PMC:7164862 / 2481-2830 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"81","span":{"begin":78,"end":86},"obj":"Species"},{"id":"82","span":{"begin":203,"end":209},"obj":"Species"},{"id":"87","span":{"begin":52,"end":63},"obj":"Chemical"},{"id":"99","span":{"begin":247,"end":254},"obj":"Disease"},{"id":"103","span":{"begin":107,"end":109},"obj":"CellLine"}],"attributes":[{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"Tax:694009"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"Tax:9606"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"MESH:D002738"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D008288"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"CVCL:4582"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":110,"end":115},"obj":"Body_part"},{"id":"T3","span":{"begin":161,"end":167},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T25","span":{"begin":78,"end":86},"obj":"Disease"},{"id":"T26","span":{"begin":247,"end":254},"obj":"Disease"}],"attributes":[{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/MONDO_0005136"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T11","span":{"begin":102,"end":115},"obj":"http://purl.obolibrary.org/obo/CLO_0051719"},{"id":"T12","span":{"begin":161,"end":167},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T13","span":{"begin":203,"end":209},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T14","span":{"begin":258,"end":259},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T19","span":{"begin":52,"end":63},"obj":"Chemical"},{"id":"T20","span":{"begin":219,"end":223},"obj":"Chemical"}],"attributes":[{"id":"A19","pred":"chebi_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":349},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T50","span":{"begin":52,"end":63},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T51","span":{"begin":78,"end":86},"obj":"SP_10"},{"id":"T52","span":{"begin":87,"end":98},"obj":"GO:0006260"},{"id":"T53","span":{"begin":102,"end":106},"obj":"CL_6"},{"id":"T54","span":{"begin":161,"end":167},"obj":"UBERON:0001969"},{"id":"T55","span":{"begin":203,"end":209},"obj":"NCBITaxon:9606"},{"id":"T56","span":{"begin":219,"end":223},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T10976","span":{"begin":52,"end":63},"obj":"CHEBI:3638;DG_10;CHEBI:3638"},{"id":"T85528","span":{"begin":78,"end":86},"obj":"SP_10"},{"id":"T53974","span":{"begin":87,"end":98},"obj":"GO:0006260"},{"id":"T6318","span":{"begin":102,"end":106},"obj":"CL_6"},{"id":"T36294","span":{"begin":161,"end":167},"obj":"UBERON:0001969"},{"id":"T60655","span":{"begin":203,"end":209},"obj":"NCBITaxon:9606"},{"id":"T6054","span":{"begin":219,"end":223},"obj":"CHEBI:23888;CHEBI:23888"}],"text":"The half-maximal inhibitory concentration (IC50) of chloroquine inhibition of SARS-CoV replication in Vero E6 cells, 8·8 μmol/L, is substantially lower than the plasma concentrations that are reached in humans when the drug is prescribed to treat malaria at a dose of 25 mg/kg over 3 days.1 For long-term prophylaxis, even lower doses could be used."}