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PMC:7191300 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
2 0-10 Chemical denotes Amantadine MESH:D000547
3 64-71 Disease denotes COVID19 MESH:C000657245
11 97-108 Gene denotes Cathepsin L Gene:1514
12 110-114 Gene denotes CTSL Gene:1514
13 231-235 Gene denotes CTSL Gene:1514
14 258-262 Gene denotes CTSL Gene:1514
15 304-308 Gene denotes CTSL Gene:1514
16 332-334 Gene denotes pH Gene:5053
17 148-156 Disease denotes CoVID-19 MESH:C000657245
21 501-505 Gene denotes CTSL Gene:1514
22 506-510 Gene denotes CTSB Gene:1508
23 521-531 Chemical denotes amantadine MESH:D000547
26 628-639 Gene denotes Cathepsin L Gene:1514
27 568-578 Chemical denotes Amantadine MESH:D000547
31 711-721 Species denotes SARS-CoV-2 Tax:2697049
32 731-739 Species denotes patients Tax:9606
33 667-677 Chemical denotes Amantadine MESH:D000547
36 920-924 Gene denotes CTSL Gene:1514
37 969-977 Disease denotes infected MESH:D007239
53 1134-1139 Gene denotes spike Gene:43740568
54 1141-1142 Gene denotes S Gene:43740568
55 1196-1201 Gene denotes spike Gene:43740568
56 1245-1256 Gene denotes Cathepsin L Gene:1514
57 1261-1272 Gene denotes Cathepsin B Gene:1508
58 1274-1278 Gene denotes CTSL Gene:1514
59 1389-1393 Gene denotes CTSL Gene:1514
60 1509-1513 Gene denotes CTSL Gene:1514
61 1536-1540 Gene denotes CTSL Gene:1514
62 1582-1586 Gene denotes CTSL Gene:1514
63 1609-1611 Gene denotes pH Gene:5053
64 1001-1019 Species denotes SARS-coronavirus 2 Tax:2697049
65 1066-1076 Species denotes SARS-Cov-2 Tax:2697049
66 1047-1055 Disease denotes COVID-19 MESH:C000657245
67 1426-1434 Disease denotes CoVID-19 MESH:C000657245
75 1768-1772 Gene denotes CTSL Gene:1514
76 1773-1777 Gene denotes CTSB Gene:1508
77 1858-1862 Gene denotes CTSL Gene:1514
78 1989-1998 Species denotes influenza Tax:11320
79 1871-1881 Chemical denotes amantadine MESH:D000547
80 1890-1900 Chemical denotes Amantadine MESH:D000547
81 2013-2032 Disease denotes Parkinson's disease MESH:D010300
91 2110-2114 Gene denotes CTSL Gene:1514
92 2272-2276 Gene denotes CTSL Gene:1514
93 2366-2376 Species denotes SARS-CoV-2 Tax:2697049
94 2386-2394 Species denotes patients Tax:9606
95 2069-2079 Chemical denotes Amantadine MESH:D000547
96 2322-2332 Chemical denotes amantadine MESH:D000547
97 2614-2624 Chemical denotes amantadine MESH:D000547
98 2628-2636 Disease denotes COVID-19 MESH:C000657245
99 2637-2646 Disease denotes infection MESH:D007239
112 2706-2722 Species denotes beta-coronavirus Tax:694002
113 2741-2749 Species denotes patients Tax:9606
114 2783-2828 Species denotes Severe acute respiratory syndrome coronavirus Tax:694009
115 2830-2840 Species denotes SARS-CoV-2 Tax:2697049
116 2944-2950 Species denotes humans Tax:9606
117 3084-3094 Species denotes SARS-CoV-2 Tax:2697049
118 3135-3143 Species denotes SARS-CoV Tax:694009
119 3182-3197 Species denotes bat coronavirus Tax:1508220
120 3217-3230 Species denotes Coronaviruses Tax:11118
121 2755-2764 Disease denotes pneumonia MESH:D011014
122 2921-2940 Disease denotes respiratory disease MESH:D012140
123 2972-2980 Disease denotes COVID-19 MESH:C000657245
138 3694-3725 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
139 3727-3731 Gene denotes ACE2 Gene:59272
140 3761-3765 Gene denotes ACE2 Gene:59272
141 3872-3876 Gene denotes ACE2 Gene:59272
142 4049-4054 Gene denotes spike Gene:43740568
143 4082-4086 Gene denotes ACE2 Gene:59272
144 4162-4166 Gene denotes ACE2 Gene:59272
145 4220-4225 Gene denotes spike Gene:43740568
146 3595-3603 Species denotes SARS-CoV Tax:694009
147 3605-3615 Species denotes SARS-Cov-2 Tax:2697049
148 4076-4081 Species denotes human Tax:9606
149 4250-4258 Species denotes SARS-CoV Tax:694009
150 3896-3919 Disease denotes cardiovascular diseases MESH:D002318
151 4579-4588 Disease denotes infection MESH:D007239
164 4720-4731 Gene denotes Cathepsin B Gene:1508
165 4739-4743 Gene denotes CTSL Gene:1514
166 4748-4752 Gene denotes CTSB Gene:1508
167 4761-4772 Gene denotes Cathepsin L Gene:1514
168 4904-4908 Gene denotes CTSL Gene:1514
169 5021-5032 Gene denotes Cathepsin L Gene:1514
170 4922-4924 Gene denotes pH Gene:5053
171 4622-4632 Species denotes SARS-CoV-2 Tax:2697049
172 4659-4667 Species denotes SARS-CoV Tax:694009
173 5072-5077 Species denotes Ebola Tax:1570291
174 5089-5097 Species denotes SARS-CoV Tax:694009
175 4951-4956 Chemical denotes thiol MESH:D013438
196 5947-5958 Gene denotes Cathepsin L Gene:1514
197 5960-5964 Gene denotes CTSL Gene:1514
198 6011-6016 Gene denotes CTSL1 Gene:1514
199 6188-6193 Gene denotes furin Gene:5045
200 6267-6299 Gene denotes Transmembrane protease, serine 2 Gene:7113
201 6301-6308 Gene denotes TMPRSS2 Gene:7113
202 6329-6336 Gene denotes TMPRSS2 Gene:7113
203 6403-6410 Gene denotes TMPRSS2 Gene:7113
204 6503-6508 Gene denotes spike Gene:43740568
205 5774-5784 Species denotes SARS-CoV-2 Tax:2697049
206 5900-5908 Species denotes SARS-CoV Tax:694009
207 6023-6033 Species denotes SARS-CoV-2 Tax:2697049
208 6092-6100 Species denotes SARS-CoV Tax:694009
209 6232-6242 Species denotes SARS-CoV-2 Tax:2697049
210 5800-5809 Chemical denotes threonine MESH:D013912
211 5814-5824 Chemical denotes methionine MESH:D008715
212 6114-6122 Chemical denotes arginine MESH:D001120
213 6127-6133 Chemical denotes serine MESH:D012694
214 6364-6382 Disease denotes SARS-CoV infection MESH:C000657245
215 6427-6445 Disease denotes SARS-CoV infection MESH:C000657245
220 6689-6693 Gene denotes CTSL Gene:1514
221 6773-6777 Gene denotes CTSL Gene:1514
222 6924-6935 Gene denotes Cathepsin L Gene:1514
223 6827-6837 Species denotes SARS-CoV-2 Tax:2697049
238 7391-7405 Gene denotes CoV2 S (Spike) Gene:43740568
239 7417-7428 Gene denotes Cathepsin L Gene:1514
240 7429-7440 Gene denotes Cathepsin B Gene:1508
241 7444-7451 Gene denotes TMPRSS2 Gene:7113
242 7684-7688 Gene denotes CTSL Gene:1514
243 7724-7728 Gene denotes CTSL Gene:1514
244 7922-7926 Gene denotes CTSL Gene:1514
245 7765-7767 Gene denotes pH Gene:5053
246 7572-7582 Species denotes SARS-CoV-2 Tax:2697049
247 8092-8100 Species denotes patients Tax:9606
248 7945-7955 Chemical denotes Amantadine MESH:D000547
249 8053-8063 Chemical denotes amantadine MESH:D000547
250 8106-8114 Disease denotes COVID-19 MESH:C000657245
251 8115-8124 Disease denotes infection MESH:D007239
263 8262-8266 Gene denotes CTSL Gene:1514
264 8797-8817 Gene denotes dopamine receptor D2 Gene:1813
265 8895-8916 Gene denotes histamine receptor H1 Gene:3269
266 8955-8959 Gene denotes CTSL Gene:1514
267 8281-8289 Species denotes SARS-CoV Tax:694009
268 8294-8303 Species denotes SARS-CoV2 Tax:2697049
269 8430-8435 Species denotes human Tax:9606
270 8823-8832 Chemical denotes serotonin MESH:D012701
271 8473-8480 CellLine denotes ARPE-19 CVCL:0145
272 8550-8557 CellLine denotes ARPE-19 CVCL:0145
273 8704-8711 CellLine denotes ARPE-19 CVCL:0145
283 9825-9829 Gene denotes CTSL Gene:1514
284 9844-9848 Gene denotes CTSL Gene:1514
285 9865-9873 Chemical denotes Baclofen MESH:D001418
286 9891-9917 Chemical denotes Triprolidine Hydrochloride MESH:D014311
287 9935-9958 Chemical denotes Brompheniramine Maleate MESH:D001977
288 9976-10000 Chemical denotes Amantadine Hydrochloride MESH:D000547
289 10018-10027 Chemical denotes Phenytoin MESH:D010672
290 10045-10061 Chemical denotes Atropine Sulfate MESH:D001285
291 9804-9810 Disease denotes DrugID
293 9736-9740 Gene denotes CTSL Gene:1514
300 9109-9113 Gene denotes CTSL Gene:1514
301 9319-9323 Gene denotes CTSL Gene:1514
302 9657-9665 Species denotes patients Tax:9606
303 9671-9680 Species denotes influenza Tax:11320
304 9564-9588 Chemical denotes Amantadine hydrochloride MESH:D000547
305 9480-9489 Disease denotes epileptic MESH:D004827
320 11066-11070 Gene denotes CTSL Gene:1514
321 10938-10940 Gene denotes pH Gene:5053
322 10472-10474 Gene denotes pH Gene:5053
323 10879-10889 Species denotes SARS-CoV-2 Tax:2697049
324 11186-11192 Species denotes humans Tax:9606
325 11535-11540 Species denotes Human Tax:9606
326 10296-10305 Species denotes influenza Tax:11320
327 10079-10089 Chemical denotes Amantadine MESH:D000547
328 10276-10286 Chemical denotes Amantadine MESH:D000547
329 10686-10690 Chemical denotes Ca2+ MESH:D000069285
330 10778-10788 Chemical denotes amantadine MESH:D000547
331 11005-11015 Chemical denotes amantadine MESH:D000547
332 11401-11415 Chemical denotes Amantadine HCl MESH:D000547
333 11583-11593 Chemical denotes amantadine MESH:D000547
335 12748-12758 Chemical denotes amantadine MESH:D000547
337 13029-13039 Chemical denotes amantadine MESH:D000547
343 13641-13645 Gene denotes GJA1 Gene:2697
344 13836-13842 Gene denotes PCYOX1 Gene:51449
345 13964-13969 Gene denotes LAMP1 Gene:3916
346 14287-14292 Gene denotes BCL10 Gene:8915
347 13899-13903 Gene denotes CTSB Gene:1508
349 13362-13372 Chemical denotes amantadine MESH:D000547
355 11645-11649 Gene denotes CTSL Gene:1514
356 11781-11791 Chemical denotes amantadine MESH:D000547
357 12116-12126 Chemical denotes Amantadine MESH:D000547
358 12469-12479 Chemical denotes amantadine MESH:D000547
359 12564-12574 Chemical denotes amantadine MESH:D000547
362 16917-16928 Gene denotes Cathepsin L Gene:1514
363 16930-16934 Gene denotes CTSL Gene:1514
387 14356-14360 Gene denotes CTSL Gene:1514
388 14628-14632 Gene denotes CTSL Gene:1514
389 14712-14716 Gene denotes CTSL Gene:1514
390 14768-14772 Gene denotes CTSL Gene:1514
391 14969-14973 Gene denotes CTSL Gene:1514
392 15459-15463 Gene denotes CTSL Gene:1514
393 15665-15669 Gene denotes CTSL Gene:1514
394 15829-15833 Gene denotes CTSL Gene:1514
395 15850-15855 Gene denotes CTSL1 Gene:1514
396 16225-16229 Gene denotes CTSL Gene:1514
397 16299-16303 Gene denotes CTSL Gene:1514
398 16474-16478 Gene denotes CTSL Gene:1514
399 16491-16498 Gene denotes TMPRSS2 Gene:7113
400 16623-16627 Gene denotes CTSL Gene:1514
401 14547-14552 Species denotes human Tax:9606
402 15583-15593 Species denotes SARS-CoV-2 Tax:2697049
403 16098-16108 Species denotes SARS-Cov-2 Tax:2697049
404 15570-15579 Disease denotes infection MESH:D007239
405 16067-16080 Disease denotes viral fitness
406 16797-16805 Disease denotes infected MESH:D007239
407 15027-15036 Mutation denotes rs2378757 rs2378757
408 15402-15413 Mutation denotes rs114063116 rs114063116
409 15876-15882 Mutation denotes C-171A rs3118869
424 17098-17102 Gene denotes CTSL Gene:1514
425 17320-17325 Gene denotes Spike Gene:43740568
426 17565-17569 Gene denotes CTSL Gene:1514
427 18227-18231 Gene denotes NPC1 Gene:4864
428 18281-18285 Gene denotes NPC1 Gene:4864
429 17261-17263 Gene denotes pH Gene:5053
430 17796-17802 Species denotes people Tax:9606
431 18035-18040 Species denotes Ebola Tax:1570291
432 18044-18051 Species denotes patient Tax:9606
433 18129-18134 Species denotes Ebola Tax:1570291
434 17526-17536 Chemical denotes amantadine MESH:D000547
435 17682-17692 Chemical denotes amantadine MESH:D000547
436 17649-17670 Disease denotes lysosomal dysfunction MESH:D016464
437 17962-18013 Disease denotes Niemann-Pick disease type C1 lipid storage disorder MESH:D052556
446 18466-18477 Gene denotes Cathepsin L Gene:1514
447 18533-18538 Gene denotes spike Gene:43740568
448 18677-18688 Gene denotes cathepsin L Gene:1514
449 18435-18446 Species denotes coronavirus Tax:11118
450 19045-19052 Species denotes patient Tax:9606
451 18549-18559 Chemical denotes Amantadine MESH:D000547
452 18819-18829 Chemical denotes Amantadine MESH:D000547
453 18899-18909 Chemical denotes amantadine MESH:D000547
456 19439-19449 Chemical denotes amantadine MESH:D000547
457 19484-19492 Disease denotes COVID-19 MESH:C000657245
472 20542-20544 Gene denotes pH Gene:5053
473 20479-20481 Gene denotes pH Gene:5053
474 19692-19698 Species denotes HPV-16 Tax:333760
475 19782-19787 Species denotes human Tax:9606
476 19935-19940 Chemical denotes Vanda
477 20125-20130 Chemical denotes water MESH:D014867
478 20132-20150 Chemical denotes dimethyl sulfoxide MESH:D004121
479 20152-20159 Chemical denotes ethanol MESH:D000431
480 20161-20169 Chemical denotes methanol MESH:D000432
481 20174-20199 Chemical denotes phosphate-buffered saline
482 20255-20287 Chemical denotes Dulbecco's Modified Eagle Medium
483 20415-20430 Chemical denotes sodium pyruvate
484 19771-19780 Disease denotes cancerous MESH:D009369
485 19684-19691 CellLine denotes ARPE-19 CVCL:0145

2_test

Id Subject Object Predicate Lexical cue
32361028-31978945-48150106 2952-2953 31978945 denotes 1
32361028-29790939-48150107 3460-3461 29790939 denotes 3
32361028-23715323-48150108 3923-3924 23715323 denotes 5
32361028-32075877-48150109 4339-4340 32075877 denotes 6
32361028-32075877-48150110 4427-4428 32075877 denotes 6
32361028-16081529-48150111 4755-4756 16081529 denotes 7
32361028-24501399-48150112 4757-4758 24501399 denotes 8
32361028-24501399-48150113 5164-5165 24501399 denotes 8
32361028-20926566-48150114 6477-6479 20926566 denotes 10
32361028-20470389-48150115 7289-7291 20470389 denotes 12
32361028-29955068-48150116 10268-10270 29955068 denotes 13
32361028-24793875-48150117 10271-10273 24793875 denotes 14
32361028-29955068-48150118 10451-10453 29955068 denotes 13
32361028-24793875-48150119 10454-10456 24793875 denotes 14
32361028-19590009-48150120 10457-10459 19590009 denotes 15
32361028-29955068-48150121 10557-10559 29955068 denotes 13
32361028-24793875-48150122 10560-10562 24793875 denotes 14
32361028-31372936-48150123 11530-11532 31372936 denotes 18
32361028-25897122-48150124 11978-11980 25897122 denotes 19
32361028-23715323-48150125 14477-14478 23715323 denotes 5
32361028-22871890-48150126 15969-15971 22871890 denotes 20
32361028-23715323-48150127 16596-16597 23715323 denotes 5
32361028-30258868-48150128 18064-18066 30258868 denotes 23
32361028-22726751-48150129 18067-18069 22726751 denotes 24
32361028-31940478-48150130 18159-18161 31940478 denotes 25
32361028-31940478-48150131 18359-18361 31940478 denotes 25
32361028-19150222-48150132 19638-19640 19150222 denotes 26
