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PMC:7166305 / 3624-11243 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T19 198-204 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T20 786-800 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T21 1406-1412 Body_part denotes Kidney http://purl.org/sig/ont/fma/fma7203
T22 2100-2107 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T23 2169-2182 Body_part denotes interleukin-6 http://purl.org/sig/ont/fma/fma264829
T24 2286-2291 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T25 2327-2332 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T26 2740-2751 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T27 2753-2755 Body_part denotes LY http://purl.org/sig/ont/fma/fma62863
T28 3515-3520 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 3602-3607 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 3689-3694 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T31 3859-3864 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T32 3949-3954 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T33 4192-4197 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T34 4198-4203 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T35 4392-4415 Body_part denotes low-density lipoprotein http://purl.org/sig/ont/fma/fma63170
T36 4417-4420 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T37 4616-4619 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T38 4839-4863 Body_part denotes high-density lipoprotein http://purl.org/sig/ont/fma/fma63171
T39 4865-4868 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T40 5052-5055 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T41 5057-5060 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T42 5285-5288 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T43 5494-5497 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T44 5503-5506 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T45 5635-5638 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T46 5640-5643 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T47 6347-6350 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T48 6356-6359 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T49 6443-6446 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T50 6448-6451 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T51 6594-6597 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T52 6938-6941 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T53 6943-6946 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T54 6963-6966 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T55 6968-6971 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T56 7257-7260 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T57 7515-7518 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T58 7520-7523 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T3 198-204 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T4 1406-1412 Body_part denotes Kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 4192-4197 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T28 129-137 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T29 139-151 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T30 153-177 Disease denotes cardiovascular disorders http://purl.obolibrary.org/obo/MONDO_0004995
T31 179-193 Disease denotes hyperlipidemia http://purl.obolibrary.org/obo/MONDO_0021187
T32 198-213 Disease denotes kidney diseases http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T34 327-335 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T35 1063-1071 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T36 1272-1287 Disease denotes Type 2 diabetes http://purl.obolibrary.org/obo/MONDO_0005148
T37 1279-1287 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T38 1313-1325 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T39 1355-1377 Disease denotes Cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T40 1406-1421 Disease denotes Kidney diseases http://purl.obolibrary.org/obo/MONDO_0001343|http://purl.obolibrary.org/obo/MONDO_0005240
T42 1614-1622 Disease denotes Diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T43 2575-2584 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 2830-2839 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45 2903-2912 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 3138-3149 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T47 3218-3226 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 4268-4276 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 4534-4543 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50 4549-4558 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 4724-4733 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 4967-4976 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 4982-4991 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54 5320-5329 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55 5525-5533 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T56 5660-5669 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T57 5933-5942 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58 6195-6204 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 7013-7021 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T60 7032-7036 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T61 7120-7128 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T62 7151-7167 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T23 66-68 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T24 75-79 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T25 75-79 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T26 84-86 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T27 93-99 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T28 198-204 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T29 198-204 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T30 198-204 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T31 291-293 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T32 449-450 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 515-518 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T34 609-612 http://purl.obolibrary.org/obo/CL_0000990 denotes CDC
T35 1197-1201 http://purl.obolibrary.org/obo/UBERON_0003101 denotes Male
T36 1197-1201 http://www.ebi.ac.uk/efo/EFO_0000970 denotes Male
T37 1202-1204 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T38 1406-1412 http://purl.obolibrary.org/obo/UBERON_0002113 denotes Kidney
T39 1406-1412 http://www.ebi.ac.uk/efo/EFO_0000927 denotes Kidney
T40 1406-1412 http://www.ebi.ac.uk/efo/EFO_0000929 denotes Kidney
T41 1466-1468 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T42 1548-1550 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T43 2140-2142 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T44 2169-2182 http://purl.obolibrary.org/obo/PR_000001393 denotes interleukin-6
