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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 24-30 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T2 212-217 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 257-282 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T4 277-282 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 290-295 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T6 303-308 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7 318-325 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T8 341-346 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T9 348-354 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T10 359-372 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T11 359-364 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T12 428-440 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T13 445-451 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T14 584-591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 806-813 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 845-850 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 865-870 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T18 1051-1058 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T19 1083-1088 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T20 1153-1162 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194
T21 1186-1208 Body_part denotes pluripotent stem cells http://purl.org/sig/ont/fma/fma70570
T22 1203-1208 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T23 1214-1220 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T24 1242-1262 Body_part denotes embryonic stem cells http://purl.org/sig/ont/fma/fma82841
T25 1257-1262 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 1285-1289 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T27 1290-1293 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T28 1312-1318 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T29 1372-1376 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T30 1413-1418 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T31 1437-1442 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 1550-1553 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T33 1761-1767 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T34 1843-1850 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T35 1925-1930 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 24-30 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 341-346 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T3 348-372 Body_part denotes kidney and blood vessels http://purl.obolibrary.org/obo/UBERON_0003517
T4 348-354 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 359-372 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T6 359-364 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T7 365-372 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T8 428-440 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T9 428-433 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 434-440 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T11 445-451 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T12 1083-1088 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T13 1153-1162 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T14 1214-1220 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T15 1312-1318 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T16 1761-1767 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 0-8 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 11-20 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 88-96 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 119-166 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 119-152 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T6 168-176 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 400-408 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 476-485 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 693-701 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 817-825 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 894-902 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 905-914 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1111-1119 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1472-1481 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1504-1512 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1591-1600 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T17 1679-1687 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1814-1822 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 24-30 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T2 24-30 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T3 24-30 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T4 64-69 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 186-191 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T6 212-217 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 266-295 http://purl.obolibrary.org/obo/CL_0000082 denotes epithelial cells in the lungs
T8 303-308 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9 341-346 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T10 341-346 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T11 341-346 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T12 341-346 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T13 348-354 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T14 348-354 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T15 348-354 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T16 359-372 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T17 359-372 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T18 422-427 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T19 428-440 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessel
T20 428-440 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessel
T21 445-451 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T22 445-451 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T23 445-451 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T24 503-511 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes by human
T25 576-577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 597-600 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T27 614-620 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T28 837-850 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T29 865-870 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T30 918-919 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 976-981 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T32 1083-1088 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T33 1147-1152 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T34 1198-1208 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T35 1214-1220 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T36 1214-1220 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T37 1214-1220 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T38 1236-1241 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T39 1252-1262 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cells
T40 1285-1289 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T41 1312-1318 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T42 1312-1318 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T43 1312-1318 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T44 1372-1376 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T45 1413-1418 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T46 1437-1442 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47 1700-1701 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T48 1898-1903 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T49 1925-1930 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 584-591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T2 636-638 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T3 806-813 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 198-211 http://purl.obolibrary.org/obo/GO_0044409 denotes entry to host
T2 1616-1633 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 1616-1633 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2
T2 76-180 Sentence denotes The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
T3 181-373 Sentence denotes This virus gains entry to host cells via ACE2, which is expressed by type 2 alveolar epithelial cells in the lungs and by cells in other tissues, including the heart, kidney and blood vessels.
T4 374-547 Sentence denotes Researchers now show that SARS-CoV-2 can infect human blood vessel and kidney organoids and that this infection can be inhibited by human recombinant soluble ACE2 (hrsACE2).
T5 548-851 Sentence denotes To assess whether hrsACE2 — a decoy protein that has already been tested in phase I and II clinical trials — can inhibit the interaction between SARS-CoV-2 and ACE2, Josef Penninger, Ali Mirazimi, Nuria Montserrat and colleagues administered the recombinant protein to SARS-CoV-2-infected Vero E6 cells.
T6 852-982 Sentence denotes Treatment of cells with hrsACE2 inhibited SARS-CoV-2 infection in a dose-dependent manner and attenuated propagation of the virus.
T7 983-1461 Sentence denotes Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat.
T8 1462-1634 Sentence denotes Following infection of the organoids with SARS-CoV-2 the researchers could detect viral RNA that increased in the days following infection, indicative of viral replication.
T9 1635-1948 Sentence denotes Addition of hrsACE2, however, again reduced SARS-CoV-2 levels in a dose-dependent manner. “Our findings not only suggest that tissue organoids can be used to study the effects of SARS-CoV-2 on extrapulmonary tissues, but also suggest that rhsACE2 might block the virus from entering target cells,” says Penninger.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 64-69 Species denotes human Tax:9606
3 0-20 Disease denotes SARS-CoV-2 infection MESH:C000657245
13 222-226 Gene denotes ACE2 Gene:59272
14 532-536 Gene denotes ACE2 Gene:59272
15 119-166 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
16 168-178 Species denotes SARS-CoV-2 Tax:2697049
17 400-410 Species denotes SARS-CoV-2 Tax:2697049
18 422-427 Species denotes human Tax:9606
19 506-511 Species denotes human Tax:9606
20 88-96 Disease denotes COVID-19 MESH:C000657245
21 476-485 Disease denotes infection MESH:D007239
27 708-712 Gene denotes ACE2 Gene:59272
28 693-703 Species denotes SARS-CoV-2 Tax:2697049
29 822-836 Disease denotes CoV-2-infected MESH:C000657245
30 894-914 Disease denotes SARS-CoV-2 infection MESH:C000657245
31 842-844 CellLine denotes E6 CVCL:4582
44 1028-1032 Gene denotes ACE2 Gene:59272
45 1341-1345 Gene denotes ACE2 Gene:59272
46 1147-1152 Species denotes human Tax:9606
47 1236-1241 Species denotes human Tax:9606
48 1504-1514 Species denotes SARS-CoV-2 Tax:2697049
49 1679-1689 Species denotes SARS-CoV-2 Tax:2697049
50 1814-1824 Species denotes SARS-CoV-2 Tax:2697049
51 1874-1881 Chemical denotes rhsACE2
52 1077-1100 Disease denotes multi-organ dysfunction MESH:D009102
53 1111-1119 Disease denotes COVID-19 MESH:C000657245
54 1472-1481 Disease denotes infection MESH:D007239
55 1591-1600 Disease denotes infection MESH:D007239