PMC:7189872 / 4339-4848 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"47","span":{"begin":200,"end":204},"obj":"Gene"},{"id":"73","span":{"begin":57,"end":61},"obj":"Disease"}],"attributes":[{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Gene:10045"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D004474"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T16","span":{"begin":4,"end":10},"obj":"Body_part"},{"id":"T17","span":{"begin":78,"end":86},"obj":"Body_part"},{"id":"T18","span":{"begin":190,"end":198},"obj":"Body_part"},{"id":"T19","span":{"begin":225,"end":228},"obj":"Body_part"},{"id":"T20","span":{"begin":256,"end":264},"obj":"Body_part"},{"id":"T21","span":{"begin":354,"end":362},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T18","span":{"begin":78,"end":86},"obj":"Chemical"},{"id":"T19","span":{"begin":190,"end":198},"obj":"Chemical"},{"id":"T20","span":{"begin":256,"end":264},"obj":"Chemical"},{"id":"T21","span":{"begin":354,"end":362},"obj":"Chemical"}],"attributes":[{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T4","span":{"begin":225,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0032774"},{"id":"T5","span":{"begin":229,"end":238},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T6","span":{"begin":402,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T7","span":{"begin":402,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T8","span":{"begin":440,"end":454},"obj":"http://purl.obolibrary.org/obo/GO_0019068"},{"id":"T9","span":{"begin":472,"end":481},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T10","span":{"begin":472,"end":481},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T11","span":{"begin":486,"end":498},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}

{"project":"LitCovid-sentences","denotations":[{"id":"T34","span":{"begin":0,"end":509},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T79","span":{"begin":4,"end":10},"obj":"SO:0001026"},{"id":"T80","span":{"begin":36,"end":55},"obj":"SO:0000236"},{"id":"T81","span":{"begin":57,"end":61},"obj":"SO:0000236"},{"id":"T82","span":{"begin":159,"end":166},"obj":"MOP:0000780"},{"id":"T83","span":{"begin":200,"end":204},"obj":"PR:000014815"},{"id":"T84","span":{"begin":205,"end":210},"obj":"PR:000000125"},{"id":"T85","span":{"begin":219,"end":224},"obj":"NCBITaxon:10239"},{"id":"T86","span":{"begin":225,"end":238},"obj":"GO:0032774"},{"id":"T87","span":{"begin":304,"end":309},"obj":"NCBITaxon:10239"},{"id":"T88","span":{"begin":402,"end":407},"obj":"NCBITaxon:10239;GO:0006260"},{"id":"T89","span":{"begin":408,"end":419},"obj":"GO:0006260"},{"id":"T90","span":{"begin":440,"end":445},"obj":"NCBITaxon:10239;GO:0019068"},{"id":"T91","span":{"begin":446,"end":454},"obj":"GO:0019068"},{"id":"T51120","span":{"begin":4,"end":10},"obj":"SO:0001026"},{"id":"T98752","span":{"begin":36,"end":55},"obj":"SO:0000236"},{"id":"T88118","span":{"begin":57,"end":61},"obj":"SO:0000236"},{"id":"T10517","span":{"begin":159,"end":166},"obj":"MOP:0000780"},{"id":"T40755","span":{"begin":200,"end":204},"obj":"PR:000014815"},{"id":"T68644","span":{"begin":205,"end":210},"obj":"PR:000000125"},{"id":"T26777","span":{"begin":219,"end":224},"obj":"NCBITaxon:10239"},{"id":"T37869","span":{"begin":225,"end":238},"obj":"GO:0032774"},{"id":"T38700","span":{"begin":304,"end":309},"obj":"NCBITaxon:10239"},{"id":"T29364","span":{"begin":402,"end":407},"obj":"NCBITaxon:10239;GO:0006260"},{"id":"T72969","span":{"begin":408,"end":419},"obj":"GO:0006260"},{"id":"T61555","span":{"begin":440,"end":445},"obj":"NCBITaxon:10239;GO:0019068"},{"id":"T24991","span":{"begin":446,"end":454},"obj":"GO:0019068"}],"text":"The genome incorporates at least 14 open reading frames (ORFs) that encode 28 proteins in three distinct classes: two large polyproteins P1a and P1ab that are cleaved into 16 non-structural proteins (nsp1–nsp16) during viral RNA synthesis; four structural proteins (S, E, M and N) that are necessary for viral entrance and gathering; and eight accessory proteins that are assumed to be dispensable for viral replication, but may facilitate viral assembly and take part in virulence and pathogenesis (Fig. 1 )."}