> top > docs > PMC:7170368 > spans > 1064-12045 > annotations

PMC:7170368 / 1064-12045 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
76 801-804 Gene denotes ACE Gene:1636
77 805-808 Gene denotes Ang Gene:283
78 812-816 Gene denotes AT1R Gene:185
79 833-837 Gene denotes ACE2 Gene:59272
80 838-846 Gene denotes Ang (1–7 Gene:284
81 933-936 Gene denotes ACE Gene:1636
82 937-940 Gene denotes Ang Gene:283
83 944-948 Gene denotes AT1R Gene:185
84 962-966 Gene denotes ACE2 Gene:59272
85 967-975 Gene denotes Ang (1–7 Gene:284
86 1183-1187 Gene denotes ACE2 Gene:59272
87 1220-1224 Gene denotes ACE2 Gene:59272
88 1275-1278 Gene denotes ACE Gene:1636
89 1279-1282 Gene denotes Ang Gene:283
90 1286-1290 Gene denotes AT1R Gene:185
91 1304-1308 Gene denotes ACE2 Gene:59272
92 1309-1317 Gene denotes Ang (1–7 Gene:284
93 1356-1359 Gene denotes ACE Gene:1636
94 1360-1363 Gene denotes Ang Gene:283
95 1367-1371 Gene denotes AT1R Gene:185
96 1463-1466 Gene denotes ACE Gene:1636
97 1467-1470 Gene denotes Ang Gene:283
98 1474-1478 Gene denotes AT1R Gene:185
99 1509-1513 Gene denotes ACE2 Gene:59272
100 1514-1522 Gene denotes Ang (1–7 Gene:284
101 45-92 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
102 94-104 Species denotes SARS-CoV-2 Tax:2697049
103 359-365 Species denotes people Tax:9606
104 561-567 Species denotes people Tax:9606
105 1109-1119 Species denotes SARS-CoV-2 Tax:2697049
106 1666-1674 Species denotes patients Tax:9606
107 1956-1964 Species denotes patients Tax:9606
108 17-25 Disease denotes COVID-19 MESH:C000657245
109 321-329 Disease denotes COVID-19 MESH:C000657245
110 371-392 Disease denotes SARS-CoV-2 infections MESH:C000657245
111 397-420 Disease denotes cardiovascular diseases MESH:D002318
112 432-444 Disease denotes hypertension MESH:D006973
113 492-504 Disease denotes hypertension MESH:D006973
114 589-601 Disease denotes hypertension MESH:D006973
115 629-641 Disease denotes hypertension MESH:D006973
116 1193-1212 Disease denotes SARS-CoV infections MESH:C000657245
117 1413-1425 Disease denotes hypertension MESH:D006973
118 1625-1646 Disease denotes coronavirus infection MESH:D018352
119 1656-1664 Disease denotes COVID-19 MESH:C000657245
120 1944-1952 Disease denotes COVID-19 MESH:C000657245
121 1970-1982 Disease denotes hypertension MESH:D006973
144 2039-2045 Species denotes People Tax:9606
145 2122-2130 Species denotes patients Tax:9606
146 2134-2142 Species denotes patients Tax:9606
147 2233-2241 Species denotes patients Tax:9606
148 2287-2293 Species denotes People Tax:9606
149 2361-2369 Species denotes patients Tax:9606
150 2429-2437 Species denotes patients Tax:9606
151 2659-2669 Species denotes SARS-CoV-2 Tax:2697049
152 3141-3147 Species denotes People Tax:9606
153 3203-3211 Species denotes patients Tax:9606
154 3290-3296 Species denotes People Tax:9606
155 3467-3475 Species denotes patients Tax:9606
156 3602-3610 Species denotes patients Tax:9606
157 2247-2255 Disease denotes COVID-19 MESH:C000657245
158 2375-2387 Disease denotes hypertension MESH:D006973
159 2420-2428 Disease denotes COVID-19 MESH:C000657245
160 3010-3018 Disease denotes COVID-19 MESH:C000657245
161 3194-3202 Disease denotes COVID-19 MESH:C000657245
162 3318-3330 Disease denotes Hypertension MESH:D006973
163 3434-3446 Disease denotes Hypertension MESH:D006973
164 3454-3466 Disease denotes Hypertensive MESH:D006973
165 3481-3489 Disease denotes COVID-19 MESH:C000657245
187 4053-4061 Species denotes patients Tax:9606
188 4098-4104 Species denotes People Tax:9606
189 4152-4160 Species denotes patients Tax:9606
190 4197-4205 Species denotes patients Tax:9606
191 4363-4371 Species denotes patients Tax:9606
192 4465-4473 Species denotes patients Tax:9606
193 4563-4571 Species denotes patients Tax:9606
194 4582-4590 Species denotes patients Tax:9606
195 4654-4662 Species denotes patients Tax:9606
196 4673-4681 Species denotes patients Tax:9606
197 4800-4808 Species denotes patients Tax:9606
198 4847-4855 Species denotes patients Tax:9606
199 5009-5017 Species denotes patients Tax:9606
200 5137-5145 Species denotes patients Tax:9606
201 4735-4742 Chemical denotes calcium MESH:D002118
202 4044-4052 Disease denotes COVID-19 MESH:C000657245
203 4178-4190 Disease denotes hypertension MESH:D006973
204 4919-4934 Disease denotes type 2 diabetes MESH:D003924
205 4945-4967 Disease denotes coronary heart disease MESH:D003324
206 4969-4972 Disease denotes CHD
207 4996-5008 Disease denotes hypertensive MESH:D006973
209 5472-5484 Disease denotes hypertension MESH:D006973
215 7828-7831 Gene denotes ACE Gene:1636
216 7941-7945 Gene denotes IL-6 Gene:3569
217 7950-7953 Gene denotes CRP Gene:1401
218 8005-8008 Gene denotes CD4 Gene:920
219 8015-8018 Gene denotes CD8 Gene:925
235 6874-6878 Gene denotes IL-6 Gene:3569
236 6946-6964 Gene denotes C-reactive protein Gene:1401
237 6966-6969 Gene denotes CRP Gene:1401
238 7054-7057 Gene denotes CD8 Gene:925
239 7188-7191 Gene denotes CD4 Gene:920
240 6267-6275 Species denotes patients Tax:9606
241 6355-6362 Species denotes patient Tax:9606
242 6412-6420 Species denotes patients Tax:9606
243 6475-6483 Species denotes patients Tax:9606
244 6790-6798 Species denotes patients Tax:9606
245 6889-6897 Species denotes patients Tax:9606
246 6363-6367 Disease denotes died MESH:D003643
247 6484-6488 Disease denotes died MESH:D003643
248 6781-6789 Disease denotes COVID-19 MESH:C000657245
249 6804-6816 Disease denotes hypertension MESH:D006973
266 8609-8612 Gene denotes ACE Gene:1636
267 8613-8616 Gene denotes Ang Gene:283
268 8620-8624 Gene denotes AT1R Gene:185
269 8392-8396 Species denotes H7N9 Tax:333278
270 8674-8682 Species denotes patients Tax:9606
271 8736-8744 Species denotes patients Tax:9606
272 8866-8874 Species denotes patients Tax:9606
273 8321-8333 Disease denotes hypertension MESH:D006973
274 8344-8355 Disease denotes lung injury MESH:D055370
275 8463-8475 Disease denotes hypertension MESH:D006973
276 8480-8505 Disease denotes inflammatory lung disease MESH:D011014
277 8661-8673 Disease denotes hypertensive MESH:D006973
278 8714-8726 Disease denotes hypertensive MESH:D006973
279 8727-8735 Disease denotes COVID-19 MESH:C000657245
280 8857-8865 Disease denotes COVID-19 MESH:C000657245
281 8880-8892 Disease denotes hypertension MESH:D006973
308 8955-8969 Gene denotes Angiotensin II Gene:183
309 9027-9041 Gene denotes Angiotensin II Gene:183
310 9201-9215 Gene denotes Angiotensin II Gene:183
311 9304-9308 Gene denotes AT1R Gene:185
312 9768-9772 Gene denotes IL-6 Gene:3569
313 8931-8939 Species denotes patients Tax:9606
