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PMC:7161517 / 23123-25807 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T138 227-237 Body_part denotes troponin I http://purl.org/sig/ont/fma/fma62340
T139 227-235 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T140 250-257 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T69 1295-1298 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T70 2251-2254 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T71 2643-2646 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T100 6-14 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T101 69-77 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 176-184 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 330-336 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T104 523-565 Disease denotes ST-segment elevation myocardial infarction http://purl.obolibrary.org/obo/MONDO_0041656
T105 544-565 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T106 626-642 Disease denotes coronary disease http://purl.obolibrary.org/obo/MONDO_0005010
T107 688-696 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 753-759 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T109 794-804 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T110 856-862 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T111 1211-1219 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 1392-1395 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T113 1453-1461 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 1463-1475 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T115 1506-1514 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 1519-1526 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 1614-1622 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 1771-1779 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 1808-1816 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 1914-1922 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 2075-2083 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 2090-2093 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T123 2203-2211 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 2308-2330 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T125 2335-2343 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 2441-2449 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 2543-2551 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 2675-2683 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T224 278-279 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T225 297-304 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T226 523-525 http://purl.obolibrary.org/obo/CLO_0009141 denotes ST
T227 523-525 http://purl.obolibrary.org/obo/CLO_0050980 denotes ST
T228 652-653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 882-883 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 1516-1518 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T231 1706-1713 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T232 2463-2468 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T233 2513-2514 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T272 250-257 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T273 297-304 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T274 523-525 Chemical denotes ST http://purl.obolibrary.org/obo/CHEBI_141393
T275 1295-1298 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T276 1374-1387 Chemical denotes ACE inhibitor http://purl.obolibrary.org/obo/CHEBI_35457
T277 1378-1387 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T278 1558-1572 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T279 1570-1572 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T280 1729-1737 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T281 1781-1789 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T282 1887-1895 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T283 2251-2254 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T284 2255-2265 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T285 2469-2480 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T286 2643-2646 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T287 2647-2657 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T66 1319-1329 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T144 0-41 Sentence denotes ACE2, COVID-19, and Cardiovascular Damage
T145 42-117 Sentence denotes Several reports have noted COVID-19 is associated with cardiac involvement.
T146 118-347 Sentence denotes In cohort studies of hospitalized patients with confirmed COVID-19, several patients presented with elevated troponin I, C-reactive protein, and N-terminal pro–B-type natriuretic peptide suggestive of myocardial injury (2,59,60).
T147 348-648 Sentence denotes Anecdotal studies have reported patients presenting with cardiac magnetic resonance imagining−verified acute myopericarditis with systolic dysfunction masquerading as diffuse ST-segment elevation myocardial infarction with elevated cardiac markers in the absence of obstructive coronary disease (59).
T148 649-810 Sentence denotes In a cohort study of 139 patients with COVID-19 hospitalized in Wuhan, China, 7.2% had acute myocardial injury, 8.7% had shock, and 16.7% had an arrhythmia (61).
T149 811-962 Sentence denotes Of the observed patients, those with cardiac injury were found to have a high risk of death both from time of symptom onset and time of admission (60).
T150 963-1195 Sentence denotes As more epidemiological studies emerge from China, Italy, and other affected areas, more data will be available to elucidate the clinical presentation of patients and the cardiovascular damage associated with this novel coronavirus.
T151 1196-1330 Sentence denotes With regard to COVID-19, there are currently several clinical studies investigating the effects of RAS inhibition and ACE2 regulation.
T152 1331-1649 Sentence denotes An ongoing study will assess the impact of ACE inhibitor and ARB treatment on the severity and prognosis of patients with COVID-19 (Hypertension in Patients Hospitalized With COVID-19 [HT-COVID19], NCT04318301; ACE Inhibitors, Angiotensin II Type-I Receptor Blockers and Severity of COVID-19 [CODIV-ACE], NCT04318418).