32361028-19150222-48150133 20694-20696 19150222 denotes 26
T4710 2952-2953 31978945 denotes 1
T44023 3460-3461 29790939 denotes 3
T27905 3923-3924 23715323 denotes 5
T39581 4339-4340 32075877 denotes 6
T34969 4427-4428 32075877 denotes 6
T56708 4755-4756 16081529 denotes 7
T170 4757-4758 24501399 denotes 8
T52972 5164-5165 24501399 denotes 8
T15931 6477-6479 20926566 denotes 10
T45538 7289-7291 20470389 denotes 12
T97903 10268-10270 29955068 denotes 13
T80135 10271-10273 24793875 denotes 14
T61405 10451-10453 29955068 denotes 13
T68228 10454-10456 24793875 denotes 14
T14750 10457-10459 19590009 denotes 15
T52231 10557-10559 29955068 denotes 13
T84352 10560-10562 24793875 denotes 14
T65189 11530-11532 31372936 denotes 18
T42076 11978-11980 25897122 denotes 19
T2516 14477-14478 23715323 denotes 5
T75786 15969-15971 22871890 denotes 20
T10878 16596-16597 23715323 denotes 5
T4299 18064-18066 30258868 denotes 23
T68295 18067-18069 22726751 denotes 24
T59423 18159-18161 31940478 denotes 25
T84607 18359-18361 31940478 denotes 25
T68319 19638-19640 19150222 denotes 26
T87507 20694-20696 19150222 denotes 26

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 20-29 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T2 30-34 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T3 338-347 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T4 401-405 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T5 1090-1094 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T6 1144-1151 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 1202-1209 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T8 1222-1226 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 1305-1314 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T10 1378-1387 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T11 1619-1628 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T12 1679-1683 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T13 1863-1867 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T14 2142-2151 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T15 3095-3101 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T16 3312-3319 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T17 3401-3408 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T18 3627-3631 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T19 3748-3755 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T20 3787-3794 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 3808-3813 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T22 3815-3820 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T23 3822-3829 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T24 3834-3843 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T25 4055-4062 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 4148-4155 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T27 4226-4233 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T28 4283-4295 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T29 4299-4306 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T30 4399-4406 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 4437-4444 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T32 4505-4512 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33 4691-4700 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T34 4701-4709 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T35 5122-5134 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T36 5142-5155 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T37 5142-5146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T38 5189-5202 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T39 5189-5193 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 5216-5223 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T41 5243-5247 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T42 5341-5359 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T43 5389-5395 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T44 5405-5414 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T45 5427-5431 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T46 5451-5458 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T47 5741-5745 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T48 5800-5809 Body_part denotes threonine http://purl.org/sig/ont/fma/fma82765
T49 5814-5824 Body_part denotes methionine http://purl.org/sig/ont/fma/fma82759
T50 5969-5978 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T51 5979-5986 Body_part denotes cystein http://purl.org/sig/ont/fma/fma82751
T52 6017-6021 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T53 6114-6122 Body_part denotes arginine http://purl.org/sig/ont/fma/fma82763
T54 6127-6133 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T55 6221-6228 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 6291-6297 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T57 6453-6475 Body_part denotes upper lobe of the lung http://purl.org/sig/ont/fma/fma7334
T58 6509-6516 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T59 6540-6544 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T60 6597-6601 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T61 6694-6698 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T62 7027-7059 Body_part denotes major histocompatibility complex http://purl.org/sig/ont/fma/fma84079
T63 7063-7066 Body_part denotes MHC http://purl.org/sig/ont/fma/fma84079
T64 7074-7090 Body_part denotes cytotoxic T cell http://purl.org/sig/ont/fma/fma70573
T65 7086-7090 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T66 7091-7102 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T67 7406-7413 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T68 7729-7738 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T69 7927-7931 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T70 8452-8461 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T71 8462-8466 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T72 8486-8490 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T73 8558-8562 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T74 8667-8672 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 8757-8769 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T76 8757-8761 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T77 8797-8814 Body_part denotes dopamine receptor http://purl.org/sig/ont/fma/fma61811
T78 8823-8842 Body_part denotes serotonin receptors http://purl.org/sig/ont/fma/fma67372
T79 8895-8913 Body_part denotes histamine receptor http://purl.org/sig/ont/fma/fma67262
T80 9444-9450 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T81 10138-10156 Body_part denotes lysosome membranes http://purl.org/sig/ont/fma/fma67156
T82 10138-10146 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T83 10175-10184 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T84 10380-10387 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 10599-10608 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T86 10617-10634 Body_part denotes lysosome membrane http://purl.org/sig/ont/fma/fma67156
T87 10617-10625 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T88 10858-10875 Body_part denotes lysosome membrane http://purl.org/sig/ont/fma/fma67156
T89 10858-10866 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T90 10944-10952 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T91 11081-11090 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T92 11194-11200 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T93 11296-11302 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T94 11541-11546 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 11550-11556 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T96 11938-11947 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T97 12098-12106 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T98 12153-12161 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T99 12325-12333 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T100 12370-12379 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T101 12502-12511 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T102 12671-12679 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T103 12847-12851 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T104 12930-12939 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T105 13132-13140 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T106 13181-13189 Body_part denotes Lysosome http://purl.org/sig/ont/fma/fma63836
T107 13239-13247 Body_part denotes Lysosome http://purl.org/sig/ont/fma/fma63836
T108 13300-13309 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T109 13374-13378 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T110 14443-14449 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T111 14514-14518 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T112 14553-14560 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T113 14646-14653 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T114 14756-14760 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T115 14841-14846 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T116 14851-14856 Body_part denotes nerve http://purl.org/sig/ont/fma/fma65132
T117 14874-14880 Body_part denotes artery http://purl.org/sig/ont/fma/fma50720
T118 14888-14893 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T119 14898-14909 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T120 15012-15016 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T121 15445-15450 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T122 15451-15457 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T123 15473-15479 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T124 15688-15692 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T125 15710-15716 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T126 16084-16088 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T127 16312-16316 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T128 16536-16543 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T129 16578-16582 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T130 16588-16594 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T131 16721-16728 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T132 16778-16783 Body_part denotes stool http://purl.org/sig/ont/fma/fma64183
T133 16871-16878 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T134 16943-16950 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T135 17004-17008 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T136 17201-17205 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T137 17251-17260 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T138 17326-17333 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T139 17391-17400 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T140 17602-17611 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T141 17649-17658 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T142 17816-17825 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T143 17991-17996 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T144 18052-18056 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T145 18201-18211 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T146 18232-18239 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 18385-18394 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T148 18539-18546 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T149 18636-18645 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T150 18704-18708 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T151 18780-18789 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T152 18938-18947 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T153 19008-19013 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T154 19526-19530 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T155 19663-19672 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T156 19673-19677 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T157 19975-19980 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T158 20025-20030 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T159 20390-20401 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T160 20806-20811 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T161 20946-20950 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T162 20962-20967 Body_part denotes Cells http://purl.org/sig/ont/fma/fma68646
T163 21008-21011 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T164 21079-21083 Body_part denotes Gene http://purl.org/sig/ont/fma/fma74402
T165 22204-22208 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T166 22453-22457 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T167 22715-22723 Body_part denotes Appendix http://purl.org/sig/ont/fma/fma14542

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 3815-3820 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T2 3834-3843 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T3 6453-6475 Body_part denotes upper lobe of the lung http://purl.obolibrary.org/obo/UBERON_0008948
T4 6459-6463 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T5 6471-6475 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 8452-8461 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483
