218 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T448 31282-31293 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T449 31347-31352 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T450 31491-31510 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T451 31491-31500 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T452 31501-31510 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T453 31514-31524 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T454 31528-31539 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T455 31582-31587 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T456 31833-31835 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T458 31848-31850 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T460 32023-32033 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T461 32110-32115 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T462 32218-32229 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T463 32256-32258 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T465 32270-32280 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T466 32344-32355 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T467 32409-32414 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T468 32526-32531 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T469 32532-32537 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T470 32705-32710 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T471 32786-32796 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T472 32797-32808 Chemical denotes ruxolitinib http://purl.obolibrary.org/obo/CHEBI_66919
T473 32826-32837 Chemical denotes tofacitinib http://purl.obolibrary.org/obo/CHEBI_71200
T474 33031-33033 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T476 33155-33161 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T477 33202-33208 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T478 33392-33398 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T479 33661-33667 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T480 33991-33997 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T481 34173-34179 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T482 34275-34281 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T483 34365-34371 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T484 34458-34464 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T485 34495-34502 Chemical denotes mixture http://purl.obolibrary.org/obo/CHEBI_60004
T486 34514-34520 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T487 34597-34603 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T488 34698-34712 Chemical denotes carbon dioxide http://purl.obolibrary.org/obo/CHEBI_16526
T489 34698-34704 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T491 34788-34794 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T492 35054-35060 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T493 35783-35789 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T494 35837-35843 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T495 35884-35890 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T496 36693-36697 Chemical denotes PEEP http://purl.obolibrary.org/obo/CHEBI_53359|http://purl.obolibrary.org/obo/CHEBI_60683
T498 36730-36735 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T499 37341-37347 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T500 37637-37641 Chemical denotes PEEP http://purl.obolibrary.org/obo/CHEBI_53359|http://purl.obolibrary.org/obo/CHEBI_60683
T502 37670-37675 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T503 37726-37732 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T504 38187-38203 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T505 38229-38245 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T506 38361-38377 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T507 38503-38512 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T508 38518-38536 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T510 38527-38536 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T511 38610-38619 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T512 38811-38830 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T513 38811-38820 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T514 38821-38830 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T515 38929-38934 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T516 39921-39926 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T517 40196-40215 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T519 40205-40215 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T520 40224-40233 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T521 40442-40446 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T522 40463-40473 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T523 40485-40490 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T524 40500-40518 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T525 40696-40719 Chemical denotes anti-inflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35472
T526 40714-40719 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T527 40743-40748 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T528 40824-40833 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T529 40834-40843 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T530 40888-40901 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T531 40924-40932 Chemical denotes glutamyl http://purl.obolibrary.org/obo/CHEBI_32483
T532 41311-41322 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T533 41323-41341 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T534 41728-41740 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T535 41786-41789 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T536 41809-41824 Chemical denotes LDL cholesterol http://purl.obolibrary.org/obo/CHEBI_47774
T537 41809-41812 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T538 41813-41824 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T539 42165-42176 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T540 42620-42625 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T541 42626-42631 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T542 42755-42762 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T543 42781-42784 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T544 42786-42795 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T547 42850-42853 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T548 42855-42878 Chemical denotes low-density lipoprotein http://purl.obolibrary.org/obo/CHEBI_39026
T549 42867-42878 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T550 43207-43217 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T551 43616-43620 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T552 43632-43642 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T553 43766-43777 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T554 43782-43791 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T555 43796-43820 Chemical denotes neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T556 43810-43820 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T557 43959-43970 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T558 43975-43984 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T559 44136-44147 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T560 44420-44436 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T561 44516-44527 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T562 44546-44570 Chemical denotes RNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_37416
T563 44561-44570 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T564 44605-44615 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T565 44652-44661 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T566 44836-44847 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T567 45105-45116 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T568 45156-45166 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T569 45238-45249 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T570 45506-45515 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T571 45584-45594 Chemical denotes ivermectin http://purl.obolibrary.org/obo/CHEBI_6078
T572 45740-45745 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T573 45843-45862 Chemical denotes protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T575 45852-45862 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T576 45869-45878 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T577 45979-45989 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T578 46209-46220 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T579 46225-46235 Chemical denotes umifenovir http://purl.obolibrary.org/obo/CHEBI_134730
T580 46351-46362 Chemical denotes Oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T581 46366-46375 Chemical denotes zanamivir http://purl.obolibrary.org/obo/CHEBI_50663
T582 46479-46490 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T583 46491-46509 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T584 46550-46561 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T585 46658-46667 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T586 46722-46731 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T587 46742-46753 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T588 46959-46967 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T589 47137-47142 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T590 47157-47159 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T592 47214-47225 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T593 47562-47580 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T594 47606-47617 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T595 47687-47691 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T99101 47925-47936 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T35786 47940-47958 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T33236 48363-48374 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T38375 48375-48393 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T43255 48643-48661 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T22535 48777-48795 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T82824 48985-49003 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T55345 49018-49030 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T89458 49192-49210 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T85954 49288-49293 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T1869 49483-49501 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T12 49650-49655 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T81198 49711-49729 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T67445 49735-49747 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T82623 49845-49857 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T20948 49873-49891 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T15096 50087-50092 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T18 50161-50179 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T4278 50265-50269 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T90933 50786-50804 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T85881 50921-50926 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T42152 51084-51102 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T24996 51257-51268 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T28167 51979-51990 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T50263 52796-52807 Chemical denotes methicillin http://purl.obolibrary.org/obo/CHEBI_6827
T63638 52885-52890 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T12136 53056-53065 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T83928 53076-53088 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T2753 53150-53162 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T998 53297-53307 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T84200 53763-53776 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T38237 54118-54137 Chemical denotes antimicrobial agent http://purl.obolibrary.org/obo/CHEBI_33281
T27580 54191-54201 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T49484 54346-54354 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T92965 54409-54424 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T10348 54751-54769 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T76382 55125-55139 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T83355 55399-55413 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T63290 55521-55535 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T34671 55536-55541 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T72854 55566-55571 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88411 55669-55684 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T98872 55928-55943 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T54230 56124-56138 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T17441 56457-56470 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T90766 56517-56530 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T70095 56718-56731 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T42283 56732-56737 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T49874 56758-56763 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T47088 56773-56778 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T59830 56873-56878 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57744 56983-56996 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T54060 56997-57002 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T69982 57019-57024 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T2436 57050-57065 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T79577 57272-57286 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T14063 57513-57527 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T69694 57677-57691 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T25050 57797-57811 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T70959 58408-58423 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T7997 58537-58551 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T21891 58720-58735 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T62412 59040-59055 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T11802 59328-59335 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T65 59400-59407 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T15169 60078-60080 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T52655 60260-60267 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T41669 60370-60381 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T61099 60617-60628 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T28602 60712-60723 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T88075 60922-60929 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T73 61077-61088 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T72663 61296-61298 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T84369 61558-61569 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T38193 61626-61628 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T71139 61787-61798 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T42677 61855-61860 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T26418 61904-61914 Chemical denotes antagonist http://purl.obolibrary.org/obo/CHEBI_48706
T58620 61939-61956 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T9262 61946-61956 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T85377 62482-62493 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T73580 62581-62586 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T92027 62951-62956 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T54631 62964-62975 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T89792 63532-63549 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T91905 63539-63549 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T11348 64041-64050 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T12438 64323-64332 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T94861 64731-64735 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14598 65095-65105 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T18588 65296-65306 Chemical denotes antivirals http://purl.obolibrary.org/obo/CHEBI_22587
T87596 65411-65422 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T51549 65423-65441 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T54232 65446-65461 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T33985 65629-65634 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T99 65829-65847 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T38634 66008-66015 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T95699 66219-66226 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T17049 66479-66485 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T3796 66761-66770 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T49322 66917-66928 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T90742 67348-67366 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T28849 67580-67598 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T57203 67904-67909 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T40359 68082-68093 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T32607 68094-68112 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T12702 68480-68487 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T60327 68557-68564 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T70825 68643-68654 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T55266 68655-68673 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T80885 69113-69123 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T73747 69369-69384 Chemical denotes corticosteroids http://purl.obolibrary.org/obo/CHEBI_50858
T40348 69567-69574 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T52269 69658-69672 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T14062 71014-71019 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T26421 71030-71035 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T69721 71138-71143 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T38758 71419-71424 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T7632 71883-71888 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T22983 72256-72261 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T82876 72461-72466 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T125 72532-72537 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T27070 72538-72547 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T16804 72552-72575 Chemical denotes anti-inflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35472
T98752 72570-72575 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 7435-7447 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 9370-9385 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T3 15789-15801 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T4 18166-18178 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T5 21043-21053 http://purl.obolibrary.org/obo/GO_0046903 denotes secretions
T6 23539-23554 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T7 24216-24227 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T8 24216-24227 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T9 24216-24227 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T10 24216-24227 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T11 24251-24264 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 31706-31718 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T13 37216-37224 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T14 44636-44651 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T15 46920-46951 http://purl.obolibrary.org/obo/GO_0043687 denotes posttranslational modifications
T16 47121-47129 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T17 47121-47129 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T18 47121-47129 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T19 47121-47129 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T20 55223-55239 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T21 55836-55844 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T22 55836-55844 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T23 55836-55844 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T24 55836-55844 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T25 55976-55988 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T26 55989-56000 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T27 56242-56254 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T28 57945-57961 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T29 58812-58824 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T30 62158-62173 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T31 63643-63658 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T17 0-12 Sentence denotes Introduction
T18 13-225 Sentence denotes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which has rapidly become epidemic in Italy and other European countries [[1], [2], [3]].
T19 226-521 Sentence denotes The disease spectrum ranges from asymptomatic/mildly symptomatic presentations to acute respiratory failure, with the true proportion of severe cases still remaining partly unclear as a result of an incomplete denominator and a possible lack of adjustment for relevant confounding factors [4,5].
T20 522-836 Sentence denotes Nonetheless, of particular clinical concern at the present time is not the relative frequency of severe cases in patients requiring ventilation support, but rather their absolute number, which is reaching or even surpassing the intensive care unit (ICU) bed capacity in the most affected regions and countries [6].
T21 837-1189 Sentence denotes From this perspective, in addition to the important prevention and restrictive measures implemented for reducing transmission [7], it remains crucial to optimize the therapeutic management of symptomatic patients requiring noninvasive oxygen therapy in order both to improve the absolute cure rates and to reduce and prevent the need for ICU admission.
T22 1190-1485 Sentence denotes However, the lack of high-level evidence, inherent to the novelty and rapid spread of COVID-19, has led to the adoption of heterogeneous approaches worldwide, often without a clear distinction between the relative weight of available evidence and expert opinion in informing therapeutic choices.
T23 1486-1766 Sentence denotes In this narrative review, we sought to summarize the available evidence on important therapeutic questions we are continuously facing as clinicians caring for COVID-19 patients in Italy, trying to find a balance between current evidence, frontline experiences and expert opinions.
T24 1768-1775 Sentence denotes Methods
T25 1776-2002 Sentence denotes Members of a panel of 17 experts from the Italian Society of Anti-infective Therapy (SITA) and the Italian Society of Pulmonology (SIP) were selected; they developed a list of 8 practical therapeutic questions to be addressed.
T26 2003-2302 Sentence denotes The members of the panel (which included infectious diseases specialists and pneumonologists) were divided into small groups and asked to summarize the available literature and their frontline-based opinion in brief (500 words maximum) narrative answers, plus a conclusive statement for each answer.
T27 2303-2423 Sentence denotes All the answers and statements were ultimately reviewed and discussed by the entire panel until a consensus was reached.
T28 2424-2504 Sentence denotes A brief summary of questions and conclusive statements is available in Table 1 .
T29 2505-2680 Sentence denotes Table 2 summarizes available or ongoing randomized controlled trial (RCT) information for off-label/compassionate-use drugs mostly used for the treatment of COVID-19 patients.
T30 2681-2911 Sentence denotes Of note, we focused on pneumologic and anti-infective/anti-inflammatory treatments; the discussion of the therapeutic approach to COVID-19–related cardiovascular/coagulative disorders is outside the scope of this narrative review.
T31 2912-2955 Sentence denotes Table 1 Summary of questions and statements
T32 2956-2974 Sentence denotes Question Statement
T33 2975-2986 Sentence denotes Question 1.
