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PMC:7161517 / 24319-25807 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T69 99-102 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T70 1055-1058 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T71 1447-1450 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T111 15-23 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 196-199 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T113 257-265 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 267-279 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T115 310-318 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 323-330 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 418-426 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 575-583 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 612-620 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 718-726 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 879-887 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 894-897 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T123 1007-1015 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 1112-1134 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T125 1139-1147 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 1245-1253 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 1347-1355 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 1479-1487 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T230 320-322 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T231 510-517 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T232 1267-1272 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T233 1317-1318 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T275 99-102 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T276 178-191 Chemical denotes ACE inhibitor http://purl.obolibrary.org/obo/CHEBI_35457
T277 182-191 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T278 362-376 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T279 374-376 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T280 533-541 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T281 585-593 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T282 691-699 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T283 1055-1058 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T284 1059-1069 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T285 1273-1284 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T286 1447-1450 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T287 1451-1461 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T66 123-133 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T151 0-134 Sentence denotes With regard to COVID-19, there are currently several clinical studies investigating the effects of RAS inhibition and ACE2 regulation.
T152 135-453 Sentence denotes An ongoing study will assess the impact of ACE inhibitor and ARB treatment on the severity and prognosis of patients with COVID-19 (Hypertension in Patients Hospitalized With COVID-19 [HT-COVID19], NCT04318301; ACE Inhibitors, Angiotensin II Type-I Receptor Blockers and Severity of COVID-19 [CODIV-ACE], NCT04318418).
T153 454-771 Sentence denotes Along these lines, there are 2 recently launched trials testing the effects of losartan among patients hospitalized with COVID-19 (Losartan for Patients With COVID-19 Requiring Hospitalization; NCT04312009) and those who are ambulatory (Losartan for Patients With COVID-19 Not Requiring Hospitalization; NCT04311177).
T154 772-1148 Sentence denotes Further studies have been launched to evaluate the effect of continuation versus replacement (Coronavirus [COVID-19] ACEi/ARB Investigation [CORONACION]; NCT04330300) or withdrawal (ACE Inhibitors or ARBs Discontinuation in Context of SARS-CoV-2 Pandemic [ACORES-2]; NCT04329195) of RAS inhibitors on the clinical outcomes in patients with cardiovascular disease and COVID-19.
T155 1149-1370 Sentence denotes There is also an ongoing pilot study assessing the effects of rhACE2 treatment in patients with COVID-19 (Recombinant Human Angiotensin-converting Enzyme 2 [rhACE2] as a Treatment for Patients With COVID-19; NCT04287686).
T156 1371-1488 Sentence denotes Currently, there is no data to support any conclusive effects of the use of RAS inhibitors in patients with COVID-19.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T39 267-279 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T40 1112-1134 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T802 15-23 SP_7 denotes COVID-19