T45 2218-2220 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T46 2226-2228 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T47 2265-2268 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T48 2284-2291 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T49 2327-2332 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T50 2615-2617 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T51 2660-2662 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T52 2721-2723 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T53 2857-2858 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 3054-3056 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T55 3098-3099 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T56 3183-3185 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T57 3208-3213 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T58 3288-3293 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T59 3379-3381 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T60 3414-3416 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T61 3466-3468 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T62 3480-3482 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T63 3509-3512 http://purl.obolibrary.org/obo/CLO_0052882 denotes CD3
T64 3509-3512 http://purl.obolibrary.org/obo/CLO_0053434 denotes CD3
T65 3515-3520 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T66 3542-3545 http://purl.obolibrary.org/obo/CLO_0001180 denotes 203
T67 3573-3576 http://purl.obolibrary.org/obo/CLO_0001203 denotes 232
T68 3596-3599 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T69 3602-3607 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T70 3683-3686 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T71 3689-3694 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T72 3767-3770 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T73 3772-3775 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T74 3852-3856 http://purl.obolibrary.org/obo/CLO_0053432 denotes CD19
T75 3859-3864 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T76 3919-3921 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T77 3949-3954 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T78 4110-4111 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 4127-4131 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T80 4830-4832 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T81 5222-5224 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T82 5264-5265 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 5464-5466 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T84 5499-5500 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T85 5508-5509 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T86 6018-6019 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87 6035-6039 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T88 6114-6116 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T89 6575-6577 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T90 6765-6767 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T91 6790-6792 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T92 6790-6792 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T93 6800-6801 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T94 6833-6834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T20 75-79 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T21 624-633 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T22 644-651 Chemical denotes arbidol http://purl.obolibrary.org/obo/CHEBI_134730
T23 653-662 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T24 678-688 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T25 734-748 Chemical denotes corticosteroid http://purl.obolibrary.org/obo/CHEBI_50858
T26 773-784 Chemical denotes thymalfasin http://purl.obolibrary.org/obo/CHEBI_135915
T27 861-867 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T28 1695-1704 Chemical denotes Lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T29 1705-1714 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T30 1870-1876 Chemical denotes Oxygen http://purl.obolibrary.org/obo/CHEBI_15379
T31 1989-1994 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T32 2100-2107 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 2184-2186 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T35 2753-2755 Chemical denotes LY http://purl.obolibrary.org/obo/CHEBI_73591
T36 3373-3375 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T38 4051-4056 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T39 4080-4085 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T40 4198-4203 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T41 4392-4415 Chemical denotes low-density lipoprotein http://purl.obolibrary.org/obo/CHEBI_39026
T42 4404-4415 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T43 4417-4420 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T44 4616-4619 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T45 4839-4863 Chemical denotes high-density lipoprotein http://purl.obolibrary.org/obo/CHEBI_39025
T46 4852-4863 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T47 4865-4868 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T48 5052-5055 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T49 5057-5060 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T50 5233-5244 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T51 5285-5288 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T52 5494-5497 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T53 5503-5506 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T54 5635-5638 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T55 5640-5643 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T56 6347-6350 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T57 6356-6359 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T58 6443-6446 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T59 6448-6451 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T60 6594-6597 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T61 6790-6792 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T62 6938-6941 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T63 6943-6946 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T64 6963-6966 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T65 6968-6971 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T66 7189-7191 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T67 7257-7260 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T68 7515-7518 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T69 7520-7523 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 7151-7167 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T42 0-10 Sentence denotes 3 Results
T43 11-100 Sentence denotes The average age of the patients was 62.5 ± 12.6 years; 52% were male and 48% were female.
T44 101-214 Sentence denotes 62% had morbidities such as diabetes, hypertension, cardiovascular disorders, hyperlipidemia, or kidney diseases.
T45 215-354 Sentence denotes The onset symptoms of the patients were: fever (86%), cough (95%), fatigue (71%), shortness of breath (43%) and diarrhea (10%) (Table 1a ).
