PMC:7172841 / 22547-24252
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T135 | 104-109 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T136 | 174-183 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T137 | 311-321 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T138 | 372-381 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T139 | 514-523 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T140 | 648-654 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T141 | 682-685 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T142 | 697-706 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T143 | 831-837 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T144 | 894-903 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T145 | 1010-1016 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T146 | 1127-1130 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T147 | 1142-1151 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T148 | 1258-1264 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T149 | 1377-1387 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T150 | 1508-1517 | Body_part | denotes | monocytes | http://purl.org/sig/ont/fma/fma62864 |
| T151 | 1529-1540 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T17 | 104-109 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T206 | 40-48 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T207 | 40-44 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T208 | 553-561 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T209 | 553-557 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T210 | 736-744 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T211 | 736-740 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T212 | 934-942 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T213 | 934-938 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T214 | 1182-1190 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T215 | 1182-1186 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T216 | 1571-1579 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T217 | 1571-1575 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T201 | 72-73 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T202 | 174-183 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T203 | 201-203 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | rs |
| T204 | 275-276 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T205 | 372-381 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T206 | 387-389 | http://purl.obolibrary.org/obo/CLO_0008882 | denotes | rs |
| T207 | 514-523 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T208 | 598-608 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T209 | 648-654 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T210 | 697-706 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T211 | 781-791 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T212 | 831-837 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T213 | 894-903 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T214 | 1010-1016 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T215 | 1142-1151 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T216 | 1258-1264 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T217 | 1508-1517 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocytes |
| T218 | 1525-1528 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T127 | 66-68 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T129 | 121-123 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T131 | 163-165 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T132 | 361-363 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T133 | 503-505 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T134 | 686-688 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T135 | 883-885 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T136 | 1061-1063 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T138 | 1131-1133 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T139 | 1309-1311 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T141 | 1322-1333 | Chemical | denotes | tocilizumab | http://purl.obolibrary.org/obo/CHEBI_64360 |
| T142 | 1495-1497 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T167 | 0-70 | Sentence | denotes | Figure 5 Immune Dysregulation Caused by SARS-CoV-2 Is Mediated by IL-6 |
| T168 | 71-184 | Sentence | denotes | (A) Negative correlation between serum amounts of IL-6 and the absolute numbers of the mHLA-DR on CD14 monocytes. |
| T169 | 185-273 | Sentence | denotes | The Spearman’s (rs) co-efficient of correlation and the respective p value are provided. |
| T170 | 274-382 | Sentence | denotes | (B) Correlation between the absolute lymphocyte count and the absolute numbers of mHLA-DR on CD14 monocytes. |
