PMC:7161517 / 30729-31087 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T185","span":{"begin":321,"end":339},"obj":"Body_part"},{"id":"T186","span":{"begin":354,"end":358},"obj":"Body_part"}],"attributes":[{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma82785"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T77","span":{"begin":354,"end":358},"obj":"Body_part"}],"attributes":[{"id":"A77","pred":"uberon_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T164","span":{"begin":217,"end":235},"obj":"Disease"},{"id":"T165","span":{"begin":226,"end":235},"obj":"Disease"}],"attributes":[{"id":"A164","pred":"mondo_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A165","pred":"mondo_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T289","span":{"begin":19,"end":27},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T290","span":{"begin":50,"end":51},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T291","span":{"begin":103,"end":108},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T292","span":{"begin":268,"end":270},"obj":"http://purl.obolibrary.org/obo/CLO_0053799"},{"id":"T293","span":{"begin":311,"end":319},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T294","span":{"begin":354,"end":358},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T295","span":{"begin":354,"end":358},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T323","span":{"begin":52,"end":70},"obj":"Chemical"},{"id":"T324","span":{"begin":150,"end":164},"obj":"Chemical"},{"id":"T325","span":{"begin":154,"end":164},"obj":"Chemical"},{"id":"T326","span":{"begin":321,"end":339},"obj":"Chemical"}],"attributes":[{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_52211"},{"id":"A324","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A325","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A326","pred":"chebi_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/CHEBI_16412"},{"id":"A327","pred":"chebi_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/CHEBI_89981"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":110,"end":320},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T1004","span":{"begin":19,"end":27},"obj":"GO:0016020"},{"id":"T1005","span":{"begin":34,"end":38},"obj":"G_3;PG_10;PR:000003622"},{"id":"T1006","span":{"begin":78,"end":89},"obj":"GO:0006260"},{"id":"T1007","span":{"begin":103,"end":108},"obj":"NCBITaxon:10239"},{"id":"T1008","span":{"begin":154,"end":164},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T1009","span":{"begin":217,"end":225},"obj":"SP_10"},{"id":"T1010","span":{"begin":291,"end":295},"obj":"G_3;PG_10;PR:000003622"},{"id":"T1011","span":{"begin":296,"end":306},"obj":"GO:0010467"},{"id":"T1012","span":{"begin":321,"end":339},"obj":"CHEBI:16412;CHEBI:16412"},{"id":"T1013","span":{"begin":354,"end":358},"obj":"UBERON:0002048"},{"id":"T92838","span":{"begin":19,"end":27},"obj":"GO:0016020"},{"id":"T55000","span":{"begin":34,"end":38},"obj":"G_3;PG_10;PR:000003622"},{"id":"T37615","span":{"begin":78,"end":89},"obj":"GO:0006260"},{"id":"T3663","span":{"begin":103,"end":108},"obj":"NCBITaxon:10239"},{"id":"T77253","span":{"begin":154,"end":164},"obj":"CHEBI:35222;CHEBI:35222"},{"id":"T68013","span":{"begin":217,"end":225},"obj":"SP_10"},{"id":"T90735","span":{"begin":291,"end":295},"obj":"G_3;PG_10;PR:000003622"},{"id":"T99855","span":{"begin":296,"end":306},"obj":"GO:0010467"},{"id":"T45949","span":{"begin":321,"end":339},"obj":"CHEBI:16412;CHEBI:16412"},{"id":"T26573","span":{"begin":354,"end":358},"obj":"UBERON:0002048"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1295","span":{"begin":34,"end":38},"obj":"Gene"},{"id":"1296","span":{"begin":150,"end":153},"obj":"Gene"},{"id":"1297","span":{"begin":291,"end":295},"obj":"Gene"},{"id":"1299","span":{"begin":217,"end":235},"obj":"Disease"},{"id":"1324","span":{"begin":321,"end":339},"obj":"Chemical"}],"attributes":[{"id":"A1295","pred":"tao:has_database_id","subj":"1295","obj":"Gene:59272"},{"id":"A1296","pred":"tao:has_database_id","subj":"1296","obj":"Gene:1636"},{"id":"A1297","pred":"tao:has_database_id","subj":"1297","obj":"Gene:59272"},{"id":"A1299","pred":"tao:has_database_id","subj":"1299","obj":"MESH:C000657245"},{"id":"A1324","pred":"tao:has_database_id","subj":"1324","obj":"MESH:D008070"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}

{"project":"2_test","denotations":[{"id":"32305401-16179584-55252999","span":{"begin":256,"end":258},"obj":"16179584"},{"id":"32305401-15159288-55253000","span":{"begin":260,"end":262},"obj":"15159288"},{"id":"32305401-15833808-55253001","span":{"begin":264,"end":266},"obj":"15833808"},{"id":"32305401-27085217-55253002","span":{"begin":268,"end":270},"obj":"27085217"},{"id":"32305401-15007027-55253003","span":{"begin":272,"end":274},"obj":"15007027"},{"id":"32305401-9461243-55253004","span":{"begin":275,"end":277},"obj":"9461243"}],"text":", it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus. The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.\nLipopolysaccharide-induced acute lung"}