T46 355-535 Sentence denotes The severities of the admitted patients were 62% of mild, 19% of severe, and 19% of critical, a classification according to Chinese Center for Disease Control (CDC) guidelines [1].
T47 536-813 Sentence denotes Patients received standard treatments based on the guidelines of Chinese CDC, including antiviral remedies (arbidol, lopinavir and ribonavir, interferon α inhalation), anti-inflammatory treatments (corticosteroid), and immune-modulator (thymalfasin, immunoglobulin) (Table 1a).
T48 814-938 Sentence denotes Severe and critical cases were given high-flow oxygen, non-invasive or invasive ventilation, depending on their morbidities.
T49 939-1025 Sentence denotes Seventeen patients recovered and were discharged, while four patients did not survive.
T50 1026-1081 Sentence denotes Table 1a Clinical characteristics of COVID-19 patients.
T51 1082-1089 Sentence denotes No. (%)
T52 1090-1143 Sentence denotes Total (n = 21) Survival (n = 17) Non-survival (n = 4)
T53 1144-1196 Sentence denotes Age, mean (s.d.) 62.5 (12.6) 61.5 (9.5) 79.7 (14.3)⁎
T54 1197-1229 Sentence denotes Male 11 (52.3) 9 (53.9) 2 (50.0)
T55 1230-1270 Sentence denotes Comorbidities 13 (61.9) 9 (53.9) 4 (100)
T56 1271-1311 Sentence denotes  Type 2 diabetes 3 (14.3) 3 (17.6) 0 (0)
T57 1312-1353 Sentence denotes  Hypertension 10 (47.6) 8 (35.3) 2 (50.0)
T58 1354-1404 Sentence denotes  Cardiovascular disease 5 (23.8) 3 (17.6) 2 (50.0)
T59 1405-1443 Sentence denotes  Kidney diseases 1 (4.8) 1 (5.8) 0 (0)
T60 1444-1458 Sentence denotes Onset symptoms
T61 1459-1493 Sentence denotes  Fever 18 (85.7) 14 (82.3) 4 (100)
T62 1494-1528 Sentence denotes  Cough 20 (95.2) 16 (94.1) 4 (100)
T63 1529-1565 Sentence denotes  Fatigue 15 (71.4) 11 (64.7) 4 (100)
T64 1566-1612 Sentence denotes  Shortness of breath 9 (42.8) 5 (29.4) 4 (100)
T65 1613-1645 Sentence denotes  Diarrhea 2 (9.5) 2 (11.7) 0 (0)
T66 1646-1655 Sentence denotes Treatment
T67 1656-1693 Sentence denotes  Arbidol 15 (71.4) 12 (70.6) 3 (75.0)
T68 1694-1741 Sentence denotes  Lopinavir/ritonavir 7 (33.3) 4 (23.5) 3 (75.0)
T69 1742-1791 Sentence denotes  Interferon inhalation 7 (33.3) 4 (23.5) 3 (75.0)
T70 1792-1831 Sentence denotes  Corticosteroid 3 (14.3) 3 (17.6) 0 (0)
T71 1832-1868 Sentence denotes  Thymalfasin 6 (28.6) 6 (35.3) 0 (0)
T72 1869-1902 Sentence denotes  Oxygen 8 (38.1) 4 (23.5) 4 (100)
T73 1903-1949 Sentence denotes  Mechanical ventilation 4 (19.0) 0 (0) 4 (100)
T74 1950-2009 Sentence denotes ⁎ p < 0.05, as compared to the patient group that survived.
T75 2010-2425 Sentence denotes In the stage of disease progression, there were significantly higher levels of C-reactive protein (CRP) (78 (28–134) versus 15 (7–36), in mg/L, p = 0.042) and interleukin-6 (IL-6) (195 (127–280) versus 12 (4–18), in pg/ml, p < 0.001), but lower levels of CD8+ subpopulation T cells (33 (23–135) versus 273 (122–377), cells/μl, p = 0.016) in non-surviving patients as compared with the patients survived (Table 1b ).
