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PMC:7187150 / 76-1948 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T2 136-141 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 181-206 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T4 201-206 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 214-219 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T6 227-232 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7 242-249 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T8 265-270 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T9 272-278 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T10 283-296 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T11 283-288 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T12 352-364 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T13 369-375 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T14 508-515 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 730-737 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 769-774 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 789-794 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18 975-982 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T19 1007-1012 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T20 1077-1086 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T21 1110-1132 Body_part denotes pluripotent stem cells http://purl.org/sig/ont/fma/fma70570
T22 1127-1132 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23 1138-1144 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T24 1166-1186 Body_part denotes embryonic stem cells http://purl.org/sig/ont/fma/fma82841
T25 1181-1186 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 1209-1213 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 1214-1217 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 1236-1242 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T29 1296-1300 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T30 1337-1342 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T31 1361-1366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 1474-1477 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T33 1685-1691 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T34 1767-1774 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T35 1849-1854 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 265-270 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T3 272-296 Body_part denotes kidney and blood vessels http://purl.obolibrary.org/obo/UBERON_0003517
T4 272-278 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 283-296 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T6 283-288 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 289-296 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T8 352-364 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T9 352-357 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 358-364 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T11 369-375 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T12 1007-1012 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T13 1077-1086 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T14 1138-1144 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T15 1236-1242 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T16 1685-1691 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 12-20 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 43-90 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 43-76 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T6 92-100 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 324-332 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 400-409 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 617-625 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 741-749 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 818-826 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 829-838 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1035-1043 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1396-1405 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1428-1436 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1515-1524 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T17 1603-1611 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1738-1746 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T5 110-115 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T6 136-141 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 190-219 http://purl.obolibrary.org/obo/CL_0000082 denotes epithelial cells in the lungs
T8 227-232 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 265-270 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T10 265-270 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T11 265-270 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T12 265-270 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T13 272-278 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T14 272-278 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T15 272-278 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T16 283-296 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T17 283-296 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T18 346-351 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T19 352-364 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T20 352-364 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T21 369-375 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T22 369-375 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T23 369-375 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T24 427-435 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes by human
T25 500-501 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 521-524 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T27 538-544 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T28 761-774 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T29 789-794 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T30 842-843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 900-905 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T32 1007-1012 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T33 1071-1076 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T34 1122-1132 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T35 1138-1144 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T36 1138-1144 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T37 1138-1144 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T38 1160-1165 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T39 1176-1186 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T40 1209-1213 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T41 1236-1242 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T42 1236-1242 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T43 1236-1242 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T44 1296-1300 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T45 1337-1342 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 1361-1366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47 1624-1625 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 1822-1827 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T49 1849-1854 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 508-515 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 560-562 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T3 730-737 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 122-135 http://purl.obolibrary.org/obo/GO_0044409 denotes entry to host
T2 1540-1557 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 1540-1557 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T2 0-104 Sentence denotes The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
T3 105-297 Sentence denotes This virus gains entry to host cells via ACE2, which is expressed by type 2 alveolar epithelial cells in the lungs and by cells in other tissues, including the heart, kidney and blood vessels.
T4 298-471 Sentence denotes Researchers now show that SARS-CoV-2 can infect human blood vessel and kidney organoids and that this infection can be inhibited by human recombinant soluble ACE2 (hrsACE2).
T5 472-775 Sentence denotes To assess whether hrsACE2 — a decoy protein that has already been tested in phase I and II clinical trials — can inhibit the interaction between SARS-CoV-2 and ACE2, Josef Penninger, Ali Mirazimi, Nuria Montserrat and colleagues administered the recombinant protein to SARS-CoV-2-infected Vero E6 cells.
T6 776-906 Sentence denotes Treatment of cells with hrsACE2 inhibited SARS-CoV-2 infection in a dose-dependent manner and attenuated propagation of the virus.
T7 907-1385 Sentence denotes Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat.
T8 1386-1558 Sentence denotes Following infection of the organoids with SARS-CoV-2 the researchers could detect viral RNA that increased in the days following infection, indicative of viral replication.
T9 1559-1872 Sentence denotes Addition of hrsACE2, however, again reduced SARS-CoV-2 levels in a dose-dependent manner. “Our findings not only suggest that tissue organoids can be used to study the effects of SARS-CoV-2 on extrapulmonary tissues, but also suggest that rhsACE2 might block the virus from entering target cells,” says Penninger.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
13 146-150 Gene denotes ACE2 Gene:59272
14 456-460 Gene denotes ACE2 Gene:59272
15 43-90 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
16 92-102 Species denotes SARS-CoV-2 Tax:2697049
17 324-334 Species denotes SARS-CoV-2 Tax:2697049
18 346-351 Species denotes human Tax:9606
19 430-435 Species denotes human Tax:9606
20 12-20 Disease denotes COVID-19 MESH:C000657245
21 400-409 Disease denotes infection MESH:D007239
27 632-636 Gene denotes ACE2 Gene:59272
28 617-627 Species denotes SARS-CoV-2 Tax:2697049
29 746-760 Disease denotes CoV-2-infected MESH:C000657245
30 818-838 Disease denotes SARS-CoV-2 infection MESH:C000657245
31 766-768 CellLine denotes E6 CVCL:4582
44 952-956 Gene denotes ACE2 Gene:59272
45 1265-1269 Gene denotes ACE2 Gene:59272
46 1071-1076 Species denotes human Tax:9606
47 1160-1165 Species denotes human Tax:9606
48 1428-1438 Species denotes SARS-CoV-2 Tax:2697049
49 1603-1613 Species denotes SARS-CoV-2 Tax:2697049
50 1738-1748 Species denotes SARS-CoV-2 Tax:2697049
51 1798-1805 Chemical denotes rhsACE2
52 1001-1024 Disease denotes multi-organ dysfunction MESH:D009102
53 1035-1043 Disease denotes COVID-19 MESH:C000657245
54 1396-1405 Disease denotes infection MESH:D007239
55 1515-1524 Disease denotes infection MESH:D007239