PMC:7187150 / 548-982 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7187150","sourcedb":"PMC","sourceid":"7187150","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7187150","text":"To assess whether hrsACE2 — a decoy protein that has already been tested in phase I and II clinical trials — can inhibit the interaction between SARS-CoV-2 and ACE2, Josef Penninger, Ali Mirazimi, Nuria Montserrat and colleagues administered the recombinant protein to SARS-CoV-2-infected Vero E6 cells. Treatment of cells with hrsACE2 inhibited SARS-CoV-2 infection in a dose-dependent manner and attenuated propagation of 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