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PMC:7170368 / 1077-3047 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
76 788-791 Gene denotes ACE Gene:1636
77 792-795 Gene denotes Ang Gene:283
78 799-803 Gene denotes AT1R Gene:185
79 820-824 Gene denotes ACE2 Gene:59272
80 825-833 Gene denotes Ang (1–7 Gene:284
81 920-923 Gene denotes ACE Gene:1636
82 924-927 Gene denotes Ang Gene:283
83 931-935 Gene denotes AT1R Gene:185
84 949-953 Gene denotes ACE2 Gene:59272
85 954-962 Gene denotes Ang (1–7 Gene:284
86 1170-1174 Gene denotes ACE2 Gene:59272
87 1207-1211 Gene denotes ACE2 Gene:59272
88 1262-1265 Gene denotes ACE Gene:1636
89 1266-1269 Gene denotes Ang Gene:283
90 1273-1277 Gene denotes AT1R Gene:185
91 1291-1295 Gene denotes ACE2 Gene:59272
92 1296-1304 Gene denotes Ang (1–7 Gene:284
93 1343-1346 Gene denotes ACE Gene:1636
94 1347-1350 Gene denotes Ang Gene:283
95 1354-1358 Gene denotes AT1R Gene:185
96 1450-1453 Gene denotes ACE Gene:1636
97 1454-1457 Gene denotes Ang Gene:283
98 1461-1465 Gene denotes AT1R Gene:185
99 1496-1500 Gene denotes ACE2 Gene:59272
100 1501-1509 Gene denotes Ang (1–7 Gene:284
101 32-79 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
102 81-91 Species denotes SARS-CoV-2 Tax:2697049
103 346-352 Species denotes people Tax:9606
104 548-554 Species denotes people Tax:9606
105 1096-1106 Species denotes SARS-CoV-2 Tax:2697049
106 1653-1661 Species denotes patients Tax:9606
107 1943-1951 Species denotes patients Tax:9606
108 4-12 Disease denotes COVID-19 MESH:C000657245
109 308-316 Disease denotes COVID-19 MESH:C000657245
110 358-379 Disease denotes SARS-CoV-2 infections MESH:C000657245
111 384-407 Disease denotes cardiovascular diseases MESH:D002318
112 419-431 Disease denotes hypertension MESH:D006973
113 479-491 Disease denotes hypertension MESH:D006973
114 576-588 Disease denotes hypertension MESH:D006973
115 616-628 Disease denotes hypertension MESH:D006973
116 1180-1199 Disease denotes SARS-CoV infections MESH:C000657245
117 1400-1412 Disease denotes hypertension MESH:D006973
118 1612-1633 Disease denotes coronavirus infection MESH:D018352
119 1643-1651 Disease denotes COVID-19 MESH:C000657245
120 1931-1939 Disease denotes COVID-19 MESH:C000657245
121 1957-1969 Disease denotes hypertension MESH:D006973

MyTest

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 857-858 25194138 denotes 3
32228222-16007097-27780683 1325-1326 16007097 denotes 5

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 741-746 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 936-940 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T6 977-981 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T7 1150-1154 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 1278-1282 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T9 1319-1323 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T10 1359-1363 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T8 675-678 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T9 741-746 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 1560-1584 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T11 1586-1589 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T12 1675-1678 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T13 1897-1900 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 4-12 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 32-79 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 32-65 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 81-89 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 308-316 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 358-366 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 369-379 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T18 384-407 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T19 419-431 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T20 479-491 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T21 576-588 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T22 616-628 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T23 1090-1094 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 1096-1104 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 1180-1188 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 1189-1199 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T27 1400-1412 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T28 1624-1633 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 1643-1651 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1931-1939 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 1957-1969 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T13 477-478 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T14 556-558 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T15 741-746 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 741-746 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 904-912 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 989-990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1150-1154 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 1367-1368 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1591-1594 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T24 675-678 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25 796-798 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T26 928-930 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T27 1270-1272 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 1351-1353 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T29 1414-1419 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T30 1458-1460 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31 1566-1577 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 1586-1589 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T33 1675-1678 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T34 1679-1689 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35 1699-1739 Chemical denotes angiotensin-converting enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T36 1699-1710 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 1722-1739 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T38 1729-1739 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T39 1741-1746 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T40 1752-1766 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T43 1752-1763 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 1764-1766 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 1897-1900 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T46 1901-1911 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-161 Sentence denotes The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to endanger global health and to hamper the world economy.
T14 162-226 Sentence denotes This outbreak started in December 2019 in Wuhan, Hubei Province.
T15 227-317 Sentence denotes Unfortunately, currently, there is still no specific and effective treatment for COVID-19.
T16 318-476 Sentence denotes Evidence shows that elderly people with SARS-CoV-2 infections and cardiovascular diseases, including hypertension, are at risk of developing severe cases [1].
T17 477-674 Sentence denotes A hypertension survey from 2012 to 2015 reported that 23.2% of Chinese people ≥18 years of age had hypertension, whereas the prevalence of hypertension was >55% among citizens ≥65 years of age [2].
T18 675-860 Sentence denotes RAS plays an important role in regulating electrolyte balance and blood pressure and comprises two pathways: the ACE/Ang II/AT1R pathway and the ACE2/Ang (1–7)/Mas receptor pathway [3].
T19 861-1078 Sentence denotes Under normal physiological conditions, the activity of the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis are in a dynamic equilibrium state, maintaining the normal function of the corresponding system.
T20 1079-1179 Sentence denotes Similar to SARS, SARS-CoV-2 is believed to invade the host through the cell entry receptor ACE2 [4].
T21 1180-1328 Sentence denotes SARS-CoV infections reduce ACE2 expression, resulting in an imbalance between the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis [5].
T22 1329-1413 Sentence denotes Targeting the ACE/Ang II/AT1R axis is a novel therapeutic strategy for hypertension.
T23 1414-1536 Sentence denotes ACEIs and ARAs not only inhibit the ACE/Ang II/AT1R pathway but also modulate the ACE2/Ang (1–7)/Mas receptor pathway [6].
T24 1537-1854 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T25 1855-1970 Sentence denotes Here, we aimed to evaluate the ability of RAS inhibitors to protect against COVID-19 in patients with hypertension.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 384-407 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T5 419-431 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 479-491 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 576-588 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 616-628 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 1400-1412 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T10 1957-1969 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 857-858 25194138 denotes 3
32228222-16007097-27780683 1325-1326 16007097 denotes 5