PMC:7190486 / 1551-3684
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1746-1753 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T2 | 1746-1753 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 68-72 | Body_part | denotes | limb | http://purl.org/sig/ont/fma/fma7182 |
| T2 | 516-521 | Body_part | denotes | Blood | http://purl.org/sig/ont/fma/fma9670 |
| T3 | 618-625 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T4 | 1068-1072 | Body_part | denotes | limb | http://purl.org/sig/ont/fma/fma7182 |
| T5 | 1198-1214 | Body_part | denotes | Popliteal artery | http://purl.org/sig/ont/fma/fma77155 |
| T6 | 1293-1309 | Body_part | denotes | popliteal artery | http://purl.org/sig/ont/fma/fma77155 |
| T7 | 1477-1481 | Body_part | denotes | limb | http://purl.org/sig/ont/fma/fma7182 |
| T8 | 1746-1753 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T9 | 1803-1829 | Body_part | denotes | superficial femoral artery | http://purl.org/sig/ont/fma/fma0323777 |
| T10 | 1873-1878 | Body_part | denotes | Blood | http://purl.org/sig/ont/fma/fma9670 |
| T11 | 1921-1925 | Body_part | denotes | limb | http://purl.org/sig/ont/fma/fma7182 |
| T12 | 1974-1982 | Body_part | denotes | Platelet | http://purl.org/sig/ont/fma/fma62851 |
| T13 | 1996-2007 | Body_part | denotes | Lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T14 | 2125-2132 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 68-72 | Body_part | denotes | limb | http://purl.obolibrary.org/obo/UBERON_0002101 |
| T2 | 516-521 | Body_part | denotes | Blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T3 | 1068-1072 | Body_part | denotes | limb | http://purl.obolibrary.org/obo/UBERON_0002101 |
| T4 | 1198-1214 | Body_part | denotes | Popliteal artery | http://purl.obolibrary.org/obo/UBERON_0002250 |
| T5 | 1208-1214 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
| T6 | 1293-1309 | Body_part | denotes | popliteal artery | http://purl.obolibrary.org/obo/UBERON_0002250 |
| T7 | 1303-1309 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
| T8 | 1477-1481 | Body_part | denotes | limb | http://purl.obolibrary.org/obo/UBERON_0002101 |
| T9 | 1815-1829 | Body_part | denotes | femoral artery | http://purl.obolibrary.org/obo/UBERON_0002060 |
| T10 | 1823-1829 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
| T11 | 1873-1878 | Body_part | denotes | Blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T12 | 1921-1925 | Body_part | denotes | limb | http://purl.obolibrary.org/obo/UBERON_0002101 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T13 | 68-81 | Disease | denotes | limb ischemia | http://purl.obolibrary.org/obo/MONDO_0000491 |
| T14 | 73-81 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T15 | 102-110 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T16 | 434-442 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T17 | 711-720 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T18 | 981-984 | Disease | denotes | PAD | http://purl.obolibrary.org/obo/MONDO_0005386 |
| T19 | 1068-1081 | Disease | denotes | limb ischemia | http://purl.obolibrary.org/obo/MONDO_0000491 |
| T20 | 1073-1081 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T21 | 1093-1101 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T22 | 1123-1131 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T23 | 1187-1191 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T24 | 1382-1384 | Disease | denotes | DM | http://purl.obolibrary.org/obo/MONDO_0005015|http://purl.obolibrary.org/obo/MONDO_0016367 |
| T26 | 1414-1424 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T27 | 1495-1514 | Disease | denotes | ischemic neuropathy | http://purl.obolibrary.org/obo/MONDO_0001408 |
| T28 | 1504-1514 | Disease | denotes | neuropathy | http://purl.obolibrary.org/obo/MONDO_0005244 |
| T29 | 1587-1591 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T30 | 1593-1630 | Disease | denotes | Chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005002 |
| T31 | 1613-1630 | Disease | denotes | pulmonary disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T32 | 1664-1676 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T33 | 1678-1680 | Disease | denotes | DM | http://purl.obolibrary.org/obo/MONDO_0005015|http://purl.obolibrary.org/obo/MONDO_0016367 |
| T35 | 1682-1699 | Disease | denotes | diabetes mellitus | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T36 | 1705-1717 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T37 | 1760-1778 | Disease | denotes | multiorgan failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T38 | 1784-1796 | Disease | denotes | polycythemia | http://purl.obolibrary.org/obo/MONDO_0005571 |
| T39 | 1921-1934 | Disease | denotes | limb ischemia | http://purl.obolibrary.org/obo/MONDO_0000491 |
| T40 | 1926-1934 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T41 | 1946-1954 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T10 | 68-72 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | limb |
