PMC:7161517 / 17805-19353
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T107 | 381-392 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
| T108 | 596-600 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T109 | 659-663 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T110 | 783-789 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T111 | 812-818 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T112 | 865-869 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T113 | 1003-1007 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T114 | 1543-1547 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T56 | 381-392 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T75 | 504-507 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T176 | 381-392 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T177 | 526-528 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
| T178 | 596-600 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T179 | 677-685 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T180 | 783-789 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T181 | 812-818 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T182 | 1055-1056 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T183 | 1057-1063 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T184 | 1318-1328 | http://purl.obolibrary.org/obo/PR_000001898 | denotes | neprilysin |
| T185 | 1467-1473 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T186 | 1509-1519 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T226 | 24-38 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T227 | 28-38 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T228 | 90-104 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T229 | 94-104 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T230 | 209-223 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T231 | 213-223 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T232 | 263-265 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T233 | 296-306 | Chemical | denotes | bradykinin | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T234 | 360-370 | Chemical | denotes | bradykinin | http://purl.obolibrary.org/obo/CHEBI_3165 |
| T235 | 434-447 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T236 | 452-464 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T237 | 459-464 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
| T239 | 631-633 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T240 | 745-753 | Chemical | denotes | losartan | http://purl.obolibrary.org/obo/CHEBI_6541 |
| T241 | 823-825 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T242 | 898-906 | Chemical | denotes | losartan | http://purl.obolibrary.org/obo/CHEBI_6541 |
| T243 | 935-943 | Chemical | denotes | losartan | http://purl.obolibrary.org/obo/CHEBI_6541 |
| T244 | 948-958 | Chemical | denotes | lisinopril | http://purl.obolibrary.org/obo/CHEBI_43755 |
| T245 | 1025-1039 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T246 | 1029-1039 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T247 | 1117-1119 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T248 | 1296-1300 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T250 | 1410-1424 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T251 | 1414-1424 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T58 | 403-415 | http://purl.obolibrary.org/obo/GO_0042311 | denotes | vasodilation |
| T59 | 486-496 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T60 | 634-643 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T61 | 1084-1097 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T113 | 0-55 | Sentence | denotes | The mechanisms by which ACE inhibitors act are complex. |
| T114 | 56-208 | Sentence | denotes | Although ACE2 is not inhibited by ACE inhibitors (19), an increase in Ang1-7 suggests their clinical effects are partly mediated by the angiotensinases. |
| T115 | 209-307 | Sentence | denotes | ACE inhibitors inhibit the conversion of Ang I to Ang II and inhibit the hydrolysis of bradykinin. |
| T116 | 308-530 | Sentence | denotes | ACE inhibition promotes the vasodilatory effects of bradykinin, improved endothelium-dependent vasodilation through increased prostaglandin and nitric oxide production, and down regulation of the AT1 receptor (50, 51, 52). |
| T117 | 531-691 | Sentence | denotes | Studies that elucidated the effect of ACE inhibition on the ACE2 gene showed that inhibition of Ang II synthesis regulated ACE2 mRNA but not ACE2 activity (53). |
| T118 | 692-831 | Sentence | denotes | However, ACE inhibition alone or in combination with losartan was demonstrated to increase plasma Ang1-7 while reducing plasma Ang II (53). |
