PMC:7172841 / 4485-4835 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T28","span":{"begin":98,"end":101},"obj":"Body_part"},{"id":"T29","span":{"begin":113,"end":122},"obj":"Body_part"},{"id":"T30","span":{"begin":146,"end":154},"obj":"Body_part"},{"id":"T31","span":{"begin":193,"end":206},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma62864"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma264829"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T49","span":{"begin":7,"end":10},"obj":"Disease"},{"id":"T50","span":{"begin":228,"end":239},"obj":"Disease"},{"id":"T51","span":{"begin":316,"end":332},"obj":"Disease"}],"attributes":[{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005229"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T34","span":{"begin":113,"end":122},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T35","span":{"begin":146,"end":154},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T36","span":{"begin":193,"end":206},"obj":"http://purl.obolibrary.org/obo/PR_000001393"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22","span":{"begin":102,"end":104},"obj":"Chemical"},{"id":"T23","span":{"begin":208,"end":210},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A24","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T24","span":{"begin":46,"end":66},"obj":"Phenotype"},{"id":"T25","span":{"begin":228,"end":239},"obj":"Phenotype"},{"id":"T26","span":{"begin":326,"end":332},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002958"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0100806"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T115","span":{"begin":46,"end":52},"obj":"UBERON:0002405;GO:0006955"},{"id":"T116","span":{"begin":53,"end":66},"obj":"GO:0006955"},{"id":"T117","span":{"begin":84,"end":94},"obj":"GO:0010467"},{"id":"T118","span":{"begin":98,"end":101},"obj":"PR:000029150"},{"id":"T119","span":{"begin":108,"end":112},"obj":"PR:000001889"},{"id":"T120","span":{"begin":113,"end":122},"obj":"CL:0000576"},{"id":"T121","span":{"begin":146,"end":154},"obj":"CL:0000576"},{"id":"T122","span":{"begin":182,"end":192},"obj":"GO:0050663"},{"id":"T123","span":{"begin":193,"end":206},"obj":"PR:000001393"},{"id":"T124","span":{"begin":208,"end":212},"obj":"PR:000001393"},{"id":"T125","span":{"begin":316,"end":325},"obj":"NCBITaxon:2"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}

{"project":"LitCovid-PubTator","denotations":[{"id":"185","span":{"begin":108,"end":112},"obj":"Gene"},{"id":"186","span":{"begin":193,"end":206},"obj":"Gene"},{"id":"187","span":{"begin":208,"end":212},"obj":"Gene"},{"id":"192","span":{"begin":25,"end":33},"obj":"Species"},{"id":"202","span":{"begin":228,"end":239},"obj":"Disease"},{"id":"203","span":{"begin":275,"end":290},"obj":"Disease"},{"id":"204","span":{"begin":326,"end":332},"obj":"Disease"},{"id":"205","span":{"begin":336,"end":339},"obj":"Disease"}],"attributes":[{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"Gene:929"},{"id":"A186","pred":"tao:has_database_id","subj":"186","obj":"Gene:3569"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Gene:3569"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Tax:9606"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D008231"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D018805"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"F have MAS and that most patients suffer from immune dysregulation dominated by low expression of HLA-DR on CD14 monocytes, which is triggered by monocyte hyperactivation, excessive release of interleukin-6 (IL-6), and profound lymphopenia. This pattern is distinct from the immunoparalysis state reported in either bacterial sepsis or SRF caused by "}