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PMC:7170368 / 1064-3047 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
76 801-804 Gene denotes ACE Gene:1636
77 805-808 Gene denotes Ang Gene:283
78 812-816 Gene denotes AT1R Gene:185
79 833-837 Gene denotes ACE2 Gene:59272
80 838-846 Gene denotes Ang (1–7 Gene:284
81 933-936 Gene denotes ACE Gene:1636
82 937-940 Gene denotes Ang Gene:283
83 944-948 Gene denotes AT1R Gene:185
84 962-966 Gene denotes ACE2 Gene:59272
85 967-975 Gene denotes Ang (1–7 Gene:284
86 1183-1187 Gene denotes ACE2 Gene:59272
87 1220-1224 Gene denotes ACE2 Gene:59272
88 1275-1278 Gene denotes ACE Gene:1636
89 1279-1282 Gene denotes Ang Gene:283
90 1286-1290 Gene denotes AT1R Gene:185
91 1304-1308 Gene denotes ACE2 Gene:59272
92 1309-1317 Gene denotes Ang (1–7 Gene:284
93 1356-1359 Gene denotes ACE Gene:1636
94 1360-1363 Gene denotes Ang Gene:283
95 1367-1371 Gene denotes AT1R Gene:185
96 1463-1466 Gene denotes ACE Gene:1636
97 1467-1470 Gene denotes Ang Gene:283
98 1474-1478 Gene denotes AT1R Gene:185
99 1509-1513 Gene denotes ACE2 Gene:59272
100 1514-1522 Gene denotes Ang (1–7 Gene:284
101 45-92 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
102 94-104 Species denotes SARS-CoV-2 Tax:2697049
103 359-365 Species denotes people Tax:9606
104 561-567 Species denotes people Tax:9606
105 1109-1119 Species denotes SARS-CoV-2 Tax:2697049
106 1666-1674 Species denotes patients Tax:9606
107 1956-1964 Species denotes patients Tax:9606
108 17-25 Disease denotes COVID-19 MESH:C000657245
109 321-329 Disease denotes COVID-19 MESH:C000657245
110 371-392 Disease denotes SARS-CoV-2 infections MESH:C000657245
111 397-420 Disease denotes cardiovascular diseases MESH:D002318
112 432-444 Disease denotes hypertension MESH:D006973
113 492-504 Disease denotes hypertension MESH:D006973
114 589-601 Disease denotes hypertension MESH:D006973
115 629-641 Disease denotes hypertension MESH:D006973
116 1193-1212 Disease denotes SARS-CoV infections MESH:C000657245
117 1413-1425 Disease denotes hypertension MESH:D006973
118 1625-1646 Disease denotes coronavirus infection MESH:D018352
119 1656-1664 Disease denotes COVID-19 MESH:C000657245
120 1944-1952 Disease denotes COVID-19 MESH:C000657245
121 1970-1982 Disease denotes hypertension MESH:D006973

MyTest

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 870-871 25194138 denotes 3
32228222-16007097-27780683 1338-1339 16007097 denotes 5

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 754-759 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 949-953 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T6 990-994 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T7 1163-1167 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 1291-1295 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T9 1332-1336 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T10 1372-1376 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T8 688-691 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T9 754-759 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 1573-1597 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T11 1599-1602 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T12 1688-1691 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T13 1910-1913 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 17-25 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 45-92 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 45-78 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 94-102 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 321-329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 371-379 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 382-392 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T18 397-420 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T19 432-444 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T20 492-504 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T21 589-601 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T22 629-641 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T23 1103-1107 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 1109-1117 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 1193-1201 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 1202-1212 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T27 1413-1425 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T28 1637-1646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 1656-1664 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1944-1952 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 1970-1982 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T13 490-491 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T14 569-571 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T15 754-759 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 754-759 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 917-925 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 1002-1003 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1163-1167 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 1380-1381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1604-1607 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T24 688-691 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25 809-811 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T26 941-943 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T27 1283-1285 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 1364-1366 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T29 1427-1432 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T30 1471-1473 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31 1579-1590 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 1599-1602 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T33 1688-1691 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T34 1692-1702 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35 1712-1752 Chemical denotes angiotensin-converting enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T36 1712-1723 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 1735-1752 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T38 1742-1752 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T39 1754-1759 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T40 1765-1779 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T43 1765-1776 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 1777-1779 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 1910-1913 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T46 1914-1924 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-12 Sentence denotes Introduction
T13 13-174 Sentence denotes The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to endanger global health and to hamper the world economy.
T14 175-239 Sentence denotes This outbreak started in December 2019 in Wuhan, Hubei Province.
T15 240-330 Sentence denotes Unfortunately, currently, there is still no specific and effective treatment for COVID-19.
T16 331-489 Sentence denotes Evidence shows that elderly people with SARS-CoV-2 infections and cardiovascular diseases, including hypertension, are at risk of developing severe cases [1].
T17 490-687 Sentence denotes A hypertension survey from 2012 to 2015 reported that 23.2% of Chinese people ≥18 years of age had hypertension, whereas the prevalence of hypertension was >55% among citizens ≥65 years of age [2].
T18 688-873 Sentence denotes RAS plays an important role in regulating electrolyte balance and blood pressure and comprises two pathways: the ACE/Ang II/AT1R pathway and the ACE2/Ang (1–7)/Mas receptor pathway [3].
T19 874-1091 Sentence denotes Under normal physiological conditions, the activity of the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis are in a dynamic equilibrium state, maintaining the normal function of the corresponding system.
T20 1092-1192 Sentence denotes Similar to SARS, SARS-CoV-2 is believed to invade the host through the cell entry receptor ACE2 [4].
T21 1193-1341 Sentence denotes SARS-CoV infections reduce ACE2 expression, resulting in an imbalance between the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis [5].
T22 1342-1426 Sentence denotes Targeting the ACE/Ang II/AT1R axis is a novel therapeutic strategy for hypertension.
T23 1427-1549 Sentence denotes ACEIs and ARAs not only inhibit the ACE/Ang II/AT1R pathway but also modulate the ACE2/Ang (1–7)/Mas receptor pathway [6].
T24 1550-1867 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T25 1868-1983 Sentence denotes Here, we aimed to evaluate the ability of RAS inhibitors to protect against COVID-19 in patients with hypertension.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 397-420 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T5 432-444 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 492-504 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 589-601 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 629-641 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 1413-1425 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T10 1970-1982 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 870-871 25194138 denotes 3
32228222-16007097-27780683 1338-1339 16007097 denotes 5