PMC:7161517 / 6972-7207 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T33","span":{"begin":23,"end":27},"obj":"Body_part"},{"id":"T34","span":{"begin":93,"end":100},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":41,"end":43},"obj":"Disease"},{"id":"T43","span":{"begin":151,"end":153},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005029"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005029"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T78","span":{"begin":83,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T79","span":{"begin":156,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T80","span":{"begin":179,"end":185},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T72","span":{"begin":35,"end":37},"obj":"Chemical"},{"id":"T73","span":{"begin":41,"end":43},"obj":"Chemical"},{"id":"T74","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T75","span":{"begin":75,"end":82},"obj":"Chemical"},{"id":"T76","span":{"begin":93,"end":100},"obj":"Chemical"},{"id":"T77","span":{"begin":144,"end":146},"obj":"Chemical"},{"id":"T78","span":{"begin":151,"end":153},"obj":"Chemical"}],"attributes":[{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_73510"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_52290"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_73510"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":203,"end":209},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T22","span":{"begin":210,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0004707"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T50","span":{"begin":0,"end":235},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T206","span":{"begin":18,"end":22},"obj":"G_3;PG_10;PR:000003622"},{"id":"T207","span":{"begin":31,"end":37},"obj":"PR:000036009"},{"id":"T208","span":{"begin":41,"end":45},"obj":"PR:000006897"},{"id":"T209","span":{"begin":61,"end":71},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T210","span":{"begin":75,"end":82},"obj":"CHEBI:52290;CHEBI:52290;PR:000000103"},{"id":"T211","span":{"begin":82,"end":109},"obj":"PR:000000103"},{"id":"T212","span":{"begin":111,"end":116},"obj":"PR:000000103"},{"id":"T213","span":{"begin":140,"end":146},"obj":"PR:000036009"},{"id":"T214","span":{"begin":151,"end":155},"obj":"PR:000006897"},{"id":"T215","span":{"begin":165,"end":178},"obj":"GO:0005576"},{"id":"T216","span":{"begin":186,"end":195},"obj":"GO:0065007"},{"id":"T217","span":{"begin":204,"end":207},"obj":"PR:000007130"},{"id":"T218","span":{"begin":210,"end":214},"obj":"PR:000000103"},{"id":"T219","span":{"begin":225,"end":229},"obj":"G_3;PG_10;PR:000003622"},{"id":"T339","span":{"begin":1,"end":5},"obj":"PR:000003622;G_3;PG_10"},{"id":"T340","span":{"begin":74,"end":79},"obj":"PR:000036013"},{"id":"T341","span":{"begin":118,"end":123},"obj":"PR:000036008"},{"id":"T342","span":{"begin":143,"end":149},"obj":"PR:000036012"},{"id":"T343","span":{"begin":186,"end":196},"obj":"PR:000001898"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"375","span":{"begin":18,"end":22},"obj":"Gene"},{"id":"376","span":{"begin":31,"end":37},"obj":"Gene"},{"id":"377","span":{"begin":75,"end":109},"obj":"Gene"},{"id":"378","span":{"begin":111,"end":116},"obj":"Gene"},{"id":"379","span":{"begin":140,"end":146},"obj":"Gene"},{"id":"380","span":{"begin":165,"end":209},"obj":"Gene"},{"id":"381","span":{"begin":210,"end":214},"obj":"Gene"},{"id":"382","span":{"begin":225,"end":229},"obj":"Gene"}],"attributes":[{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Gene:59272"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Gene:183"},{"id":"A377","pred":"tao:has_database_id","subj":"377","obj":"Gene:5594"},{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"Gene:5594"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Gene:183"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Gene:5594"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Gene:5594"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29)."}