PMC:7190487 / 4583-5573
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T29 | 92-95 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T30 | 189-206 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T31 | 201-206 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T32 | 274-291 | Body_part | denotes | endothelial cells | http://purl.org/sig/ont/fma/fma66772 |
| T33 | 286-291 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T34 | 892-897 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T26 | 44-48 | Disease | denotes | Zika | http://purl.obolibrary.org/obo/MONDO_0018661 |
| T27 | 55-59 | Disease | denotes | Zika | http://purl.obolibrary.org/obo/MONDO_0018661 |
| T28 | 732-740 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T29 | 859-867 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T30 | 981-989 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T59 | 49-54 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T60 | 60-65 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T61 | 74-75 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T62 | 96-101 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T63 | 106-107 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T64 | 108-116 | http://purl.obolibrary.org/obo/NCBITaxon_7157 | denotes | mosquito |
| T65 | 141-142 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T66 | 155-161 | http://purl.obolibrary.org/obo/CLO_0004307 | denotes | HUVECs |
| T67 | 166-171 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T68 | 189-206 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T69 | 274-291 | http://purl.obolibrary.org/obo/CL_0000115 | denotes | endothelial cells |
| T70 | 298-308 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T71 | 354-364 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activators |
| T72 | 474-483 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activated |
| T73 | 535-540 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T74 | 604-607 | http://purl.obolibrary.org/obo/CLO_0009915 | denotes | MX1 |
| T75 | 744-745 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T76 | 759-762 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T77 | 885-891 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
| T78 | 885-891 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
| T79 | 885-891 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
| T80 | 885-891 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
| T81 | 892-897 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T82 | 934-935 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T67 | 172-179 | Chemical | denotes | retinal | http://purl.obolibrary.org/obo/CHEBI_15035 |
| T68 | 349-364 | Chemical | denotes | AMPK activators | http://purl.obolibrary.org/obo/CHEBI_85053 |
| T69 | 366-375 | Chemical | denotes | metformin | http://purl.obolibrary.org/obo/CHEBI_6801 |
| T70 | 380-410 | Chemical | denotes | 5-aminoimidazole-4-carboxamide | http://purl.obolibrary.org/obo/CHEBI_2030 |
| T71 | 382-396 | Chemical | denotes | aminoimidazole | http://purl.obolibrary.org/obo/CHEBI_22512 |
| T72 | 399-410 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
| T74 | 411-425 | Chemical | denotes | ribonucleotide | http://purl.obolibrary.org/obo/CHEBI_26561 |
| T75 | 427-432 | Chemical | denotes | AICAR | http://purl.obolibrary.org/obo/CHEBI_18406 |
| T76 | 552-561 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T77 | 834-836 | Chemical | denotes | DG | http://purl.obolibrary.org/obo/CHEBI_73450 |
| T78 | 963-972 | Chemical | denotes | metformin | http://purl.obolibrary.org/obo/CHEBI_6801 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T42 | 5-22 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | Viral replication |
| T43 | 5-22 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | Viral replication |
| T44 | 228-232 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T45 | 228-232 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T46 | 228-232 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T47 | 312-316 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T48 | 312-316 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T49 | 312-316 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T50 | 349-353 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T51 | 349-353 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T52 | 349-353 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T53 | 484-488 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T54 | 484-488 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T55 | 484-488 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T56 | 777-801 | http://purl.obolibrary.org/obo/GO_0045820 | denotes | inhibition of glycolysis |
| T57 | 791-801 | http://purl.obolibrary.org/obo/GO_0006096 | denotes | glycolysis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T39 | 0-23 | Sentence | denotes | 2.4 Viral replication: |
| T40 | 24-54 | Sentence | denotes | Lessons learnt from Zika virus |
| T41 | 55-140 | Sentence | denotes | Zika virus (ZIKV), a single-stranded RNA virus, is a mosquito transmitted flavivirus. |
| T42 | 141-297 | Sentence | denotes | A study using HUVECs and human retinal vascular endothelial cells (HRvECs) showed that AMPK restricts the replication of ZIKV in the endothelial cells [16]. |
| T43 | 298-473 | Sentence | denotes | Activation of AMPK with the help of two well-known AMPK activators, metformin and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) led to attenuation of ZIKV replication. |
| T44 | 474-668 | Sentence | denotes | Activated AMPK further potentiated the expression of certain genes with known antiviral properties such as IFNs, OAS2, ISG15, and MX1 while inhibiting inflammatory mediators like TNF-α and CCL5. |
| T45 | 669-743 | Sentence | denotes | It would be useful to explore whether the same is observed for SARS-CoV-2. |
| T46 | 744-903 | Sentence | denotes | A recent study has reported that inhibition of glycolysis by non-toxic concentration of 2-DG completely attenuated SARS-CoV-2 replication in Caco-2 cells [17]. |
| T47 | 904-990 | Sentence | denotes | All of these indicate towards a possible frontline role of metformin against COVID-19. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32360697-32086387-25244891 | 293-295 | 32086387 | denotes | 16 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 216 | 228-232 | Gene | denotes | AMPK | Gene:5563 |
| 217 | 312-316 | Gene | denotes | AMPK | Gene:5563 |
| 218 | 349-353 | Gene | denotes | AMPK | Gene:5563 |
| 219 | 484-488 | Gene | denotes | AMPK | Gene:5563 |
| 220 | 587-591 | Gene | denotes | OAS2 | Gene:4939 |
| 221 | 593-598 | Gene | denotes | ISG15 | Gene:9636 |
| 222 | 604-607 | Gene | denotes | MX1 | Gene:4599 |
| 223 | 653-658 | Gene | denotes | TNF-α | Gene:7124 |
| 224 | 663-667 | Gene | denotes | CCL5 | Gene:6352 |
| 225 | 55-65 | Species | denotes | Zika virus | Tax:64320 |
| 226 | 67-71 | Species | denotes | ZIKV | Tax:64320 |
| 227 | 74-101 | Species | denotes | a single-stranded RNA virus | Tax:674971 |
| 228 | 166-171 | Species | denotes | human | Tax:9606 |
| 229 | 262-266 | Species | denotes | ZIKV | Tax:64320 |
| 230 | 456-460 | Species | denotes | ZIKV | Tax:64320 |
| 231 | 732-742 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 232 | 859-869 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 233 | 366-375 | Chemical | denotes | metformin | MESH:D008687 |
| 234 | 380-425 | Chemical | denotes | 5-aminoimidazole-4-carboxamide ribonucleotide | MESH:C031143 |
| 235 | 427-432 | Chemical | denotes | AICAR | MESH:C031143 |
| 236 | 832-836 | Chemical | denotes | 2-DG | MESH:D003847 |
| 237 | 963-972 | Chemical | denotes | metformin | MESH:D008687 |
| 238 | 981-989 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 239 | 885-891 | CellLine | denotes | Caco-2 | CVCL:0025 |