T34 2987-3086 Sentence denotes How to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation?
T35 3087-3281 Sentence denotes Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo2 lower than 90% and it should be aimed at reaching values not higher than 96%.
T36 3282-3586 Sentence denotes Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion).
T37 3587-3669 Sentence denotes However, no clear indications/criteria can be provided pending further experience.
T38 3670-3905 Sentence denotes Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be carefully monitored for worsening respiratory function for rapidly prompting tracheal intubation and mechanical ventilation.
T39 3906-3917 Sentence denotes Question 2.
T40 3918-3958 Sentence denotes Should antiviral agents be administered?
T41 3959-4089 Sentence denotes At the present time, evidence from the first published RCT does not support off-label treatment with LPV/RTV in COVID-19 patients.
T42 4090-4234 Sentence denotes This result should also discourage the use of other protease inhibitors (e.g. darunavir), at least until results of dedicated RCT are available.
T43 4235-4457 Sentence denotes Although promising in preclinical studies, remdesivir should be currently provided to COVID-19 patients only within RCT (preferentially) or compassionate-use/expanded-access programmes, owing to its investigational nature.
T44 4458-4642 Sentence denotes Pending high-level supporting evidence, favipiravir and umifenovir should not be provided an outside RCT, at least in those countries where they are not approved for other indications.
T45 4643-4750 Sentence denotes Oseltamivir or zanamivir should be provided only in the presence of suspected/proven concomitant influenza.
T46 4751-4762 Sentence denotes Question 3.
T47 4763-4817 Sentence denotes Should chloroquine/hydroxychloroquine be administered?
T48 4818-5067 Sentence denotes Pending results of RCT, the use of hydroxychloroquine may be considered for treating worsening patients with COVID-19 only if no important drug interactions can be anticipated and with close monitoring of hepatic, renal function and QT prolongation.
T49 5068-5277 Sentence denotes This is based on its activity in vitro against SARS-CoV-2 (although weak) and on the availability of low-level clinical evidence of anticipation of virus clearance from a small controlled, nonrandomized study.
T50 5278-5450 Sentence denotes However, it should also be kept in mind that the study was highly susceptible to bias and there are still no data regarding hard clinical endpoints such as crude mortality.
T51 5451-5575 Sentence denotes For these reasons, hydroxychloroquine should be preferentially administered within the framework of investigational studies.
T52 5576-5685 Sentence denotes When this is unfeasible, off-label use may be considered according to local protocols and consent procedures.
T53 5686-5882 Sentence denotes In view of the absence of evidence, we are currently unable to support the use of hydroxychloroquine in asymptomatic or mildly symptomatic nonhospitalized patients outside investigational studies.
T54 5883-5920 Sentence denotes The same applies to prophylactic use.
T55 5921-5932 Sentence denotes Question 4.
T56 5933-5968 Sentence denotes Should antibiotics be administered?
T57 5969-6151 Sentence denotes In our opinion, it might be prudent to consider empiric antibiotic treatment in critically ill patients with pneumonia due to COVID-19 in whom bacterial infection cannot be excluded.
T58 6152-6389 Sentence denotes This suggestion is based on the fact that bacterial coinfection (a) is common in patients with viral pneumonia and (b) can be associated with a substantial risk of delaying appropriate treatment, thereby potentially increasing mortality.
T59 6390-6637 Sentence denotes Because of the limited available data on both the microbiologic epidemiology (and the prevalence of antimicrobial resistance) of bacterial superinfections in COVID-19 patients, it is difficult to provide specific pathogen-oriented recommendations.
T60 6638-7052 Sentence denotes Therefore, pending further studies, we suggest to empirically treat COVID-19 patients according to their clinical syndrome (e.g. community-acquired pneumonia, hospital-acquired pneumonia), choosing the best antimicrobial agent or agents on the basis of local guidelines and local antibiotic susceptibility patterns, with early de-escalation or discontinuation according to microbiology results, whenever available.
T61 7053-7064 Sentence denotes Question 5.
T62 7065-7097 Sentence denotes Should steroids be administered?
T63 7098-7251 Sentence denotes So far, no definitive efficacy or effectiveness data are available on the benefit of corticosteroid administration in patients with SARS-CoV-2 infection.
T64 7252-7395 Sentence denotes As the WHO underlines, there is an important need for efficacy data from RCT for supporting corticosteroid therapy in patients with SARS-Cov-2.
T65 7396-7842 Sentence denotes However, considering that overwhelming inflammation and cytokine-related lung injury might be responsible for rapidly progressive pneumonia and clinical deterioration in COVID-19 patients, we suggest (expert opinion only) to consider administration of corticosteroids in critically ill COVID-19 patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections (independent of ICU admission).
T66 7843-8075 Sentence denotes Yet in the absence of convincing evidence, the following cannot currently be supported: (1) steroid administration stratified according to inflammatory markers; and (b) steroid administration in non–critically ill COVID-19 patients.
T67 8076-8087 Sentence denotes Question 6.
T68 8088-8169 Sentence denotes Should other immunosuppressive and/or immunomodulatory therapies be administered?
T69 8170-8324 Sentence denotes Owing to the lack of high-level evidence, administration of tocilizumab to patients with COVID-19 should preferentially occur within the framework of RCT.
T70 8325-8651 Sentence denotes Off-label use according to local protocols and consent procedures may be considered only in those COVID-19 patients excluded from RCT (or hospitalized where RCT are not available or still to be implemented) and who are worsening while receiving standard supportive care (in the absence of concomitant/superimposed infections).
T71 8652-9121 Sentence denotes In our opinion, this could be a reasonable off-label use of tocilizumab in these early phases of the COVID-19 pandemic, although patients and physicians should be aware that currently there is only a non–peer-reviewed, noncomparative, observational experience (very low evidence from an unreviewed cases series) and that it only supports a potential favourable effect on inflammatory signs and symptoms, while there is no information on any possible effect on survival.
T72 9122-9327 Sentence denotes In the absence of clinical studies, we suggest to preferentially administer also other immunosuppressive and/or immunomodulatory therapies (e.g. anakinra, Janus kinase family enzyme inhibitors) within RCT.
T73 9328-9646 Sentence denotes This also applies to modifications of the immune response through high-dose intravenous immunoglobulins or plasma from convalescent patients, which, although promising in small case series, both deserve dedicated RCT investigation to clearly understand their role in impacting COVID-19 outcomes and their tolerability.
T74 9647-9658 Sentence denotes Question 7.
T75 9659-9710 Sentence denotes What is the optimal timing of treatment initiation?
T76 9711-10006 Sentence denotes Supportive therapy (symptomatic therapy, rehydration and oxygen supplementation, if necessary), should be initiated as soon as the patient manifests respiratory or systemic symptoms, including severe asthenia, high fever, persistent cough and/or clinical or radiologic signs of lung involvement.
T77 10007-10277 Sentence denotes Pending further evidence, in our opinion, antiviral treatments should not be provided to patients with SARS-CoV-2 infection outside RCT or compassionate-use programmes (with the exception of early oseltamivir initiation in patients with suspected concomitant influenza).
T78 10278-10549 Sentence denotes Corticosteroids should be provided early in well-defined categories of patients (patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections), while their role in other COVID-19 patients still remains uncertain.
T79 10550-10936 Sentence denotes Although based on low-level evidence and pending RCT results, in our opinion, early hydroxychloroquine administration may be considered in COVID-19 patients manifesting moderate to severe symptoms, whereas further data are needed to better delineate the true balance between possible favourable effects and toxicity of hydroxychloroquine in mildly symptomatic and asymptomatic patients.
T80 10937-10948 Sentence denotes Question 8.
T81 10949-10988 Sentence denotes What is the optimal treatment duration?
T82 10989-11288 Sentence denotes Chloroquine/hydroxychloroquine treatment should be continued for at least 5 days, and possibly up to 20 days, according to some expert opinions, although it should be noted that data regarding the relative safety of different lengths of administration in COVID-19 patients are currently unavailable.
T83 11289-11416 Sentence denotes Early discontinuation should be considered in the presence of adverse effects (e.g. QT prolongation or hepatic/renal toxicity).
T84 11417-11694 Sentence denotes If the administration of remdesivir is approved within compassionate-use/expanded-access programmes, treatment duration should follow compassionate or expanded access protocols (e.g. up to 10 days according to the most recent compassionate protocol at the time of this review).
T85 11695-11812 Sentence denotes If corticosteroids are provided, we suggest a total treatment duration of 7–10 days, with progressive dose reduction.
T86 11813-12083 Sentence denotes If the patient's condition deteriorates with worsening lung physiology after withdrawal of steroid treatment in the absence of bacterial or fungal superinfection, a second course of corticosteroid treatment may be considered, followed by slow tapering after improvement.
T87 12084-12459 Sentence denotes ARDS, acute respiratory distress syndrome; COVID-19, coronavirus disease 2019; CPAP, continuous positive airway pressure; HFNC, high-flow nasal cannula; ICU, intensive care unit; LPV/RTV, lopinavir/ritonavir; PEEP, positive end expiratory pressure; RCT, randomized controlled trial; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WHO, World Health Organization.
T88 12460-12635 Sentence denotes Table 2 Available and ongoing RCT on anti-infective and anti-inflammatory drugs most provided as off-label/compassionate treatments in the first phase of the COVID-19 pandemic
T89 12636-12787 Sentence denotes Drug Class/mechanism Published RCT Ongoing RCT for treatment/prevention of COVID-19 (recruiting or not yet recruiting) registered at ClinicalTrials.gov
T90 12788-12854 Sentence denotes Lopinavir/ritonavir Lopinavir is an HIV type 1 protease inhibitor.
T91 12855-13047 Sentence denotes Ritonavir is a CYP3A4 inhibitor that boosts lopinavir concentrations • Open-label RCT comparing lopinavir/ritonavir (99 patients) vs. standard of care (100) in patients with COVID-19 in China.
T92 13048-13125 Sentence denotes Lopinavir/ritonavir was administered at the dosage of 400/100 mg for 14 days.
T93 13126-13205 Sentence denotes The primary time-to-event endpoint was clinical improvement from randomization.
T94 13206-13594 Sentence denotes In the primary study population (ITT), no statistically significant differences were observed with regard to the primary endpoint of clinical improvement (HR 1.24 with standard of care as reference, 95% CI 0.90 to 1.72) and the secondary endpoint of 28-day mortality (19.2% vs. 25.0% in investigational and comparator arms, respectively; percentage difference −5.8%, 95% CI −17.3 to 5.7).
T95 13595-13748 Sentence denotes In the mITT population, lopinavir/ritonavir led to a median time to clinical improvement that was shorter by 1 day than that observed with standard care.
T96 13749-13921 Sentence denotes Median time between symptoms onset and randomization was 13 days (IQR 11–16) [22] • Comparison of lopinavir/ritonavir vs. hydroxychloroquine in patients with mild COVID-19.
T97 13922-13963 Sentence denotes Open-label RCT (NCT04307693, recruiting).
T98 13964-14023 Sentence denotes Primary endpoint: virus load at day 3, 5, 7, 10, 14 and 18.
T99 14024-14127 Sentence denotes • Comparison of ASC09/ritonavir vs. lopinavir/ritonavir in patients with confirmed COVID-19 pneumoniae.
T100 14128-14177 Sentence denotes Open-label RCT (NCT04261907, not yet recruiting).
T101 14178-14347 Sentence denotes Primary endpoint: adverse outcome at day 14 (composite of Spo 2 ≤ 93% without oxygen supplementation, PaO2/FiO2 ≤ 300 mm Hg or respiratory rate ≥ 30 breaths per minute).
T102 14348-14450 Sentence denotes • Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus umifenovir in patients with COVID-19.
T103 14451-14492 Sentence denotes Open-label RCT (NCT04252885, recruiting).
T104 14493-14569 Sentence denotes Primary endpoint: rate of virus inhibition at day 0, 2, 4, 7, 10, 14 and 21.
T105 14570-14695 Sentence denotes • Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus ribavirin plus interferon beta 1b in patients with COVID-19.
T106 14696-14737 Sentence denotes Open-label RCT (NCT04276688, recruiting).
T107 14738-14820 Sentence denotes Primary endpoint: time to negative nasopharyngeal swab RT-PCR (follow-up 30 days).