| T119 | 832-1103 | Sentence | denotes | Compared with the degree of ACE2 mRNA upregulation seen with post-losartan monotherapy, combination of losartan and lisinopril resulted in suppressed upregulation of ACE2 mRNA, which suggested ACE inhibitors might override a signal that regulates ACE2 transcription (53). |
| T120 | 1104-1385 | Sentence | denotes | Although Ang II is the predominant substrate, ACE2 can also convert Ang I into Ang 1-9, which, in turn, could be converted to Ang 1-7 via ACE; Ang I can be directly converted into Ang 1-7 via zinc metallopeptidase neprilysin (17), although with less favorable kinetics at baseline. |
| T121 | 1386-1548 | Sentence | denotes | Thus, it can be assumed ACE inhibitors disrupt the balance between catalytically active ACE and ACE2, resulting in favored activation of the ACE2/Ang1-7/Mas axis. |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T662 | 28-38 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T663 | 65-69 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T664 | 94-104 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T665 | 126-130 | PR:000036013 | denotes | Ang1 |
| T666 | 213-223 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T667 | 250-253 | PR:000036008 | denotes | Ang |
| T668 | 254-255 | PR:000036008;CHEBI:16382;CHEBI:16382 | denotes | I |
| T669 | 259-262 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | Ang |
| T670 | 263-265 | PR:000036009 | denotes | II |
| T671 | 282-292 | MOP:0000619 | denotes | hydrolysis |
| T672 | 296-306 | CHEBI:3165;CHEBI:3165 | denotes | bradykinin |
| T673 | 360-370 | CHEBI:3165;CHEBI:3165 | denotes | bradykinin |
| T674 | 381-392 | UBERON:0001986;GO:0017156 | denotes | endothelium |
| T675 | 392-402 | GO:0017156 | denotes | -dependent |
| T676 | 403-415 | GO:0042311 | denotes | vasodilation |
| T677 | 434-447 | CHEBI:26333;CHEBI:26333 | denotes | prostaglandin |
| T678 | 452-464 | CHEBI:16480;CHEBI:16480 | denotes | nitric oxide |
| T679 | 504-507 | PR:000001251 | denotes | AT1 |
| T680 | 591-595 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T681 | 596-600 | SO:0000704 | denotes | gene |
| T682 | 627-630 | CHEBI:37886;CHEBI:37886;PR:000036009;GO:0034205 | denotes | Ang |
| T683 | 631-633 | PR:000036009;GO:0034205 | denotes | II |
| T684 | 634-643 | GO:0034205 | denotes | synthesis |
| T685 | 644-653 | GO:0065007 | denotes | regulated |
| T686 | 654-658 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T687 | 672-676 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T688 | 745-753 | CHEBI:6541;CHEBI:6541 | denotes | losartan |
| T689 | 783-789 | UBERON:0001969 | denotes | plasma |
| T690 | 790-794 | PR:000036013 | denotes | Ang1 |
| T691 | 812-818 | UBERON:0001969 | denotes | plasma |
| T692 | 819-825 | PR:000036009 | denotes | Ang II |
| T693 | 860-864 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T694 | 898-906 | CHEBI:6541;CHEBI:6541 | denotes | losartan |
| T695 | 935-943 | CHEBI:6541;CHEBI:6541 | denotes | losartan |
| T696 | 948-958 | CHEBI:43755;CHEBI:43755 | denotes | lisinopril |
| T697 | 998-1002 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T698 | 1029-1039 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T699 | 1069-1078 | GO:0065007 | denotes | regulates |
| T700 | 1079-1083 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T701 | 1113-1119 | PR:000036009 | denotes | Ang II |
| T702 | 1150-1154 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T703 | 1172-1177 | PR:000036008 | denotes | Ang I |
| T704 | 1183-1188 | PR:000036012 | denotes | Ang 1 |
| T705 | 1247-1252 | PR:000036008 | denotes | Ang I |
| T706 | 1284-1289 | PR:000036013 | denotes | Ang 1 |
| T707 | 1318-1328 | PR:000001898 | denotes | neprilysin |
| T708 | 1414-1424 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T709 | 1482-1486 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T710 | 1527-1531 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T711 | 1532-1536 | PR:000036013 | denotes | Ang1 |
| T7666 | 46-54 | CHEBI:6541;CHEBI:6541 | denotes | complex |
| T40696 | 84-90 | UBERON:0001969 | denotes | ed by |
| T51121 | 91-95 | PR:000036013 | denotes | CE i |
| T58974 | 113-119 | UBERON:0001969 | denotes | incre |
| T80784 | 120-126 | PR:000036009 | denotes | se in |
| T33334 | 161-165 | G_3;PG_10;PR:000003622 | denotes | cts |
| T83597 | 199-207 | CHEBI:6541;CHEBI:6541 | denotes | nsinases |
| T62347 | 236-244 | CHEBI:6541;CHEBI:6541 | denotes | conversi |
| T16234 | 249-259 | CHEBI:43755;CHEBI:43755 | denotes | Ang I to |
| T90761 | 299-303 | G_3;PG_10;PR:000003622 | denotes | dyki |
| T25248 | 330-340 | CHEBI:35222;CHEBI:35222 | denotes | s the vaso |