| T11 | 94-101 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T12 | 182-183 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T13 | 249-258 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | extremely |
| T14 | 391-399 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T15 | 391-399 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T16 | 482-489 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T17 | 516-521 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | Blood |
| T18 | 516-521 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | Blood |
| T19 | 522-529 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | testing |
| T20 | 543-544 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T21 | 693-699 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T22 | 1068-1072 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | limb |
| T23 | 1193-1195 | http://purl.obolibrary.org/obo/CLO_0004265 | denotes | HT |
| T24 | 1208-1214 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | artery |
| T25 | 1208-1214 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | artery |
| T26 | 1303-1309 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | artery |
| T27 | 1303-1309 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | artery |
| T28 | 1377-1381 | http://purl.obolibrary.org/obo/CLO_0001319 | denotes | 3 72 |
| T29 | 1477-1481 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | limb |
| T30 | 1701-1703 | http://purl.obolibrary.org/obo/CLO_0004265 | denotes | HT |
| T31 | 1815-1829 | http://purl.obolibrary.org/obo/UBERON_0002060 | denotes | femoral artery |
| T32 | 1831-1832 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T33 | 1873-1878 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | Blood |
| T34 | 1873-1878 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | Blood |
| T35 | 1879-1883 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | test |
| T36 | 1921-1925 | http://www.ebi.ac.uk/efo/EFO_0000876 | denotes | limb |
| T37 | 2096-2099 | http://purl.obolibrary.org/obo/CLO_0001053 | denotes | 121 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 13-15 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T2 | 217-222 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T3 | 618-625 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T4 | 1382-1384 | Chemical | denotes | DM | http://purl.obolibrary.org/obo/CHEBI_141426 |
| T5 | 1387-1390 | Chemical | denotes | SFA | http://purl.obolibrary.org/obo/CHEBI_26607 |
| T6 | 1455-1469 | Chemical | denotes | prostaglandins | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T7 | 1520-1522 | Chemical | denotes | PV | http://purl.obolibrary.org/obo/CHEBI_27446|http://purl.obolibrary.org/obo/CHEBI_74800 |
| T9 | 1632-1635 | Chemical | denotes | DIC | http://purl.obolibrary.org/obo/CHEBI_4305|http://purl.obolibrary.org/obo/CHEBI_53092 |
| T11 | 1678-1680 | Chemical | denotes | DM | http://purl.obolibrary.org/obo/CHEBI_141426 |
| T12 | 1746-1753 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T13 | 1780-1782 | Chemical | denotes | PV | http://purl.obolibrary.org/obo/CHEBI_27446|http://purl.obolibrary.org/obo/CHEBI_74800 |
| T15 | 1798-1801 | Chemical | denotes | SFA | http://purl.obolibrary.org/obo/CHEBI_26607 |
| T16 | 1870-1872 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T17 | 2125-2132 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 550-571 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 0-167 | Sentence | denotes | Tables I and II summarize four cases presenting with acute critical limb ischemia in patients testing COVID-19 (+) with no previous vascular consultations or symptoms. |
| T10 | 168-223 | Sentence | denotes | We identified a delayed diagnosis for the entire group. |
| T11 | 224-387 | Sentence | denotes | The patients were either extremely fearful about coming to the hospital or underdiagnosed during hospitalization, as confirmed with written commentary from nurses. |
| T12 | 388-515 | Sentence | denotes | An arterial thrombotic event presented in two COVID-19 patients who were asymptomatic despite testing positive for the disease. |
| T13 | 516-721 | Sentence | denotes | Blood testing demonstrated a high inflammatory response in all of these patients (D-dimer, C-reactive protein) that was significantly higher in those who were hospitalized with active and severe pneumonia. |
| T14 | 722-842 | Sentence | denotes | Interestingly, procalcitonin values were normal in all of these patients, indicating an evolving inflammatory condition. |
| T15 | 843-1000 | Sentence | denotes | Although no strong conclusions can be drawn from this initial description, it may serve as guidance for future studies seeking to improve PAD identification. |
| T16 | 1001-1105 | Sentence | denotes | Table I Clinical data and outcomes of patients with acute critical limb ischemia (ACLI) and COVID-19 (+) |
| T17 | 1106-1181 | Sentence | denotes | Age, years Other COVID-19 symptomsa Vascular bed affected Treatment Outcome |