T108 14821-14964 Sentence denotes • Comparison of only supportive treatment vs. lopinavir/ritonavir vs. oseltamivir vs. umifenovir in patients with confirmed COVID-19 pneumonia.
T109 14965-15006 Sentence denotes Open-label RCT (NCT04255017, recruiting).
T110 15007-15282 Sentence denotes Primary endpoints: (a) rate of disease remission (mild disease: fever, cough and other symptoms relieved with improved lung CT; severe disease: fever, cough and other symptoms relieved with improved lung CT, Spo 2 > 93% or Pao 2/Fio 2 > 300 mm Hg); (b) time to lung recovery.
T111 15283-15395 Sentence denotes • Comparison of chemoprophylaxis with lopinavir/ritonavir vs. placebo in healthcare workers exposed to COVID-19.
T112 15396-15447 Sentence denotes Double-blind RCT (NCT04328285, not yet recruiting).
T113 15448-15542 Sentence denotes Primary endpoint: occurrence of a symptomatic or asymptomatic COVID-19 (follow-up 2.5 months).
T114 15543-15659 Sentence denotes • Comparison of carrimycin vs. lopinavir/ritonavir or umifenovir or chloroquine in patients with COVID-19 pneumonia.
T115 15660-15709 Sentence denotes Open-label RCT (NCT04286503, not yet recruiting).
T116 15710-15892 Sentence denotes Primary endpoints: (a) fever to normal time (follow-up 30 days); (b) pulmonary inflammation resolution time (follow-up 30 days); (c) negative conversion of throat swab RT-PCR at EOT.
T117 15893-16075 Sentence denotes • Comparison of lopinavir/ritonavir vs. lopinavir/ritonavir plus xiyanping (injectable component derived from a plant used in traditional Chinese medicine) in patients with COVID-19.
T118 16076-16125 Sentence denotes Open-label RCT (NCT04295551, not yet recruiting).
T119 16126-16187 Sentence denotes Primary endpoint: clinical recovery time (follow-up 28 days).
T120 16188-16357 Sentence denotes • Comparison of lopinavir/ritonavir plus inhaled interferon alfa vs. lopinavir/ritonavir plus inhaled interferon alfa plus xiyanping injection in patients with COVID-19.
T121 16358-16407 Sentence denotes Open-label RCT (NCT04275388, not yet recruiting).
T122 16408-16469 Sentence denotes Primary endpoint: clinical recovery time (follow-up 14 days).
T123 16470-16649 Sentence denotes • Comparison of lopinavir/ritonavir plus inhaled interferon alfa vs. lopinavir/ritonavir plus inhaled interferon alfa plus traditional Chinese medicines in patients with COVID-19.
T124 16650-16691 Sentence denotes Open-label RCT (NCT04251871, recruiting).
T125 16692-16769 Sentence denotes Primary endpoint: time to complete remission of symptoms (follow-up 28 days).
T126 16770-16985 Sentence denotes • Comparison of lopinavir/ritonavir plus hydroxychloroquine vs. lopinavir/ritonavir plus hydroxychloroquine plus levamisole pill plus budesonide plus formoterol inhaler in patients with nonsevere COVID-19 pneumonia.
T127 16986-17039 Sentence denotes Partly blinded RCT (NCT04331470, not yet recruiting).
T128 17040-17121 Sentence denotes Primary endpoint: (a) clear CT scan at 3–7 days; (b) negative RT-PCR at 3–7 days.
T129 17122-17233 Sentence denotes • Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. losartan vs. placebos in patients with COVID-19.
T130 17234-17295 Sentence denotes Double-blind, adaptive RCT (NCT04328012, not yet recruiting).
T131 17296-17372 Sentence denotes Primary endpoint: NIAID COVID-19 ordinal severity scale (follow-up 60 days).
T132 17373-17542 Sentence denotes • Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. lopinavir/ritonavir plus interferon beta 1a vs. remdesivir vs. standard of care in patients with COVID-19.
T133 17543-17596 Sentence denotes Double-blind, adaptive RCT (NCT04315948, recruiting).
T134 17597-17668 Sentence denotes Primary endpoint: severity rating on a 7-point ordinal scale at day 15.
T135 17669-17968 Sentence denotes • Comparison of lopinavir/ritonavir or umifenovir or chloroquine or hydroxychloroquine or oseltamivir (with or without azithromycin) vs. natural honey plus lopinavir/ritonavir or umifenovir or chloroquine or hydroxychloroquine or oseltamivir (with or without azithromycin) in patients with COVID-19.
T136 17969-18020 Sentence denotes Single-blind RCT (NCT04323345, not yet recruiting).
T137 18021-18214 Sentence denotes Primary endpoints: (a) positive to negative swabs at day 14; (b) fever to normal temperature in days (follow-up 14 days); (c) resolution of lung inflammation in CT or X-ray (follow-up 30 days).
T138 18215-18352 Sentence denotes • Comparison of colchicine (with or without lopinavir/ritonavir) vs. local standard of care in patients with moderate to severe COVID-19.
T139 18353-18402 Sentence denotes Open-label RCT (NCT04328480, not yet recruiting).
T140 18403-18461 Sentence denotes Primary endpoint: all-cause mortality (follow-up 30 days).
T141 18462-18866 Sentence denotes • Comparison of oseltamivir plus chloroquine vs. oseltamivir plus lopinavir/ritonavir in patients with mild COVID-19 and of lopinavir/ritonavir plus oseltamivir vs. darunavir/ritonavir plus oseltamivir vs. favipiravir plus lopinavir/ritonavir vs. darunavir/ritonavir plus oseltamivir plus chloroquine vs. darunavir/ritonavir plus favipiravir plus oseltamivir in patients with moderate to severe COVID-19.
T142 18867-18916 Sentence denotes Open-label RCT (NCT04303299, not yet recruiting).
T143 18917-18984 Sentence denotes Primary endpoint: SARS-CoV-2 eradication time (follow-up 24 weeks).
T144 18985-19015 Sentence denotes Remdesivir Adenosine analogue.
T145 19016-19181 Sentence denotes It binds to RNA-dependent RNA polymerase and acts as an RNA-chain terminator • Not available • Comparison of remdesivir vs. placebo in patients with severe COVID-19.
T146 19182-19225 Sentence denotes Double-blind RCT (NCT04257656, recruiting).
T147 19226-19315 Sentence denotes Primary endpoint: clinical status, assessed by an ordinal scale at days 7, 14, 21 and 28.
T148 19316-19398 Sentence denotes • Comparison of remdesivir vs. placebo in patients with mild to moderate COVID-19.
T149 19399-19442 Sentence denotes Double-blind RCT (NCT04252664, recruiting).
T150 19443-19516 Sentence denotes Primary endpoint: time to clinical recovery in hours (follow-up 28 days).
T151 19517-19604 Sentence denotes • Comparison of remdesivir vs. local standard of care in patients with severe COVID-19.
T152 19605-19646 Sentence denotes Open-label RCT (NCT04252664, recruiting).
T153 19647-19754 Sentence denotes Primary endpoint: composite of fever normalization and oxygen saturation normalization (follow-up 14 days).
T154 19755-19844 Sentence denotes • Comparison of remdesivir vs. local standard of care in patients with moderate COVID-19.
T155 19845-19886 Sentence denotes Open-label RCT (NCT04292730, recruiting).
T156 19887-19933 Sentence denotes Primary endpoint: discharged status at day 14.
T157 19934-19999 Sentence denotes • Comparison of remdesivir vs. placebo in patients with COVID-19.
T158 20000-20043 Sentence denotes Double-blind RCT (NCT04280705, recruiting).
T159 20044-20115 Sentence denotes Primary endpoint: severity rating on a 8-point ordinal scale at day 15.
T160 20116-20231 Sentence denotes • Comparison of remdesivir vs. hydroxychloroquine vs. remdesivir plus hydroxychloroquine in patients with COVID-19.
T161 20232-20290 Sentence denotes Open-label adaptive RCT (NCT04321616, not yet recruiting).
T162 20291-20361 Sentence denotes Primary endpoint: all-cause in-hospital mortality (follow-up 3 weeks).
T163 20362-20531 Sentence denotes • Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. lopinavir/ritonavir plus interferon beta 1a vs. remdesivir vs. standard of care in patients with COVID-19.
T164 20532-20585 Sentence denotes Double-blind, adaptive RCT (NCT04315948, recruiting).
T165 20586-20657 Sentence denotes Primary endpoint: severity rating on a 7-point ordinal scale at day 15.
T166 20658-20725 Sentence denotes Darunavir/cobicistat Darunavir is an HIV type 1 protease inhibitor.
T167 20726-20906 Sentence denotes Cobicistat is a CYP3A4 inhibitor that boosts darunavir concentrations • Not available • Comparison of darunavir/cobicistat vs. standard of care in patients with COVID-19 pneumonia.
T168 20907-20948 Sentence denotes Open-label RCT (NCT04252274, recruiting).
T169 20949-21063 Sentence denotes Primary endpoint: virologic clearance rate of throat swabs, sputum or lower respiratory tract secretions at day 7.
T170 21064-21370 Sentence denotes Favipiravir Anti-influenza RNA-dependent RNA polymerase inhibitor • In a recent RCT published on a preprint server and comparing 120 COVID-19 patients treated with favipiravir vs. 120 COVID-19 patients receiving umifenovir, higher rates of clinical recovery were observed in patients receiving favipiravir.
T171 21371-21546 Sentence denotes The manuscript is publicly available but still to be peer reviewed [30] • Comparison of favipiravir vs. tocilizumab vs. favipiravir plus tocilizumab in patients with COVID-19.
T172 21547-21588 Sentence denotes Open-label RCT (NCT04310228, recruiting).
T173 21589-21642 Sentence denotes Primary endpoint: clinical cure (follow-up 3 months).
T174 21643-22047 Sentence denotes • Comparison of oseltamivir plus chloroquine vs. oseltamivir plus lopinavir/ritonavir in patients with mild COVID-19 and of lopinavir/ritonavir plus oseltamivir vs. darunavir/ritonavir plus oseltamivir vs. favipiravir plus lopinavir/ritonavir vs. darunavir/ritonavir plus oseltamivir plus chloroquine vs. darunavir/ritonavir plus favipiravir plus oseltamivir in patients with moderate to severe COVID-19.
T175 22048-22097 Sentence denotes Open-label RCT (NCT04303299, not yet recruiting).
T176 22098-22165 Sentence denotes Primary endpoint: SARS-CoV-2 eradication time (follow-up 24 weeks).
T177 22166-22274 Sentence denotes • Comparison of hydroxychloroquine plus darunavir/cobicistat vs. standard of care in patients with COVID-19.
T178 22275-22316 Sentence denotes Open-label RCT (NCT04304053, recruiting).
T179 22317-22434 Sentence denotes Primary endpoint: incidence of secondary cases among contacts of a case and contacts of contacts (follow-up 14 days).
T180 22435-22534 Sentence denotes • Comparison of chloroquine plus favipiravir vs. favipiravir vs. placebo in patients with COVID-19.
T181 22535-22578 Sentence denotes Double-blind RCT (NCT04319900, recruiting).
T182 22579-22750 Sentence denotes Primary endpoints: (a) time to improvement/recovery and frequency of improvement/recovery (follow-up 10 days); (b) time to negative swab/sputum RT-PCR (follow-up 10 days).
T183 22751-22826 Sentence denotes • Comparison of favipiravir vs. standard of care in patients with COVID-19.
T184 22827-22876 Sentence denotes Open-label RCT (NCT04333589, not yet recruiting).
T185 22877-22989 Sentence denotes Primary endpoint: viral nucleic acid test negative conversion rate in nasopharyngeal swabs (follow-up 5 months).
T186 22990-23394 Sentence denotes • Comparison of oseltamivir plus chloroquine vs. oseltamivir plus lopinavir/ritonavir in patients with mild COVID-19 and of lopinavir/ritonavir plus oseltamivir vs. darunavir/ritonavir plus oseltamivir vs. favipiravir plus lopinavir/ritonavir vs. darunavir/ritonavir plus oseltamivir plus chloroquine vs. darunavir/ritonavir plus favipiravir plus oseltamivir in patients with moderate to severe COVID-19.
T187 23395-23444 Sentence denotes Open-label RCT (NCT04303299, not yet recruiting).
T188 23445-23512 Sentence denotes Primary endpoint: SARS-CoV-2 eradication time (follow-up 24 weeks).
