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PMC:7172841 / 25816-26460 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T177 130-134 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T178 153-161 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T179 208-217 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T180 253-257 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T181 336-339 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T19 130-134 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T20 253-257 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T226 93-101 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T227 93-97 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T236 29-30 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T161 230-232 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T163 310-312 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T165 340-342 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T31 153-172 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T32 598-625 http://purl.obolibrary.org/obo/GO_0050728 denotes anti-inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T186 0-354 Sentence denotes In conclusion, we identified a unique signature of immune dysregulation in the patients with SARS-CoV-2, characterized on the one hand by normal or high cytokine production capacity and increased circulating cytokines (especially IL-6) and on the other hand by defects in the lymphoid function associated with IL-6-mediated decrease in HLA-DR expression.
T187 355-644 Sentence denotes These findings support the rationale of launched clinical trials on the efficacy of Anakinra, Sarilumab, Siltuximab, and Tocilizumab (Clinicaltrials.gov NCT04330638, NCT04317092, and NCT04315298 and EudraCT number 2020-001039-29) to elaborate anti-inflammatory responses in these patients.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T92 51-71 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T815 51-57 UBERON:0002405;GO:0006955 denotes immune
T816 58-71 GO:0006955 denotes dysregulation
T817 93-103 SP_7 denotes SARS-CoV-2
T818 230-234 PR:000001393 denotes IL-6
T819 310-314 PR:000001393 denotes IL-6
T820 336-339 PR:000029150 denotes HLA
T821 343-353 GO:0010467 denotes expression
T822 449-458 DG_39 denotes Sarilumab
T823 476-487 DG_35 denotes Tocilizumab
T50203 39-47 SP_7 denotes ignature
T29702 148-153 UBERON:0002405;GO:0006955 denotes high
T17561 154-167 GO:0006955 denotes ytokine produ
T90888 189-199 SP_7 denotes reased cir
T69958 326-330 PR:000001393 denotes crea
T56935 406-410 PR:000001393 denotes inic
T72906 432-435 PR:000029150 denotes acy
T21106 439-449 GO:0010467 denotes Anakinra,
T43307 546-555 DG_39 denotes 298 and E
T89983 573-584 DG_35 denotes -001039-29)

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1012 230-234 Gene denotes IL-6 Gene:3569
1013 310-314 Gene denotes IL-6 Gene:3569
1014 79-87 Species denotes patients Tax:9606
1015 93-103 Species denotes SARS-CoV-2 Tax:2697049
1016 635-643 Species denotes patients Tax:9606
1017 449-458 Chemical denotes Sarilumab MESH:C000592401
1018 460-470 Chemical denotes Siltuximab MESH:C504234
1019 476-487 Chemical denotes Tocilizumab MESH:C502936