PMC:7172841 / 1661-2061 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T20","span":{"begin":218,"end":228},"obj":"Body_part"},{"id":"T21","span":{"begin":305,"end":318},"obj":"Body_part"}],"attributes":[{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma264829"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T24","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"T25","span":{"begin":159,"end":178},"obj":"Disease"},{"id":"T26","span":{"begin":195,"end":203},"obj":"Disease"},{"id":"T27","span":{"begin":218,"end":248},"obj":"Disease"}],"attributes":[{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0021113"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/MONDO_0015545"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T18","span":{"begin":229,"end":239},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T19","span":{"begin":305,"end":318},"obj":"http://purl.obolibrary.org/obo/PR_000001393"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T15","span":{"begin":274,"end":281},"obj":"Chemical"},{"id":"T16","span":{"begin":323,"end":325},"obj":"Chemical"}],"attributes":[{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A16","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A17","pred":"chebi_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":71,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T13","span":{"begin":218,"end":239},"obj":"http://purl.obolibrary.org/obo/GO_0042116"},{"id":"T14","span":{"begin":274,"end":294},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T18","span":{"begin":85,"end":319},"obj":"Sentence"},{"id":"T19","span":{"begin":320,"end":400},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T11","span":{"begin":159,"end":178},"obj":"Phenotype"},{"id":"T12","span":{"begin":354,"end":374},"obj":"Phenotype"}],"attributes":[{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0002878"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0002958"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T73","span":{"begin":21,"end":29},"obj":"SP_7"},{"id":"T74","span":{"begin":159,"end":170},"obj":"UBERON:0001004"},{"id":"T75","span":{"begin":195,"end":203},"obj":"SP_7"},{"id":"T76","span":{"begin":218,"end":228},"obj":"CL:0000235;GO:0042116"},{"id":"T77","span":{"begin":229,"end":239},"obj":"GO:0042116"},{"id":"T78","span":{"begin":274,"end":281},"obj":"CHEBI:59132;CHEBI:59132"},{"id":"T79","span":{"begin":305,"end":318},"obj":"PR:000001393"},{"id":"T80","span":{"begin":323,"end":327},"obj":"PR:000001393"},{"id":"T81","span":{"begin":354,"end":360},"obj":"UBERON:0002405;GO:0006955"},{"id":"T82","span":{"begin":361,"end":374},"obj":"GO:0006955"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}

{"project":"LitCovid-PubTator","denotations":[{"id":"95","span":{"begin":305,"end":318},"obj":"Gene"},{"id":"96","span":{"begin":323,"end":327},"obj":"Gene"},{"id":"97","span":{"begin":391,"end":399},"obj":"Species"},{"id":"98","span":{"begin":21,"end":29},"obj":"Disease"},{"id":"99","span":{"begin":159,"end":178},"obj":"Disease"},{"id":"100","span":{"begin":195,"end":203},"obj":"Disease"},{"id":"101","span":{"begin":218,"end":248},"obj":"Disease"}],"attributes":[{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Gene:3569"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"Gene:3569"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"Tax:9606"},{"id":"A98","pred":"tao:has_database_id","subj":"98","obj":"MESH:C000657245"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D012131"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:C000657245"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:D055501"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Proper management of COVID-19 mandates better understanding of disease pathogenesis. Giamarellos-Bourboulis et al. describe two main features preceding severe respiratory failure associated with COVID-19: the first is macrophage activation syndrome; the second is defective antigen-presentation driven by interleukin-6. An IL-6 blocker partially rescues immune dysregulation in vitro and in patients."}