T189 23513-23805 Sentence denotes Umifenovir Anti-influenza membrane fusion inhibitor • In a recent RCT published on a preprint server and comparing 120 COVID-19 patients treated with favipiravir vs. 120 COVID-19 patients receiving umifenovir, higher rates of clinical recovery were observed in patients receiving favipiravir.
T190 23806-23962 Sentence denotes The manuscript is publicly available but still to be peer reviewed [30] • Comparison of umifenovir vs. standard of care in patients with COVID-19 pneumonia.
T191 23963-24012 Sentence denotes Open-label RCT (NCT04260594, not yet recruiting).
T192 24013-24081 Sentence denotes Primary endpoint: virus negative conversion rate (follow-up 7 days).
T193 24082-24461 Sentence denotes Chloroquine, hydroxychloroquine Some proposed mechanisms are the following: increase in the endosomal Ph necessary for the virus/host cell fusion; interference with the glycosylation of cell receptors; immunomodulatory activity • Not available • Comparison of different hydroxychloroquine dosages vs. placebo in three cohorts (outpatients, inpatients, healthcare workers a risk).
T194 24462-24586 Sentence denotes Double-blind RCT for outpatients and healthcare workers and open-label RCT for inpatients (NCT04329923, not yet recruiting).
T195 24587-24784 Sentence denotes Primary endpoints: (a) release from quarantine (outpatients, follow-up 14 days); (b) discharge (inpatients, follow-up 14 days); (c) development of COVID-19 (healthcare workers, follow-up 2 months).
T196 24785-24871 Sentence denotes • Comparison of hydroxychloroquine vs. ascorbic acid in contacts of COVID-19 patients.
T197 24872-24923 Sentence denotes Double-blind RCT (NCT04328961, not yet recruiting).
T198 24924-24992 Sentence denotes Primary endpoint: laboratory-confirmed COVID-19 (follow-up 14 days).
T199 24993-25129 Sentence denotes • Comparison of tocilizumab plus hydroxychloroquine plus azithromycin vs. tocilizumab plus hydroxychloroquine in patients with COVID-19.
T200 25130-25179 Sentence denotes Open-label RCT (NCT04332094, not yet recruiting).
T201 25180-25407 Sentence denotes Primary endpoints: (a) in-hospital mortality (follow-up 2 weeks); (b) need for mechanical ventilation in the ICU (follow-up 2 weeks).• Comparison of ciclesonide plus hydroxychloroquine vs. ciclesonide in patients with COVID-19.
T202 25408-25457 Sentence denotes Open-label RCT (NCT04330586, not yet recruiting).
T203 25458-25531 Sentence denotes Primary endpoint: SARS-CoV-2 eradication (based on virus load) at day 14.
T204 25532-25658 Sentence denotes • Comparison of hydroxychloroquine vs. placebo in patients with COVID-19 and under biological treatment and/or JAK inhibitors.
T205 25659-25710 Sentence denotes Double-blind RCT (NCT04330495, not yet recruiting).
T206 25711-25921 Sentence denotes Primary endpoints: (a) incidence rate of COVID-19 (follow-up 27 weeks); (b) prevalence of COVID-19 (follow-up 27 weeks); (c) case fatality rate (follow-up 27 weeks); (d) ICU admission rate (follow-up 27 weeks).
T207 25922-26030 Sentence denotes • Comparison of hydroxychloroquine vs. placebo for the prevention of COVID-19 in healthcare workers at risk.
T208 26031-26082 Sentence denotes Double-blind RCT (NCT04328467, not yet recruiting).
T209 26083-26145 Sentence denotes Primary endpoint: prevalence of COVID-19 (follow-up 12 weeks).
T210 26146-26258 Sentence denotes • Comparison of chemoprophylaxis with lopinavir/ritonavir vs. placebo in healthcare workers exposed to COVID-19.
T211 26259-26310 Sentence denotes Double-blind RCT (NCT04328285, not yet recruiting).
T212 26311-26328 Sentence denotes Primary endpoint:
T213 26329-26417 Sentence denotes Occurrence of a symptomatic or asymptomatic SARS-CoV-2 infection (follow-up 2.5 months).
T214 26418-26539 Sentence denotes • Comparison of hydroxychloroquine vs. placebo in symptomatic COVID-19 patients or exposed healthcare workers/households.
T215 26540-26583 Sentence denotes Double-blind RCT (NCT04308668, recruiting).
T216 26584-26731 Sentence denotes Primary endpoints: (a) incidence of symptomatic COVID-19 among asymptomatic participants; (b) severity rating on a 3-point ordinal scale at day 14.
T217 26732-26847 Sentence denotes • Comparison of remdesivir vs. hydroxychloroquine vs. remdesivir plus hydroxychloroquine in patients with COVID-19.
T218 26848-26906 Sentence denotes Open-label adaptive RCT (NCT04321616, not yet recruiting).
T219 26907-26977 Sentence denotes Primary endpoint: all-cause in-hospital mortality (follow-up 3 weeks).
T220 26978-27089 Sentence denotes • Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. losartan vs. placebos in patients with COVID-19.
T221 27090-27151 Sentence denotes Double-blind, adaptive RCT (NCT04328012, not yet recruiting).
T222 27152-27228 Sentence denotes Primary endpoint: NIAID COVID-19 Ordinal Severity Scale (follow-up 60 days).
T223 27229-27387 Sentence denotes • Comparison of convalescent plasma plus hydroxychloroquine plus azithromycin vs. hydroxychloroquine plus azithromycin in hospitalized patients with COVID-19.
T224 27388-27437 Sentence denotes Open-label RCT (NCT04332835, not yet recruiting).
T225 27438-27617 Sentence denotes Primary endpoints: (a) change in virus load at days 0, 4, 7, 14 and 28; (b) change in IgM COVID-19 titers at days 0, 4, 7, 14 and 28; (c) change in IgG at days 0, 4, 7, 14 and 28.
T226 27618-27787 Sentence denotes • Comparison of lopinavir/ritonavir vs. hydroxychloroquine vs. lopinavir/ritonavir plus interferon beta-1a vs. remdesivir vs. standard of care in patients with COVID-19.
T227 27788-27841 Sentence denotes Double-blind, adaptive RCT (NCT04315948, recruiting).
T228 27842-27913 Sentence denotes Primary endpoint: severity rating on a 7-point ordinal scale at day 15.
T229 27914-28276 Sentence denotes Methylprednisolone A subgroup of patients with severe COVID-19 might develop a cytokine storm syndrome which causes rapidly progressive pneumonia, ARDS and clinical deterioration and corticosteroids administration may halt the dysregulated cytokine release • Not available • Comparison of methylprednisolone vs. standard of care in patients with severe COVID-19.
T230 28277-28318 Sentence denotes Open-label RCT (NCT04244591, recruiting).
T231 28319-28385 Sentence denotes Primary endpoint: lower Murray lung injury score at days 7 and 14.
T232 28386-28468 Sentence denotes • Comparison of methylprednisolone vs. standard of care in patients with COVID-19.
T233 28469-28510 Sentence denotes Open-label RCT (NCT04273321, recruiting).
T234 28511-28567 Sentence denotes Primary endpoint: treatment failure (follow-up 14 days).
T235 28568-28768 Sentence denotes • Comparison of inhaled alpha interferon plus methylprednisolone plus umifenovir vs. thalidomide plus inhaled alpha interferon plus methylprednisolone plus umifenovir in patients with severe COVID-19.
T236 28769-28820 Sentence denotes Double-blind RCT (NCT04273581, not yet recruiting).
T237 28821-28888 Sentence denotes Primary endpoint: time to clinical improvement (follow-up 28 days).
T238 28889-28971 Sentence denotes • Comparison of different dosages of methylprednisolone in patients with COVID-19.
T239 28972-29013 Sentence denotes Open-label RCT (NCT04263402, recruiting).
T240 29014-29095 Sentence denotes Primary endpoints: (a) disease readmission at day 7; (b) critical stage at day 7.
T241 29096-29204 Sentence denotes • Comparison of siltuximab (anti–IL-6 monoclonal antibody) vs. methylprednisolone in patients with COVID-19.
T242 29205-29254 Sentence denotes Open-label RCT (NCT04329650, not yet recruiting).
T243 29255-29306 Sentence denotes Primary endpoint: ICU admission (follow-up 29 days)
T244 29307-29423 Sentence denotes Tocilizumab Humanized monoclonal IgG1 antibody, tocilizumab inhibits both membrane-bound and soluble IL-6 receptors.
T245 29424-29674 Sentence denotes IL-6, is one of the main drivers of immunologic response and symptoms in patients with dysregulated cytokine release that has been observed in severe COVID-19 • Not available • Comparison of tocilizumab vs. standard of care in patients with COVID-19.
T246 29675-29724 Sentence denotes Open-label RCT (NCT04331808, not yet recruiting).
T247 29725-29827 Sentence denotes Primary endpoint: WHO progression scale at day 7 and 14 (severity rating on a 10-point ordinal scale).
T248 29828-29931 Sentence denotes • Comparison of favipiravir vs. tocilizumab vs. favipiravir plus tocilizumab in patients with COVID-19.
T249 29932-29973 Sentence denotes Open-label RCT (NCT04310228, recruiting).
T250 29974-30027 Sentence denotes Primary endpoint: clinical cure (follow-up 3 months).
T251 30028-30107 Sentence denotes • Comparison of tocilizumab vs. placebo in hospitalized patients with COVID-19.
T252 30108-30159 Sentence denotes Double-blind RCT (NCT04320615, not yet recruiting).
T253 30160-30231 Sentence denotes Primary endpoint: severity rating on a 7-point ordinal scale at day 28.
T254 30232-30368 Sentence denotes • Comparison of tocilizumab plus hydroxychloroquine plus azithromycin vs. tocilizumab plus hydroxychloroquine in patients with COVID-19.
T255 30369-30418 Sentence denotes Open-label RCT (NCT04332094, not yet recruiting).
T256 30419-30552 Sentence denotes Primary endpoints: (a) in-hospital mortality (follow-up 2 weeks); (b) need for mechanical ventilation in the ICU (follow-up 2 weeks).
T257 30553-30708 Sentence denotes • Comparison of chloroquine analog (GNS651) vs. tocilizumab vs. nivolumab vs. standard of care in patients with advanced or metastatic cancer and COVID-19.
T258 30709-30758 Sentence denotes Open-label RCT (NCT04333914, not yet recruiting).
T259 30759-30776 Sentence denotes Primary endpoint:
T260 30777-30793 Sentence denotes 28-day survival.
T261 30794-30995 Sentence denotes • Comparison of tocilizumab intravenously vs. tocilizumab subcutaneously vs. sarilumab (anti-interleukin 6 receptor α monoclonal antibody) subcutaneously vs. standard of care in patients with COVID-19.
T262 30996-31045 Sentence denotes Open-label RCT (NCT04322773, not yet recruiting).
T263 31046-31139 Sentence denotes Primary endpoint: time to independence from supplementary oxygen therapy (follow-up 28 days).
T264 31140-31341 Sentence denotes • Comparison of tocilizumab vs. anakinra (recombinant IL-1 receptor antagonist) vs. siltuximab vs. anakinra plus siltuximab vs. anakinra plus tocilizumab vs. standard of care in patients with COVID-19.
T265 31342-31391 Sentence denotes Open-label RCT (NCT04330638, not yet recruiting).
T266 31392-31459 Sentence denotes Primary endpoint: time to clinical improvement (follow-up 15 days).
T267 31460-31576 Sentence denotes • Comparison of carrimycin vs. lopinavir/ritonavir or umifenovir or chloroquine in patients with COVID-19 pneumonia.
T268 31577-31626 Sentence denotes Open-label RCT (NCT04286503, not yet recruiting).
T269 31627-31809 Sentence denotes Primary endpoints: (a) fever to normal time (follow-up 30 days); (b) pulmonary inflammation resolution time (follow-up 30 days); (c) negative conversion of throat swab RT-PCR at EOT.
T270 31810-31847 Sentence denotes Anakinra Antagonist of IL-1 receptor.
T271 31848-32104 Sentence denotes IL-1 is one of the main drivers of immunologic response and symptoms in patients with cytokine-release syndrome. • Not available • Comparison of anakinra vs. emapalumab (anti–interferon γ monoclonal antibody) vs. standard of care in patients with COVID-19.
