PMC:7172841 / 6891-9350 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7172841","sourcedb":"PMC","sourceid":"7172841","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7172841","text":"Table 1 Baseline Clinical and Laboratory Characteristics of the Cohorts of Bacterial CAP and of Pneumonia Caused by SARS-CoV-2\nNo respiratory failure Severe respiratory failure\nBacterial SARS-CoV-2 p value Bacterial SARS-CoV-2 p value\nNumber of patients 48 26 56 28\nAge (years, mean ± SD) 74.8 ± 16.8 59.2 ± 10.3 \u003c0.0001 74.0 ± 12.6∗ 67.8 ± 10.8# \u003c0.0001\nMale gender (n, %) 25 (52.1) 15 (57.7) 0.807 27 (48.2)∗ 25 (89.3)∗∗ 0.0003\nAPACHE II score (mean ± SD) 18.50 ± 8.19 5.88 ± 3.40 \u003c0.0001 26.63 ± 8.52∗∗ 10.17 ± 3.64## \u003c0.0001\nSOFA score (mean ± SD) 7.87 ± 3.81 1.50 ± 0.82 \u003c0.0001 11.46 ± 3.15∗∗ 5.71 ± 2.19## \u003c0.0001\nCCI (mean ± SD) 5.53 ± 2.13 2.16 ± 1.46 \u003c0.0001 5.57 ± 2.20∗ 3.39 ± 2.16## \u003c0.0001\nPSI (mean ± SD) 146.5 ± 43.2 80.0 ± 30.7 \u003c0.0001 177.4 ± 40.4∗∗∗ 121.2 ± 28.3## \u003c0.0001\nLaboratory values (mean ± SD)\n Total white blood cell count (/mm3) 13,852.7 ± 7279.3 6379.6 ± 1993.9 \u003c0.0001 17,666.9 ± 12,799.9∗ 9447.8 ± 3308.6## \u003c0.0001\n Absolute platelet count (x103 /mm3) 201.3 ± 124.8 243.8 ± 109.1 0.141 224.3 ± 111.0∗ 213.9 ± 71.8∗ 0.654\n INR 1.28 ± 0.64 1.11 ± 0.15 0.187 1.33 ± 0.45∗ 1.17 ± 0.20∗ 0.077\n aPTT (secs) 37.19 ± 12.95 33.40 ± 6.22 0.165 38.42 ± 23.00∗ 37.52 ± 9.88∗ 0.844\n Fibrinogen (mg/dl) 475.6 ± 196.3 528.9 ± 152.5 0.234 495.3 ± 290.5∗ 693.5 ± 188.6# 0.002\n D-dimers (g/dl) 7.66 ± 13.9 2.76 ± 2.02 0.079 1.46 ± 1.62∗∗ 5.43 ± 6.41∗ \u003c0.0001\n Creatinine (mg/dl) 1.55 ± 1.00 0.85 ± 0.19 0.001 1.71 ± 0.90∗ 1.11 ± 0.43# 0.001\n Total bilirubin (mg/dl) 1.43 ± 1.92 0.67 ± 0.50 0.052 1.17 ± 1.88∗ 0.97 ± 0.68∗ 0.588\n AST (U/l) 155.1 ± 308.1 39.9 ± 28.5 0.062 311.7 ± 748.2∗ 76.6 ± 59.2# 0.102\n ALT (U/l) 234.6 ± 764.3 40.2 ± 24.9 0.200 175.8 ± 378.0∗ 64.3 ± 62.2∗ 0.126\nMain comorbidities (n, %)\n Type 2 diabetes mellitus 13 (27.1) 4 (15.4) 0.386 21 (37.5)∗ 6 (21.4)∗ 0.214\n Chronic heart failure 8 (16.7) 3 (11.5) 0.737 18 (32.1)∗ 4 (14.3)∗ 0.114\n Coronary heart disease 7 (14.6) 2 (7.7) 0.479 10 (17.9) 5 (17.9)∗ 1.0\nComparisons with the respective groups without respiratory failure by the Student’s t test: ∗p-non-significant; ∗∗p \u003c 0.05; #p \u003c 0.001; ##p \u003c 0.0001. Abbreviations are as follows: ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; APACHE, acute physiology and chronic health evaluation; CCI, Charlson’s comorbidity index; INR, international normalized ratio; PSI, pneumonia severity index; SD, standard deviation; SOFA, sequential organ failure 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