314 8990-8996 Species denotes people Tax:9606
315 9175-9183 Species denotes patients Tax:9606
316 9405-9413 Species denotes patients Tax:9606
317 9473-9481 Species denotes patients Tax:9606
318 9615-9623 Species denotes patients Tax:9606
319 9895-9903 Species denotes patients Tax:9606
320 9856-9859 Chemical denotes LPS MESH:D008070
321 10319-10327 Chemical denotes ACEI/ARB
322 8922-8930 Disease denotes COVID-19 MESH:C000657245
323 9057-9069 Disease denotes hypertension MESH:D006973
324 9074-9086 Disease denotes lung failure MESH:D012131
325 9162-9171 Disease denotes mortality MESH:D003643
326 9189-9195 Disease denotes sepsis MESH:D018805
327 9396-9404 Disease denotes COVID-19 MESH:C000657245
328 9464-9472 Disease denotes COVID-19 MESH:C000657245
329 9606-9614 Disease denotes COVID-19 MESH:C000657245
330 9629-9641 Disease denotes hypertension MESH:D006973
331 9868-9884 Disease denotes pneumonic injury MESH:D011014
332 9909-9930 Disease denotes chronic heart failure MESH:D006333
333 10276-10287 Disease denotes lung injury MESH:D055370
338 10777-10785 Species denotes patients Tax:9606
339 10827-10835 Species denotes patients Tax:9606
340 10768-10776 Disease denotes COVID-19 MESH:C000657245
341 10791-10803 Disease denotes hypertension MESH:D006973

MyTest

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 870-871 25194138 denotes 3
32228222-16007097-27780683 1338-1339 16007097 denotes 5
32228222-16007097-27780684 8398-8399 16007097 denotes 5
32228222-31838905-27780685 9197-9198 31838905 denotes 9
32228222-31805278-27780686 9886-9888 31805278 denotes 11
32228222-15067208-27780687 10061-10063 15067208 denotes 12

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 754-759 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 949-953 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T6 990-994 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T7 1163-1167 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 1291-1295 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T9 1332-1336 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T10 1372-1376 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T11 4954-4959 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T12 5119-5124 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T13 5914-5919 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T14 6038-6043 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T15 6957-6964 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T16 7061-7066 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17 7195-7199 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 7521-7537 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T19 7533-7537 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T20 7546-7556 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T21 7565-7573 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T22 7968-7973 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 8022-8027 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T24 8042-8047 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T25 8344-8348 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T26 8493-8497 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T27 9074-9078 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T28 9268-9277 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T29 9355-9364 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T30 9917-9922 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T31 10007-10015 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T32 10040-10048 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T33 10144-10157 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T34 10183-10187 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T35 10276-10280 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T8 688-691 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T9 754-759 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 1573-1597 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T11 1599-1602 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T12 1688-1691 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T13 1910-1913 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T14 4954-4959 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T15 5119-5124 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T16 5914-5919 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T17 6038-6043 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T18 7527-7532 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 7968-7973 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 8042-8047 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T21 8281-8284 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T22 8344-8348 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 8415-8418 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T24 8493-8497 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 8517-8520 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T26 8839-8842 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T27 9074-9078 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T28 9101-9104 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T29 9515-9518 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T30 9917-9922 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T31 10144-10157 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T32 10276-10280 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 10386-10389 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T34 10720-10723 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T11 17-25 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 45-92 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 45-78 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T14 94-102 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 321-329 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 371-379 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 382-392 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T18 397-420 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T19 432-444 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T20 492-504 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T21 589-601 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T22 629-641 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T23 1103-1107 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T24 1109-1117 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 1193-1201 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 1202-1212 