T272 32105-32154 Sentence denotes Open-label RCT (NCT04324021, not yet recruiting).
T273 32155-32201 Sentence denotes Primary endpoint: treatment success at day 15.
T274 32202-32403 Sentence denotes • Comparison of tocilizumab vs. anakinra (recombinant IL-1 receptor antagonist) vs. siltuximab vs. anakinra plus siltuximab vs. anakinra plus tocilizumab vs. standard of care in patients with COVID-19.
T275 32404-32453 Sentence denotes Open-label RCT (NCT04330638, not yet recruiting).
T276 32454-32521 Sentence denotes Primary endpoint: time to clinical improvement (follow-up 15 days).
T277 32522-32655 Sentence denotes Off-label drugs mostly provided in Italy during the first phase of the COVID-19 pandemic according to the authors' direct experience.
T278 32656-32839 Sentence denotes Of note, there are also registered RCT for other drugs to be investigated in patients with COVID-19 (e.g. the Janus kinase family inhibitors ruxolitinib, baricitinib and tofacitinib).
T279 32840-33359 Sentence denotes ARDS = acute respiratory distress syndrome; CI, confidence interval; COVID-19, coronavirus disease 2019; CT, computed tomography; EOT, end of treatment; HR, hazard ratio; Ig, immunoglobulin; IL-1, interleukin 1; IQR, interquartile range; ITT, intent to treat; mITT, modified intent to treat; Pao2/Fio2, of arterial oxygen partial pressure to fractional inspired oxygen; RCT, randomized controlled trial; RT-PCR, real-time PCR; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WHO, World Health Organization.
T280 33361-33472 Sentence denotes Question 1. how to use at best oxygen therapy and noninvasive mechanical ventilation for preventing intubation?
T281 33473-33676 Sentence denotes In moderate to severe cases, COVID-19 usually presents as a lung disease (mostly in the form of bilateral interstitial pneumonia) causing hypoxic respiratory failure and requiring passive oxygen therapy.
T282 33677-33775 Sentence denotes The prevalence of hypoxic respiratory failure in patients with COVID-19 may be as high as 19% [8].
T283 33776-33978 Sentence denotes In observational studies conducted in China, 4% to 13% of COVID-19 patients received noninvasive positive pressure ventilation, and 2.3% to 12% required invasive mechanical ventilation [[8], [9], [10]].
T284 33979-34267 Sentence denotes In general, oxygen treatment should be provided to patients with shortness of breath or hypoxaemia, or those in shock, which is aimed at maintaining an appropriate level of peripheral capillary oxygen saturation (Spo 2), avoiding values of Spo 2 lower than 90% (92–95% in pregnant women).
T285 34268-34333 Sentence denotes During oxygen supplementation, Spo 2 should not surpass 96% [11].
T286 34334-34446 Sentence denotes An alternative to conventional oxygen supplementation is supplementation through high-flow nasal cannula (HFNC).
T287 34447-34548 Sentence denotes HFNC is an oxygen supply system that provides a mixture of air and oxygen with a known concentration.
T288 34549-34830 Sentence denotes HFNC provides high concentrations of humidified oxygen and low levels of positive end-expiratory pressure; it can also facilitate the elimination of carbon dioxide, thereby potentially reducing the need for intubation compared to standard oxygen supplementation [[12], [13], [14]].
T289 34831-35145 Sentence denotes However, it should also be considered that there are no standard evidence-based guidelines for the use of HFNC and that the experience in patients with COVID-19 is still limited (and without adjusted comparison to standard oxygen supplement) to provide universal recommendations, at least pending further data [9].
T290 35146-35528 Sentence denotes Other relevant things to be considered are: (a) HFNC should be used in settings with rapid availability of endotracheal intubation in the case of rapid deterioration [15]; and (b) the possible increased risk of contracting the infection for healthcare personnel as a result of aerosol generation should be appropriately managed (HFNC should be used in negative-pressure rooms) [16].
T291 35529-35991 Sentence denotes These two considerations also apply to continuous positive airway pressure (CPAP) with helmet (the most frequent system of noninvasive mechanical ventilation used in real life), which can be considered if the patient does not respond to standard or HFNC oxygen supplementation (i.e. if the ratio of arterial oxygen partial pressure to fractional inspired oxygen (Pao 2/Fio 2) has a decreasing trend) and there is no urgent indication for endotracheal intubation.
T292 35992-36141 Sentence denotes As for HFNC, also in the case of CPAP with helmet, close monitoring and short interval assessment for worsening of respiratory failure are mandatory.
T293 36142-36529 Sentence denotes In addition, it should be necessarily noted that although CPAP with helmet has become an established procedure for primary hypoxemic lung failure in the last few years, some experts do not support its use for COVID-19 [15], arguing that success rates in critically ill COVID-19 patients may be limited and there could be a risk of delayed intubation unfavourably influencing the outcome.
T294 36530-36868 Sentence denotes However, considering the atypical physiopathology of acute lung injury in patients with COVID-19 [17], gentle ventilation with a positive end expiratory pressure (PEEP) not higher than 10 to 12 cm of water may represent a reasonable approach for avoiding excessive damage during CPAP with helmet and possibly also the need for intubation.
T295 36869-37003 Sentence denotes Large studies, possibly RCT, are urgently needed to definitely clarify the precise role of CPAP with helmet in patients with COVID-19.
T296 37004-37304 Sentence denotes Finally, borrowing from what is already known and used in intensive care, pronation, although certainly more difficult to implement during noninvasive than invasive mechanical ventilation, may allow improved gas exchange and decreased respiratory distress, and may also promote lung recruitment [18].
T297 37306-37326 Sentence denotes Question 1 statement
T298 37327-37523 Sentence denotes Supplementary oxygen should be administered to patients with hypoxic respiratory failure for avoiding values of Spo 2 lower than 90%, and it should be aimed at reaching values not higher than 96%.
T299 37524-37828 Sentence denotes Although still without firm evidence, we currently support the use of CPAP helmet (with gentle ventilation and a PEEP of no more than 10–12 cm of water) if the patient does not respond to standard/HFNC oxygen supplementation and there is no urgent indication for endotracheal intubation (expert opinion).
T300 37829-37911 Sentence denotes However, no clear indications/criteria can be provided pending further experience.
T301 37912-38166 Sentence denotes Finally, it should be kept in mind that patients with COVID-19 can get worse in a few hours, so they should be closely monitored for worsening respiratory function so that tracheal intubation and mechanical ventilation can be quickly performed if needed.
T302 38168-38220 Sentence denotes Question 2. should antiviral agents be administered?
T303 38221-38502 Sentence denotes Several antiviral agents have demonstrated in vitro activity against SARS-CoV-2 or other coronaviruses, but currently there are no approved antiviral agents for coronavirus-related diseases, and there are still no favourable efficacy results from RCT available at the present time.
T304 38503-38651 Sentence denotes Lopinavir is a protease inhibitor used for the treatment of HIV patients, administered in combination with ritonavir to improve its serum half-life.
T305 38652-38953 Sentence denotes On the basis of its activity against SARS-CoV-1 and/or Middle East respiratory syndrome (MERS)-CoV observed in in vitro and animal studies [[19], [20], [21]], lopinavir/ritonavir (LPV/RTV) was compared to supportive care alone for the treatment of COVID-19 patients in an open-label RCT in China [22].
T306 38954-39202 Sentence denotes The primary time-to-event endpoint was clinical improvement from randomization (defined as a composite of discharge from the hospital or improvement of two points on a seven-category ordinal scale, ranging from no need of hospitalization to death).
T307 39203-39306 Sentence denotes Overall, 199 patients were enrolled (99 and 100 in the LPV/RTV and supportive care arms, respectively).
T308 39307-39504 Sentence denotes No differences were observed in the intent-to-treat population with regard to clinical improvement (hazard ratio 1.24 with standard of care as reference, 95% confidence interval (CI) 0.90 to 1.72).
T309 39505-39773 Sentence denotes In addition, no associations were observed with regard to 28-day mortality, although a smaller number of deaths were registered in the LPV/RTV arm (19.2% vs. 25.0% in investigational and comparator arms, respectively; percentage difference −5.8%, 95% CI −17.3 to 5.7).
T310 39774-40420 Sentence denotes Although some important considerations preclude a definite judgement on the possible efficacy of LPV/RTV (e.g. some major limitations are the open-label nature of the trial and the fact that LPV/RTV was initiated late with respect to the onset of symptoms; see question 7), especially in the case of early therapy initiation, the results of this RCT provide evidence currently discouraging the use of LPV/RTV (or of other protease inhibitors such as darunavir) in COVID-19 patients (also considering the potential side effects; Table 3 ), unless favourable results from other ongoing RCT in specific subgroups of patients are available (Table 2).
T311 40421-40635 Sentence denotes Furthermore, harmful drug interactions of antivirals with other drugs (such as hydroxychloroquine) cannot be excluded a priori because there are currently no large clinical data about the use of these combinations.
T312 40636-40803 Sentence denotes Table 3 Known adverse events of marketed anti-infective and anti-inflammatory drugs mostly provided as off-label treatments in the first phase of the COVID-19 pandemic
T313 40804-40823 Sentence denotes Drug Adverse events
T314 40824-40909 Sentence denotes Lopinavir/ritonavir • Hypercholesterolaemia and increased serum triglycerides (3–39%)
T315 40910-40953 Sentence denotes • Increased γ-glutamyl transferase (10–29%)
T316 40954-41005 Sentence denotes • Diarrhoea (7–28%; greater with once-daily dosing)
T317 41006-41039 Sentence denotes • Increased serum ALT (grade 3/4:
T318 41040-41046 Sentence denotes 1–11%)
T319 41047-41063 Sentence denotes • Nausea (5–16%)
T320 41064-41105 Sentence denotes • Upper respiratory tract infection (14%)
T321 41106-41130 Sentence denotes • Abdominal pain (1–11%)
T322 41131-41148 Sentence denotes • Vomiting (2–7%)
T323 41149-41163 Sentence denotes • Fatigue (8%)
T324 41164-41210 Sentence denotes • Increased serum amylase and/or lipase (3–8%)
T325 41211-41228 Sentence denotes • Headache (2–6%)
T326 41229-41246 Sentence denotes • Skin rash (≤5%)
T327 41247-41272 Sentence denotes • Neutropenia (grade 3/4:
T328 41273-41278 Sentence denotes 1–5%)
T329 41279-41293 Sentence denotes • Anxiety (4%)
T330 41294-41310 Sentence denotes • Insomnia (≤4%)
T331 41311-41381 Sentence denotes Chloroquine/hydroxychloroquine • Retinopathy (4% of treated patients)a
T332 41382-41633 Sentence denotes • Other adverse effects with unknown frequency included Stevens-Johnson syndrome, abdominal pain, diarrhoea, nausea, vomiting, agranulocytosis, leukopenia, thrombocytopenia, abnormal hepatic function tests, acute hepatic ailure, myopathy, bronchospasm
T333 41634-41740 Sentence denotes • Risk of prolonged QT interval, further increased when administered with fluoroquinolones or azithromycin
T334 41741-41796 Sentence denotes Tocilizumab • Increased serum ALT (≤36%) and AST (≤22%)
T335 41797-41832 Sentence denotes • Increased LDL cholesterol (9–10%)
T336 41833-41866 Sentence denotes • Injection site reaction (4–10%)
T337 41867-41890 Sentence denotes • Neutropenia (grade 3:
T338 41891-41918 Sentence denotes 2–7% of all adult patients)
T339 41919-41936 Sentence denotes • Headache (1–7%)
T340 41937-41958 Sentence denotes • Hypertension (1–6%)
T341 41959-41975 Sentence denotes • Dizziness (3%)
T342 41976-41998 Sentence denotes • Hypothyroidism (<2%)
T343 41999-42020 Sentence denotes • Abdominal pain (2%)
T344 42021-42057 Sentence denotes • Oral mucosa or gastric ulcers (2%)
T345 42058-42231 Sentence denotes • Infections due to Pneumocystis, Mycobacterium tuberculosis and varicella zoster have been reported after tocilizumab, but their prevalence has not been clearly established
T346 42232-42276 Sentence denotes Anakinra • Injection site reactionb (24–71%)
T347 42277-42390 Sentence denotes • Antibody development (up to 50% of the patients but no correlation of antibody development and adverse effects)
T348 42391-42423 Sentence denotes • Headache and vomiting (12–14%)
T349 42424-42445 Sentence denotes • Arthralgia (10–12%)
T350 42446-42462 Sentence denotes • Fever (10–12%)
T351 42463-42557 Sentence denotes • Haematologic disorder including eosinophilia, leukopenia and change in platelet count (2–9%)
T352 42558-42587 Sentence denotes • Nausea and diarrhoea (7–8%)
T353 42588-42615 Sentence denotes • Serious infectionc (2–3%)
T354 42616-42749 Sentence denotes Off-label drugs mostly provided in Italy during the first phase of the COVID-19 pandemic according to the authors' direct experience.