T76 2426-2585 Sentence denotes Furthermore, in surviving patients, increases in levels of high-sensitivity CRP (hsCRP) were significantly associated with the disease severity (pre-infection:
T77 2586-2614 Sentence denotes 1.2 (0.7–5.9); on admission:
T78 2615-2650 Sentence denotes 11 (5.9–26), p < 0.02; progression:
T79 2651-2675 Sentence denotes 9.8 (5.3–45); discharge:
T80 2676-2725 Sentence denotes 2.2 (1.2–7.0), in mg/L) (Supplementary Table S1).
T81 2726-2913 Sentence denotes The number of lymphocytes (LY) decreased significantly at the time of admission as compared with before infection; it did not show a full recovery at the time of discharge (pre-infection:
T82 2914-2942 Sentence denotes 1.6 (1.4–2.2); on admission:
T83 2943-2980 Sentence denotes 1.0 (0.8–1.5), p < 0.02; progression:
T84 2981-3006 Sentence denotes 0.9 (0.5–1.4); discharge:
T85 3007-3058 Sentence denotes 1.2 (0.8–1.9), in x109/L) (Supplementary Table S1).
T86 3059-3187 Sentence denotes In patients did not survive, there was a continuous increase in hsCRP level or lymphopenia until death (Supplementary Table S1).
T87 3188-3276 Sentence denotes Table 1b Laboratory tests for COVID-19 patients during the stage of disease progression.
T88 3277-3317 Sentence denotes Laboratory tests Reference value No. (%)
T89 3318-3372 Sentence denotes Total (n = 21) Survival (n = 17) Non-survival(n = 4) p
T90 3373-3445 Sentence denotes IL-6 (pg/ml) 0.1–2.9 15 (8–79, 19) 12 (4–18, 15) 195 (127–280, 4) <0.001
T91 3446-3508 Sentence denotes CRP (mg/L) <4 20 (7–45, 21) 15 (7–36, 17) 78 (28–134, 4) 0.042
T92 3509-3595 Sentence denotes CD3+ (cells/μl) 805 to 4459 562 (203–939, 19) 680 (303–945, 15) 232 (129–340, 4) 0.062
T93 3596-3682 Sentence denotes CD4+ (cells/μl) 345 to 2350 297 (135–557, 19) 416 (172–557, 15) 168 (108–250, 4) 0.121
T94 3683-3766 Sentence denotes CD8+ (cells/μl) 345 to 2350 166 (50–336, 19) 273 (122–377, 15) 33 (23–135, 4) 0.016
T95 3767-3851 Sentence denotes CD4+/CD8+ ratio 0.96–2.05 1.7 (1.2–3.1, 19) 1.6 (1.3–2.4, 15) 5.0 (2.0–6.2, 4) 0.079
T96 3852-3935 Sentence denotes CD19+ (cells/μl) 240 to 1317 104 (49–174, 19) 104 (49–236, 15) 84 (34–134, 4) 0.650
T97 3936-4026 Sentence denotes CD16+/CD56+ (cells/μl) 210 to 1514 164 (49–252, 19) 168 (106–252, 15) 33 (10–223, 4) 0.124
T98 4027-4132 Sentence denotes P value is compared the group that survived with the group that did not survive by a Mann-Whitney U test.
T99 4133-4170 Sentence denotes Data is presented as median (IQR, n).
T100 4171-4326 Sentence denotes We next analyzed the serum lipid levels (in mmol/L) of the patients before they were infected by SARS-CoV-2 and during their entire courses of the disease.
T101 4327-4387 Sentence denotes The average timeline of disease course was shown in Fig. 1 .