T7 11550-11556 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T8 14443-14449 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 14734-14740 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T10 14809-14815 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T11 14851-14856 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T12 14874-14880 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T13 14888-14893 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T14 15012-15016 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T15 15451-15457 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T16 15473-15479 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T17 15688-15692 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 15710-15716 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T19 16578-16582 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T20 16588-16594 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T21 16667-16673 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T22 16778-16783 Body_part denotes stool http://purl.obolibrary.org/obo/UBERON_0001988
T23 19008-19013 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T24 19663-19672 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 64-71 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 148-156 Disease denotes CoVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 711-719 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 1001-1017 Disease denotes SARS-coronavirus http://purl.obolibrary.org/obo/MONDO_0005091
T5 1047-1055 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 1066-1070 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T7 1426-1434 Disease denotes CoVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1989-1998 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T9 2013-2032 Disease denotes Parkinson's disease http://purl.obolibrary.org/obo/MONDO_0005180
T10 2366-2374 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 2628-2636 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 2637-2646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 2755-2764 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T14 2783-2816 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T15 2830-2838 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 2921-2940 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T17 2972-2980 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 3084-3092 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 3135-3143 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 3595-3603 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 3605-3609 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T22 3896-3919 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T23 4250-4258 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 4579-4588 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 4622-4630 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 4659-4667 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 5072-5077 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T28 5089-5097 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 5774-5782 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 5900-5908 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 6023-6031 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 6092-6100 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 6232-6240 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 6364-6382 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T35 6373-6382 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36 6427-6445 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T37 6436-6445 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38 6827-6835 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T39 7572-7580 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T40 8106-8114 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 8115-8124 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T42 8281-8289 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 8294-8298 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T44 9671-9680 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T45 10296-10305 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T46 10879-10887 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 13674-13678 Disease denotes CLN5 http://purl.obolibrary.org/obo/MONDO_0009745
T48 13772-13776 Disease denotes CLN5 http://purl.obolibrary.org/obo/MONDO_0009745
T49 15570-15579 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50 15583-15591 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T51 16098-16102 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 17816-17842 Disease denotes lysosomal storage diseases http://purl.obolibrary.org/obo/MONDO_0002561
T53 17962-17990 Disease denotes Niemann-Pick disease type C1 http://purl.obolibrary.org/obo/MONDO_0009757
T54 17962-17982 Disease denotes Niemann-Pick disease http://purl.obolibrary.org/obo/MONDO_0001982
T55 17970-17982 Disease denotes Pick disease http://purl.obolibrary.org/obo/MONDO_0008243
T56 18035-18040 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T57 18129-18134 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T58 18227-18231 Disease denotes NPC1 http://purl.obolibrary.org/obo/MONDO_0009757
T59 18281-18285 Disease denotes NPC1 http://purl.obolibrary.org/obo/MONDO_0009757
T60 19484-19492 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 20-29 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T2 30-34 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T3 47-48 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T4 263-271 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T5 338-347 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T6 371-372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 401-405 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T8 590-591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 768-769 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 846-851 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T11 1088-1094 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T12 1222-1226 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13 1271-1272 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T14 1279-1280 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T15 1305-1314 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T16 1378-1387 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T17 1541-1549 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 1619-1628 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T19 1649-1650 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 1679-1683 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T21 1863-1867 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T22 1964-1965 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 2053-2054 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 2142-2151 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T25 2205-2210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 2236-2237 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 2423-2424 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28 2494-2499 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T29 2674-2675 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 2912-2913 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 2944-2950 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T32 2993-2994 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 3182-3185 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T34 3332-3333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 3509-3514 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T36 3518-3519 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 3627-3631 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T38 3733-3741 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T39 3769-3770 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 3778-3786 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T41 3808-3813 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T42 3815-3820 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T43 3815-3820 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T44 3815-3820 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T45 3815-3820 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T46 3822-3829 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T47 3822-3829 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T48 3822-3829 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T49 3834-3843 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T50 3834-3843 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T51 3969-3972 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T52 4076-4081 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T53 4095-4098 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T54 4407-4410 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T55 4475-4477 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T56 4482-4484 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T57 4482-4484 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T58 4553-4563 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T59 4642-4643 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 4730-4731 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T61 4776-4777 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T62 4816-4823 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T63 4856-4858 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2
T64 4912-4918 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T65 5048-5049 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T66 5142-5146 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T67 5147-5155 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T68 5189-5193 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T69 5194-5202 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T70 5243-5247 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T71 5268-5269 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 5277-5284 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T73 5292-5294 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T74 5292-5294 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T75 5350-5359 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T76 5427-5431 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T77 5478-5480 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T78 5485-5487 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T79 5485-5487 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T80 5521-5523 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T81 5521-5523 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T82 5552-5554 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T83 5552-5554 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T84 5565-5567 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T85 5565-5567 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T86 5611-5621 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T87 5636-5643 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T88 5741-5745 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T89 5751-5753 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T90 5754-5756 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T91 5754-5756 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T92 5846-5849 http://purl.obolibrary.org/obo/CLO_0001008 denotes 697
T93 5856-5858 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T94 5859-5861 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T95 5859-5861 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T96 5915-5918 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 5967-5968 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 5969-5978 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T99 6017-6021 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T100 6039-6042 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T101 6043-6044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T102 6337-6340 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T103 6471-6475 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T104 6471-6475 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T105 6540-6544 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T106 6597-6601 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T107 6634-6635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 6694-6698 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T109 6754-6759 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T110 7084-7090 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T111 7169-7171 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T112 7439-7440 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T113 7521-7522 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T114 7583-7588 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T115 7729-7738 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T116 7777-7783 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T117 7927-7931 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T118 8430-8435 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T119 8462-8471 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T120 8473-8480 http://purl.obolibrary.org/obo/CLO_0001749 denotes ARPE-19
T121 8486-8490 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T122 8539-8544 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T123 8550-8562 http://purl.obolibrary.org/obo/CLO_0001749 denotes ARPE-19 cell
T124 8594-8595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T125 8667-8672 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T126 8704-8711 http://purl.obolibrary.org/obo/CLO_0001749 denotes ARPE-19
T127 8722-8723 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 8757-8761 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T129 8797-8805 http://purl.obolibrary.org/obo/CHEBI_18243 denotes dopamine
T130 8815-8817 http://purl.obolibrary.org/obo/CLO_0002668 denotes D2
T131 8823-8832 http://purl.obolibrary.org/obo/CHEBI_28790 denotes serotonin