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T27 1413-1425 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T28 1637-1646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29 1656-1664 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1944-1952 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T31 1970-1982 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T32 2247-2255 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T33 2375-2387 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T34 2420-2428 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T35 2659-2667 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 3010-3018 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 3194-3202 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 3318-3330 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T39 3434-3446 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T40 3481-3489 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 4044-4052 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 4178-4190 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T43 4549-4552 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T44 4612-4615 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T45 4640-4643 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T46 4831-4834 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T47 4876-4879 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T48 4919-4934 Disease denotes type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T49 4926-4934 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T50 4936-4939 Disease denotes T2D http://purl.obolibrary.org/obo/MONDO_0005148
T51 4945-4967 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T52 4954-4967 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T53 4969-4972 Disease denotes CHD http://purl.obolibrary.org/obo/MONDO_0005010
T54 5472-5484 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T55 5523-5526 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T56 5550-5553 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T57 5707-5710 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T58 5737-5740 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T59 5856-5859 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T60 5892-5895 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T61 5964-5967 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T62 6088-6091 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T63 6292-6295 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T64 6394-6397 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T65 6547-6550 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T66 6594-6597 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T67 6745-6748 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T68 6781-6789 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T69 6804-6816 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T70 6912-6915 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T71 7079-7082 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T72 7140-7143 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T73 7401-7404 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T74 7461-7464 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T75 7810-7813 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T76 7832-7835 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T77 8321-8333 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T78 8338-8355 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T80 8349-8355 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T81 8383-8387 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T82 8463-8475 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T83 8493-8505 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T84 8586-8589 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T85 8727-8735 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T86 8857-8865 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T87 8880-8892 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T88 8922-8930 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T89 9057-9069 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T90 9396-9404 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 9464-9472 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 9606-9614 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T93 9629-9641 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T94 9680-9683 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T95 9833-9836 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T96 9878-9884 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T97 9917-9930 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T98 10101-10104 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T99 10281-10287 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T100 10324-10327 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T101 10768-10776 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 10791-10803 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T103 10900-10903 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T13 490-491 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T14 569-571 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T15 754-759 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T16 754-759 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T17 917-925 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T18 1002-1003 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1163-1167 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 1380-1381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1604-1607 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T22 2173-2174 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 2310-2312 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T24 2572-2573 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T25 2809-2810 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 2989-2992 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T27 3391-3395 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018
