> top > docs > PMC:7170415 > spans > 22790-27330 > annotations

PMC:7170415 / 22790-27330 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
350 979-986 Species denotes persons Tax:9606
351 1613-1621 Species denotes patients Tax:9606
352 1773-1780 Species denotes persons Tax:9606
353 991-999 Disease denotes COVID-19 MESH:C000657245
354 1101-1110 Disease denotes infection MESH:D007239
355 1764-1772 Disease denotes infected MESH:D007239
358 2849-2859 Species denotes SARS–CoV-2 Tax:2697049
359 2668-2693 Chemical denotes phosphate-buffered saline
366 3080-3088 Species denotes patients Tax:9606
367 3168-3175 Species denotes persons Tax:9606
368 3272-3280 Species denotes patients Tax:9606
369 3866-3874 Species denotes patients Tax:9606
370 4492-4497 Species denotes human Tax:9606
371 4506-4521 Disease denotes trypanosomiasis MESH:D014352

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T42 93-97 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T43 2184-2193 Body_part denotes turbinate http://purl.org/sig/ont/fma/fma57456
T44 2323-2329 Body_part denotes saliva http://purl.org/sig/ont/fma/fma59862
T45 2366-2372 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T22 93-97 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T23 2323-2329 Body_part denotes saliva http://purl.obolibrary.org/obo/UBERON_0001836
T24 2366-2372 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T102 991-999 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 1101-1110 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T104 2849-2853 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 4492-4521 Disease denotes human African trypanosomiasis http://purl.obolibrary.org/obo/MONDO_0005459
T106 4506-4521 Disease denotes trypanosomiasis http://purl.obolibrary.org/obo/MONDO_0000940

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T207 31-35 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Test
T208 78-85 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T209 93-97 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face
T210 101-102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 160-167 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T212 434-439 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T213 721-732 http://purl.obolibrary.org/obo/OBI_0000968 denotes instruments
T214 744-747 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T215 779-781 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T216 841-845 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T217 923-927 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T218 1155-1162 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T219 1228-1239 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing, as
T220 1394-1401 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T221 1407-1410 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T222 1574-1581 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T223 1660-1667 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T224 1851-1858 http://purl.obolibrary.org/obo/OBI_0000968 denotes Devices
T225 2058-2061 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T226 2156-2159 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T227 2299-2308 http://purl.obolibrary.org/obo/UBERON_0001353 denotes posterior
T228 2452-2453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 2460-2462 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T230 2469-2472 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T231 2473-2476 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T232 2486-2487 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 2741-2744 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T234 2868-2870 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T235 2907-2914 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T236 3729-3734 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T237 4141-4146 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T238 4435-4442 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T239 4492-4497 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T34 57-63 Chemical denotes Access http://purl.obolibrary.org/obo/CHEBI_34922
T35 464-472 Chemical denotes reagents http://purl.obolibrary.org/obo/CHEBI_33893
T36 671-683 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T37 679-683 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T38 2668-2677 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T42 3715-3722 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T20 1864-1873 http://purl.obolibrary.org/obo/GO_0006810 denotes Transport
T21 2009-2024 http://purl.obolibrary.org/obo/GO_0046794 denotes viral transport
T22 2015-2024 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T23 2554-2569 http://purl.obolibrary.org/obo/GO_0046794 denotes viral transport
T24 2560-2569 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T25 2619-2634 http://purl.obolibrary.org/obo/GO_0046794 denotes viral transport
T26 2625-2634 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T27 2820-2829 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T28 3251-3265 http://purl.obolibrary.org/obo/GO_0019076 denotes viral shedding