| T171 | 383-458 | Sentence | denotes | The rs co-efficient of correlation and the respective p value are provided. |
| T172 | 459-655 | Sentence | denotes | (C) Changes of the absolute numbers of mHLA-DR on CD14 monocytes of four patients infected by SARS-CoV-2 with intermediate state of immune activation after incubation with medium and their plasma. |
| T173 | 656-838 | Sentence | denotes | (D) Changes of the MFI of HLA-DR on CD14 monocytes of four patients infected by SARS-CoV-2 with intermediate state of immune activation after incubation with medium and their plasma. |
| T174 | 839-1100 | Sentence | denotes | (E) Changes of the absolute numbers of mHLA-DR on CD14 monocytes of eight patients infected by SARS-CoV-2 with immune dysregulation after incubation with medium and their plasma; modulation by the addition of the specific IL-6 blocker Tocilizumab is also shown. |
| T175 | 1101-1348 | Sentence | denotes | (F) Changes of the MFI of HLA-DR on CD14 monocytes of eight patients infected by SARS-CoV-2 with immune dysregulation after incubation with medium and their plasma; modulation by the addition of the specific IL-6 blocker tocilizumab is also shown. |
| T176 | 1349-1463 | Sentence | denotes | (G) Changes of the absolute lymphocyte count of six patients before and after start of treatment with Tocilizumab. |
| T177 | 1464-1608 | Sentence | denotes | (H) Intracellular staining for IL-6 in CD14 monocytes and in CD4 lymphocytes of three patients infected by SARS-CoV-2 with immune dysregulation. |
| T178 | 1609-1705 | Sentence | denotes | Statistical comparisons are indicated by the arrows; ns: non-significant; ∗p < 0.05; ∗∗p < 0.01. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T82 | 9-29 | Phenotype | denotes | Immune Dysregulation | http://purl.obolibrary.org/obo/HP_0002958 |
| T83 | 950-970 | Phenotype | denotes | immune dysregulation | http://purl.obolibrary.org/obo/HP_0002958 |
| T84 | 1198-1218 | Phenotype | denotes | immune dysregulation | http://purl.obolibrary.org/obo/HP_0002958 |
| T85 | 1587-1607 | Phenotype | denotes | immune dysregulation | http://purl.obolibrary.org/obo/HP_0002958 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T671 | 16-29 | GO:0065007 | denotes | Dysregulation |
| T672 | 40-50 | SP_7 | denotes | SARS-CoV-2 |
| T673 | 66-70 | PR:000001393 | denotes | IL-6 |
| T674 | 104-109 | UBERON:0001977 | denotes | serum |
| T675 | 121-125 | PR:000001393 | denotes | IL-6 |
| T676 | 169-173 | PR:000001889 | denotes | CD14 |
| T677 | 174-183 | CL:0000576 | denotes | monocytes |
| T678 | 311-321 | CL:0000542 | denotes | lymphocyte |
| T679 | 367-371 | PR:000001889 | denotes | CD14 |
| T680 | 372-381 | CL:0000576 | denotes | monocytes |
| T681 | 509-513 | PR:000001889 | denotes | CD14 |
| T682 | 514-523 | CL:0000576 | denotes | monocytes |
| T683 | 553-563 | SP_7 | denotes | SARS-CoV-2 |
| T684 | 591-597 | UBERON:0002405 | denotes | immune |
| T685 | 648-654 | UBERON:0001969 | denotes | plasma |
| T686 | 675-678 | GO:0005675 | denotes | MFI |
| T687 | 682-685 | PR:000029150 | denotes | HLA |
| T688 | 692-696 | PR:000001889 | denotes | CD14 |
| T689 | 697-706 | CL:0000576 | denotes | monocytes |
| T690 | 736-746 | SP_7 | denotes | SARS-CoV-2 |
| T691 | 774-780 | UBERON:0002405 | denotes | immune |
| T692 | 831-837 | UBERON:0001969 | denotes | plasma |
| T693 | 889-893 | PR:000001889 | denotes | CD14 |
| T694 | 894-903 | CL:0000576 | denotes | monocytes |
| T695 | 934-944 | SP_7 | denotes | SARS-CoV-2 |
| T696 | 950-956 | UBERON:0002405 | denotes | immune |
| T697 | 957-970 | GO:0065007 | denotes | dysregulation |
| T698 | 1010-1016 | UBERON:0001969 | denotes | plasma |
| T699 | 1018-1028 | GO:0065007 | denotes | modulation |
| T700 | 1061-1065 | PR:000001393 | denotes | IL-6 |
| T701 | 1074-1085 | DG_35 | denotes | Tocilizumab |
| T702 | 1127-1130 | PR:000029150 | denotes | HLA |
| T703 | 1137-1141 | PR:000001889 | denotes | CD14 |
| T704 | 1142-1151 | CL:0000576 | denotes | monocytes |
| T705 | 1182-1192 | SP_7 | denotes | SARS-CoV-2 |
| T706 | 1198-1204 | UBERON:0002405 | denotes | immune |
| T707 | 1205-1218 | GO:0065007 | denotes | dysregulation |
| T708 | 1258-1264 | UBERON:0001969 | denotes | plasma |
| T709 | 1266-1276 | GO:0065007 | denotes | modulation |
| T710 | 1309-1313 | PR:000001393 | denotes | IL-6 |
| T711 | 1322-1333 | DG_35 | denotes | tocilizumab |
| T712 | 1377-1387 | CL:0000542 | denotes | lymphocyte |
| T713 | 1451-1462 | DG_35 | denotes | Tocilizumab |
| T714 | 1468-1481 | GO:0005622 | denotes | Intracellular |
| T715 | 1495-1499 | PR:000001393 | denotes | IL-6 |
| T716 | 1503-1507 | PR:000001889 | denotes | CD14 |
| T717 | 1508-1517 | CL:0000576 | denotes | monocytes |
| T718 | 1525-1528 | PR:000001004 | denotes | CD4 |
| T719 | 1529-1540 | CL:0000542 | denotes | lymphocytes |
| T720 | 1571-1581 | SP_7 | denotes | SARS-CoV-2 |