T28 3643-3645 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T29 3853-3857 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T30 3938-3944 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T31 3963-3967 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T32 4029-4030 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T33 4954-4959 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T34 4954-4959 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T35 4954-4959 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T36 4954-4959 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T37 5093-5095 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T38 5119-5124 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 5119-5124 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 5329-5331 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T41 5329-5331 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T42 5435-5440 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T43 5435-5440 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T44 5914-5919 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T45 5914-5919 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T46 5914-5919 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T47 5914-5919 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T48 6038-6043 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T49 6038-6043 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T50 6038-6043 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T51 6038-6043 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T52 6180-6182 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T53 6180-6182 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T54 6303-6305 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T55 6499-6500 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T56 6839-6840 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T57 6853-6854 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 7017-7018 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T59 7045-7048 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T60 7045-7048 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T61 7054-7057 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T62 7059-7066 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T63 7188-7191 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T64 7193-7199 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T65 7527-7532 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 7533-7537 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T67 7844-7845 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T68 7924-7925 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T69 7968-7973 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T70 7968-7973 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T71 7999-8002 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T72 7999-8002 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T73 8005-8008 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T74 8015-8018 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T75 8020-8027 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T76 8042-8047 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T77 8042-8047 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T78 8188-8196 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T79 8291-8292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 8344-8348 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T81 8344-8348 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T82 8366-8373 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T83 8419-8427 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 8493-8497 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T85 8493-8497 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T86 9074-9078 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T87 9074-9078 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T88 9290-9300 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T89 9571-9574 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T90 9886-9888 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T91 9917-9922 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T92 9917-9922 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T93 9917-9922 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T94 9917-9922 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T95 9935-9938 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T96 10117-10118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T97 10144-10157 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T98 10181-10187 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T99 10276-10280 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T100 10276-10280 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T24 688-691 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T25 809-811 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T26 941-943 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T27 1283-1285 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T28 1364-1366 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T29 1427-1432 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T30 1471-1473 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T31 1579-1590 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T32 1599-1602 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T33 1688-1691 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T34 1692-1702 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T35 1712-1752 Chemical denotes angiotensin-converting enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T36 1712-1723 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 1735-1752 Chemical denotes enzyme inhibitors http://purl.obolibrary.org/obo/CHEBI_23924
T38 1742-1752 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T39 1754-1759 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T40 1765-1779 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T43 1765-1776 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T44 1777-1779 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T45 1910-1913 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T46 1914-1924 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T47 2612-2614 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T48 3531-3552 Chemical denotes antihypertensive drug http://purl.obolibrary.org/obo/CHEBI_35674
T49 3548-3552 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T50 4256-4278 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T51 4273-4278 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T52 4390-4406 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T53 4512-4528 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674