T355 42750-42879 Sentence denotes ALT, alanine aminotransferase; AST, aspartate aminotransferase; COVID-19, coronavirus disease 2019; LDL, low-density lipoprotein.
T356 42880-43020 Sentence denotes a Serum concentration dependent adverse effect; early changes are generally reversible but may progress despite discontinuation if advanced.
T357 43021-43089 Sentence denotes b Injection site reactions were considered serious in 2–3% of cases.
T358 43090-43173 Sentence denotes c Serious infections included cellulitis, pneumonia, and bone and joint infections.
T359 43174-43429 Sentence denotes Remdesivir is an investigational nucleotide analogue undergoing clinical development for Ebola and showing in vitro activity against coronaviruses (SARS-CoV-2, SARS-CoV-1 and MERS-CoV) and favourable effects in animal MERS models [[23], [24], [25], [26]].
T360 43430-43533 Sentence denotes Following these promising preclinical findings, RCT in COVID-19 patients have been initiated (Table 2).
T361 43534-43765 Sentence denotes However, pending their results, and considering the investigational nature of the drug, access to remdesivir outside RCT is currently provided only within strictly regulated and limited compassionate-use/expanded-access frameworks.
T362 43766-43925 Sentence denotes Oseltamivir and zanamivir are neuraminidase inhibitors used for treating influenza which are also being tested in RCT for treating COVID-19 patients (Table 2).
T363 43926-44235 Sentence denotes However, no apparent activity of oseltamivir and zanamivir has previously been observed against SARS-CoV-1 in vitro [27], and the fact that up to 76% of the first critically ill patients with COVID-19 received oseltamivir may also be related to the suspicion of infection (or coinfection) with influenza [28].
T364 44236-44413 Sentence denotes Overall, this information is currently insufficient for supporting the use of these agents in COVID-19 patients unless in the presence of suspected/proven concomitant influenza.
T365 44414-44667 Sentence denotes Other antiviral agents currently being investigated in RCT for the treatment of COVID-19 patients are favipiravir, an RNA-dependent RNA polymerase inhibitor with anti-influenza activity, and umifenovir, and anti-influenza membrane fusion inhibitor [29].
T366 44668-45030 Sentence denotes Even though these two agents attracted important media attention in the last few months, and even though there were some favourable preliminary results, especially for favipiravir, released as preprints, we advocate caution in using these agents outside investigational studies until completion of the standard peer-review processes of the first released trials.
T367 45031-45496 Sentence denotes For example, in a recent RCT comparing 120 COVID-19 patients treated with favipiravir versus 120 COVID-19 patients receiving umifenovir, higher rates of clinical recovery were observed in patients receiving favipiravir, but it is of note that the all-cause mortality was 0 in the entire study population, making it uncertain whether, if confirmed, these favourable results may be extrapolated to relevant survival endpoints in critically ill COVID-19 patients [30].
T368 45497-45637 Sentence denotes Finally, antiviral activity against SARS-CoV-2 in vitro has been recently reported for ivermectin, but clinical data are still lacking [31].
T369 45639-45659 Sentence denotes Question 2 statement
T370 45660-45790 Sentence denotes At the present time, evidence from the first published RCT does not support off-label treatment with LPV/RTV in COVID-19 patients.
T371 45791-45935 Sentence denotes This result should also discourage the use of other protease inhibitors (e.g. darunavir), at least until results of dedicated RCT are available.
T372 45936-46168 Sentence denotes Although promising in preclinical studies, remdesivir should be currently provided for treating COVID-19 patients only within RCT (preferentially) or compassionate-use/expanded-access programmes, owing to its investigational nature.
T373 46169-46350 Sentence denotes Pending high-level supporting evidence, favipiravir and umifenovir should not be provided outside RCT, at least in those countries where they are not approved for other indications.
T374 46351-46458 Sentence denotes Oseltamivir or zanamivir should be provided only in the presence of suspected/proven concomitant influenza.
T375 46460-46526 Sentence denotes Question 3. should chloroquine/hydroxychloroquine be administered?
T376 46527-46706 Sentence denotes The rationale of using chloroquine for treating COVID-19 patients is based on two potential and non–mutually exclusive mechanisms: antiviral activity and immunomodulatory effects.
T377 46707-47040 Sentence denotes With regard to antiviral activity, chloroquine has been shown to inhibit various viruses in cell cultures, including SARS-CoV-1 and SARS-CoV-2, possibly via pH-dependent inhibition of virus–endosome fusion and/or posttranslational modifications of CoV proteins, although other mechanisms may also contribute [[32], [33], [34], [35]].
T378 47041-47389 Sentence denotes With regard to the immunomodulatory effects, the attenuated production of tumor necrosis factor alpha, interleukin (IL)-6 and interferons that follows the administration of chloroquine might help counteract an exaggerated proinflammatory response, which is thought to contribute to the organ damage observed in SARS-CoV-2–infected patients [36,37].
T379 47390-47545 Sentence denotes However, some authors have pointed out that an unfavourable immunomodulatory effect cannot be excluded, based on a reduced T helper 2 differentiation [38].
T380 47546-47768 Sentence denotes In our opinion, hydroxychloroquine should be preferred over chloroquine because of its less toxic profile (reduced ocular toxicity and fewer drug interactions) and its more potent in vitro activity against SARS-CoV-2 [39].
T381 47769-48028 Sentence denotes Recently, Cortegiani et al. [40] reviewed the available information on ongoing case series, comparative observational studies and RCT evaluating the use of chloroquine or hydroxychloroquine in patients with COVID-19 and registered in Chinese or US registries.
T382 48029-48081 Sentence denotes They found 23 studies, all being conducted in China.
T383 48082-48271 Sentence denotes However, in the few weeks after the paper was made available online (10 March 2020), the number of registered studies being conducted in countries other than China has multiplied (Table 2).
T384 48272-48552 Sentence denotes In particular, results of registered RCT are necessary to guide (or discourage) the use of chloroquine/hydroxychloroquine in two different settings: prophylaxis of exposed individuals and treatment of proven cases, stratified for the severity of clinical presentation/progression.
T385 48553-48695 Sentence denotes In the meantime, a small controlled nonrandomized study of COVID-19 patients treated with hydroxychloroquine has been recently published [41].
T386 48696-48949 Sentence denotes In this study, Gautret et al. enrolled 26 COVID-19 patients to receive 200 mg of hydroxychloroquine every 8 hours for 10 days, whereas a total of 16 patients who denied consent as well as untreated patients from another centre were included as controls.
T387 48950-49031 Sentence denotes Of note, six patients treated with hydroxychloroquine also received azithromycin.
T388 49032-49166 Sentence denotes The primary endpoint was virologic clearance (based on results of real-time PCR on nasopharyngeal specimens) at day 6 after inclusion.
T389 49167-49522 Sentence denotes At day 6, 70% (14/20) of hydroxychloroquine-treated patients were virologically cured versus 12.5% (2/16) in the control group (p 0.001), although it cannot be excluded that selection bias and baseline virus load played a role in influencing results, thereby biasing results towards observing a favourable effect of hydroxychloroquine administration [42].
T390 49523-49754 Sentence denotes Furthermore, the opposite results (apparent absence of reduction of virus clearance) were recently described by another French group (albeit in a tiny sample size of 11 patients receiving hydroxychloroquine plus azithromycin) [43].
T391 49755-50103 Sentence denotes Uncertainty also surrounds the more marked positive effect observed in patients receiving azithromycin in addition to hydroxychloroquine in the study by Gautret et al., especially because of the very small number of patients in the combined treatment subgroup and the possible increased risk of QT prolongation by combining the two drugs (Table 3).
T392 50105-50125 Sentence denotes Question 3 statement
T393 50126-50384 Sentence denotes Pending results of RCT, the use of hydroxychloroquine may be considered for treating worsening patients with COVID-19 only if no important drug interactions can be anticipated and with close monitoring of hepatic function, renal function and QT prolongation.
T394 50385-50593 Sentence denotes This is based on its activity in vitro against SARS-CoV-2 (although weak) and on the availability of low-level clinical evidence of anticipation of virus clearance from a small controlled nonrandomized study.
T395 50594-50766 Sentence denotes However, it should also be kept in mind that the study was highly susceptible to bias and there are still no data regarding hard clinical endpoints such as crude mortality.
T396 50767-50891 Sentence denotes For these reasons, hydroxychloroquine should be preferentially administered within the framework of investigational studies.
T397 50892-51001 Sentence denotes When this is unfeasible, off-label use may be considered according to local protocols and consent procedures.
T398 51002-51198 Sentence denotes In view of the absence of evidence, we are currently unable to support the use of hydroxychloroquine in asymptomatic or mildly symptomatic nonhospitalized patients outside investigational studies.
T399 51199-51236 Sentence denotes The same applies to prophylactic use.
T400 51238-51285 Sentence denotes Question 4. should antibiotics be administered?
T401 51286-51488 Sentence denotes Bacterial infections can present simultaneously with COVID-19 or occur later during the course of the disease, worsening clinical conditions of patients who were recovering from primary viral pneumonia.
T402 51489-51589 Sentence denotes Information regarding the prevalence of bacterial coinfection or superinfection is scant [28,44,45].
T403 51590-51724 Sentence denotes According to the available reports, prevalence of bacterial infections in patients with COVID-19 ranges between 1% and 10% [28,44,46].
T404 51725-51857 Sentence denotes In these reports, bacterial infections were due to Gram-negative bacteria including Enterobacterales and nonfermenting rods [28,44].
T405 51858-52156 Sentence denotes It is of note that up to 98% of COVID-19 patients in available experiences received intravenous broad-spectrum empirical antibiotics [28,44,45,47], probably reflecting the frequent inability to exclude the presence of bacterial coinfection at the onset of severe clinical presentations of COVID-19.
T406 52157-52242 Sentence denotes This could have possibly lowered the overall prevalence of bacterial superinfections.
T407 52243-52485 Sentence denotes Extrapolating data from experiences on bacterial superinfection in pneumonia due to other viruses in a retrospective case series of critically ill patients with MERS in Saudi Arabia, bacterial infection was registered in 18% of patients [48].
T408 52486-52624 Sentence denotes With similar prevalence, bacterial pneumonia occurred in about 20% of patients hospitalized for primary influenza virus infection [49,50].
T409 52625-52730 Sentence denotes In these studies, mortality related to influenza was mostly due to secondary bacterial pneumonia [49,50].
T410 52731-52917 Sentence denotes Common bacteria implicated were Staphylococcus aureus, including methicillin-resistant strains [51], Streptococcus pneumoniae, Haemophilus influenzae and group A streptococci [49,52,53].
T411 52918-53089 Sentence denotes There are currently no large data regarding any possible favourable effects in COVID-19 patients related to possible anti-inflammatory or antiviral effect of azithromycin.
T412 53090-53218 Sentence denotes Furthermore, the small experiences of the administration of azithromycin in COVID-19 patients have provided conflicting results.
T413 53220-53240 Sentence denotes Question 4 statement
T414 53241-53423 Sentence denotes In our opinion, it might be prudent to consider empiric antibiotic treatment in critically ill patients with pneumonia due to COVID-19 in whom bacterial infection cannot be excluded.
T415 53424-53662 Sentence denotes This suggestion is based on the facts that bacterial coinfection is common in patients with viral pneumonia and that it can be associated with a substantial risk of delaying appropriate treatment, thereby potentially increasing mortality.
T416 53663-53910 Sentence denotes Because of the limited available data on both the microbiologic epidemiology (and the prevalence of antimicrobial resistance) of bacterial superinfections in COVID-19 patients, it is difficult to provide specific pathogen-oriented recommendations.