T132 8847-8849 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T133 8953-8954 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T134 8960-8961 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T135 9052-9058 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T136 9139-9145 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T137 9221-9222 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 9444-9450 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T139 9444-9450 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T140 9444-9450 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T141 9444-9450 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T142 9590-9591 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 9681-9682 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T144 10138-10146 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T145 10147-10156 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T146 10175-10184 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T147 10195-10196 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 10306-10307 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T149 10404-10409 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T150 10501-10509 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T151 10517-10518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T152 10538-10543 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T153 10599-10608 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T154 10617-10625 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T155 10626-10634 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T156 10691-10700 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T157 10713-10721 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T158 10800-10801 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T159 10858-10866 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T160 10867-10875 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T161 10890-10895 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T162 10919-10921 http://purl.obolibrary.org/obo/CLO_0009421 denotes tt
T163 10919-10921 http://purl.obolibrary.org/obo/CLO_0009935 denotes tt
T164 10919-10921 http://purl.obolibrary.org/obo/CLO_0052184 denotes tt
T165 10919-10921 http://purl.obolibrary.org/obo/CLO_0052185 denotes tt
T166 10944-10952 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T167 10979-10989 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T168 11081-11090 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T169 11099-11104 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T170 11186-11192 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T171 11194-11200 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T172 11296-11302 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T173 11450-11451 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T174 11530-11532 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T175 11535-11546 http://purl.obolibrary.org/obo/CLO_0053065 denotes Human cells
T176 11600-11601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T177 11748-11753 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T178 11848-11853 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T179 11916-11921 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T180 11938-11947 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T181 12098-12106 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T182 12153-12161 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T183 12170-12175 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T184 12282-12287 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T185 12325-12333 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T186 12342-12347 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T187 12370-12379 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T188 12450-12455 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T189 12502-12511 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T190 12628-12633 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T191 12671-12679 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T192 12688-12693 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T193 12930-12939 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T194 13010-13015 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T195 13132-13140 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T196 13181-13189 http://purl.obolibrary.org/obo/GO_0005764 denotes Lysosome
T197 13239-13247 http://purl.obolibrary.org/obo/GO_0005764 denotes Lysosome
T198 13300-13309 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T199 13374-13378 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T200 14392-14400 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T201 14514-14518 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T202 14547-14552 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T203 14734-14740 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T204 14756-14766 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T205 14809-14815 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T206 14841-14846 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T207 14851-14856 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T208 14865-14872 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose
T209 14874-14880 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T210 14874-14880 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T211 14882-14893 http://purl.obolibrary.org/obo/UBERON_0000178 denotes whole blood
T212 14882-14893 http://www.ebi.ac.uk/efo/EFO_0000296 denotes whole blood
T213 14898-14909 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T214 14989-14990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T215 15012-15016 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T216 15012-15016 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T217 15188-15189 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 15445-15450 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T219 15688-15692 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T220 15688-15692 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T221 15773-15774 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T222 15809-15810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T223 16084-16088 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T224 16312-16316 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T225 16375-16376 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T226 16578-16582 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T227 16578-16582 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T228 16588-16594 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T229 16588-16594 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T230 16588-16594 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T231 16655-16656 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T232 16667-16673 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organs
T233 16844-16849 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T234 16880-16882 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T235 16959-16966 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T236 16977-16982 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T237 16977-16982 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T238 17113-17114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 17172-17177 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T240 17201-17205 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T241 17251-17260 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T242 17334-17344 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T243 17391-17400 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T244 17467-17472 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T245 17586-17587 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 17602-17611 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T247 17649-17658 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T248 17816-17825 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T249 17873-17880 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T250 17988-17990 http://purl.obolibrary.org/obo/CLO_0051741 denotes C1
T251 18052-18062 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T252 18087-18090 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T253 18150-18157 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T254 18277-18280 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T255 18299-18300 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T256 18385-18394 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T257 18479-18480 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 18636-18645 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T259 18704-18708 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T260 18765-18766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T261 18780-18789 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T262 18846-18847 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 18938-18947 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T264 19008-19013 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T265 19130-19136 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T266 19333-19338 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T267 19468-19469 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 19526-19530 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T269 19673-19682 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T270 19684-19698 http://purl.obolibrary.org/obo/CLO_0001750 denotes ARPE-19/HPV-16
T271 19724-19725 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 19782-19787 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T273 19801-19802 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T274 19917-19919 http://purl.obolibrary.org/obo/CLO_0009141 denotes St
T275 19917-19919 http://purl.obolibrary.org/obo/CLO_0050980 denotes St
T276 19928-19930 http://purl.obolibrary.org/obo/CLO_0007815 denotes MO
T277 19975-19980 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T278 20020-20024 http://purl.obolibrary.org/obo/CLO_0001035 denotes 10e5
T279 20025-20030 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T280 20096-20097 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 20578-20579 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T282 20806-20811 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T283 20946-20950 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T284 20962-20967 http://purl.obolibrary.org/obo/GO_0005623 denotes Cells
T285 21079-21083 http://purl.obolibrary.org/obo/OGG_0000000002 denotes Gene
T286 21127-21132 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T287 21340-21341 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T288 21402-21404 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T289 21657-21658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T290 22204-22208 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T291 22451-22452 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T292 22453-22457 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T293 22547-22548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T294 22589-22590 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 0-10 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T2 389-393 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T3 521-531 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T4 553-563 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T5 568-578 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T6 667-677 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T7 1144-1151 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T8 1202-1209 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 1667-1671 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 1871-1881 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T11 1890-1900 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T12 2063-2067 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T13 2069-2079 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T14 2322-2332 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T15 2614-2624 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T16 2706-2710 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T17 3694-3705 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T18 3748-3755 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 3787-3794 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 4011-4013 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T21 4055-4062 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 4148-4155 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T23 4226-4233 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T24 4283-4295 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T25 4299-4306 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26 4399-4406 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T27 4437-4444 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T28 4482-4484 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T29 4505-4512 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T30 4701-4709 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T31 4816-4823 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32 4856-4858 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T33 4951-4956 Chemical denotes thiol http://purl.obolibrary.org/obo/CHEBI_29256|http://purl.obolibrary.org/obo/CHEBI_29917
T35 5122-5134 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T36 5216-5223 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T37 5277-5284 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T38 5292-5294 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T39 5451-5458 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T40 5485-5487 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T41 5521-5523 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T42 5552-5554 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T43 5565-5567 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T44 5636-5643 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T45 5754-5756 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T46 5800-5809 Chemical denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T47 5814-5824 Chemical denotes methionine http://purl.obolibrary.org/obo/CHEBI_16811|http://purl.obolibrary.org/obo/CHEBI_64558