T54 4553-4558 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T55 4616-4621 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T56 4644-4649 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T57 4701-4723 Chemical denotes antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35674
T58 4718-4723 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T59 4735-4759 Chemical denotes calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38215
T60 4735-4742 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T62 4783-4792 Chemical denotes diuretics http://purl.obolibrary.org/obo/CHEBI_35498
T63 4835-4840 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T64 4880-4885 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 5329-5331 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T66 5527-5532 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T67 5554-5559 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T68 5711-5716 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T69 5741-5746 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T70 5860-5865 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T71 5896-5901 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T72 5968-5973 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 6092-6097 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T74 6180-6182 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T75 6296-6301 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T76 6398-6403 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77 6551-6556 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T78 6598-6603 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T79 6749-6754 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T80 6874-6876 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T82 6916-6921 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T83 6957-6964 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T84 7083-7088 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T85 7144-7149 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T86 7405-7410 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T87 7465-7470 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88 7586-7593 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T89 7642-7644 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T90 7814-7819 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T91 7836-7841 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T92 7941-7943 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T94 8281-8284 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T95 8415-8418 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T96 8517-8520 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T97 8576-8581 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T98 8617-8619 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T99 8651-8656 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T100 8839-8842 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T101 8843-8853 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T102 8955-8969 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T103 8967-8969 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T104 9027-9041 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T105 9039-9041 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T106 9101-9104 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T107 9105-9115 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T108 9201-9215 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T109 9213-9215 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T110 9489-9494 Chemical denotes ACEIs http://purl.obolibrary.org/obo/CHEBI_35457
T111 9515-9518 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T112 9768-9770 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T114 9856-9859 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T117 10386-10389 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T118 10390-10400 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T119 10474-10483 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T120 10720-10723 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T121 10724-10734 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T122 10908-10924 Chemical denotes antihypertensive http://purl.obolibrary.org/obo/CHEBI_35674

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 8447-8459 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2 9707-9728 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3 10040-10059 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T4 10417-10442 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibit viral replication
T5 10425-10442 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T6 10425-10442 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T7 10523-10565 http://purl.obolibrary.org/obo/GO_0050728 denotes inhibiting inflammatory responses, and the
T8 10534-10556 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-12 Sentence denotes Introduction
T13 13-174 Sentence denotes The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to endanger global health and to hamper the world economy.
T14 175-239 Sentence denotes This outbreak started in December 2019 in Wuhan, Hubei Province.
T15 240-330 Sentence denotes Unfortunately, currently, there is still no specific and effective treatment for COVID-19.
T16 331-489 Sentence denotes Evidence shows that elderly people with SARS-CoV-2 infections and cardiovascular diseases, including hypertension, are at risk of developing severe cases [1].
T17 490-687 Sentence denotes A hypertension survey from 2012 to 2015 reported that 23.2% of Chinese people ≥18 years of age had hypertension, whereas the prevalence of hypertension was >55% among citizens ≥65 years of age [2].
T18 688-873 Sentence denotes RAS plays an important role in regulating electrolyte balance and blood pressure and comprises two pathways: the ACE/Ang II/AT1R pathway and the ACE2/Ang (1–7)/Mas receptor pathway [3].
T19 874-1091 Sentence denotes Under normal physiological conditions, the activity of the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis are in a dynamic equilibrium state, maintaining the normal function of the corresponding system.
T20 1092-1192 Sentence denotes Similar to SARS, SARS-CoV-2 is believed to invade the host through the cell entry receptor ACE2 [4].
T21 1193-1341 Sentence denotes SARS-CoV infections reduce ACE2 expression, resulting in an imbalance between the ACE/Ang II/AT1R axis and the ACE2/Ang (1–7)/Mas receptor axis [5].
T22 1342-1426 Sentence denotes Targeting the ACE/Ang II/AT1R axis is a novel therapeutic strategy for hypertension.