T153 1650-1967 Sentence denotes Along these lines, there are 2 recently launched trials testing the effects of losartan among patients hospitalized with COVID-19 (Losartan for Patients With COVID-19 Requiring Hospitalization; NCT04312009) and those who are ambulatory (Losartan for Patients With COVID-19 Not Requiring Hospitalization; NCT04311177).
T154 1968-2344 Sentence denotes Further studies have been launched to evaluate the effect of continuation versus replacement (Coronavirus [COVID-19] ACEi/ARB Investigation [CORONACION]; NCT04330300) or withdrawal (ACE Inhibitors or ARBs Discontinuation in Context of SARS-CoV-2 Pandemic [ACORES-2]; NCT04329195) of RAS inhibitors on the clinical outcomes in patients with cardiovascular disease and COVID-19.
T155 2345-2566 Sentence denotes There is also an ongoing pilot study assessing the effects of rhACE2 treatment in patients with COVID-19 (Recombinant Human Angiotensin-converting Enzyme 2 [rhACE2] as a Treatment for Patients With COVID-19; NCT04287686).
T156 2567-2684 Sentence denotes Currently, there is no data to support any conclusive effects of the use of RAS inhibitors in patients with COVID-19.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T34 523-543 Phenotype denotes ST-segment elevation http://purl.obolibrary.org/obo/HP_0012251
T35 544-565 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T36 626-642 Phenotype denotes coronary disease http://purl.obolibrary.org/obo/HP_0001677
T37 770-775 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T38 794-804 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T39 1463-1475 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T40 2308-2330 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T784 0-4 G_3;PG_10;PR:000003622 denotes ACE2
T785 6-14 SP_7 denotes COVID-19
T786 20-34 UBERON:0004535 denotes Cardiovascular
T787 69-77 SP_7 denotes COVID-19
T788 97-104 UBERON:0000948 denotes cardiac
T789 176-184 SP_7 denotes COVID-19
T790 239-257 PR:000005897 denotes C-reactive protein
T791 319-329 UBERON:0002349 denotes myocardial
T792 405-412 UBERON:0000948 denotes cardiac
T793 544-554 UBERON:0002349 denotes myocardial
T794 580-587 UBERON:0000948 denotes cardiac
T795 626-634 UBERON:0001621 denotes coronary
T796 688-696 SP_7 denotes COVID-19
T797 742-752 UBERON:0002349 denotes myocardial
T798 848-855 UBERON:0000948 denotes cardiac
T799 897-902 GO:0016265 denotes death
T800 1134-1148 UBERON:0004535 denotes cardiovascular
T801 1183-1194 NCBITaxon:11118 denotes coronavirus
T802 1211-1219 SP_7 denotes COVID-19
T803 1314-1318 G_3;PG_10;PR:000003622 denotes ACE2
T804 1319-1329 GO:0065007 denotes regulation
T805 1378-1387 CHEBI:35222;CHEBI:35222 denotes inhibitor
T806 1453-1461 SP_7 denotes COVID-19
T807 1506-1514 SP_7 denotes COVID-19
T808 1519-1526 SP_7 denotes COVID19
T809 1558-1572 DG_37;PR:000036009 denotes Angiotensin II
T810 1614-1622 SP_7 denotes COVID-19
T811 1729-1737 CHEBI:6541;CHEBI:6541 denotes losartan
T812 1771-1779 SP_7 denotes COVID-19
T813 1808-1816 SP_7 denotes COVID-19
T814 1875-1885 GO:0040011 denotes ambulatory
T815 1914-1922 SP_7 denotes COVID-19
T816 2062-2073 NCBITaxon:11118 denotes Coronavirus
T817 2075-2083 SP_7 denotes COVID-19
