PMC:7161517 / 22164-23121 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	fma_id
T132	57-61	Body_part	denotes	axis	http://purl.org/sig/ont/fma/fma12520
T133	198-205	Body_part	denotes	Insulin	http://purl.org/sig/ont/fma/fma83365
T134	419-424	Body_part	denotes	cells	http://purl.org/sig/ont/fma/fma68646
T135	583-589	Body_part	denotes	Tissue	http://purl.org/sig/ont/fma/fma9637
T136	654-658	Body_part	denotes	axis	http://purl.org/sig/ont/fma/fma12520
T137	791-795	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T67	53-56	Body_part	denotes	RAS	http://purl.obolibrary.org/obo/UBERON_0018229
T68	583-589	Body_part	denotes	Tissue	http://purl.obolibrary.org/obo/UBERON_0000479

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T92	147-155	Disease	denotes	diabetes	http://purl.obolibrary.org/obo/MONDO_0005015
T93	194-233	Disease	denotes	Non-Insulin Dependent Diabetes Mellitus	http://purl.obolibrary.org/obo/MONDO_0005148
T94	198-233	Disease	denotes	Insulin Dependent Diabetes Mellitus	http://purl.obolibrary.org/obo/MONDO_0005147
T95	235-240	Disease	denotes	NIDDM	http://purl.obolibrary.org/obo/MONDO_0005148\|http://purl.obolibrary.org/obo/MONDO_0007455
T97	505-524	Disease	denotes	myocardial ischemia	http://purl.obolibrary.org/obo/MONDO_0024644
T98	516-524	Disease	denotes	ischemia	http://purl.obolibrary.org/obo/MONDO_0005053
T99	549-571	Disease	denotes	Cardiovascular Disease	http://purl.obolibrary.org/obo/MONDO_0004995

Id	Subject	Object	Predicate	Lexical cue
T220	105-113	http://purl.obolibrary.org/obo/CLO_0001658	denotes	activity
T221	198-205	http://purl.obolibrary.org/obo/PR_000009054	denotes	Insulin
T222	419-424	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T223	791-795	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell

Id	Subject	Object	Predicate	Lexical cue	chebi_id
T268	53-56	Chemical	denotes	RAS	http://purl.obolibrary.org/obo/CHEBI_63620
T269	181-192	Chemical	denotes	candesartan	http://purl.obolibrary.org/obo/CHEBI_3347
T270	198-205	Chemical	denotes	Insulin	http://purl.obolibrary.org/obo/CHEBI_5931
T271	246-257	Chemical	denotes	Angiotensin	http://purl.obolibrary.org/obo/CHEBI_2719

Id	Subject	Object	Predicate	Lexical cue
T139	0-70	Sentence	denotes	Ongoing clinical studies assessing the modulation of RAS axis include:
T140	71-285	Sentence	denotes	1) the assessment of the relative activity of ACE and ACE2 in patients with diabetes following treatment with candesartan (Non-Insulin Dependent Diabetes Mellitus [NIDDM] and Angiotensin Converting Enzyme 2 [ACE2]:
T141	286-604	Sentence	denotes	Diabetic Patients Treated With Antihypertensive Drugs; NCT00192803); and 2) the overexpression of ACE2/Ang 1-7 in cardiac progenitor cells to assess for enhancement in reparative function and the potential to attenuate myocardial ischemia−induced cardiac damage (Cardiovascular Disease Protection Tissue; NCT02348515).
T142	605-811	Sentence	denotes	It is evident that targeting the ACE2/Ang1-7/Mas axis is going to be interesting in clinical settings because of the observed cardioprotective effects in the in vivo murine and in vitro cell culture models.
T143	812-957	Sentence	denotes	However, further investigation is required to demonstrate whether these favorable experimental effects could be translated into clinical benefit.

