PMC:7170368 / 3057-5083
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7170368","sourcedb":"PMC","sourceid":"7170368","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7170368","text":"This study was approved by the Shenzhen Third People’s Hospital Ethical Committee. Verbal informed consent was obtained from all patients or patients’ family members. We performed a retrospective review of medical records from hospitalized patients with COVID-19 admitted to the Shenzhen Third People’s Hospital from 11 January to 23 February 2020. The information on patients with hypertension was extracted from all enrolled COVID-19 patients. We reviewed the clinical data extracted from electronic medical records, including clinical symptoms, signs and laboratory findings. A commercial real-time PCR kit (GeneoDX Co., Ltd., Shanghai, China) was used to detect SARS-CoV-2. Samples were considered positive if the cycle threshold value (Ct-value) less than 37 and negative if Ct-value more than 40. Samples with a Ct-value between 37 and 40 require confirmation by retesting. Samples identified as positive by the local laboratory were further validated by the key laboratory of the Shenzhen CDC. The severity of COVID-19 wasidentified during the hospitalization according to the guidelines established by the National Health Commission of the People’s Republic of China. Therapeutic regimens for COVID-19 patients complied with guidelines established by the National Health Commission of the People’s Republic of China. Hypertension was classified as Grade 1, Grade 2 and Grade 3 according to 2018 guidelines of the European Society of Hypertension (ESH). Hypertensive patients with COVID-19 were divided into two subgroups based on antihypertensive drug treatments. Detailed information on the enrolled patients is shown in supplementary Table S1. The SPSS 18.0 software package was used for statistical analysis. Measurement data are expressed as the median and interquartile range (IQR), and the difference between groups was compared by an unpaired t test. Count data are expressed as percentages, and the difference between groups was tested by the Chi-square test. P \u003c 0.05 was considered statistically 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