T102 4388-4559 Sentence denotes The low-density lipoprotein (LDL) levels in all patients showed significant decreases at the time on admission as compared to the levels prior to infection (pre-infection:
T103 4560-4585 Sentence denotes 3.5 (3.0–4.4); admission:
T104 4586-4834 Sentence denotes 2.8 (2.3–3.1), p < 0.01); the LDL levels remained relatively low during the treatment (2.5 (2.3–3.0)) and returned to the levels prior to infection in patients that survived by the time of discharge (3.6 (2.7–4.1)) (Fig. 1, Supplementary Table S1).
T105 4835-4992 Sentence denotes The high-density lipoprotein (HDL) levels also showed significant decreases at the time on admission as compared to levels prior to infection (pre-infection:
T106 4993-5018 Sentence denotes 1.4 (1.0–1.8); admission:
T107 5019-5044 Sentence denotes 1.1 (0.8–1.4), p = 0.03).
T108 5045-5151 Sentence denotes Unlike LDL, HDL levels remained relatively low during the treatment stage and after recovery (progression:
T109 5152-5177 Sentence denotes 1.2 (1.0–1.4); discharge:
T110 5178-5226 Sentence denotes 1.0 (1.0–1.4)) (Fig. 1, Supplementary Table S1).
T111 5227-5330 Sentence denotes Total cholesterol (TC) levels showed a pattern similar to LDL during the disease course (pre-infection:
T112 5331-5356 Sentence denotes 5.2 (4.6–6.5); admission:
T113 5357-5394 Sentence denotes 3.5 (3.3–4.1), p < 0.01; progression:
T114 5395-5420 Sentence denotes 4.5 (4.0–4.8); discharge:
T115 5421-5468 Sentence denotes 5.2 (4.4–6.1); Fig. 1, Supplementary Table S1).
T116 5469-5572 Sentence denotes Fig. 1 Ratio changes for LDL (A), HDL (B) and TC (C) in COVID-19 patients during the course of disease.
T117 5573-5691 Sentence denotes For each data point, the ratio is normalized to the levels of LDL, HDL and TC prior to infection for the same patient.
T118 5692-5782 Sentence denotes The days listed are the duration (median (IQR)) for each period during the disease course.
T119 5783-5823 Sentence denotes The date on admission is set as “day 0”.
T120 5824-6040 Sentence denotes Data is presented as “mean ± 95% confidence interval”. # indicates p < 0.05 as compared to the levels of pre-infection stage, and * indicates p < 0.05 as compared to the levels on admission, by a Mann-Whitney U test.
T121 6041-6117 Sentence denotes The sample actual values at each stage are listed in Supplementary Table S1.
T122 6118-6226 Sentence denotes The ratios of hsCRP at each time point are normalized to the levels prior to infection in the same patients.
T123 6227-6438 Sentence denotes Pearson correlation coefficient analysis show the ratios of hsCRP significantly inversely correlated with the ratios of LDL (D), HDL (E) and TC (F) during the disease course; n = 33 data pairs for each analysis.
T124 6439-6579 Sentence denotes The LDL, HDL and TC levels in the patients that did not survive (n = 4) decreased continuously until death (Fig. 1, Supplementary Table S1).
T125 6580-6769 Sentence denotes Particularly, LDL levels showed an irreversible decrease by the most percentage (~60%) until death (1.1 (0.9–1.2), p = 0.02 versus the levels on admission) (Fig. 1, Supplementary Table S1).
T126 6770-6962 Sentence denotes Supplementary table S2 showed a timeline of disease course for a non-surviving patient, from hospital admission to death, with continuous and irreversible decreases in LDL, HDL, and TC levels.
T127 6963-7193 Sentence denotes LDL, HDL and TC levels in normal subjects and non-COVID-19 patients (COPD) control groups did not show significant difference as compared with the levels in COVID-19 patients before their viral infections (Supplementary Table S3).
T128 7194-7346 Sentence denotes Logistic regression analysis showed increasing odds of lowered LDL levels associated with disease progression (Chi-Square = 7.49; p = 0.006; odds ratio:
T129 7347-7360 Sentence denotes 4.48, 95% IC:
T130 7361-7453 Sentence denotes 1.55–12.92, p = 0.006) and in-hospital mortality (Chi-Square = 10.87; p = 0.001; odds ratio:
T131 7454-7468 Sentence denotes 21.72, 95% IC:
T132 7469-7493 Sentence denotes 1.40–337.54, p = 0.028).
