PMC:7187150 / 983-1948
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T18 | 68-75 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T19 | 100-105 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
T20 | 170-179 | Body_part | denotes | capillary | http://purl.org/sig/ont/fma/fma63194 |
T21 | 203-225 | Body_part | denotes | pluripotent stem cells | http://purl.org/sig/ont/fma/fma70570 |
T22 | 220-225 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T23 | 231-237 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
T24 | 259-279 | Body_part | denotes | embryonic stem cells | http://purl.org/sig/ont/fma/fma82841 |
T25 | 274-279 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T26 | 302-306 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T27 | 307-310 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T28 | 329-335 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
T29 | 389-393 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T30 | 430-435 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T31 | 454-459 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T32 | 567-570 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T33 | 778-784 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
T34 | 860-867 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
T35 | 942-947 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T12 | 100-105 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
T13 | 170-179 | Body_part | denotes | capillary | http://purl.obolibrary.org/obo/UBERON_0001982 |
T14 | 231-237 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
T15 | 329-335 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
T16 | 778-784 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T13 | 128-136 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T14 | 489-498 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T15 | 521-529 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T16 | 608-617 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T17 | 696-704 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T18 | 831-839 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T32 | 100-105 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
T33 | 164-169 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T34 | 215-225 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
T35 | 231-237 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
T36 | 231-237 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
T37 | 231-237 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
T38 | 253-258 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T39 | 269-279 | http://purl.obolibrary.org/obo/CL_0000034 | denotes | stem cells |
T40 | 302-306 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T41 | 329-335 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
T42 | 329-335 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
T43 | 329-335 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
T44 | 389-393 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T45 | 430-435 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T46 | 454-459 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T47 | 717-718 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T48 | 915-920 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T49 | 942-947 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 633-650 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T3 | 633-650 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T7 | 0-478 | Sentence | denotes | Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat. |
T8 | 479-651 | Sentence | denotes | Following infection of the organoids with SARS-CoV-2 the researchers could detect viral RNA that increased in the days following infection, indicative of viral replication. |
T9 | 652-965 | Sentence | denotes | Addition of hrsACE2, however, again reduced SARS-CoV-2 levels in a dose-dependent manner. “Our findings not only suggest that tissue organoids can be used to study the effects of SARS-CoV-2 on extrapulmonary tissues, but also suggest that rhsACE2 might block the virus from entering target cells,” says Penninger. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
44 | 45-49 | Gene | denotes | ACE2 | Gene:59272 |
45 | 358-362 | Gene | denotes | ACE2 | Gene:59272 |
46 | 164-169 | Species | denotes | human | Tax:9606 |
47 | 253-258 | Species | denotes | human | Tax:9606 |
48 | 521-531 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
49 | 696-706 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
50 | 831-841 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
51 | 891-898 | Chemical | denotes | rhsACE2 | |
52 | 94-117 | Disease | denotes | multi-organ dysfunction | MESH:D009102 |
53 | 128-136 | Disease | denotes | COVID-19 | MESH:C000657245 |
54 | 489-498 | Disease | denotes | infection | MESH:D007239 |
55 | 608-617 | Disease | denotes | infection | MESH:D007239 |