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T159 0-44 Sentence denotes Unmet Needs and the Diagnostic Test Pipeline
T160 46-85 Sentence denotes Scaling Up Access to Diagnostic Testing
T161 86-250 Sentence denotes In the face of a public health emergency, important first steps to expand testing capacity include relaxing and streamlining regulatory requirements and procedures.
T162 251-478 Sentence denotes Local public health laboratories and academic diagnostic laboratories in the United States are being rapidly enabled to perform EUA-granted commercial assays and laboratory-developed tests using research use–only reagents (61).
T163 479-648 Sentence denotes University research laboratories could also add capacity, although concerns exist regarding quality control and the absence of protocols for managing clinical specimens.
T164 649-783 Sentence denotes Flexibility regarding nucleic acid extraction methods and amplification instruments when using CDC protocols is being introduced (34).
T165 784-942 Sentence denotes National agencies are expeditiously making materials for test development and validation available to clinical laboratories and diagnostic test manufacturers.
T166 943-1111 Sentence denotes Safely evaluating clinically stable persons for COVID-19 at traditional health care access points is resource intensive and slow, and risks exposing staff to infection.
T167 1112-1342 Sentence denotes Many jurisdictions are enabling innovative testing venues, such as external tents or drive-through or “phone booth” testing, as well as home assessment teams to expedite specimen collection while limiting potential exposures (62).
T168 1343-1430 Sentence denotes Telemedicine combined with at-home nasal swab self-testing also has been proposed (63).
T169 1431-1622 Sentence denotes Of importance, in jurisdictions without universal health care coverage, policy solutions must be introduced to eliminate financial barriers to testing for uninsured and underinsured patients.
T170 1623-1800 Sentence denotes Efforts to increase accessibility of testing for multiple use cases need to be coupled to appropriate public health interventions to isolate infected persons and their contacts.
T171 1802-1879 Sentence denotes Alternatives to Usual Specimen Types, Collection Devices, and Transport Media
T172 1880-1953 Sentence denotes Nasopharyngeal swabs are the recommended specimen for molecular analysis.
T173 1954-2131 Sentence denotes The sudden demand for flocked nasopharyngeal swabs and viral transport medium generated by the pandemic has put enormous pressures on supply chain capacities for these products.
T174 2132-2284 Sentence denotes As of 19 March 2020 the CDC made oropharyngeal, mid-turbinate, and nasal swabs acceptable specimen types if nasopharyngeal swabs are not available (31).
T175 2285-2464 Sentence denotes Early-morning posterior oropharyngeal saliva samples (coughed up by clearing the throat) also have been assessed as useful specimen types and would not require use of a swab (48).
T176 2465-2732 Sentence denotes The CDC has released a standard operating procedure for laboratories to create their own viral transport medium (64); other solutions also may be used if viral transport medium is unavailable, including phosphate-buffered saline, liquid Amies, and normal saline (65).
T177 2733-2872 Sentence denotes The FDA has provided guidance on its Web site for alternative materials to collect and transport samples for RT-PCR SARS–CoV-2 assays (34).
T178 2873-2964 Sentence denotes The diagnostic value of molecular testing of nonrespiratory specimens currently is unclear.
T179 2966-3015 Sentence denotes Diagnostics Pipeline in the Short and Medium Term
T180 3016-3352 Sentence denotes Although excellent tools exist for the diagnosis of symptomatic patients in well-equipped laboratories, important gaps remain in screening asymptomatic persons in the incubation phase, as well as for the accurate determination of live viral shedding among patients in the convalescence phase to inform de-isolation decisions (Figure 2).
T181 3353-3473 Sentence denotes Further, it is critical to advance solutions that require less well-equipped laboratories to curb the pandemic globally.
T182 3474-3707 Sentence denotes The Foundation for Innovative New Diagnostics (FIND) and others have created online resources to collate the rapidly evolving set of assays at various stages of development, from proof of concept to full regulatory approval (20, 53).
T183 3708-3917 Sentence denotes Simple antigen-based tests, if sensitive enough, might be useful in lower-resource and home settings to inform quarantine and spatial distancing measures for patients without severe illness and their contacts.
T184 3918-4247 Sentence denotes Novel technologies, such as Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)-based diagnostics are being used to develop rapid, simple, low-cost, portable, temperature-stable assays for deployment in the field in nontraditional and resource-limited settings, such as airports and border crossings (20, 51, 54).
T185 4248-4340 Sentence denotes Other technologies might be deployed to lower-resource settings if they can be standardized.
T186 4341-4540 Sentence denotes For example, it might be possible to leverage existing loop-mediated isothermal amplification testing networks established for other diseases, such as human African trypanosomiasis surveillance (66).