T803 118-122 G_3;PG_10;PR:000003622 denotes ACE2
T804 123-133 GO:0065007 denotes regulation
T805 182-191 CHEBI:35222;CHEBI:35222 denotes inhibitor
T806 257-265 SP_7 denotes COVID-19
T807 310-318 SP_7 denotes COVID-19
T808 323-330 SP_7 denotes COVID19
T809 362-376 DG_37;PR:000036009 denotes Angiotensin II
T810 418-426 SP_7 denotes COVID-19
T811 533-541 CHEBI:6541;CHEBI:6541 denotes losartan
T812 575-583 SP_7 denotes COVID-19
T813 612-620 SP_7 denotes COVID-19
T814 679-689 GO:0040011 denotes ambulatory
T815 718-726 SP_7 denotes COVID-19
T816 866-877 NCBITaxon:11118 denotes Coronavirus
T817 879-887 SP_7 denotes COVID-19
T818 1007-1017 SP_7 denotes SARS-CoV-2
T819 1059-1069 CHEBI:35222;CHEBI:35222 denotes inhibitors
T820 1112-1126 UBERON:0004535 denotes cardiovascular
T821 1139-1147 SP_7 denotes COVID-19
T822 1245-1253 SP_7 denotes COVID-19
T823 1267-1272 SP_6;NCBITaxon:9606;PG_10 denotes Human
T824 1273-1304 PG_10;PR:000003622 denotes Angiotensin-converting Enzyme 2
T825 1347-1355 SP_7 denotes COVID-19
T826 1451-1461 CHEBI:35222;CHEBI:35222 denotes inhibitors
T827 1479-1487 SP_7 denotes COVID-19
T76836 17-25 SP_7 denotes VID-19,
T3029 163-174 NCBITaxon:11118 denotes the impact
T36086 176-184 SP_7 denotes f ACE in
T82622 304-314 SP_7 denotes With COVI
T40928 356-366 CHEBI:35222;CHEBI:35222 denotes tors, Angi
T14768 409-423 UBERON:0004535 denotes erity of COVID
T50691 436-444 SP_7 denotes E], NCT0
T93421 541-549 SP_7 denotes among p
T67192 564-569 SP_6;NCBITaxon:9606;PG_10 denotes lized
T67994 570-601 PG_10;PR:000003622 denotes with COVID-19 (Losartan for Pat
T78338 645-653 SP_7 denotes n; NCT04
T89352 750-760 CHEBI:35222;CHEBI:35222 denotes zation; NC
T71976 778-786 SP_7 denotes r studie
T44016 788-792 G_3;PG_10;PR:000003622 denotes have
T47722 797-807 SP_7 denotes launched
T88225 808-816 SP_10 denotes o evalua
T20549 869-879 SP_7 denotes onavirus [
T74305 931-944 NCBITaxon:11118 denotes 330300) or wi
T20522 972-976 G_3;PG_10;PR:000003622 denotes ARBs
T10417 1082-1089 NCBITaxon:10239 denotes cal out
T82275 1172-1181 SP_7 denotes g pilot s
T54073 1191-1195 G_3;PG_10;PR:000003622 denotes sing
T59849 1257-1265 SP_10 denotes combinan
T87907 1272-1282 SP_7 denotes Angiotens
T87618 1292-1296 G_3;PG_10;PR:000003622 denotes ing
T56047 1335-1342 GO:0009986 denotes tients
T52387 1359-1368 PG_1 denotes T04287686
T22150 1378-1382 G_3;PG_10;PR:000003622 denotes ly,
T49602 1402-1407 NCBITaxon:10239 denotes suppo
T68685 1468-1473 NCBITaxon:10239 denotes ients

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1083 118-122 Gene denotes ACE2 Gene:59272
1084 178-181 Gene denotes ACE Gene:1636
1085 346-349 Gene denotes ACE Gene:1636
1086 362-376 Gene denotes Angiotensin II Gene:183
1087 434-437 Gene denotes ACE Gene:1636
1088 1273-1304 Gene denotes Angiotensin-converting Enzyme 2 Gene:59272
1089 954-957 Gene denotes ACE Gene:1636
1090 243-251 Species denotes patients Tax:9606
1091 283-291 Species denotes Patients Tax:9606
1092 548-556 Species denotes patients Tax:9606
1093 598-606 Species denotes Patients Tax:9606
1094 704-712 Species denotes Patients Tax:9606
1095 866-877 Species denotes Coronavirus Tax:11118
1096 1007-1017 Species denotes SARS-CoV-2 Tax:2697049
1097 1098-1106 Species denotes patients Tax:9606
1098 1231-1239 Species denotes patients Tax:9606
1099 1267-1272 Species denotes Human Tax:9606
1100 1333-1341 Species denotes Patients Tax:9606
1101 1465-1473 Species denotes patients Tax:9606
1102 533-541 Chemical denotes losartan MESH:D019808
1103 585-593 Chemical denotes Losartan MESH:D019808
1104 691-699 Chemical denotes Losartan MESH:D019808
1105 1211-1217 Chemical denotes rhACE2
1106 1306-1312 Chemical denotes rhACE2
1107 15-23 Disease denotes COVID-19 MESH:C000657245
1108 257-265 Disease denotes COVID-19 MESH:C000657245
1109 267-279 Disease denotes Hypertension MESH:D006973
1110 310-318 Disease denotes COVID-19 MESH:C000657245
1111 320-330 Disease denotes HT-COVID19 MESH:C000657245
1112 418-426 Disease denotes COVID-19 MESH:C000657245
1113 575-583 Disease denotes COVID-19 MESH:C000657245
1114 612-620 Disease denotes COVID-19 MESH:C000657245
1115 718-726 Disease denotes COVID-19 MESH:C000657245
1116 879-887 Disease denotes COVID-19 MESH:C000657245
1117 1112-1134 Disease denotes cardiovascular disease MESH:D002318
1118 1139-1147 Disease denotes COVID-19 MESH:C000657245
1119 1245-1253 Disease denotes COVID-19 MESH:C000657245
1120 1347-1355 Disease denotes COVID-19 MESH:C000657245
1121 1479-1487 Disease denotes COVID-19 MESH:C000657245