T417 53911-54325 Sentence denotes Therefore, pending further studies, we suggest to empirically treat COVID-19 patients according to their clinical syndrome (e.g. community-acquired pneumonia, hospital-acquired pneumonia), choosing the best antimicrobial agent or agents on the basis of local guidelines and local antibiotic susceptibility patterns, with early de-escalation or discontinuation according to microbiology results, whenever available.
T418 54327-54371 Sentence denotes Question 5. should steroids be administered?
T419 54372-54614 Sentence denotes So far, no RCT has been performed on corticosteroids administration in patients with COVID-19, and there are controversial opinions regarding the extrapolation of inference from previous studies in SARS-CoV-1 and MERS-CoV patients [15,54,55].
T420 54615-55023 Sentence denotes In an observational study conducted in 84 COVID-19 patients with acute respiratory distress syndrome (ARDS) in China, administration of methylprednisolone was associated with reduced progression to death (hazard ratio 0.38, 95% confidence interval 0.20–0.72, p 0.003), although the unadjusted analysis and the relatively small sample size preclude firm generalization and call for further investigation [47].
T421 55024-55240 Sentence denotes Indirect data on the possible efficacy (RCT) or effectiveness (observational comparative studies) of corticosteroid therapy come from studies performed in patients with MERS-CoV, SARS-CoV-1 or other viral infections.
T422 55241-55429 Sentence denotes With regard to patients with mild clinical presentation, a RCT including 16 not critically ill patients with SARS-CoV-1 did not report a beneficial effect of hydrocortisone administration.
T423 55430-55577 Sentence denotes Of note, higher viraemia was observed in the second and third weeks after infection in the hydrocortisone group compared to the control group [56].
T424 55578-55899 Sentence denotes Moreover, as reported in a systematic review and meta-analysis of observational studies on corticosteroids provided to patients with SARS-CoV-1, only four studies provided conclusive data, reporting no survival benefit and possible harms including avascular necrosis, psychosis, diabetes and delayed virus clearance [57].
T425 55900-56104 Sentence denotes In critically ill patients, corticosteroids may be provided to decrease the inflammation–coagulation–fibroproliferation observed during acute respiratory distress syndrome (ARDS) [[58], [59], [60], [61]].
T426 56105-56374 Sentence denotes A meta-analysis on corticosteroid use in ARDS including eight controlled studies reported a significant reduction in markers of systemic inflammation, pulmonary and extrapulmonary organ dysfunction scores, duration of mechanical ventilation and ICU length of stay [62].
T427 56375-56481 Sentence denotes A recent multicentre RCT included 277 patients with ARDS to assess the effects of dexamethasone treatment.
T428 56482-56628 Sentence denotes Patients in the study arm received dexamethasone 20 mg once daily from day 1 to day 5, which was reduced to 10 mg once daily from day 6 to day 10.
T429 56629-56908 Sentence denotes This study reported a significant reduction in duration of mechanical ventilation in the dexamethasone group than in the control group (between-group difference 4.8 days, p < 0.0001) and a significant reduction in mortality at 60 days (between-group difference −15.3%, p 0.0047).
T430 56909-57030 Sentence denotes The proportion of adverse events did not differ significantly between the dexamethasone group and the control group [63].
T431 57031-57179 Sentence denotes Data on the use of corticosteroids in critically ill patients with SARS-CoV-1 and MERS-CoV infection are available, albeit with conflicting results.
T432 57180-57428 Sentence denotes In a retrospective observational study of 152 SARS-CoV-1–infected, critically ill patients, corticosteroid therapy was found to reduce mortality and shorten the length of hospital stay (odds ratio 0.08, 95% confidence intervals 0.01–0.97, p 0.046).
T433 57429-57548 Sentence denotes The study did not report increased secondary infections or other complications with corticosteroid administration [64].
T434 57549-57783 Sentence denotes Conversely, in a retrospective observational study on 309 critically ill patients with MERS-CoV, the administration of a median hydrocortisone equivalent dose of 300 mg per day was not associated with a difference in 90-day mortality.
T435 57784-57923 Sentence denotes In addition, corticosteroid administration was associated with delayed clearance of MERS-CoV RNA from the patients' respiratory tract [65].
T436 57924-58165 Sentence denotes With regard to other viral infections, it is worth noting that a recent meta-analysis on patients with influenza pneumonia (including ten observational studies with a total of 6548 included patients) reported increased mortality (risk ratio:
T437 58166-58245 Sentence denotes 1.75, 95% CI 1.3–2.4; p 0.0002), increased length of ICU stay (mean difference:
T438 58246-58353 Sentence denotes 2.1, 95% CI 1.2–3.1; p < 0.0001) and increased rate of secondary bacterial or fungal infection (risk ratio:
T439 58354-58429 Sentence denotes 2.0, 95% CI 1.0–3.8; p 0.04) in patients who received corticosteroids [66].
T440 58431-58451 Sentence denotes Question 5 statement
T441 58452-58605 Sentence denotes So far, no definitive efficacy or effectiveness data are available on the benefit of corticosteroid administration in patients with SARS-CoV-2 infection.
T442 58606-58772 Sentence denotes As the World Health Organization underlines, there is an important need for efficacy data from RCT for supporting corticosteroids therapy in patients with SARS-CoV-2.
T443 58773-59234 Sentence denotes However, considering that overwhelming inflammation and cytokine-related lung injury might be responsible for the rapidly progressive pneumonia and clinical deterioration in COVID-19 patients [44,58,67], we suggest (expert opinion only) to consider administration of corticosteroids in critically ill COVID-19 patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections (independent of ICU admission).
T444 59235-59463 Sentence denotes However, in the absence of convincing evidence, the following cannot currently be supported: steroid administration stratified according to inflammatory markers and steroid administration in non–critically ill COVID-19 patients.
T445 59465-59558 Sentence denotes Question 6. should other immunosuppressive and/or immunomodulatory therapies be administered?
T446 59559-59844 Sentence denotes According to some recent evidence, some patients with COVID-19 may develop secondary haemophagocytic lymphohistiocytosis, an underrecognized hyperinflammatory syndrome characterized by a fulminant and fatal hypercytokinaemia, with development of ARDS and multiorgan failure [46,47,67].
T447 59845-59980 Sentence denotes Consequently, immunosuppressive and/or immunomodulatory therapies have been proposed to contrast COVID-19–associated hyperinflammation.
T448 59981-60353 Sentence denotes Tocilizumab is a recombinant humanized monoclonal antibody inhibiting membrane-bound and soluble IL-6 receptors [68] and is currently approved for the treatment of patients with rheumatoid arthritis, giant-cell arteritis, juvenile idiopathic arthritis and patients with chimeric antigen receptor T-cell–induced severe or life-threatening cytokine release syndrome [68,69].
T449 60354-60509 Sentence denotes In this regard, tocilizumab may help mitigate the cytokine release syndrome by decreasing cytokine concentrations and acute-phase reactant production [70].
T450 60510-60629 Sentence denotes In a recent preprint paper, Xu et al. [71] reported their experience of treating 21 COVID-19 patients with tocilizumab.
T451 60630-61020 Sentence denotes In their still-to-be-peer-reviewed case series, the following were observed after tocilizumab administration: (a) reduction in body temperature (21/21, 100%); (b) improved blood oxygenation (15/21, 71.4%); (c) normalization of lymphocyte count (10/17, 58.8%); (d) normalization of C-reactive protein (16/19, 82.4%); and (c) resolution of abnormalities on computed tomography (19/21, 90.5%).
T452 61021-61147 Sentence denotes Interestingly, no adverse reactions were observed after tocilizumab administration, but long-term follow-up was not available.
T453 61148-61306 Sentence denotes Tocilizumab has been deemed by Chinese National Health Commission to be a possible treatment option for patients with severe COVID-19 with elevated IL-6 [72].
T454 61307-61489 Sentence denotes The recommended dose is 4 to 8 mg/kg or 400 mg standard dose provided intravenously once, with the option to repeat a dose after 8 to 12 hours (not to exceed a total dose of 800 mg).
T455 61490-61687 Sentence denotes However, it should be noted that the optimal time for administering tocilizumab has not yet been fully elucidated; nor is there a clear IL-6 threshold associated with progression to severe disease.
T456 61688-61830 Sentence denotes At the time of writing, there are at least eight ongoing RCT evaluating the efficacy and safety of tocilizumab in COVID-19 patients (Table 2).
T457 61831-62027 Sentence denotes Other immune-modulatory drugs including anakinra (interleukin 1 receptor antagonist) or Janus kinase family enzyme inhibitors have been proposed for the management of SARS-CoV-2–infected patients.
T458 62028-62127 Sentence denotes Notably, there is currently no supporting clinical evidence, and RCT are ongoing (Table 2) [67,73].
T459 62128-62399 Sentence denotes Finally, modifications of the immune response through administration of high-dose intravenous immunoglobulin or convalescent plasma have also been proposed or used in small case series, and they merit further investigation in dedicated RCT [[74], [75], [76], [77], [78]].
T460 62401-62421 Sentence denotes Question 6 statement
T461 62422-62576 Sentence denotes Owing to the lack of high-level evidence, administration of tocilizumab in patients with COVID-19 should preferentially occur within the framework of RCT.
T462 62577-62903 Sentence denotes Off-label use according to local protocols and consent procedures may be considered only in those COVID-19 patients excluded from RCT (or hospitalized where RCT are not available or still to be implemented) and who are worsening while receiving standard supportive care (in the absence of concomitant/superimposed infections).
T463 62904-63380 Sentence denotes In our opinion, this could be a reasonable off-label use of tocilizumab in these early phases of the COVID-19 pandemic, although patients and physicians should be fully aware that currently there is only a non–peer-reviewed, noncomparative, observational experience (very low evidence from an unreviewed cases series), and that it only supports a potential favourable effect on inflammatory signs and symptoms, while there is no information on any possible effect on survival.
T464 63381-63600 Sentence denotes In the absence of clinical studies, we suggest that also other immunosuppressive and/or immunomodulatory therapies (e.g. anakinra, Janus kinase family enzyme inhibitors) should be preferentially administered within RCT.
T465 63601-63939 Sentence denotes This also applies to modifications of the immune response through high-dose intravenous immunoglobulins or plasma from convalescent patients, which, although promising in very small case series, both deserve dedicated RCT investigation to clearly understand their tolerability as well as the role they play in affecting COVID-19 outcomes.
T466 63941-64004 Sentence denotes Question 7. what is the optimal timing of treatment initiation?
T467 64005-64205 Sentence denotes Most clinical data on the timing of antiviral therapy initiation are derived from studies on viruses other than SARS-CoV-2, and it remains unclear whether these data can be extrapolated to SARS-CoV-2.
T468 64206-64389 Sentence denotes Previous studies in SARS-CoV-1 and influenza showed a possible favourable impact on mortality of early initiation of antiviral treatment after symptoms onset [[79], [80], [81], [82]].
T469 64390-64793 Sentence denotes With regard to SARS-CoV-2, although the results of the previously cited RCT comparing LPV/RTV versus standard of care eventually does not support the use of LPV/RTV in patients with COVID-19, it is also of note that the median time between symptom onset and randomization was 13 days (interquartile range, 11–16 days), so in most cases, the drug was initiated late during the course of the disease [22].
T470 64794-64922 Sentence denotes Consequently, we cannot exclude the possibility that an earlier initiation of LPV/RTV may be associated with improved prognosis.
T471 64923-65142 Sentence denotes In this regard, we think the results of this RCT may be hypothesis generating and may help guide the design of further RCT evaluating the efficacy of LPV/RTV (and/or other antivirals) in an earlier phase of the disease.
T472 65143-65390 Sentence denotes However, until such RCT will be available, we think the currently available clinical evidence is insufficient to support the use of LPV/RTV and/or other antivirals for treating COVID-19 outside the framework of RCT or compassionate-use programmes.
T473 65391-65495 Sentence denotes The optimal time of chloroquine/hydroxychloroquine and corticosteroids initiation still remains unknown.
T474 65496-65992 Sentence denotes Although based on low-level evidence, the positive effect of virus clearance observed by Gautret et al. [41] was observed in a mixed group of non-ICU patients with upper respiratory tract symptoms, non-ICU patients with lower respiratory tract symptoms and asymptomatic subjects, which overall may support a positive effect of early hydroxychloroquine initiation in non-ICU settings (although information on the exact time of treatment initiation with respect to symptoms onset was not provided).