T133 7494-7619 Sentence denotes The ratio changes of LDL, HDL and TC inversely correlated with the ratio changes of hsCRP during the disease course (Fig. 1).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 139-151 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 179-193 Phenotype denotes hyperlipidemia http://purl.obolibrary.org/obo/HP_0003077
T6 198-213 Phenotype denotes kidney diseases http://purl.obolibrary.org/obo/HP_0000112
T7 256-261 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T8 269-274 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T9 282-289 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T10 297-316 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T11 327-335 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T12 1272-1287 Phenotype denotes Type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T13 1313-1325 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T14 1355-1377 Phenotype denotes Cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T15 1406-1421 Phenotype denotes Kidney diseases http://purl.obolibrary.org/obo/HP_0000112
T16 1460-1465 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T17 1495-1500 Phenotype denotes Cough http://purl.obolibrary.org/obo/HP_0012735
T18 1530-1537 Phenotype denotes Fatigue http://purl.obolibrary.org/obo/HP_0012378
T19 1567-1586 Phenotype denotes Shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T20 1614-1622 Phenotype denotes Diarrhea http://purl.obolibrary.org/obo/HP_0002014
T21 3138-3149 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T22 7032-7036 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T45 153-167 UBERON:0004535 denotes cardiovascular
T46 198-204 UBERON:0002113 denotes kidney
T47 310-316 UBERON:0002048 denotes breath
T48 644-651 CHEBI:2511;DG_49;CHEBI:2511 denotes arbidol
T49 653-662 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T50 678-690 PR:000024938 denotes interferon α
T51 734-748 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T52 755-761 UBERON:0002405 denotes immune
T53 786-800 GO:0019814 denotes immunoglobulin
T54 1063-1071 SP_7 denotes COVID-19
T55 1355-1369 UBERON:0004535 denotes Cardiovascular
T56 1406-1412 UBERON:0002113 denotes Kidney
T57 1657-1667 DG_49 denotes Arbidol 15
T58 1695-1704 DG_23 denotes Lopinavir
T59 1705-1716 DG_30 denotes ritonavir 7
T60 1793-1809 CHEBI:50858;CHEBI:50858 denotes Corticosteroid 3
T62 2089-2107 PR:000005897 denotes C-reactive protein
T63 2169-2182 PR:000001393 denotes interleukin-6
T64 2184-2188 PR:000001393 denotes IL-6
T65 2740-2751 CL:0000542 denotes lymphocytes
T66 3156-3161 GO:0016265 denotes death
T67 3218-3226 SP_7 denotes COVID-19
T68 3375-3377 PR:Q84LH8 denotes -6
T69 3932-3940 PR:000001483 denotes 650 CD16
T70 3942-3946 PR:000001024 denotes CD56
T72 4192-4197 UBERON:0001977 denotes serum
T73 4198-4203 CHEBI:18059;CHEBI:18059 denotes lipid
T74 4268-4278 SP_7 denotes SARS-CoV-2
T75 5233-5244 CHEBI:16113;CHEBI:16113 denotes cholesterol
T76 5525-5533 SP_7 denotes COVID-19
T78 6540-6545 GO:0016265 denotes death
T79 6673-6678 GO:0016265 denotes death
T80 6885-6890 GO:0016265 denotes death
T81 7013-7021 SP_7 denotes COVID-19
T82 7120-7128 SP_7 denotes COVID-19