T49 5859-5861 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T50 6114-6122 Chemical denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T53 6127-6133 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T54 6221-6228 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T55 6291-6297 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T56 6509-6516 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T57 7406-7413 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T58 7945-7955 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T59 8053-8063 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T60 8183-8197 Chemical denotes pharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217
T61 8436-8443 Chemical denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035
T62 8688-8702 Chemical denotes antipsychotics http://purl.obolibrary.org/obo/CHEBI_35476
T63 8797-8805 Chemical denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905
T65 8815-8817 Chemical denotes D2 http://purl.obolibrary.org/obo/CHEBI_29294
T66 8823-8832 Chemical denotes serotonin http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546
T68 8883-8885 Chemical denotes M3 http://purl.obolibrary.org/obo/CHEBI_51083|http://purl.obolibrary.org/obo/CHEBI_53453
T70 8895-8904 Chemical denotes histamine http://purl.obolibrary.org/obo/CHEBI_18295|http://purl.obolibrary.org/obo/CHEBI_58432
T72 9293-9298 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T73 9405-9410 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T74 9460-9473 Chemical denotes antihistamine http://purl.obolibrary.org/obo/CHEBI_37956
T75 9510-9519 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T76 9564-9588 Chemical denotes Amantadine hydrochloride http://purl.obolibrary.org/obo/CHEBI_2619
T77 9564-9574 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T78 9575-9588 Chemical denotes hydrochloride http://purl.obolibrary.org/obo/CHEBI_36807
T79 9607-9622 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T80 9704-9709 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T81 9787-9792 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T82 9904-9917 Chemical denotes Hydrochloride http://purl.obolibrary.org/obo/CHEBI_17883
T83 9935-9950 Chemical denotes Brompheniramine http://purl.obolibrary.org/obo/CHEBI_3183
T84 9976-10000 Chemical denotes Amantadine Hydrochloride http://purl.obolibrary.org/obo/CHEBI_2619
T85 9976-9986 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T86 9987-10000 Chemical denotes Hydrochloride http://purl.obolibrary.org/obo/CHEBI_17883
T87 10045-10053 Chemical denotes Atropine http://purl.obolibrary.org/obo/CHEBI_16684
T88 10054-10061 Chemical denotes Sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T89 10079-10089 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T90 10276-10286 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T91 10365-10367 Chemical denotes M2 http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112
T93 10368-10371 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T94 10380-10387 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T95 10586-10591 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T96 10778-10788 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T97 11005-11015 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T98 11110-11112 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T99 11128-11132 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T100 11401-11411 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T101 11412-11415 Chemical denotes HCl http://purl.obolibrary.org/obo/CHEBI_17883
T102 11583-11593 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T103 11781-11791 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T104 12469-12479 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T105 12564-12574 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T106 12748-12758 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T107 12874-12879 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T108 13029-13039 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T109 13058-13065 Chemical denotes Pathway http://purl.obolibrary.org/obo/CHEBI_34922
T110 13362-13372 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T111 13401-13403 Chemical denotes ID http://purl.obolibrary.org/obo/CHEBI_141439
T112 13409-13419 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T113 13932-13935 Chemical denotes STS http://purl.obolibrary.org/obo/CHEBI_15738
T114 15940-15950 Chemical denotes xenobiotic http://purl.obolibrary.org/obo/CHEBI_35703
T115 16567-16569 Chemical denotes GI http://purl.obolibrary.org/obo/CHEBI_73907
T116 16996-16999 Chemical denotes TPM http://purl.obolibrary.org/obo/CHEBI_63631
T117 17326-17333 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T118 17526-17536 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T119 17682-17692 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T120 17991-17996 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T121 18201-18211 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T122 18201-18206 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T123 18207-18211 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T124 18232-18239 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T125 18539-18546 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T126 18549-18559 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T127 18819-18829 Chemical denotes Amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T128 19276-19280 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T129 19333-19338 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T130 19439-19449 Chemical denotes amantadine http://purl.obolibrary.org/obo/CHEBI_2618
T131 19543-19547 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T132 19647-19654 Chemical denotes retinal http://purl.obolibrary.org/obo/CHEBI_15035
T133 19738-19742 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T134 20098-20102 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T135 20111-20115 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T136 20125-20130 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T137 20132-20150 Chemical denotes dimethyl sulfoxide http://purl.obolibrary.org/obo/CHEBI_28262
T138 20132-20140 Chemical denotes dimethyl http://purl.obolibrary.org/obo/CHEBI_33601|http://purl.obolibrary.org/obo/CHEBI_42266
T140 20141-20150 Chemical denotes sulfoxide http://purl.obolibrary.org/obo/CHEBI_22063
T141 20152-20159 Chemical denotes ethanol http://purl.obolibrary.org/obo/CHEBI_16236
T142 20161-20169 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T143 20174-20183 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T147 20200-20208 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T148 20390-20401 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T149 20390-20395 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T150 20396-20401 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T151 20415-20430 Chemical denotes sodium pyruvate http://purl.obolibrary.org/obo/CHEBI_50144
T152 20415-20421 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T153 20422-20430 Chemical denotes pyruvate http://purl.obolibrary.org/obo/CHEBI_15361
T154 20545-20554 Chemical denotes indicator http://purl.obolibrary.org/obo/CHEBI_47867
T155 20592-20596 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T156 20891-20895 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T157 21106-21111 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T158 21405-21419 Chemical denotes antipsychotics http://purl.obolibrary.org/obo/CHEBI_35476
T159 21716-21721 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T160 22039-22043 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T161 22044-22049 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T162 22176-22181 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T163 22318-22323 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T164 22361-22366 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T165 22388-22393 Chemical denotes probe http://purl.obolibrary.org/obo/CHEBI_50406
T166 22514-22516 Chemical denotes KS http://purl.obolibrary.org/obo/CHEBI_74568
T167 22574-22576 Chemical denotes KS http://purl.obolibrary.org/obo/CHEBI_74568

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 30-45 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T2 401-416 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3 1679-1694 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T4 5033-5044 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T5 5147-5162 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T6 5194-5209 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T7 5715-5726 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T8 6201-6213 http://purl.obolibrary.org/obo/GO_0075733 denotes viral egress
T9 6509-6527 http://purl.obolibrary.org/obo/GO_0016485 denotes protein processing
T10 6597-6612 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T11 7027-7059 http://purl.obolibrary.org/obo/GO_0046776 denotes major histocompatibility complex
T12 7118-7134 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T13 8225-8240 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T14 8486-8501 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T15 9720-9735 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T16 10368-10379 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channel
T17 10472-10484 http://purl.obolibrary.org/obo/GO_0045851 denotes pH reduction
T18 10501-10516 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T19 10691-10700 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T20 10736-10743 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T21 10970-10989 http://purl.obolibrary.org/obo/GO_0008233 denotes protease activities
T22 11691-11701 http://purl.obolibrary.org/obo/GO_0006351 denotes transcript
T23 12418-12435 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptionally
T24 12978-12995 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptionally
T25 14514-14529 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T26 15012-15025 http://purl.obolibrary.org/obo/GO_0060424 denotes lung specific
T27 15362-15370 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T28 15649-15657 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T29 15670-15680 http://purl.obolibrary.org/obo/GO_0006351 denotes transcript
T30 15904-15917 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T31 17826-17833 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T32 17991-18004 http://purl.obolibrary.org/obo/GO_0019915 denotes lipid storage
T33 17997-18004 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T34 18704-18719 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T35 18862-18883 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T36 18862-18875 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T37 20854-20863 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T38 20854-20863 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T39 20946-20961 http://purl.obolibrary.org/obo/GO_0010467 denotes Gene expression
T40 21079-21094 http://purl.obolibrary.org/obo/GO_0010467 denotes Gene expression
T41 22204-22219 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 2755-2764 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 3896-3919 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-46 Sentence denotes Amantadine disrupts lysosomal gene expression:
T2 47-81 Sentence denotes A hypothesis for COVID19 treatment
T3 83-93 Sentence denotes Highlights
T4 94-167 Sentence denotes • Cathepsin L (CTSL) disruption offers potential for CoVID-19 therapies.
T5 168-349 Sentence denotes The mechanisms of disruption include: decreasing expression of CTSL, direct inhibition of CTSL activity and affecting the conditions of CTSL environment (increased pH in lysosomes).
T6 350-564 Sentence denotes • We have conducted a high throughput drug screen gene expression analysis to identify potential compounds that would down regulate the expression of CTSL/CTSB and found amantadine to be one of the top inhibitors.
T7 565-663 Sentence denotes • Amantadine may act as a lysosomotropic agent and alters the Cathepsin L functional environment.
T8 664-896 Sentence denotes • Amantadine could decrease the viral load in SARS-CoV-2 positive patients and as such it may serve as a potent therapeutic agent, decreasing the replication and infectivity of the virus likely, leading to better clinical outcomes.
T9 897-990 Sentence denotes • Genetic variants in CTSL are likely affecting course and outcomes of infected individuals.
T10 992-1000 Sentence denotes Abstract
T11 1001-1065 Sentence denotes SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak.
T12 1066-1273 Sentence denotes SARS-Cov-2 entry into a cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on cleavage of the spike protein by the host cell proteases such as Cathepsin L and Cathepsin B.
T13 1274-1388 Sentence denotes CTSL/B are crucial elements of lysosomal pathway and both enzymes are almost exclusively located in the lysosomes.
T14 1389-1445 Sentence denotes CTSL disruption offers potential for CoVID-19 therapies.
T15 1446-1630 Sentence denotes The mechanisms of disruption include: decreasing expression of CTSL, direct inhibition of CTSL activity and affecting the conditions of CTSL environment (increase pH in the lysosomes).