T23 1427-1549 Sentence denotes ACEIs and ARAs not only inhibit the ACE/Ang II/AT1R pathway but also modulate the ACE2/Ang (1–7)/Mas receptor pathway [6].
T24 1550-1867 Sentence denotes The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown.
T25 1868-1983 Sentence denotes Here, we aimed to evaluate the ability of RAS inhibitors to protect against COVID-19 in patients with hypertension.
T26 1985-1992 Sentence denotes Methods
T27 1993-2075 Sentence denotes This study was approved by the Shenzhen Third People’s Hospital Ethical Committee.
T28 2076-2159 Sentence denotes Verbal informed consent was obtained from all patients or patients’ family members.
T29 2160-2341 Sentence denotes We performed a retrospective review of medical records from hospitalized patients with COVID-19 admitted to the Shenzhen Third People’s Hospital from 11 January to 23 February 2020.
T30 2342-2438 Sentence denotes The information on patients with hypertension was extracted from all enrolled COVID-19 patients.
T31 2439-2571 Sentence denotes We reviewed the clinical data extracted from electronic medical records, including clinical symptoms, signs and laboratory findings.
T32 2572-2670 Sentence denotes A commercial real-time PCR kit (GeneoDX Co., Ltd., Shanghai, China) was used to detect SARS-CoV-2.
T33 2671-2795 Sentence denotes Samples were considered positive if the cycle threshold value (Ct-value) less than 37 and negative if Ct-value more than 40.
T34 2796-2872 Sentence denotes Samples with a Ct-value between 37 and 40 require confirmation by retesting.
T35 2873-2993 Sentence denotes Samples identified as positive by the local laboratory were further validated by the key laboratory of the Shenzhen CDC.
T36 2994-3168 Sentence denotes The severity of COVID-19 wasidentified during the hospitalization according to the guidelines established by the National Health Commission of the People’s Republic of China.
T37 3169-3317 Sentence denotes Therapeutic regimens for COVID-19 patients complied with guidelines established by the National Health Commission of the People’s Republic of China.
T38 3318-3453 Sentence denotes Hypertension was classified as Grade 1, Grade 2 and Grade 3 according to 2018 guidelines of the European Society of Hypertension (ESH).
T39 3454-3564 Sentence denotes Hypertensive patients with COVID-19 were divided into two subgroups based on antihypertensive drug treatments.
T40 3565-3646 Sentence denotes Detailed information on the enrolled patients is shown in supplementary Table S1.
T41 3647-3712 Sentence denotes The SPSS 18.0 software package was used for statistical analysis.
T42 3713-3858 Sentence denotes Measurement data are expressed as the median and interquartile range (IQR), and the difference between groups was compared by an unpaired t test.
T43 3859-3968 Sentence denotes Count data are expressed as percentages, and the difference between groups was tested by the Chi-square test.
T44 3969-4019 Sentence denotes P < 0.05 was considered statistically significant.
T45 4021-4028 Sentence denotes Results
T46 4029-4139 Sentence denotes A total of 417 COVID-19 patients were admitted to the Shenzhen Third People’s Hospital as of 23 February 2020.
T47 4140-4191 Sentence denotes Among these patients, 51 (12.23%) had hypertension.
T48 4192-4349 Sentence denotes Nine patients (17.6%) with Grade 1hypertension did not take any antihypertensive drugs during hospitalization and were excluded from the subsequent analysis.
T49 4350-4448 Sentence denotes The other 42 patients (82.4%) receiving antihypertensive therapy were included in further studies.
T50 4449-4793 Sentence denotes The 42 analyzed patients were divided into two groups based on antihypertensive therapies: the ACEI/ARB group (17 patients) included patients treated with ACEI or ARB drugs, and the non-ACEI/ARB group (25 patients) included patients treated with other antihypertensive drugs, including calcium channel blockers (CCBs), β-blockers and diuretics.
T51 4794-4974 Sentence denotes Eight patients (32%) in the non-ACEI/ARB group and 5 patients (29.41%)in the ACEI/ARB group had other comorbidities, such as type 2 diabetes (T2D) and coronary heart disease (CHD).
T52 4975-5114 Sentence denotes The vast majority of hypertensive patients had received the current therapeutic regimens shown in supplementary Table S1 for over one year.