| T50049 | 370-379 | GO:0065007 | denotes | , improve |
| T45483 | 380-384 | G_3;PG_10;PR:000003622 | denotes | end |
| T32689 | 414-420 | PR:000036009 | denotes | n thro |
| T27991 | 451-455 | PR:000003622;G_3;PG_10 | denotes | nit |
| T22569 | 474-479 | PR:000036008 | denotes | n, an |
| T41693 | 485-490 | PR:000036012 | denotes | regu |
| T9119 | 549-554 | PR:000036008 | denotes | dated |
| T90264 | 586-591 | PR:000036013 | denotes | the |
| T46244 | 618-628 | PR:000001898 | denotes | ition of A |
| T39670 | 714-724 | CHEBI:35222;CHEBI:35222 | denotes | n alone or |
| T35970 | 782-786 | G_3;PG_10;PR:000003622 | denotes | pla |
| T45388 | 827-831 | G_3;PG_10;PR:000003622 | denotes | 53). |
| T37721 | 832-836 | PR:000036013 | denotes | Comp |
| T77914 | 922-936 | GO:0007596 | denotes | mbination of l |
| T92396 | 965-969 | G_3;PG_10;PR:000003622 | denotes | ed i |
| T36791 | 970-974 | PR:000036013 | denotes | sup |
| T91226 | 977-980 | PR:000001563 | denotes | sse |
| T41455 | 1045-1049 | G_3;PG_10;PR:000003622 | denotes | ove |
| T47287 | 1054-1058 | PR:000036013 | denotes | a s |
| T94041 | 1078-1082 | G_3;PG_10;PR:000003622 | denotes | ACE |
| T46256 | 1083-1092 | GO:0065007 | denotes | transcri |
| T27522 | 1119-1125 | PR:000036009 | denotes | is th |
| T18328 | 1126-1129 | PR:000001251 | denotes | pr |
| T97445 | 1171-1175 | G_3;PG_10;PR:000003622 | denotes | Ang |
| T95349 | 1176-1180 | PR:000036013 | denotes | I in |
| T57032 | 1299-1311 | UBERON:0001004 | denotes | c metallopep |
| T84387 | 1348-1366 | UBERON:0002012 | denotes | less favorable ki |
| T17302 | 1389-1394 | NCBITaxon:39107 | denotes | s, it |
| T83070 | 1423-1432 | GO:0065007 | denotes | s disrupt |
| T26990 | 1503-1509 | NCBITaxon:9606 | denotes | vored |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 796 | 24-27 | Gene | denotes | ACE | Gene:1636 |
| 797 | 65-69 | Gene | denotes | ACE2 | Gene:59272 |
| 798 | 90-93 | Gene | denotes | ACE | Gene:1636 |
| 799 | 126-132 | Gene | denotes | Ang1-7 | Gene:284 |
| 800 | 209-212 | Gene | denotes | ACE | Gene:1636 |
| 801 | 296-306 | Gene | denotes | bradykinin | Gene:3827 |
| 802 | 308-311 | Gene | denotes | ACE | Gene:1636 |
| 803 | 360-370 | Gene | denotes | bradykinin | Gene:3827 |
| 804 | 569-572 | Gene | denotes | ACE | Gene:1636 |
| 805 | 591-595 | Gene | denotes | ACE2 | Gene:59272 |
| 806 | 627-633 | Gene | denotes | Ang II | Gene:183 |
| 807 | 654-658 | Gene | denotes | ACE2 | Gene:59272 |
| 808 | 672-676 | Gene | denotes | ACE2 | Gene:59272 |
| 809 | 701-704 | Gene | denotes | ACE | Gene:1636 |
| 810 | 790-796 | Gene | denotes | Ang1-7 | Gene:284 |
| 811 | 819-825 | Gene | denotes | Ang II | Gene:183 |
| 812 | 860-864 | Gene | denotes | ACE2 | Gene:59272 |
| 813 | 998-1002 | Gene | denotes | ACE2 | Gene:59272 |
| 814 | 1025-1028 | Gene | denotes | ACE | Gene:1636 |
| 815 | 1079-1083 | Gene | denotes | ACE2 | Gene:59272 |
| 816 | 1113-1119 | Gene | denotes | Ang II | Gene:183 |
| 817 | 1150-1154 | Gene | denotes | ACE2 | Gene:59272 |
| 818 | 1183-1190 | Gene | denotes | Ang 1-9 | Gene:284 |
| 819 | 1230-1237 | Gene | denotes | Ang 1-7 | Gene:284 |
| 820 | 1242-1245 | Gene | denotes | ACE | Gene:1636 |
| 821 | 1247-1252 | Gene | denotes | Ang I | Gene:183 |
| 822 | 1284-1291 | Gene | denotes | Ang 1-7 | Gene:284 |
| 823 | 1318-1328 | Gene | denotes | neprilysin | Gene:4311 |
| 824 | 1410-1413 | Gene | denotes | ACE | Gene:1636 |
| 825 | 1474-1477 | Gene | denotes | ACE | Gene:1636 |
| 826 | 1482-1486 | Gene | denotes | ACE2 | Gene:59272 |
| 827 | 1527-1531 | Gene | denotes | ACE2 | Gene:59272 |
| 828 | 1532-1538 | Gene | denotes | Ang1-7 | Gene:284 |
| 829 | 259-265 | Gene | denotes | Ang II | Gene:183 |
| 830 | 1172-1177 | Gene | denotes | Ang I | Gene:183 |
| 831 | 250-255 | Gene | denotes | Ang I | Gene:183 |
| 832 | 434-447 | Chemical | denotes | prostaglandin | MESH:D011453 |
| 833 | 452-464 | Chemical | denotes | nitric oxide | MESH:D009569 |
| 834 | 745-753 | Chemical | denotes | losartan | MESH:D019808 |
| 835 | 898-906 | Chemical | denotes | losartan | MESH:D019808 |
| 836 | 935-943 | Chemical | denotes | losartan | MESH:D019808 |
| 837 | 948-958 | Chemical | denotes | lisinopril | MESH:D017706 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32305401-2849100-55252964 | 106-108 | 2849100 | denotes | 19 |
| 32305401-10892668-55252965 | 518-520 | 10892668 | denotes | 50 |
| 32305401-8793704-55252966 | 522-524 | 8793704 | denotes | 51 |
| 32305401-9461243-55252967 | 687-689 | 9461243 | denotes | 53 |
| 32305401-9461243-55252968 | 827-829 | 9461243 | denotes | 53 |
| 32305401-9461243-55252969 | 1099-1101 | 9461243 | denotes | 53 |
| 32305401-15283675-55252970 | 1330-1332 | 15283675 | denotes | 17 |