T475 65993-66140 Sentence denotes With regard to steroid treatment, there is currently no evidence of a positive impact of early initiation in non–critically ill, non-ARDS patients.
T476 66141-66399 Sentence denotes Although lack of evidence is not a synonym of lack of effect, in our opinion, steroid treatment, considering also its potential detrimental effects, should currently be limited to ARDS patients or non-ARDS patients with worsening conditions (see question 5).
T477 66401-66421 Sentence denotes Question 7 statement
T478 66422-66718 Sentence denotes Supportive therapy (symptomatic therapy, rehydration and oxygen supplementation, if necessary) should be provided as soon as the patient presents with respiratory or systemic symptoms including severe asthenia, high fever, persistent cough and/or clinical or radiologic signs of lung involvement.
T479 66719-66990 Sentence denotes Pending further evidence, in our opinion, antiviral treatments should not be initiated in patients with SARS-CoV-2 infection outside RCT or compassionate-use programmes (with the exception of early oseltamivir initiation in patients with suspected concomitant influenza).
T480 66991-67263 Sentence denotes Corticosteroids should be initiated early in well-defined categories of patients (patients with ARDS or with worsening of non-ARDS respiratory failure in the absence of bacterial/fungal superinfections), while their role in other COVID-19 patients still remains uncertain.
T481 67264-67647 Sentence denotes Although based on low-level evidence and pending RCT results, in our opinion, early hydroxychloroquine administration may be considered in COVID-19 patients who have moderate to severe symptoms, whereas further data are needed to better delineate the true balance between possible favourable effects and toxicity of hydroxychloroquine in mildly symptomatic and asymptomatic patients.
T482 67649-67700 Sentence denotes Question 8. what is the optimal treatment duration?
T483 67701-68004 Sentence denotes In the absence of proven effective treatment, treatment duration also remains unclear; it is currently based on expert opinion which is based on treatment durations in other approved indications for the drugs provided and aimed at a balance between potential activity and risk of undesired side effects.
T484 68005-68052 Sentence denotes Nonetheless, suggested durations vary markedly.
T485 68053-68458 Sentence denotes For example, a wide range of chloroquine/hydroxychloroquine treatment durations (from 5 to 20 days) have been recommended/provided in different centres/studies, making it impossible to provide an univocal recommendation in the absence of direct comparisons of different lengths of treatment with regard to relevant clinical endpoints (e.g. mortality, ICU admission) and safety [33,40,41,[83], [84], [85]].
T486 68459-68620 Sentence denotes There is no standard steroid treatment duration, with different consensus/study groups suggesting steroid administration for no longer than 7 to 10 days [54,85].
T487 68622-68642 Sentence denotes Question 8 statement
T488 68643-68950 Sentence denotes Chloroquine/hydroxychloroquine treatment should be continued for at least 5 days and possibly prolonged up to 20 days according to some expert opinions, although it should be noted that data regarding the relative safety of different lengths of administration in COVID-19 patients are currently unavailable.
T489 68951-69087 Sentence denotes Early discontinuation should be considered in the presence of adverse effects (e.g. QT prolongation or hepatic/renal toxicity; Table 3).
T490 69088-69365 Sentence denotes If the administration of remdesivir is approved within compassionate-use/expanded-access programmes, treatment duration should follow compassionate or expanded access protocols (e.g. up to 10 days according to the most recent compassionate protocol at the time of this review).
T491 69366-69490 Sentence denotes If corticosteroids are administered, we suggest a total treatment duration of 7 to 10 days, with progressive dose reduction.
T492 69491-69746 Sentence denotes If the patient deteriorates with worsening lung physiology after removal of steroid treatment in the absence of bacterial or fungal superinfection, a second course of corticosteroid treatment may be considered, followed by slow tapering after improvement.
T493 69748-69767 Sentence denotes Future perspectives
T494 69768-70278 Sentence denotes In these first phases of the COVID-19 pandemic, where there are no clearly supported and approved treatments, there are two apparently mutually exclusive forces driving therapeutic choices supported only by preclinical and/or low-level clinical evidence: the willingness to administer potentially active therapies to COVID-19 patients; and the willingness not to harm by administering potentially inactive therapies that may unfavourably influence the outcome because of either expected or unexpected toxicity.
T495 70279-70451 Sentence denotes Finding the right balance between these two forces is certainly not simple, but it remains more necessary than ever if we want to rapidly find effective and safe treatment.
T496 70452-70665 Sentence denotes For this reason, RCT should always be the first option to be proposed to patients because RCT are the only way to provide high-level efficacy and safety information for optimizing the treatment of future patients.
T497 70666-70981 Sentence denotes However, even when rapidly implemented during evolving pandemics, RCT are usually not immediately available (e.g. even if accelerated, local approval still and correctly requires time to guarantee ethical standards), and also many patients are usually excluded from RCT because of strict selection criteria [86,87].
T498 70982-71275 Sentence denotes For some of these patients, off-label uses (for drugs approved for other indications) and compassionate-use/expanded-access programmes (for investigational drugs) may represent an ethically justifiable option in the case of worsening conditions and unlikely survival with only supportive care.
T499 71276-71473 Sentence denotes Against this background, the role of the attending physician is crucial, by favouring and not discouraging RCT participation (in favour of off-label administration) whenever the former is possible.
T500 71474-71748 Sentence denotes Otherwise, scientific data will still be produced, but most information will be burdened by only partially adjustable selection biases and confounding factors, with consequent risks of inconclusive results and low-level supporting evidence for the various treatment options.
T501 71749-72039 Sentence denotes If participation in RCT is maximized, high-level evidence will be available for guiding treatment, with lower-level evidence from off-label uses still remaining useful for hypothesis-generating purposes in order to better design further RCT (and not for directly guiding treatment choices).
T502 72040-72509 Sentence denotes Notably, this is what, in our opinion, happened with LPV/RTV: (a) preclinical data supported activity against coronaviruses; (b) patients were enrolled onto RCT whenever possible, and otherwise they were offered off-label administration when not spontaneously improving; (c) because many patients were rapidly enrolled onto the first RCT, evidence rapidly become available that in our opinion discouraged a universal off-label provision of LPV/RTV in COVID-19 patients.
T503 72511-72522 Sentence denotes Conclusions
T504 72523-72644 Sentence denotes Many off-label antiviral and anti-inflammatory drugs are being administered in this first phase of the COVID-19 pandemic.
T505 72645-72906 Sentence denotes While we do not discourage their use, physicians must be aware that because of the lack of high-level evidence, they may be ethically justifiable only in those worsening patients unlikely to improve with only supportive care and who cannot be enrolled onto RCT.
T506 72907-73108 Sentence denotes Implementation of well-designed RCT should be expanded as much as possible, as RCTs are the most secure way to change for the better our approach to COVID-19 patients, including our frontline opinions.
T507 73110-73134 Sentence denotes Transparency Declaration
T508 73135-73204 Sentence denotes All authors report no conflicts of interest relevant to this article.

2_test

Id Subject Object Predicate Lexical cue
32360444-32178769-22369750 833-834 32178769 denotes 6
32360444-32119825-22369751 964-965 32119825 denotes 7
32360444-32187464-22369752 13827-13829 32187464 denotes 22
32360444-32105632-22369753 33968-33969 32105632 denotes 9
32360444-25981908-22369754 34813-34815 25981908 denotes 12
32360444-19467849-22369755 34819-34821 19467849 denotes 13
32360444-28860265-22369756 34825-34827 28860265 denotes 14
32360444-32105632-22369757 35142-35143 32105632 denotes 9
32360444-32105633-22369758 35524-35526 32105633 denotes 16
32360444-23688302-22369759 37300-37302 23688302 denotes 18
32360444-27585965-22369760 38793-38795 27585965 denotes 19
32360444-27344959-22369761 38799-38801 27344959 denotes 20
32360444-26198719-22369762 38805-38807 26198719 denotes 21
32360444-32187464-22369763 38949-38951 32187464 denotes 22
32360444-32020029-22369764 43406-43408 32020029 denotes 23
32360444-31924756-22369765 43412-43414 31924756 denotes 24
32360444-32054787-22369766 43418-43420 32054787 denotes 25
32360444-15200845-22369767 44043-44045 15200845 denotes 27
32360444-32007143-22369768 44231-44233 32007143 denotes 28
32360444-32147628-22369769 44663-44665 32147628 denotes 29
32360444-32251768-22369770 45633-45635 32251768 denotes 31
32360444-15351731-22369771 47017-47019 15351731 denotes 32
32360444-32203437-22369772 47035-47037 32203437 denotes 35
32360444-9002011-22369773 47382-47384 9002011 denotes 36
32360444-32194152-22369774 47764-47766 32194152 denotes 39
32360444-32007143-22369775 51579-51581 32007143 denotes 28
32360444-31986264-22369776 51582-51584 31986264 denotes 44
32360444-32109013-22369777 51585-51587 32109013 denotes 45
32360444-32007143-22369778 51714-51716 32007143 denotes 28
32360444-31986264-22369779 51717-51719 31986264 denotes 44
32360444-32007143-22369780 51850-51852 32007143 denotes 28
32360444-31986264-22369781 51853-51855 31986264 denotes 44
32360444-32007143-22369782 51992-51994 32007143 denotes 28
32360444-31986264-22369783 51995-51997 31986264 denotes 44
32360444-32109013-22369784 51998-52000 32109013 denotes 45
32360444-31573350-22369785 52481-52483 31573350 denotes 48
32360444-22387143-22369786 52617-52619 22387143 denotes 49
32360444-20508031-22369787 52620-52622 20508031 denotes 50
32360444-22387143-22369788 52723-52725 22387143 denotes 49
32360444-20508031-22369789 52726-52728 20508031 denotes 50
32360444-16707043-22369790 52827-52829 16707043 denotes 51
32360444-22387143-22369791 52907-52909 22387143 denotes 49
32360444-22291193-22369792 52910-52912 22291193 denotes 52
32360444-20377405-22369793 52913-52915 20377405 denotes 53
32360444-32122468-22369794 54607-54609 32122468 denotes 54
32360444-32043983-22369795 54610-54612 32043983 denotes 55
32360444-15494274-22369796 55573-55575 15494274 denotes 56
32360444-16968120-22369797 55895-55897 16968120 denotes 57
32360444-22088618-22369798 56081-56083 22088618 denotes 58
32360444-7587435-22369799 56087-56089 7587435 denotes 59
32360444-11934726-22369800 56093-56095 11934726 denotes 60
32360444-21983371-22369801 56099-56101 21983371 denotes 61
32360444-19325471-22369802 56370-56372 19325471 denotes 62
32360444-32043986-22369803 57026-57028 32043986 denotes 63
32360444-16778260-22369804 57544-57546 16778260 denotes 64
32360444-29161116-22369805 57919-57921 29161116 denotes 65
32360444-30917856-22369806 58425-58427 30917856 denotes 66
32360444-31986264-22369807 58966-58968 31986264 denotes 44
32360444-22088618-22369808 58969-58971 22088618 denotes 58
32360444-32192578-22369809 58972-58974 32192578 denotes 67
32360444-32192578-22369810 59840-59842 32192578 denotes 67
32360444-24834925-22369811 60094-60096 24834925 denotes 68
32360444-24834925-22369812 60346-60348 24834925 denotes 68
32360444-18358927-22369813 60349-60351 18358927 denotes 69
32360444-32192578-22369814 62120-62122 32192578 denotes 67
32360444-32032529-22369815 62123-62125 32032529 denotes 73
32360444-32167489-22369816 62370-62372 32167489 denotes 74
32360444-32258207-22369817 62388-62390 32258207 denotes 77
32360444-32178711-22369818 62394-62396 32178711 denotes 78
32360444-14660806-22369819 64366-64368 14660806 denotes 79
32360444-30304487-22369820 64372-64374 30304487 denotes 80
32360444-22843781-22369821 64378-64380 22843781 denotes 81
32360444-24815805-22369822 64384-64386 24815805 denotes 82
32360444-32187464-22369823 64789-64791 32187464 denotes 22
32360444-32164085-22369824 68447-68449 32164085 denotes 84
32360444-32122468-22369825 68613-68615 32122468 denotes 54
32360444-29240890-22369826 70974-70976 29240890 denotes 86
32360444-31607179-22369827 70977-70979 31607179 denotes 87