T53 5115-5225 Sentence denotes The blood pressure of patients was well-controlled with the above therapeutic regimens during hospitalization.
T54 5226-5332 Sentence denotes The comparison of baseline characteristics between the two groups is summarized in supplementary Table S2.
T55 5333-5441 Sentence denotes The median age of the analyzed subjects was 64.5 years (IQR, 55.8–69.0 years), and 57.1% of them were males.
T56 5442-5560 Sentence denotes No significant differences in hypertension grades were observed between the ACEI/ARB group and the non-ACEI/ARB group.
T57 5561-5607 Sentence denotes Both groups showed similar signs and symptoms.
T58 5608-5747 Sentence denotes The median number of days from the onset of symptoms to hospital admission was 2.0 in the non-ACEI/ARB group and 3.0 in the ACEI/ARB group.
T59 5748-5902 Sentence denotes Meanwhile, the median number of days from symptom onset to hospital discharge was 16.5 days in the non-ACEI/ARB group and 20.0 days in the ACEI/ARB group.
T60 5903-6011 Sentence denotes The median heart rate and respiratory rate from the non-ACEI/ARB group were 90.5 bpm and 20.0, respectively.
T61 6012-6135 Sentence denotes In comparison, the median heart rate and respiratory rate from the non-ACEI/ARB group were 80.0 bmp and 20.0, respectively.
T62 6136-6239 Sentence denotes All baseline characteristics shown in Table S2 were not significantly different between the two groups.
T63 6240-6368 Sentence denotes During hospitalization, 12 patients in the non-ACEI/ARB group (48%) were categorized into severe subgroups and one patient died.
T64 6369-6503 Sentence denotes In contrast, in the ACEI/ARB group, only 4 patients (23.5%) were categorized into severe subgroups and no patients died (Figure 1(A)).
T65 6504-6697 Sentence denotes The percentage of severe cases in the ACEI/ARB group was higher than that in the non-ACEI/ARB group, but this difference was not significant, possibly due to the small number of clinical cases.
T66 6698-6817 Sentence denotes We next examined the effects of taking ACEI or ARB drugs on laboratory findings of COVID-19 patients with hypertension.
T67 6818-6922 Sentence denotes As shown in Figure 1(B), there was a trend toward lower IL-6 levels in patients from the ACEI/ARB group.
T68 6923-7021 Sentence denotes No marked variation in C-reactive protein (CRP) was observed between the two groups (Figure 1(B)).
T69 7022-7150 Sentence denotes The absolute number of CD3+ and CD8+ T cells in the ACEI/ARB group was significantly higher than that in the non-ACEI/ARB group.
T70 7151-7244 Sentence denotes There were no significant changes in CD4+ T cell counts between the two groups (Figure 1(C)).
T71 7245-7485 Sentence denotes In addition, although the viral load was not different between the two groups at hospital admission, the peak viral load during hospitalization in the ACEI/ARB group was significantly lower than that in the non-ACEI/ARB group (Figure 1(D)).
T72 7486-7714 Sentence denotes Other laboratory findings, such as white blood cell counts, neutrophil counts, platelet counts, and lactate dehydrogenase, are shown in supplementary Table S3, and no significant differences were observed between the two groups.
T73 7715-7724 Sentence denotes Figure 1.
T74 7725-8127 Sentence denotes Summarized clinical, inflammatory, immunological, and viral findings in the non-ACEI/ARB group and the ACE/ARB group. (A) The disease severity distribution of the two groups during hospitalization. (B) The levels of IL-6 and CRP in peripheral blood. (C) Absolute numbers of CD3+, CD4+, and CD8+ T cells in peripheral blood. (D) Viral load on hospital admission and maximum value during hospitalization.
T75 8128-8173 Sentence denotes The data are expressed as the median and IQR.
T76 8174-8243 Sentence denotes An unpaired t test was used, and P < 0.05 was considered significant.
T77 8245-8255 Sentence denotes Discussion
T78 8256-8403 Sentence denotes It was reported that the RAS plays a critical role in regulating hypertension and acute lung injury caused by viruses, such as SARS and H7N9 [5,7].
T79 8404-8506 Sentence denotes Changes in RAS activity are related to the pathogenesis of hypertension and inflammatory lung disease.