T16 1631-1778 Sentence denotes We have conducted a high throughput drug screen gene expression analysis to identify compounds that would downregulate the expression of CTSL/CTSB.
T17 1779-1889 Sentence denotes One of the top significant results shown to downregulate the expression of the CTSL gene is amantadine (10uM).
T18 1890-2033 Sentence denotes Amantadine was approved by the US Food and Drug Administration in 1968 as a prophylactic agent for influenza and later for Parkinson's disease.
T19 2034-2068 Sentence denotes It is available as a generic drug.
T20 2069-2224 Sentence denotes Amantadine in addition to downregulating CTSL appears to further disrupt lysosomal pathway, hence, interfering with the capacity of the virus to replicate.
T21 2225-2543 Sentence denotes It acts as a lysosomotropic agent altering the CTSL functional environment.  We hypothesize that amantadine could decrease the viral load in SARS-CoV-2 positive patients and as such it may serve as a potent therapeutic decreasing the replication and infectivity of the virus likely leading to better clinical outcomes.
T22 2544-2647 Sentence denotes Clinical studies will be needed to examine the therapeutic utility of amantadine in COVID-19 infection.
T23 2649-2664 Sentence denotes 1 Introduction
T24 2665-2782 Sentence denotes Recently a novel type of highly virulent beta-coronavirus was discovered in patients with pneumonia of unknown cause.
T25 2783-2955 Sentence denotes Severe acute respiratory syndrome coronavirus (SARS-CoV-2) as detected by sequencing of the samples was found to be the cause of a severe respiratory disease in humans [1].
T26 2956-3079 Sentence denotes The outbreak of COVID-19 resulted in a global epidemic with the number of confirmed cased surpassing 722,000 in March 2020.
T27 3080-3216 Sentence denotes The SARS-CoV-2 genome shares about 80% similarity with SARS-CoV and is even more similar (96%) to the bat coronavirus BatCoV RaTG13 [2].
T28 3217-3463 Sentence denotes Coronaviruses are characterized by large genetic diversity and frequent recombination of their genomes, hence pose a challenge in terms of public health, currently based on 1455 viral genomes and predicted 24.5 genetic substitutions per year [3].
T29 3464-3583 Sentence denotes Understanding the mechanism of action of the virus is a fundamental step in delineating the optimal therapeutic agents.
T30 3584-3760 Sentence denotes Similar to SARS-CoV, SARS-Cov-2 enters the cell by the means of binding of cellular receptor(s) including the Angiotensin-converting enzyme 2 (ACE2) membrane bound protein [4].
T31 3761-3926 Sentence denotes ACE2 is a type I membrane protein expressed in lungs, heart, kidneys and intestine and decreased expression of ACE2 is associated with cardiovascular diseases [2,5].
T32 3927-4117 Sentence denotes The structural basis for this recognition has been recently mapped out and the cryo-EM structure of the full length viral spike protein that targets human ACE2 complex has been reported [2].
T33 4118-4266 Sentence denotes The authors show that viral S protein binds ACE2 at least 10 times more tightly, when compared to the spike protein of the previous SARS-CoV strain.
T34 4267-4342 Sentence denotes The viral spike glycoprotein (S protein) mediates receptor recognition [6].
T35 4343-4430 Sentence denotes Recently the 3.5-angstrom-resolution structure of the S protein has been described [6].
T36 4431-4485 Sentence denotes The S protein is cleaved into two subunits: S1 and S2.
T37 4486-4593 Sentence denotes This cleavage of S protein by host proteases is critical for viral activation and subsequent infection [2].
T38 4594-4658 Sentence denotes Host protease dependence of SARS-CoV-2 entry is a critical step.
T39 4659-4760 Sentence denotes SARS-CoV takes advantage of the endosomal cysteine proteases Cathepsin B and L (CTSL and CTSB) [7,8].
T40 4761-4903 Sentence denotes Cathepsin L is a peptidase that preferentially cleaves peptide bonds with aromatic residues in P2 and hydrophobic residues in P3 position [9].
T41 4904-5020 Sentence denotes CTSL is active at pH 3-6.5, in the presence of thiol and its enzymatic stability is dependent on ionic strength [9].
T42 5021-5167 Sentence denotes Cathepsin L proteolysis is a crucial mechanism for Ebola as well as SARS-CoV for processing of viral glycoprotein before cell membrane fusion [8].
T43 5168-5302 Sentence denotes Specifically, during cell membrane fusion the S protein is cleaved by host cell proteases, exposing a fusion peptide of the S2 domain.
T44 5303-5432 Sentence denotes This leads to the fusion of viral and cellular membranes and the release of the viral genome into the cytoplasm of the host cell.
T45 5433-5496 Sentence denotes Cleavage of the S protein occurs between the S1 and S2 domains.
T46 5497-5564 Sentence denotes Subsequently within the S2 domain additional cleavage (S2’) occurs.
T47 5565-5644 Sentence denotes S2’ cleavage is responsible for unmasking and activating of the fusion peptide.
T48 5645-5746 Sentence denotes Cleavage at both sites is believed to be necessary for viral entry by endocytosis into the host cell.
T49 5747-5850 Sentence denotes The S1/S2 cleavage site of SARS-CoV-2 is between the threonine and methionine at positions 696 and 697.
T50 5851-6022 Sentence denotes This S1/S2 cleavage site is identical to that of SARS-CoV which has been shown to be cleaved by Cathepsin L (CTSL), a lysosomal cystein protease encoded by the CTSL1 gene.
T51 6023-6159 Sentence denotes SARS-CoV-2 also has a furin-like protease cleavage site not found in SARS-CoV, between the arginine and serine at positions 685 and 686.
T52 6160-6214 Sentence denotes This site may be cleaved by furin during viral egress.
T53 6215-6314 Sentence denotes The S protein of SARS-CoV-2 might be also primed by Transmembrane protease, serine 2 (TMPRSS2) [4].
T54 6315-6383 Sentence denotes Inhibition of TMPRSS2 has been shown to suppress SARS-CoV infection.
T55 6384-6481 Sentence denotes High expression of TMPRSS2 correlates with SARS-CoV infection in the upper lobe of the lung [10].
T56 6482-6667 Sentence denotes Interfering with the spike protein processing by the host cell, whether by affecting the environment or modulating gene expression levels, hence offers a potential therapeutic strategy.
T57 6668-6760 Sentence denotes Genetic variation in CTSL gene could in theory affect the propagation capacity of the virus.
T58 6761-6994 Sentence denotes Furthermore CTSL polymorphisms could affect the susceptibility to SARS-CoV-2 where for example individuals with certain genetic variant have reduced expression of Cathepsin L and in turn could be protected or have lower viral titers.
T59 6995-7173 Sentence denotes Additionally, elements of hosts major histocompatibility complex I (MHC I) and cytotoxic T cell lymphocytes (CTL) mediated immune responses might affect viral proliferation [11].
T60 7174-7293 Sentence denotes There are susceptibility factors spanning from ethnicity background to age related groups, to comorbid conditions [12].
T61 7294-7589 Sentence denotes Novel therapeutics identified by high throughput screening assay, shown to block the cleavage of CoV2 S (Spike) protein by Cathepsin L,Cathepsin B or TMPRSS2 (or any other protease) at predicted/selected binding sites, will be a viable approach to functionally target and limit SARS-CoV-2 virus.
T62 7590-7768 Sentence denotes Other therapeutic mechanisms of action could involve lowering or modulating the expression of CTSL or affecting the conditions of the CTSL lysosomal environment by modulating pH.
T63 7769-7932 Sentence denotes Here we tested compounds that could help identify potential therapeutic agents with the capacity to decrease expression or inhibit the expression of the CTSL gene.
T64 7933-7988 Sentence denotes We identify Amantadine among top significant compounds.
T65 7989-8125 Sentence denotes Further clinical studies should be conducted to examine whether amantadine could be useful in treating patients with COVID-19 infection.
T66 8127-8137 Sentence denotes 2 RESULTS
T67 8139-8159 Sentence denotes 2.1 Drugs screening
T68 8160-8399 Sentence denotes To discover potential, pharmaceutical agents caable of affecting transcriptional expression levels of CTSL implicated in SARS-CoV and SARS-CoV2 patho-physiology, we have screened 466 compounds belonging to 14 different therapeutic classes.
T69 8400-8545 Sentence denotes Screening was conducted using human retinal pigment epithelia cell line (ARPE-19) and gene expression changes were collected across 12,490 genes.
T70 8546-8703 Sentence denotes The ARPE-19 cell line was initially selected as a well suited model for the study of compounds that affect neuronal type cells, in particular antipsychotics.
T71 8704-8917 Sentence denotes ARPE-19 expresses a variety of well known, neuronal, cell surface receptors that include the dopamine receptor D2, the serotonin receptors 1A, 2A, and 2C, the muscarinic receptor M3, and the histamine receptor H1.
T72 8918-9069 Sentence denotes Here, we describe the discovery of a CTSL/B, lysosomotropic signature which might give insights into the therapeutic potential of the tested compounds.
T73 9070-9146 Sentence denotes We analyzed the expression profiles of CTSL across all 466 compounds tested.
T74 9147-9278 Sentence denotes In order to find positive hits we selected only those results that showed a reduction of expression of CTSL (1.5 -fold difference).
T75 9279-9352 Sentence denotes There were no drugs that would decrease CTSL expression by more than 40%.
T76 9353-9520 Sentence denotes Between the most 5 potent compounds (Table 1 ) were drugs from various therapeutic areas – muscle relaxer, antihistamine, anti-epileptic, anticholigenic and antiviral.