Id	Subject	Object	Predicate	Lexical cue	hp_id
T31	194-233	Phenotype	denotes	Non-Insulin Dependent Diabetes Mellitus	http://purl.obolibrary.org/obo/HP_0005978
T32	235-240	Phenotype	denotes	NIDDM	http://purl.obolibrary.org/obo/HP_0005978
T33	549-571	Phenotype	denotes	Cardiovascular Disease	http://purl.obolibrary.org/obo/HP_0001626

Id	Subject	Object	Predicate	Lexical cue
T766	39-49	GO:0065007	denotes	modulation
T767	125-129	G_3;PG_10;PR:000003622	denotes	ACE2
T768	198-205	PR:000009054	denotes	Insulin
T769	246-277	PG_10;PR:000003622	denotes	Angiotensin Converting Enzyme 2
T770	279-283	G_3;PG_10;PR:000003622	denotes	ACE2
T771	334-339	CHEBI:23888;CHEBI:23888	denotes	Drugs
T772	366-380	GO:0010467	denotes	overexpression
T773	384-388	G_3;PG_10;PR:000003622	denotes	ACE2
T774	389-396	PR:000036013	denotes	Ang 1-7
T775	400-407	UBERON:0000948	denotes	cardiac
T776	505-515	UBERON:0002349	denotes	myocardial
T777	533-540	UBERON:0000948	denotes	cardiac
T778	549-563	UBERON:0004535	denotes	Cardiovascular
T779	583-589	UBERON:0000479	denotes	Tissue
T780	638-642	G_3;PG_10;PR:000003622	denotes	ACE2
T781	643-647	PR:000036013	denotes	Ang1
T782	771-777	NCBITaxon:39107	denotes	murine
T783	782-795	CL:0001034	denotes	in vitro cell
T83220	71-76	NCBITaxon:39107	denotes	1) th
T99627	81-94	CL:0001034	denotes	essment of th
T57790	257-261	G_3;PG_10;PR:000003622	denotes	Con
T74175	263-271	SP_7	denotes	rting En
T41191	277-291	UBERON:0004535	denotes	[ACE2]: Diabe
T25778	326-334	SP_7	denotes	tensive
T84221	354-361	UBERON:0000948	denotes	and 2)
T89571	432-440	SP_7	denotes	ss for e
T85711	495-514	PR:000005897	denotes	attenuate myocardia
T57094	576-586	UBERON:0002349	denotes	ection Tis
T15258	663-670	UBERON:0000948	denotes	oing to
T1531	803-813	UBERON:0002349	denotes	models. H
T97341	839-846	UBERON:0000948	denotes	ion is
T2733	885-893	UBERON:0001621	denotes	avorable
T89171	947-955	SP_7	denotes	l benefi

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
974	117-120	Gene	denotes	ACE	Gene:1636
975	125-129	Gene	denotes	ACE2	Gene:59272
976	246-277	Gene	denotes	Angiotensin Converting Enzyme 2	Gene:59272
977	279-283	Gene	denotes	ACE2	Gene:59272
978	384-388	Gene	denotes	ACE2	Gene:59272
979	389-396	Gene	denotes	Ang 1-7	Gene:284
980	638-642	Gene	denotes	ACE2	Gene:70008
981	643-649	Gene	denotes	Ang1-7	Gene:11727
982	133-141	Species	denotes	patients	Tax:9606
983	295-303	Species	denotes	Patients	Tax:9606
984	771-777	Species	denotes	murine	Tax:10090
985	147-155	Disease	denotes	diabetes	MESH:D003920
986	194-233	Disease	denotes	Non-Insulin Dependent Diabetes Mellitus	MESH:D003924
987	235-240	Disease	denotes	NIDDM	MESH:D003924
988	286-294	Disease	denotes	Diabetic	MESH:D003920
989	505-524	Disease	denotes	myocardial ischemia	MESH:D003324
990	533-547	Disease	denotes	cardiac damage	MESH:D006331
991	549-571	Disease	denotes	Cardiovascular Disease	MESH:D002318