T83 7151-7156 NCBITaxon:10239 denotes viral
T8077 153-167 UBERON:0004535 denotes cardiovascular
T60693 198-204 UBERON:0002113 denotes kidney
T9803 310-316 UBERON:0002048 denotes breath
T56327 644-651 CHEBI:2511;DG_49;CHEBI:2511 denotes arbidol
T71601 653-662 CHEBI:31781;DG_23;CHEBI:31781 denotes lopinavir
T81588 678-690 PR:000024938 denotes interferon α
T72727 734-748 CHEBI:50858;CHEBI:50858 denotes corticosteroid
T85122 755-761 UBERON:0002405 denotes immune
T13301 786-800 GO:0019814 denotes immunoglobulin
T10728 1063-1071 SP_7 denotes COVID-19
T4676 1355-1369 UBERON:0004535 denotes Cardiovascular
T31009 1406-1412 UBERON:0002113 denotes Kidney
T31002 1657-1667 DG_49 denotes Arbidol 15
T45645 1695-1704 DG_23 denotes Lopinavir
T6788 1705-1716 DG_30 denotes ritonavir 7
T70091 1793-1809 CHEBI:50858;CHEBI:50858 denotes Corticosteroid 3
T23504 2214-2216 PR:Q84LH8 denotes (
T9285 2730-2738 PR:000001483 denotes number o
T21132 2740-2744 PR:000001024 denotes lymp
T71 2993-3001 SP_7 denotes ); disch
T24283 3218-3223 UBERON:0001977 denotes COVID
T55143 3224-3228 CHEBI:18059;CHEBI:18059 denotes 19 p
T37903 3293-3303 SP_7 denotes Reference
T51291 4259-4270 CHEBI:16113;CHEBI:16113 denotes ected by SA
T27254 4549-4557 SP_7 denotes infectio
T77 5525-5533 SP_7 denotes COVID-19
T38577 6540-6545 GO:0016265 denotes death
T80979 6673-6678 GO:0016265 denotes death
T59342 6885-6890 GO:0016265 denotes death
T45173 7013-7021 SP_7 denotes COVID-19
T71757 7120-7128 SP_7 denotes COVID-19
T14996 7151-7156 NCBITaxon:10239 denotes viral

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
100 1695-1714 Chemical denotes Lopinavir/ritonavir MESH:C558899
101 1279-1287 Disease denotes diabetes MESH:D003920
102 1313-1325 Disease denotes Hypertension MESH:D006973
103 1355-1377 Disease denotes Cardiovascular disease MESH:D002318
104 1406-1421 Disease denotes Kidney diseases MESH:D007674
105 1450-1465 Disease denotes symptoms  Fever MESH:D051271
106 1495-1500 Disease denotes Cough MESH:D003371
107 1530-1537 Disease denotes Fatigue MESH:D005221
108 1567-1586 Disease denotes Shortness of breath MESH:D004417
109 1614-1622 Disease denotes Diarrhea MESH:D003967
112 1072-1080 Species denotes patients Tax:9606
113 1063-1071 Disease denotes COVID-19 MESH:C000657245
115 1981-1988 Species denotes patient Tax:9606
136 34-42 Species denotes patients Tax:9606
137 241-249 Species denotes patients Tax:9606
138 386-394 Species denotes patients Tax:9606
139 536-544 Species denotes Patients Tax:9606
140 949-957 Species denotes patients Tax:9606
141 1000-1008 Species denotes patients Tax:9606
142 644-651 Chemical denotes arbidol MESH:C086979
143 653-662 Chemical denotes lopinavir MESH:D061466
144 667-676 Chemical denotes ribonavir
145 861-867 Chemical denotes oxygen MESH:D010100
146 129-137 Disease denotes diabetes MESH:D003920
147 139-151 Disease denotes hypertension MESH:D006973
148 153-177 Disease denotes cardiovascular disorders MESH:D002318
149 179-193 Disease denotes hyperlipidemia MESH:D006949
150 198-213 Disease denotes kidney diseases MESH:D007674
151 256-261 Disease denotes fever MESH:D005334
152 269-274 Disease denotes cough MESH:D003371