T77 9521-9683 Sentence denotes These top results (top 5 of 466) included, Amantadine hydrochloride, a known and safe antiviral agent that was previously used to treat patients with influenza A.
T78 9684-9803 Sentence denotes Table 1 List of top drugs affecting transcriptional CTSL downregulation (log2 of normalized Affymetrix probe intensity)
T79 9804-9864 Sentence denotes DrugID log2(treated) CTSL log2(control) CTSL log2 difference
T80 9865-9890 Sentence denotes Baclofen 9.58 10.40 -0.82
T81 9891-9934 Sentence denotes Triprolidine Hydrochloride 9.54 10.33 -0.79
T82 9935-9975 Sentence denotes Brompheniramine Maleate 9.57 10.33 -0.75
T83 9976-10017 Sentence denotes Amantadine Hydrochloride 9.62 10.33 -0.70
T84 10018-10044 Sentence denotes Phenytoin 9.56 10.26 -0.70
T85 10045-10078 Sentence denotes Atropine Sulfate 9.63 10.33 -0.70
T86 10079-10275 Sentence denotes Amantadine due to its high lipophilicity, can pass through lysosome membranes and accumulate in lysosomes acting at a higher micromolar concentrations as lysosomotropic alkalinizing agent [13,14].
T87 10276-10461 Sentence denotes Amantadine inhibits influenza A replication at low micromolar concentration, by blocking M2 ion channel protein which acidifies virus interior and releases its nucleoprotein [13,14,15].
T88 10462-10564 Sentence denotes It causes pH reduction which abrogates membrane fusion a necessary step for virus replication [13,14].
T89 10565-10771 Sentence denotes Other lysosomotropic drugs affect lysosomes through lysosome membrane permeabilization and accumulation also blocking of Ca2+ signaling, and enzyme activity inhibition or storage material accumulation [16].
T90 10772-10995 Sentence denotes Since amantadine behaves as a lysosomotropic substance that passes easily through the lysosome membrane of SARS-CoV-2 virus and accumulates in it, tt could lower the pH of lysosome thus inhibit the protease activities [17].
T91 10996-11105 Sentence denotes Moreover amantadine may directly affect viral entry bydown-modulating CTSL and other lysosomal pathway genes.
T92 11106-11193 Sentence denotes The PK profile of the drug makes it particularly suitable for administration to humans.
T93 11194-11295 Sentence denotes Plasma concentration is in the range of 200-800ng/mL depending on the formulation and dosing regimen.
T94 11296-11332 Sentence denotes Plasma half-life is 17 hours (range:
T95 11333-11400 Sentence denotes 10 to 25 hours) with renal clearance as main elimination mechanism.
T96 11401-11534 Sentence denotes Amantadine HCl immediate release is available as a 100-mg tablet and 50 mg/5 mL syrup and is typically administered twice daily [18].
T97 11535-11638 Sentence denotes Human cells in tissue culture readily tolerated amantadine up to a concentration of 100 ug/mL (~657uM).
T98 11639-11792 Sentence denotes Since CTSL was not the top differentially expressed transcript, we decided to extend our analysis to all the genes that were downregulated by amantadine.
T99 11793-12014 Sentence denotes Among the top 500 differentially expressed probes (383 genes, all with at least 50% expression reduction) we have found 21 genes were related to lysosomal terms using David Enrichment [19] tool (GO:005764, p=2.49 × 10−5).
T100 12015-12115 Sentence denotes Moreover, the top significant pathway by ENRICHR enrichment analysis tool was KEGG lysosome pathway.
T101 12116-12220 Sentence denotes Amantadine's significant effect upon lysosome pathway genes is shown on Fig. 1 and Table 2 and Table 3 .
T102 12221-12348 Sentence denotes Fig. 1 displays notable difference in over-representation of genes with downregulated expression across lysosome pathway genes.
T103 12349-12480 Sentence denotes Table 2 displays top lysosomal ontology terms over-represented among transcriptionally downregulated genes treated with amantadine.
T104 12481-12575 Sentence denotes Table 3 displays top lysosomal expression probes downregulated post treatment with amantadine.
T105 12576-12694 Sentence denotes Fig. 1 Notable difference in over-representation of genes with downregulated expression across lysosome pathway genes.
T106 12695-12844 Sentence denotes Black columns represent average expression levels of amantadine treated samples, gray columns represent average expression levels of control samples.
T107 12845-12917 Sentence denotes Y-axis represents Affymetrix probe intensity associated with expression.
T108 12918-13040 Sentence denotes Table 2 Top lysosomal ontology terms over-represented among transcriptionally downregulated genes treated with amantadine.
T109 13041-13120 Sentence denotes Term Count (n) % Pathway Fold Enrichment P-value P-value Bonferroni P-value FDR
T110 13121-13180 Sentence denotes GO:0005764~lysosome 21 5.19 4.42 6.65E-08 2.49E-05 9.19E-05
T111 13181-13229 Sentence denotes Lysosome 19 4.69 3.75 3.77E-06 0.001389 0.005193
T112 13230-13287 Sentence denotes hsa04142:Lysosome 14 3.46 4.37 1.55E-05 0.003425 0.019698
T113 13288-13373 Sentence denotes Table 3 Top lysosomal expression probes downregulated post treatment with amantadine.
T114 13374-13510 Sentence denotes Gene Name Affymetrix Probe ID Mean amantadine treated expression (log2) Mean control expression (log2) Mean expression difference (log2)
T115 13511-13544 Sentence denotes CTSH 202295_s_at 9.62 12.13 -2.51
T116 13545-13575 Sentence denotes GALC 204417_at 6.58 8.64 -2.06
T117 13576-13608 Sentence denotes RNASET2 217983_s_at 8 9.82 -1.81
T118 13609-13640 Sentence denotes CTSK 202450_s_at 7.09 8.9 -1.81
T119 13641-13673 Sentence denotes GJA1 201667_at 11.23 12.99 -1.76
T120 13674-13706 Sentence denotes CLN5 204085_s_at 5.93 7.67 -1.74
T121 13707-13740 Sentence denotes SCARB2 201647_s_at 6.97 8.6 -1.63
T122 13741-13771 Sentence denotes AGA 204333_s_at 6.57 8.17 -1.6
T123 13772-13804 Sentence denotes CLN5 214252_s_at 6.13 7.71 -1.57
T124 13805-13835 Sentence denotes MAR3 213256_at 5.55 7.12 -1.57
T125 13836-13868 Sentence denotes PCYOX1 203803_at 7.15 8.71 -1.57
T126 13869-13898 Sentence denotes CPQ 203501_at 6.41 7.96 -1.55
T127 13899-13931 Sentence denotes CTSB 213274_s_at 7.75 9.23 -1.48
T128 13932-13963 Sentence denotes STS 203767_s_at 5.55 7.02 -1.47
T129 13964-13996 Sentence denotes LAMP1 201551_s_at 7.87 9.27 -1.4
T130 13997-14029 Sentence denotes AGA 204332_s_at 9.18 10.57 -1.39
T131 14030-14060 Sentence denotes AGA 216064_s_at 8.12 9.5 -1.38
T132 14061-14095 Sentence denotes PSAP 200866_s_at 10.59 11.95 -1.36
T133 14096-14126 Sentence denotes LGMN 201212_at 8.33 9.68 -1.35
T134 14127-14157 Sentence denotes CPQ 208454_s_at 7.3 8.65 -1.34
T135 14158-14191 Sentence denotes CD164 208654_s_at 8.7 10.04 -1.34
T136 14192-14224 Sentence denotes CTBS 218924_s_at 6.59 7.91 -1.32
T137 14225-14255 Sentence denotes RAB38 219412_at 6.51 7.81 -1.3
T138 14256-14286 Sentence denotes GNS 212334_at 9.71 10.97 -1.27
T139 14287-14318 Sentence denotes BCL10 205263_at 7.44 8.69 -1.25
T140 14319-14429 Sentence denotes We investigated natural variation of CTSL expression across ethnicities, focusing on common and rare variants.
T141 14430-14684 Sentence denotes The Genotype-Tissue Expression (GTEx) project [5] provides genotype information and gene expression levels across 49 human tissues from 838 donors, allowing us to examine the expression patterns of CTSL, both across tissues as well as across individuals.
T142 14685-14767 Sentence denotes Fig. 2 shows expression of CTSL across different organs and associated cell types.
T143 14768-14911 Sentence denotes CTSL is widely expressed in many crucial organs (increase expression in: lungs, in nerve-tibial, adipose, artery, whole blood and fibroblasts).
T144 14912-15084 Sentence denotes Looking at expression quantitative trait loci (eQTLs) in CTSL, we have found a very significant and lung specific (rs2378757) variant conferring highly variable expression.
T145 15085-15265 Sentence denotes The genotype (Supplementary Figure 1a) confers lower baseline expression and is likely associated with a better response and conversely higher expression perhaps higher viral load.
T146 15266-15458 Sentence denotes In addition, there are several splice quantitative trait loci (sQTLs) (hence variants affecting splicing ratios of transcripts) such as rs114063116 significant and present in the lungs tissue.
T147 15459-15772 Sentence denotes CTSL genotype-tissue analysis points to potential variants that may constitute susceptibility or resilience to infection of SARS-CoV-2 in certain individuals. Interestingly, the alternative splicing of the CTSL transcript in the lung further displays tissue specific regulatory programs (Supplementary Figure 1b).
T148 15773-15973 Sentence denotes A recent functional study points to a common variant in CTSL in the proximal CTSL1 promoter, (position C-171A), confirmed to alter transcription via alteration of the xenobiotic response element [20].