T818 2203-2213 SP_7 denotes SARS-CoV-2
T819 2255-2265 CHEBI:35222;CHEBI:35222 denotes inhibitors
T820 2308-2322 UBERON:0004535 denotes cardiovascular
T821 2335-2343 SP_7 denotes COVID-19
T822 2441-2449 SP_7 denotes COVID-19
T823 2463-2468 SP_6;NCBITaxon:9606;PG_10 denotes Human
T824 2469-2500 PG_10;PR:000003622 denotes Angiotensin-converting Enzyme 2
T825 2543-2551 SP_7 denotes COVID-19
T826 2647-2657 CHEBI:35222;CHEBI:35222 denotes inhibitors
T827 2675-2683 SP_7 denotes COVID-19
T74256 196-201 GO:0016265 denotes tient
T20349 430-444 UBERON:0004535 denotes e imagining−ve
T79848 479-490 NCBITaxon:11118 denotes ystolic dys
T82178 507-515 SP_7 denotes ding as
T45 69-77 SP_7 denotes COVID-19
T46 97-104 UBERON:0000948 denotes cardiac
T31987 40-50 UBERON:0002349 denotes e Several
T2470 147-154 UBERON:0000948 denotes ized pa
T26035 610-614 G_3;PG_10;PR:000003622 denotes of
T10049 615-625 GO:0065007 denotes bstructive
T65218 674-683 CHEBI:35222;CHEBI:35222 denotes patients
T55523 752-760 SP_7 denotes injury,
T53933 804-812 SP_7 denotes (61). O
T49807 817-824 SP_7 denotes observ
T79663 856-870 DG_37;PR:000036009 denotes injury were fo
T15361 912-920 SP_7 denotes time of
T52890 1030-1038 CHEBI:6541;CHEBI:6541 denotes affecte
T87551 1071-1079 SP_7 denotes ble to e
T34732 1108-1116 SP_7 denotes ation of
T23219 1174-1184 GO:0040011 denotes is novel c
T76836 1213-1221 SP_7 denotes VID-19,
T3029 1359-1370 NCBITaxon:11118 denotes the impact
T36086 1372-1380 SP_7 denotes f ACE in
T82622 1500-1510 SP_7 denotes With COVI
T40928 1552-1562 CHEBI:35222;CHEBI:35222 denotes tors, Angi
T14768 1605-1619 UBERON:0004535 denotes erity of COVID
T50691 1632-1640 SP_7 denotes E], NCT0
T93421 1737-1745 SP_7 denotes among p
T67192 1760-1765 SP_6;NCBITaxon:9606;PG_10 denotes lized
T67994 1766-1797 PG_10;PR:000003622 denotes with COVID-19 (Losartan for Pat
T78338 1841-1849 SP_7 denotes n; NCT04
T89352 1946-1956 CHEBI:35222;CHEBI:35222 denotes zation; NC
T71976 1974-1982 SP_7 denotes r studie
T44016 1984-1988 G_3;PG_10;PR:000003622 denotes have
T47722 1993-2003 SP_7 denotes launched
T88225 2004-2012 SP_10 denotes o evalua
T20549 2065-2075 SP_7 denotes onavirus [
T74305 2127-2140 NCBITaxon:11118 denotes 330300) or wi
T20522 2168-2172 G_3;PG_10;PR:000003622 denotes ARBs
T10417 2278-2285 NCBITaxon:10239 denotes cal out
T82275 2368-2377 SP_7 denotes g pilot s
T54073 2387-2391 G_3;PG_10;PR:000003622 denotes sing
T59849 2453-2461 SP_10 denotes combinan
T87907 2468-2478 SP_7 denotes Angiotens
T87618 2488-2492 G_3;PG_10;PR:000003622 denotes ing
T56047 2531-2538 GO:0009986 denotes tients
T52387 2555-2564 PG_1 denotes T04287686
T22150 2574-2578 G_3;PG_10;PR:000003622 denotes ly,
T49602 2598-2603 NCBITaxon:10239 denotes suppo
T68685 2664-2669 NCBITaxon:10239 denotes ients

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
995 0-4 Gene denotes ACE2 Gene:59272
996 6-14 Disease denotes COVID-19 MESH:C000657245
997 20-41 Disease denotes Cardiovascular Damage MESH:D002318
1021 239-257 Gene denotes C-reactive protein Gene:1401
1022 152-160 Species denotes patients Tax:9606
1023 194-202 Species denotes patients Tax:9606
1024 380-388 Species denotes patients Tax:9606