153 282-289 Disease denotes fatigue MESH:D005221
154 297-316 Disease denotes shortness of breath MESH:D004417
155 327-335 Disease denotes diarrhea MESH:D003967
162 3373-3377 Gene denotes IL-6 Gene:3569
163 3596-3599 Gene denotes CD4 Gene:920
164 3683-3686 Gene denotes CD8 Gene:925
165 3767-3770 Gene denotes CD4 Gene:920
166 3772-3775 Gene denotes CD8 Gene:925
167 3446-3449 Gene denotes CRP Gene:1401
170 3227-3235 Species denotes patients Tax:9606
171 3218-3226 Disease denotes COVID-19 MESH:C000657245
186 2089-2107 Gene denotes C-reactive protein Gene:1401
187 2109-2112 Gene denotes CRP Gene:1401
188 2169-2182 Gene denotes interleukin-6 Gene:3569
189 2184-2188 Gene denotes IL-6 Gene:3569
190 2265-2268 Gene denotes CD8 Gene:925
191 2365-2373 Species denotes patients Tax:9606
192 2395-2403 Species denotes patients Tax:9606
193 2452-2460 Species denotes patients Tax:9606
194 3062-3070 Species denotes patients Tax:9606
195 2575-2584 Disease denotes infection MESH:D007239
196 2830-2839 Disease denotes infection MESH:D007239
197 2903-2912 Disease denotes infection MESH:D007239
198 3138-3149 Disease denotes lymphopenia MESH:D008231
199 3156-3161 Disease denotes death MESH:D003643
210 5534-5542 Species denotes patients Tax:9606
211 5683-5690 Species denotes patient Tax:9606
212 6217-6225 Species denotes patients Tax:9606
213 5515-5517 Chemical denotes TC
214 5648-5650 Chemical denotes TC
215 6368-6370 Chemical denotes TC
216 5525-5533 Disease denotes COVID-19 MESH:C000657245
217 5660-5669 Disease denotes infection MESH:D007239
218 5933-5942 Disease denotes infection MESH:D007239
219 6195-6204 Disease denotes infection MESH:D007239
234 4230-4238 Species denotes patients Tax:9606
235 4268-4278 Species denotes SARS-CoV-2 Tax:2697049
236 4436-4444 Species denotes patients Tax:9606
237 4737-4745 Species denotes patients Tax:9606
238 4198-4203 Chemical denotes lipid MESH:D008055
239 5233-5244 Chemical denotes cholesterol MESH:D002784
240 5246-5248 Chemical denotes TC
241 4256-4264 Disease denotes infected MESH:D007239
242 4534-4543 Disease denotes infection MESH:D007239
243 4549-4558 Disease denotes infection MESH:D007239
244 4724-4733 Disease denotes infection MESH:D007239
245 4967-4976 Disease denotes infection MESH:D007239
246 4982-4991 Disease denotes infection MESH:D007239
247 5320-5329 Disease denotes infection MESH:D007239
264 6473-6481 Species denotes patients Tax:9606
265 6849-6856 Species denotes patient Tax:9606
266 7022-7030 Species denotes patients Tax:9606
267 7129-7137 Species denotes patients Tax:9606
268 6456-6458 Chemical denotes TC
269 6952-6954 Chemical denotes TC
270 6976-6978 Chemical denotes TC
271 7528-7530 Chemical denotes TC
272 6540-6545 Disease denotes death MESH:D003643
273 6673-6678 Disease denotes death MESH:D003643
274 6885-6890 Disease denotes death MESH:D003643
275 7013-7021 Disease denotes COVID-19 MESH:C000657245
276 7032-7036 Disease denotes COPD MESH:D029424
277 7120-7128 Disease denotes COVID-19 MESH:C000657245
278 7151-7167 Disease denotes viral infections MESH:D001102
279 7400-7409 Disease denotes mortality MESH:D003643

2_test

Id Subject Object Predicate Lexical cue
32320740-32009228-69344057 532-533 32009228 denotes 1