PMC:7161517 / 4279-4686 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":17,"end":20},"obj":"Body_part"},{"id":"T15","span":{"begin":403,"end":406},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":257,"end":260},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0008840"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T30","span":{"begin":309,"end":318},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T44","span":{"begin":17,"end":20},"obj":"Chemical"},{"id":"T45","span":{"begin":78,"end":89},"obj":"Chemical"},{"id":"T46","span":{"begin":129,"end":131},"obj":"Chemical"},{"id":"T47","span":{"begin":140,"end":149},"obj":"Chemical"},{"id":"T48","span":{"begin":208,"end":210},"obj":"Chemical"},{"id":"T49","span":{"begin":246,"end":248},"obj":"Chemical"},{"id":"T50","span":{"begin":403,"end":406},"obj":"Chemical"}],"attributes":[{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_46761"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T12","span":{"begin":309,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T13","span":{"begin":309,"end":318},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-sentences","denotations":[{"id":"T30","span":{"begin":0,"end":100},"obj":"Sentence"},{"id":"T31","span":{"begin":101,"end":171},"obj":"Sentence"},{"id":"T32","span":{"begin":172,"end":272},"obj":"Sentence"},{"id":"T33","span":{"begin":273,"end":407},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T119","span":{"begin":67,"end":72},"obj":"PR:000013883"},{"id":"T120","span":{"begin":78,"end":91},"obj":"PR:000036008"},{"id":"T121","span":{"begin":93,"end":98},"obj":"PR:000036008"},{"id":"T122","span":{"begin":101,"end":104},"obj":"CHEBI:37886;CHEBI:37886;PR:000036008"},{"id":"T123","span":{"begin":105,"end":106},"obj":"PR:000036008;CHEBI:16382;CHEBI:16382"},{"id":"T124","span":{"begin":110,"end":121},"obj":"GO:0008152"},{"id":"T125","span":{"begin":125,"end":128},"obj":"CHEBI:37886;CHEBI:37886"},{"id":"T126","span":{"begin":204,"end":210},"obj":"PR:000036009"},{"id":"T127","span":{"begin":242,"end":248},"obj":"PR:000036009"},{"id":"T128","span":{"begin":287,"end":291},"obj":"G_3;PG_10;PR:000003622"},{"id":"T45363","span":{"begin":371,"end":375},"obj":"G_3;PG_10;PR:000003622"},{"id":"T60689","span":{"begin":385,"end":389},"obj":"NCBITaxon:10088"},{"id":"T27389","span":{"begin":395,"end":401},"obj":"PR:000036009"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"LitCovid-PubTator","denotations":[{"id":"161","span":{"begin":67,"end":72},"obj":"Gene"},{"id":"162","span":{"begin":78,"end":91},"obj":"Gene"},{"id":"163","span":{"begin":93,"end":98},"obj":"Gene"},{"id":"164","span":{"begin":204,"end":210},"obj":"Gene"},{"id":"165","span":{"begin":287,"end":291},"obj":"Gene"},{"id":"166","span":{"begin":101,"end":106},"obj":"Gene"},{"id":"167","span":{"begin":48,"end":63},"obj":"Gene"},{"id":"168","span":{"begin":167,"end":170},"obj":"Gene"},{"id":"169","span":{"begin":125,"end":128},"obj":"Gene"}],"attributes":[{"id":"A161","pred":"tao:has_database_id","subj":"161","obj":"Gene:5972"},{"id":"A162","pred":"tao:has_database_id","subj":"162","obj":"Gene:183"},{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"Gene:183"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Gene:183"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Gene:59272"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Gene:183"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Gene:183"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Gene:1636"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Gene:283"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}

{"project":"2_test","denotations":[{"id":"32305401-29217510-55252919","span":{"begin":212,"end":213},"obj":"29217510"},{"id":"32305401-10773230-55252920","span":{"begin":215,"end":216},"obj":"10773230"},{"id":"32305401-8307637-55252921","span":{"begin":218,"end":219},"obj":"8307637"}],"text":"Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I). Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE. The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors. Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS."}