T80 8507-8575 Sentence denotes Targeting RAS is an effective antihypertension therapeutic strategy.
T81 8576-8683 Sentence denotes ACEIs and ARB, which inhibit the ACE/Ang II/AT1R system, are commonly used drugs for hypertensive patients.
T82 8684-8789 Sentence denotes Recent evidence suggests that hypertensive COVID-19 patients are predisposed to develop severe cases [1].
T83 8790-8893 Sentence denotes Thus, it is important to determine the effect of RAS inhibitors on COVID-19 patients with hypertension.
T84 8894-9001 Sentence denotes Studies have suggested that COVID-19 patients have increased Angiotensin II compared to healthy people [8].
T85 9002-9087 Sentence denotes The abnormal increase in Angiotensin II was related to hypertension and lung failure.
T86 9088-9200 Sentence denotes In addition, RAS inhibitors have been shown to be associated with reduced mortality in patients with sepsis [9].
T87 9201-9314 Sentence denotes Angiotensin II positively regulates the expression of inflammatory cytokines through the activation of AT1R [10].
T88 9315-9414 Sentence denotes Excessively high levels of inflammatory cytokines are harmful to the outcomes of COVID-19 patients.
T89 9415-9519 Sentence denotes Thus, it was suggested that it is beneficial for COVID-19 patients to use ACEIs/ARBs to inhibit the RAS.
T90 9520-9590 Sentence denotes However, until now, no confirmed clinical evidence has been available.
T91 9591-9890 Sentence denotes In this study, COVID-19 patients with hypertension were enrolled, and we found that ACEI/ARB therapy attenuated the inflammatory response, potentially through the inhibition of IL-6 levels, which is consistent with the findings that ACEI and ARB therapy alleviated LPS-induced pneumonic injury [11].
T92 9891-10065 Sentence denotes For patients with chronic heart failure, it has been proven that ACEI therapy was associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production [12].
T93 10066-10198 Sentence denotes This study also suggests that ACEI/ARB therapy had a beneficial effect on the immune system by avoiding peripheral T cell depletion.
T94 10199-10292 Sentence denotes Furthermore, the viral load was reported to be highly correlated with severe lung injury [8].
T95 10293-10648 Sentence denotes It was also observed that ACEI/ARB therapy decreased the viral load, but we hypothesize that RAS inhibitors do not directly inhibit viral replication; rather, they play an indirect antiviral role by regulating immune function and inhibiting inflammatory responses, and the mechanism needs to be clarified through in vitro and in vivostudies in the future.
T96 10649-10935 Sentence denotes Taken together, this is the first clinical evidence demonstrating that RAS inhibitors improve the clinical outcomes of COVID-19 patients with hypertension, suggesting that these patients could benefit from the persistent or preferential usage of ACEI/ARB for antihypertensive treatment.
T97 10937-10959 Sentence denotes Supplementary Material
T98 10960-10981 Sentence denotes Supplemental Material

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 397-420 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T5 432-444 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 492-504 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 589-601 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 629-641 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 1413-1425 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T10 1970-1982 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T11 2375-2387 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T12 3318-3330 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 3434-3446 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T14 3454-3466 Phenotype denotes Hypertensive http://purl.obolibrary.org/obo/HP_0000822
T15 4178-4190 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T16 4919-4934 Phenotype denotes type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T17 5472-5484 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T18 6804-6816 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T19 8321-8333 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T20 8338-8355 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T21 8463-8475 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T22 8493-8505 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T23 8880-8892 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 9057-9069 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T25 9189-9195 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T26 9629-9641 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 9909-9930 Phenotype denotes chronic heart failure http://purl.obolibrary.org/obo/HP_0001635
T28 10791-10803 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822

2_test

Id Subject Object Predicate Lexical cue
32228222-25194138-27780682 870-871 25194138 denotes 3
32228222-16007097-27780683 1338-1339 16007097 denotes 5
32228222-16007097-27780684 8398-8399 16007097 denotes 5
32228222-31838905-27780685 9197-9198 31838905 denotes 9
32228222-31805278-27780686 9886-9888 31805278 denotes 11
32228222-15067208-27780687 10061-10063 15067208 denotes 12