PMC:7161517 / 6792-7144 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7161517","sourcedb":"PMC","sourceid":"7161517","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7161517","text":"nregulated ACE2 mRNA in cardiac myocytes, it only reduced ACE2 activity in fibroblasts (29). In myocytes, endothelin (ET)-1 also significantly decreased ACE2 mRNA production (29). This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extrace","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T28","span":{"begin":16,"end":20},"obj":"Body_part"},{"id":"T29","span":{"begin":24,"end":40},"obj":"Body_part"},{"id":"T30","span":{"begin":75,"end":86},"obj":"Body_part"},{"id":"T31","span":{"begin":96,"end":104},"obj":"Body_part"},{"id":"T32","span":{"begin":158,"end":162},"obj":"Body_part"},{"id":"T33","span":{"begin":203,"end":207},"obj":"Body_part"},{"id":"T34","span":{"begin":273,"end":280},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma14067"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma63877"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma67328"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T41","span":{"begin":118,"end":120},"obj":"Disease"},{"id":"T42","span":{"begin":221,"end":223},"obj":"Disease"},{"id":"T43","span":{"begin":331,"end":333},"obj":"Disease"}],"attributes":[{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005029"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005029"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005029"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T74","span":{"begin":24,"end":40},"obj":"http://purl.obolibrary.org/obo/CL_0000746"},{"id":"T75","span":{"begin":63,"end":71},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T76","span":{"begin":75,"end":86},"obj":"http://purl.obolibrary.org/obo/CL_0000057"},{"id":"T77","span":{"begin":96,"end":104},"obj":"http://purl.obolibrary.org/obo/CL_0000187"},{"id":"T78","span":{"begin":263,"end":272},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T79","span":{"begin":336,"end":344},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T74","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T71","span":{"begin":118,"end":120},"obj":"Chemical"},{"id":"T72","span":{"begin":215,"end":217},"obj":"Chemical"},{"id":"T73","span":{"begin":221,"end":223},"obj":"Chemical"},{"id":"T74","span":{"begin":241,"end":251},"obj":"Chemical"},{"id":"T75","span":{"begin":255,"end":262},"obj":"Chemical"},{"id":"T76","span":{"begin":273,"end":280},"obj":"Chemical"},{"id":"T77","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"T78","span":{"begin":331,"end":333},"obj":"Chemical"}],"attributes":[{"id":"A71","pred":"chebi_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/CHEBI_73510"},{"id":"A72","pred":"chebi_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A73","pred":"chebi_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/CHEBI_73510"},{"id":"A74","pred":"chebi_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A75","pred":"chebi_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/CHEBI_52290"},{"id":"A76","pred":"chebi_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A78","pred":"chebi_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/CHEBI_73510"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T49","span":{"begin":93,"end":179},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T49","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T198","span":{"begin":11,"end":15},"obj":"G_3;PG_10;PR:000003622"},{"id":"T199","span":{"begin":24,"end":31},"obj":"UBERON:0000948;CL:0000746"},{"id":"T200","span":{"begin":32,"end":40},"obj":"CL:0000746"},{"id":"T201","span":{"begin":58,"end":62},"obj":"G_3;PG_10;PR:000003622"},{"id":"T202","span":{"begin":75,"end":86},"obj":"CL:0000057"},{"id":"T203","span":{"begin":96,"end":104},"obj":"CL:0000187"},{"id":"T204","span":{"begin":106,"end":116},"obj":"UBERON:0001986"},{"id":"T205","span":{"begin":153,"end":157},"obj":"G_3;PG_10;PR:000003622"},{"id":"T206","span":{"begin":198,"end":202},"obj":"G_3;PG_10;PR:000003622"},{"id":"T207","span":{"begin":211,"end":217},"obj":"PR:000036009"},{"id":"T208","span":{"begin":221,"end":225},"obj":"PR:000006897"},{"id":"T209","span":{"begin":241,"end":251},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T210","span":{"begin":255,"end":262},"obj":"CHEBI:52290;CHEBI:52290;PR:000000103"},{"id":"T211","span":{"begin":262,"end":289},"obj":"PR:000000103"},{"id":"T212","span":{"begin":291,"end":296},"obj":"PR:000000103"},{"id":"T213","span":{"begin":320,"end":326},"obj":"PR:000036009"},{"id":"T214","span":{"begin":331,"end":335},"obj":"PR:000006897"},{"id":"T332","span":{"begin":11,"end":24},"obj":"PR:000036013"},{"id":"T333","span":{"begin":28,"end":32},"obj":"PR:000036013"},{"id":"T334","span":{"begin":40,"end":53},"obj":"GO:0005576"},{"id":"T335","span":{"begin":61,"end":70},"obj":"GO:0065007"},{"id":"T336","span":{"begin":85,"end":89},"obj":"PR:000000103"},{"id":"T337","span":{"begin":100,"end":106},"obj":"PR:000036009"},{"id":"T338","span":{"begin":170,"end":174},"obj":"PR:000036013"},{"id":"T339","span":{"begin":181,"end":185},"obj":"PR:000003622;G_3;PG_10"},{"id":"T340","span":{"begin":254,"end":259},"obj":"PR:000036013"},{"id":"T341","span":{"begin":298,"end":303},"obj":"PR:000036008"},{"id":"T342","span":{"begin":323,"end":329},"obj":"PR:000036012"}],"attributes":[{"subj":"T198","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T199","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T200","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T201","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T202","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T203","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T204","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T205","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T206","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T207","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T208","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T209","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T210","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T211","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T212","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T213","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T214","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T332","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T333","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T334","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T335","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T336","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T337","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T338","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T339","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T340","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T341","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T342","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"372","span":{"begin":11,"end":15},"obj":"Gene"},{"id":"373","span":{"begin":58,"end":62},"obj":"Gene"},{"id":"374","span":{"begin":153,"end":157},"obj":"Gene"},{"id":"375","span":{"begin":198,"end":202},"obj":"Gene"},{"id":"376","span":{"begin":211,"end":217},"obj":"Gene"},{"id":"377","span":{"begin":255,"end":289},"obj":"Gene"},{"id":"378","span":{"begin":291,"end":296},"obj":"Gene"},{"id":"379","span":{"begin":320,"end":326},"obj":"Gene"}],"attributes":[{"id":"A372","pred":"tao:has_database_id","subj":"372","obj":"Gene:59272"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"Gene:59272"},{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"Gene:59272"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Gene:59272"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Gene:183"},{"id":"A377","pred":"tao:has_database_id","subj":"377","obj":"Gene:5594"},{"id":"A378","pred":"tao:has_database_id","subj":"378","obj":"Gene:5594"},{"id":"A379","pred":"tao:has_database_id","subj":"379","obj":"Gene:183"},{"subj":"372","pred":"source","obj":"LitCovid-PubTator"},{"subj":"373","pred":"source","obj":"LitCovid-PubTator"},{"subj":"374","pred":"source","obj":"LitCovid-PubTator"},{"subj":"375","pred":"source","obj":"LitCovid-PubTator"},{"subj":"376","pred":"source","obj":"LitCovid-PubTator"},{"subj":"377","pred":"source","obj":"LitCovid-PubTator"},{"subj":"378","pred":"source","obj":"LitCovid-PubTator"},{"subj":"379","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#e9ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#d593ec"},{"id":"LitCovid-PD-CLO","color":"#93ecbb"},{"id":"LitCovid-PD-CHEBI","color":"#eca193"},{"id":"LitCovid-sentences","color":"#939fec"},{"id":"LitCovid-PMC-OGER-BB","color":"#b9ec93"},{"id":"LitCovid-PubTator","color":"#ec93d3"}]}]}}