| T721 | 1587-1593 | UBERON:0002405 | denotes | immune |
| T722 | 1594-1607 | GO:0065007 | denotes | dysregulation |
| T723 | 136-147 | SP_7 | denotes | solute numb |
| T724 | 163-167 | PR:000001393 | denotes | DR o |
| T725 | 201-206 | UBERON:0001977 | denotes | rs) c |
| T726 | 218-222 | PR:000001393 | denotes | of c |
| T727 | 265-269 | PR:000001889 | denotes | rovi |
| T728 | 270-279 | CL:0000576 | denotes | ed. (B) C |
| T729 | 408-418 | CL:0000542 | denotes | rrelation |
| T730 | 463-467 | PR:000001889 | denotes | Chan |
| T731 | 468-477 | CL:0000576 | denotes | es of the |
| T732 | 606-610 | PR:000001889 | denotes | on a |
| T733 | 611-620 | CL:0000576 | denotes | ter incub |
| T734 | 650-660 | SP_7 | denotes | asma. (D) |
| T735 | 688-693 | UBERON:0002405 | denotes | on C |
| T736 | 744-750 | UBERON:0001969 | denotes | -2 wit |
| T737 | 771-774 | GO:0005675 | denotes | of |
| T738 | 779-782 | PR:000029150 | denotes | e a |
| T739 | 789-793 | PR:000001889 | denotes | on a |
| T740 | 794-803 | CL:0000576 | denotes | ter incub |
| T741 | 833-843 | SP_7 | denotes | asma. (E) |
| T742 | 872-877 | UBERON:0002405 | denotes | rs of |
| T743 | 928-934 | UBERON:0001969 | denotes | ed by |
| T744 | 986-990 | PR:000001889 | denotes | n wi |
| T745 | 991-1000 | CL:0000576 | denotes | h medium |
| T746 | 1031-1041 | SP_7 | denotes | the addit |
| T747 | 1047-1052 | UBERON:0002405 | denotes | the |
| T748 | 1053-1066 | GO:0065007 | denotes | pecific IL-6 |
| T749 | 1106-1112 | UBERON:0001969 | denotes | hanges |
| T750 | 1114-1124 | GO:0065007 | denotes | f the MFI |
| T751 | 1157-1161 | PR:000001393 | denotes | ght |
| T752 | 1170-1181 | DG_35 | denotes | infected by |
| T753 | 1224-1227 | PR:000029150 | denotes | in |
| T754 | 1234-1238 | PR:000001889 | denotes | n wi |
| T755 | 1239-1248 | CL:0000576 | denotes | h medium |
| T756 | 1279-1289 | SP_7 | denotes | the addit |
| T757 | 1295-1300 | UBERON:0002405 | denotes | the |
| T758 | 1301-1314 | GO:0065007 | denotes | pecific IL-6 |
| T759 | 1354-1360 | UBERON:0001969 | denotes | hanges |
| T760 | 1362-1372 | GO:0065007 | denotes | f the abso |
| T761 | 1405-1409 | PR:000001393 | denotes | ents |
| T762 | 1418-1429 | DG_35 | denotes | nd after st |
| T763 | 1473-1483 | CL:0000542 | denotes | cellular s |
| T764 | 1547-1558 | DG_35 | denotes | ee patients |
| T765 | 1564-1577 | GO:0005622 | denotes | ted by SARS-C |
| T766 | 1592-1596 | PR:000001393 | denotes | e dy |
| T767 | 1600-1604 | PR:000001889 | denotes | ulat |
| T768 | 1605-1614 | CL:0000576 | denotes | on. Stati |
| T769 | 1622-1625 | PR:000001004 | denotes | omp |
| T770 | 1626-1637 | CL:0000542 | denotes | risons are |
| T771 | 1668-1678 | SP_7 | denotes | n-signific |
| T772 | 1684-1689 | UBERON:0002405 | denotes | p < 0 |
| T773 | 1690-1703 | GO:0065007 | denotes | 05; ∗∗p < 0.0 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 849 | 40-50 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 852 | 121-125 | Gene | denotes | IL-6 | Gene:3569 |
| 853 | 169-173 | Gene | denotes | CD14 | Gene:929 |
| 855 | 367-371 | Gene | denotes | CD14 | Gene:929 |
| 860 | 509-513 | Gene | denotes | CD14 | Gene:929 |
| 861 | 532-540 | Species | denotes | patients | Tax:9606 |
| 862 | 553-563 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 863 | 541-549 | Disease | denotes | infected | MESH:D007239 |
| 868 | 692-696 | Gene | denotes | CD14 | Gene:929 |
| 869 | 715-723 | Species | denotes | patients | Tax:9606 |
| 870 | 736-746 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 871 | 724-732 | Disease | denotes | infected | MESH:D007239 |
| 878 | 889-893 | Gene | denotes | CD14 | Gene:929 |
| 879 | 1061-1065 | Gene | denotes | IL-6 | Gene:3569 |
| 880 | 913-921 | Species | denotes | patients | Tax:9606 |
| 881 | 934-944 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 882 | 1074-1085 | Chemical | denotes | Tocilizumab | MESH:C502936 |
| 883 | 922-930 | Disease | denotes | infected | MESH:D007239 |
| 890 | 1137-1141 | Gene | denotes | CD14 | Gene:929 |
| 891 | 1309-1313 | Gene | denotes | IL-6 | Gene:3569 |
| 892 | 1161-1169 | Species | denotes | patients | Tax:9606 |
| 893 | 1182-1192 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 894 | 1322-1333 | Chemical | denotes | tocilizumab | MESH:C502936 |
| 895 | 1170-1178 | Disease | denotes | infected | MESH:D007239 |
| 898 | 1401-1409 | Species | denotes | patients | Tax:9606 |
| 899 | 1451-1462 | Chemical | denotes | Tocilizumab | MESH:C502936 |
| 906 | 1495-1499 | Gene | denotes | IL-6 | Gene:3569 |
| 907 | 1503-1507 | Gene | denotes | CD14 | Gene:929 |
| 908 | 1525-1528 | Gene | denotes | CD4 | Gene:920 |
| 909 | 1550-1558 | Species | denotes | patients | Tax:9606 |
| 910 | 1571-1581 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 911 | 1559-1567 | Disease | denotes | infected | MESH:D007239 |