T149 15974-16109 Sentence denotes This and similar other variants likely affect natural diversity in baseline expression hence viral fitness at cell entry of SARS-Cov-2.
T150 16110-16230 Sentence denotes Additionally, we checked in the gnomAD [21] database the number of rare variants and variation tolerance status of CTSL.
T151 16231-16389 Sentence denotes The results show that there are on average 167 missense variants in CTSL and the gene is predicted to be loss-of-function variant tolerant with a pLI of 0.01.
T152 16390-16490 Sentence denotes Together with significant eQTLs this indicates large effect of genetic variation on CTSL expression.
T153 16491-16599 Sentence denotes TMPRSS2 is also widely expressed in multiple tissues including those in the GI system, lung, and kidney [5].
T154 16600-16884 Sentence denotes The high expression of CTSL and TRMPSS2 transcripts in a series of organs could explain the viral manifestation in these tissues such as recent studies showing viral presence in stool samples from infected individuals as well as effects of the virus seen across multiple tissues [22].
T155 16885-17053 Sentence denotes Fig. 2 Normalized Expression of Cathepsin L (CTSL) across tissues between females (red) and males (blue) log10(TPM) (x-axis log10 of Transcripts per Million, plus one).
T156 17055-17068 Sentence denotes 3 Discussion
T157 17069-17206 Sentence denotes Decreasing the expression of CTSL is likely a potential mechanism that would lower the capacity of the virus to enter the next host cell.
T158 17207-17345 Sentence denotes Another symbiotic, therapeutic mechanism is lysosomal pH modulationthat would further interfere with proteolytic Spike protein activation.
T159 17346-17514 Sentence denotes Therapeutic agents capable of perturbing the lysosomes, their function or microenvironment may offer protection from the virus or decrease the severity of the symptoms.
T160 17515-17773 Sentence denotes Given that amantadine does not only down-regulate CTSL expression, but a number of key lysosomal enzymes, we can now hypothesize that lysosomal dysfunction induced by amantadine administration can be protective against viral entry and ultimately replication.
T161 17774-17881 Sentence denotes Our hypothesisis that people with certain lysosomal storage diseases are resistant to one of these viruses.
T162 17882-17949 Sentence denotes Along these lines there is suggestive evidence for this to be true.
T163 17950-18071 Sentence denotes For example Niemann-Pick disease type C1 lipid storage disorder offers resistance to Ebola in patient cell lines [23,24].
T164 18072-18163 Sentence denotes Interestingly, bat species show selective sensitivity to Ebola versus Marburg viruses [25].
T165 18164-18363 Sentence denotes The differences are primarily due to amino acid differences in NPC1 protein indicating that the heterogeneity of bat NPC1 orthologs is a crucial factor affecting varied degree of susceptibility [25].
T166 18364-18884 Sentence denotes Interfering with the lysosomal milieu can have protective effects from coronavirus which we know uses Cathepsin L, a pH sensitive enzyme, to process the cleavage of the spike protein.  Amantadine would be predicted by physical and chemical properties to accumulate in the lysosomes and raise pH, interfering with cathepsin L function.  The gene expression pattern reported in this paper suggests that a more general lysosomal program is down-regulated by Amantadine, likely through a common set of transcription factors.
T167 18885-19098 Sentence denotes Additionally, amantadine's property to accumulate in lysosomes, if effective, could reduce viral load, decrease intra-host organ spread and decrease individual-patient, associated disease severity and progression.
T168 19099-19255 Sentence denotes Importantly, the dose that was tested in High Throughput Screen Assay is within one order of magnitude of expected pharmacokinetic, clinical profile (~5uM).
T169 19256-19346 Sentence denotes That would mean the drug can be administered per existing, safe and approved label dosing.
T170 19347-19493 Sentence denotes Further studies including clinical trials would be required in order to examine the role of amantadine administration as a treatment for COVID-19.
T171 19495-19519 Sentence denotes 4 Materials and Methods
T172 19521-19557 Sentence denotes 4.1 Cell culture and drug treatment
T173 19558-19642 Sentence denotes Drugs screening was carried out, the same one as applied in our previous study [26].
T174 19643-19820 Sentence denotes The retinal pigment epithelia cell line, ARPE-19/HPV-16, was chosen to establish a database of drug profiles because of its non-cancerous, human origin, with a normal karyotype.
T175 19821-19880 Sentence denotes It can also be easily grown as monolayer in 96-well plates.
T176 19881-19974 Sentence denotes Compounds were obtained from Sigma (St. Louis, MO) or Vanda Pharmaceuticals (Washington, DC).
T177 19975-20210 Sentence denotes Cells were aliquoted on 96-well plates (~2 × 10e5 cells/well) and incubated for 24 h prior to providing fresh media with a drug, or the drug vehicle (water, dimethyl sulfoxide, ethanol, methanol, or phosphate-buffered saline solution).
T178 20211-20288 Sentence denotes Drugs were diluted 1000 fold in buffered in Dulbecco's Modified Eagle Medium:
T179 20289-20431 Sentence denotes Nutrient Mixture F-12 (D-MEM/F-12) culture medium (Invitrogen, Carlsbad, CA) containing nonessential amino acids and 110 mg/L sodium pyruvate.
T180 20432-20577 Sentence denotes In these conditions, no significant changes of pH were expected, which was confirmed by the monitoring of the pH indicator present in the medium.
T181 20578-20698 Sentence denotes A final 10 μM drug concentration was chosen because it is believed to fit in the range of physiological conditions [26].
T182 20699-20864 Sentence denotes Microscopic inspection of each well was conducted at the end of the treatment to discard any samples where cells had morphological changes consistent with apoptosis.
T183 20865-20939 Sentence denotes We also verified that the drug had not precipitated in the culture medium.
T184 20941-20961 Sentence denotes 4.2 Gene expression
T185 20962-21078 Sentence denotes Cells were harvested 24 h after treatment and RNA was extracted using the RNeasy 96 protocol (Qiagen, Valencia, CA).
T186 21079-21245 Sentence denotes Gene expression for 22,238 probe sets of 12,490 genes was generated with U133A2.0 microarrays following the manufacturer's instructions (Affymetrix, Santa Clara, CA).
T187 21246-21339 Sentence denotes Drugs were profiled in duplicate or triplicate, with multiple vehicle controls on each plate.
T188 21340-21483 Sentence denotes A total of 708 microarrays were analyzed including 74 for the 18 antipsychotics, 499 for the other 448 compounds, and 135 for vehicle controls.
T189 21484-21579 Sentence denotes The raw scan data were first converted to average difference values using MAS 5.0 (Affymetrix).
T190 21580-21682 Sentence denotes The average difference values of both treatment and control data were set to a minimum of 50 or lower.
T191 21683-21895 Sentence denotes For each treatment category, all probe sets were then ranked based on their amplitude, or level of expression relative to the vehicle control (or the average of controls was selected when more than one was used).
T192 21896-22033 Sentence denotes Amplitude was defined as the ratio of expression (t−v) / [(t+v) / 2] where t corresponds to treatment instance and v to vehicle instance.
T193 22034-22280 Sentence denotes Each drug group profile was created using our novel Weighted Influence Model, Rank of Ranks (WIMRR) method which underscores the rank of each probe set across the entire gene expression profile rather than the specific change in expression level.
T194 22281-22450 Sentence denotes WIMRR takes the average rank of each probe set across all of the members of the group and then reranks the probe sets from smallest average rank to largest average rank.
T195 22451-22528 Sentence denotes A gene-set enrichment metric based on the Kolmogorov– Smirnov (KS) statistic.
T196 22529-22713 Sentence denotes Specifically, for a given set of probes, the KS score gives a measure of how up (positive) or down (negative) the set of probes occurs within the profile of another treatment instance.
T197 22715-22748 Sentence denotes Appendix Supplementary materials
T198 22750-22766 Sentence denotes Acknowledgements
T199 22767-22832 Sentence denotes We thank all the reviewers for valuable comments and suggestions.
T200 22834-22846 Sentence denotes Declarations
T201 22848-22856 Sentence denotes Funding:
T202 22857-22878 Sentence denotes Vanda Pharmaceuticals
T203 22880-22900 Sentence denotes Competing Interests:
T204 22901-22905 Sentence denotes None
T205 22907-22924 Sentence denotes Ethical Approval:
T206 22925-23068 Sentence denotes Not required Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.ijantimicag.2020.106004.

PubTator4TogoVar

Id Subject Object Predicate Lexical cue resolved_to
4060 15402-15413 SNP denotes rs114063116 tmVar:rs114063116;VariantGroup:0;CorrespondingGene:100506834;RS#:114063116;CorrespondingSpecies:9606
4062 15027-15036 SNP denotes rs2378757 tmVar:rs2378757;VariantGroup:1;CorrespondingGene:1514;RS#:2378757;CorrespondingSpecies:9606

PubTatorOnTogoVar

Id Subject Object Predicate Lexical cue resolved_to
4060 15402-15413 SNP denotes rs114063116 tmVar:rs114063116;VariantGroup:0;CorrespondingGene:100506834;RS#:114063116;CorrespondingSpecies:9606
4062 15027-15036 SNP denotes rs2378757 tmVar:rs2378757;VariantGroup:1;CorrespondingGene:1514;RS#:2378757;CorrespondingSpecies:9606
T1 15402-15413 SNP denotes rs114063116 tmVar:rs114063116;VariantGroup:0;CorrespondingGene:100506834;RS#:114063116;CorrespondingSpecies:9606
T2 15027-15036 SNP denotes rs2378757 tmVar:rs2378757;VariantGroup:1;CorrespondingGene:1514;RS#:2378757;CorrespondingSpecies:9606