1025 674-682 Species denotes patients Tax:9606
1026 827-835 Species denotes patients Tax:9606
1027 1117-1125 Species denotes patients Tax:9606
1028 1177-1194 Species denotes novel coronavirus Tax:2697049
1029 69-77 Disease denotes COVID-19 MESH:C000657245
1030 97-116 Disease denotes cardiac involvement MESH:D006331
1031 176-184 Disease denotes COVID-19 MESH:C000657245
1032 319-336 Disease denotes myocardial injury MESH:D009202
1033 451-472 Disease denotes acute myopericarditis MESH:D059787
1034 478-498 Disease denotes systolic dysfunction MESH:D006331
1035 544-565 Disease denotes myocardial infarction MESH:D009203
1036 603-642 Disease denotes absence of obstructive coronary disease MESH:D003324
1037 688-696 Disease denotes COVID-19 MESH:C000657245
1038 742-759 Disease denotes myocardial injury MESH:D009202
1039 770-775 Disease denotes shock MESH:D012769
1040 794-804 Disease denotes arrhythmia MESH:D001145
1041 848-862 Disease denotes cardiac injury MESH:D006331
1042 897-902 Disease denotes death MESH:D003643
1043 1134-1155 Disease denotes cardiovascular damage MESH:D002318
1083 1314-1318 Gene denotes ACE2 Gene:59272
1084 1374-1377 Gene denotes ACE Gene:1636
1085 1542-1545 Gene denotes ACE Gene:1636
1086 1558-1572 Gene denotes Angiotensin II Gene:183
1087 1630-1633 Gene denotes ACE Gene:1636
1088 2469-2500 Gene denotes Angiotensin-converting Enzyme 2 Gene:59272
1089 2150-2153 Gene denotes ACE Gene:1636
1090 1439-1447 Species denotes patients Tax:9606
1091 1479-1487 Species denotes Patients Tax:9606
1092 1744-1752 Species denotes patients Tax:9606
1093 1794-1802 Species denotes Patients Tax:9606
1094 1900-1908 Species denotes Patients Tax:9606
1095 2062-2073 Species denotes Coronavirus Tax:11118
1096 2203-2213 Species denotes SARS-CoV-2 Tax:2697049
1097 2294-2302 Species denotes patients Tax:9606
1098 2427-2435 Species denotes patients Tax:9606
1099 2463-2468 Species denotes Human Tax:9606
1100 2529-2537 Species denotes Patients Tax:9606
1101 2661-2669 Species denotes patients Tax:9606
1102 1729-1737 Chemical denotes losartan MESH:D019808
1103 1781-1789 Chemical denotes Losartan MESH:D019808
1104 1887-1895 Chemical denotes Losartan MESH:D019808
1105 2407-2413 Chemical denotes rhACE2
1106 2502-2508 Chemical denotes rhACE2
1107 1211-1219 Disease denotes COVID-19 MESH:C000657245
1108 1453-1461 Disease denotes COVID-19 MESH:C000657245
1109 1463-1475 Disease denotes Hypertension MESH:D006973
1110 1506-1514 Disease denotes COVID-19 MESH:C000657245
1111 1516-1526 Disease denotes HT-COVID19 MESH:C000657245
1112 1614-1622 Disease denotes COVID-19 MESH:C000657245
1113 1771-1779 Disease denotes COVID-19 MESH:C000657245
1114 1808-1816 Disease denotes COVID-19 MESH:C000657245
1115 1914-1922 Disease denotes COVID-19 MESH:C000657245
1116 2075-2083 Disease denotes COVID-19 MESH:C000657245
1117 2308-2330 Disease denotes cardiovascular disease MESH:D002318
1118 2335-2343 Disease denotes COVID-19 MESH:C000657245
1119 2441-2449 Disease denotes COVID-19 MESH:C000657245
1120 2543-2551 Disease denotes COVID-19 MESH:C000657245
1121 2675-2683 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32305401-31986264-55252981 338-339 31986264 denotes 2