PMC:7194141 / 21537-24265
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7194141","sourcedb":"PMC","sourceid":"7194141","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7194141","text":"Heavy metals\nDr. Cathrine Hoyo from North Carolina State University presented on heavy metal exposure and cardiometabolic phenotypes. She shared results from her work in the Newborn Epigenetic Study (NEST) evaluating metals exposures and obesity in just over 310 children living in North Carolina, USA. Exposures discussed included cadmium and lead, which was found in the blood samples of pregnant women during the first trimester. Women with elevated cadmium and lead exposure were geographically clustered based on prenatal mailing addresses. This clustering in space of women with elevated levels of cadmium and lead was followed by sampling and measuring soil, house dust, and water to identify potential sources and routes of exposure and guide prevention efforts 20. Although no cadmium or lead was found in water, these metals contaminated soils and house dust of women with elevated concentrations suggesting soil tracked indoors and part of house dust could represent an important source of cadmium and lead exposures. Concentrations of these metals were also higher on hand wipes of this geographic cluster, suggesting that inadvertent ingestion of contaminated house dust could be a potential route of exposure.\nCadmium and lead are in the top ten chemicals of concern by the International Agency for Research on Cancer ( IARC) and Agency for Toxic Substances and Disease Registry ( ATSDR), because: their industrial applications are numerous, they are poorly excreted (hence the heavy metal burden increases with increasing age), and they sizably contribute to cardiovascular and metabolic disease, which are diseases in the top ten global causes of mortality. While smoking is a major source of cadmium, it is estimated that non-smokers also ingest ~1µg per day from diet as plants take up this compound from the air, contaminated soil, and water 21. The European Union estimates that cadmium exposure will increase with the projected increase in the production of batteries for electric vehicles, for which cadmium is an important component 21. The yet unexplained higher propensity for exposure among women will affect unborn children and their offspring for generations to come as observed with juvenile obesity 22. In addition to key highlights to her research on the health effects of metals in children, Dr. Hoyo described considerations for biosample collection for investigators interested in studying metals. Notably, she described recent advances in Inductively Coupled Plasma-Mass Spectrometry that can be leveraged to identify multiple metals in limited specimens. She also described contamination issues that may arise when collecting samples, and methods to help obtain good data for these exposures.","divisions":[{"label":"title","span":{"begin":0,"end":12}},{"label":"p","span":{"begin":13,"end":1223}}],"tracks":[{"project":"2_test","denotations":[{"id":"32382703-26449855-29212","span":{"begin":770,"end":772},"obj":"26449855"},{"id":"32382703-29511319-29213","span":{"begin":2229,"end":2231},"obj":"29511319"}],"attributes":[{"subj":"32382703-26449855-29212","pred":"source","obj":"2_test"},{"subj":"32382703-29511319-29213","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93d2","default":true}]}]}}