PMC:7161517 / 29803-30139 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T179","span":{"begin":119,"end":123},"obj":"Body_part"},{"id":"T180","span":{"begin":171,"end":179},"obj":"Body_part"},{"id":"T181","span":{"begin":206,"end":219},"obj":"Body_part"},{"id":"T182","span":{"begin":206,"end":210},"obj":"Body_part"},{"id":"T183","span":{"begin":266,"end":271},"obj":"Body_part"}],"attributes":[{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T159","span":{"begin":3,"end":11},"obj":"Disease"},{"id":"T160","span":{"begin":241,"end":250},"obj":"Disease"}],"attributes":[{"id":"A159","pred":"mondo_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A160","pred":"mondo_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T281","span":{"begin":119,"end":123},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T282","span":{"begin":206,"end":210},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T283","span":{"begin":211,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T284","span":{"begin":266,"end":271},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T322","span":{"begin":171,"end":179},"obj":"Chemical"}],"attributes":[{"id":"A322","pred":"chebi_id","subj":"T322","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T78","span":{"begin":155,"end":168},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T79","span":{"begin":294,"end":303},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T182","span":{"begin":0,"end":336},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T978","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T979","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T980","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T981","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T982","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T983","span":{"begin":307,"end":321},"obj":"GO:0005634"},{"id":"T28163","span":{"begin":3,"end":13},"obj":"SP_7"},{"id":"T43635","span":{"begin":26,"end":30},"obj":"G_3;PG_10;PR:000003622"},{"id":"T8828","span":{"begin":86,"end":90},"obj":"G_3;PG_10;PR:000003622"},{"id":"T1098","span":{"begin":91,"end":102},"obj":"SO:0000243"},{"id":"T6321","span":{"begin":201,"end":219},"obj":"GO:0033644"},{"id":"T55209","span":{"begin":307,"end":321},"obj":"GO:0005634"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1281","span":{"begin":26,"end":30},"obj":"Gene"},{"id":"1282","span":{"begin":86,"end":90},"obj":"Gene"},{"id":"1284","span":{"begin":3,"end":13},"obj":"Species"},{"id":"1285","span":{"begin":110,"end":118},"obj":"Disease"},{"id":"1286","span":{"begin":241,"end":250},"obj":"Disease"}],"attributes":[{"id":"A1281","pred":"tao:has_database_id","subj":"1281","obj":"Gene:59272"},{"id":"A1282","pred":"tao:has_database_id","subj":"1282","obj":"Gene:59272"},{"id":"A1284","pred":"tao:has_database_id","subj":"1284","obj":"Tax:2697049"},{"id":"A1285","pred":"tao:has_database_id","subj":"1285","obj":"MESH:D007239"},{"id":"A1286","pred":"tao:has_database_id","subj":"1286","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}

{"project":"2_test","denotations":[{"id":"32305401-25720466-55252996","span":{"begin":332,"end":334},"obj":"25720466"}],"text":"If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66)."}