| T18 | 1182-1273 | Sentence | denotes | 1 72 COPD, HT + Popliteal artery (right) LMWH alone Death 1 day after consultationDIC + MOF |
| T19 | 1274-1376 | Sentence | denotes | 2 53 – – Iliac and popliteal artery (left) LMWH and delayed thrombectomy at day 7 Clinical improvement |
| T20 | 1377-1514 | Sentence | denotes | 3 72 DM – SFA, popliteal with distal thrombosis (right) Thrombectomy + LMWH + prostaglandins 10-day limb salvage, 50% ischemic neuropathy |
| T21 | 1515-1586 | Sentence | denotes | 4 70 PV + Infragenicular (right) LMWH alone 2 days—clinical improvement |
| T22 | 1587-1830 | Sentence | denotes | COPD, Chronic obstructive pulmonary disease; DIC, disseminated intravascular coagulopathy; DM, diabetes mellitus; HT, hypertension; LMWH, low-molecular-weight heparin; MOF, multiorgan failure; PV, polycythemia; SFA, superficial femoral artery. |
| T23 | 1831-1863 | Sentence | denotes | a Includes respiratory or fever. |
| T24 | 1864-1958 | Sentence | denotes | Table II Blood test data of patients with acute critical limb ischemia (ACLI) and COVID-19 (+) |
| T25 | 1959-2030 | Sentence | denotes | D-dimer, ng/mL Platelet count, 109 L Lymphocytes count, /mm3 CRP, mg/dL |
| T26 | 2031-2048 | Sentence | denotes | 1 6531 50 900 184 |
| T27 | 2049-2067 | Sentence | denotes | 2 1415 335 800 9.1 |
| T28 | 2068-2088 | Sentence | denotes | 3 3235 228 1800 58.9 |
| T29 | 2089-2108 | Sentence | denotes | 4 7528 121 400 77.7 |
| T30 | 2109-2133 | Sentence | denotes | CRP, C-reactive protein. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T5 | 711-720 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T6 | 981-984 | Phenotype | denotes | PAD | http://purl.obolibrary.org/obo/HP_0004950 |
| T7 | 1187-1191 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T8 | 1504-1514 | Phenotype | denotes | neuropathy | http://purl.obolibrary.org/obo/HP_0009830 |
| T9 | 1587-1591 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
| T10 | 1593-1630 | Phenotype | denotes | Chronic obstructive pulmonary disease | http://purl.obolibrary.org/obo/HP_0006510 |
| T11 | 1664-1676 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
| T12 | 1682-1699 | Phenotype | denotes | diabetes mellitus | http://purl.obolibrary.org/obo/HP_0000819 |
| T13 | 1705-1717 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T14 | 1784-1796 | Phenotype | denotes | polycythemia | http://purl.obolibrary.org/obo/HP_0001901 |
| T15 | 1857-1862 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 29 | 1123-1131 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 30 | 1187-1191 | Disease | denotes | COPD | MESH:D029424 |
| 31 | 1193-1195 | Disease | denotes | HT | MESH:D006973 |
| 32 | 1234-1239 | Disease | denotes | Death | MESH:D003643 |
| 33 | 1382-1384 | Disease | denotes | DM | MESH:D009223 |
| 34 | 1414-1424 | Disease | denotes | thrombosis | MESH:D013927 |
| 35 | 1495-1514 | Disease | denotes | ischemic neuropathy | MESH:D007511 |
| 39 | 1039-1047 | Species | denotes | patients | Tax:9606 |
| 40 | 1073-1081 | Disease | denotes | ischemia | MESH:D007511 |
| 41 | 1093-1101 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 53 | 1746-1753 | Chemical | denotes | heparin | MESH:D006493 |
| 54 | 1587-1591 | Disease | denotes | COPD | MESH:D029424 |
| 55 | 1593-1630 | Disease | denotes | Chronic obstructive pulmonary disease | MESH:D029424 |
| 56 | 1632-1635 | Disease | denotes | DIC | MESH:D004211 |
| 57 | 1637-1676 | Disease | denotes | disseminated intravascular coagulopathy | MESH:D004211 |
| 58 | 1678-1680 | Disease | denotes | DM | MESH:D009223 |
| 59 | 1682-1699 | Disease | denotes | diabetes mellitus | MESH:D003920 |
| 60 | 1701-1703 | Disease | denotes | HT | MESH:D006973 |
| 61 | 1705-1717 | Disease | denotes | hypertension | MESH:D006973 |
| 62 | 1760-1778 | Disease | denotes | multiorgan failure | MESH:D009102 |
| 63 | 1784-1796 | Disease | denotes | polycythemia | MESH:D011086 |
| 65 | 1857-1862 | Disease | denotes | fever | MESH:D005334 |
| 67 | 2020-2023 | Gene | denotes | CRP | Gene:1401 |
| 71 | 1892-1900 | Species | denotes | patients | Tax:9606 |
| 72 | 1926-1934 | Disease | denotes | ischemia | MESH:D007511 |
| 73 | 1946-1954 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 76 | 2109-2112 | Gene | denotes | CRP | Gene:1401 |
| 77 | 2114-2132 | Gene | denotes | C-reactive protein | Gene:1401 |
| 89 | 607-625 | Gene | denotes | C-reactive protein | Gene:1401 |
| 90 | 85-93 | Species | denotes | patients | Tax:9606 |
| 91 | 228-236 | Species | denotes | patients | Tax:9606 |
| 92 | 443-451 | Species | denotes | patients | Tax:9606 |
| 93 | 588-596 | Species | denotes | patients | Tax:9606 |
| 94 | 786-794 | Species | denotes | patients | Tax:9606 |
| 95 | 68-81 | Disease | denotes | limb ischemia | MESH:D007511 |
| 96 | 102-110 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 97 | 400-410 | Disease | denotes | thrombotic | MESH:D013927 |
| 98 | 434-442 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 99 | 711-720 | Disease | denotes | pneumonia | MESH:D011014 |