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PMC:7161517 / 1614-33323 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 1206-1210 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T6 1387-1392 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T7 1420-1425 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T8 2310-2317 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T9 3108-3120 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T10 3157-3165 Body_part denotes bronchus http://purl.org/sig/ont/fma/fma7409
T11 3167-3182 Body_part denotes lung parenchyma http://purl.org/sig/ont/fma/fma27360
T12 3184-3189 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T13 3191-3202 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T14 3204-3211 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T15 3213-3221 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T16 3227-3242 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T17 3611-3624 Body_part denotes phenylalanine http://purl.org/sig/ont/fma/fma82754
T18 3846-3853 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 3874-3884 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T20 3907-3916 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T21 3925-3931 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T22 4192-4202 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T23 4217-4228 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T24 4293-4297 Body_part denotes Axis http://purl.org/sig/ont/fma/fma12520
T25 4630-4639 Body_part denotes G protein http://purl.org/sig/ont/fma/fma61788
T26 5055-5071 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T27 5084-5095 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T28 5194-5198 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T29 5202-5218 Body_part denotes cardiac myocytes http://purl.org/sig/ont/fma/fma14067
T30 5253-5264 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T31 5274-5282 Body_part denotes myocytes http://purl.org/sig/ont/fma/fma67328
T32 5336-5340 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T33 5381-5385 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T34 5451-5458 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 5676-5689 Body_part denotes cardiomyocyte http://purl.org/sig/ont/fma/fma14067
T36 5814-5825 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T37 5839-5856 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T38 5851-5856 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T39 5935-5939 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T40 6315-6321 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T41 6326-6332 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T42 6850-6854 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T43 6904-6913 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T44 6930-6941 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T45 6942-6948 Body_part denotes (IL)-1 http://purl.org/sig/ont/fma/fma86583
T46 6943-6945 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T47 6951-6953 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T48 6957-6965 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T49 6982-6989 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T50 7044-7048 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T51 7178-7182 Body_part denotes Axis http://purl.org/sig/ont/fma/fma12520
T52 7550-7565 Body_part denotes adrenal medulla http://purl.org/sig/ont/fma/fma15633
T53 7570-7590 Body_part denotes antidiuretic hormone http://purl.org/sig/ont/fma/fma74646
T54 7600-7619 Body_part denotes posterior pituitary http://purl.org/sig/ont/fma/fma74636
T55 8684-8700 Body_part denotes zona glomerulosa http://purl.org/sig/ont/fma/fma69225
T56 8708-8723 Body_part denotes adrenal medulla http://purl.org/sig/ont/fma/fma15633
T57 8942-8961 Body_part denotes posterior pituitary http://purl.org/sig/ont/fma/fma74636
T58 8981-9001 Body_part denotes antidiuretic hormone http://purl.org/sig/ont/fma/fma74646
T59 9056-9063 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T60 9426-9430 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T61 9880-9887 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T62 9938-9945 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T63 10290-10294 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T64 10302-10324 Body_part denotes peritoneal macrophages http://purl.org/sig/ont/fma/fma83025
T65 10425-10429 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T66 10480-10502 Body_part denotes peritoneal macrophages http://purl.org/sig/ont/fma/fma83025
T67 10529-10536 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T68 10700-10707 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T69 10832-10840 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T70 10849-10860 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T71 10889-10894 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T72 11048-11052 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T73 11124-11128 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T74 11297-11308 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T75 11635-11642 Body_part denotes adenine http://purl.org/sig/ont/fma/fma82774
T76 11704-11732 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T77 11727-11732 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T78 12393-12397 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T79 12428-12443 Body_part denotes thoracic aortas http://purl.org/sig/ont/fma/fma3786
T80 12636-12650 Body_part denotes thoracic aorta http://purl.org/sig/ont/fma/fma3786
T81 12856-12872 Body_part denotes carotid arteries http://purl.org/sig/ont/fma/fma3939
T82 12864-12872 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T83 12961-12965 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T84 12970-12977 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 13016-13030 Body_part denotes arterial blood http://purl.org/sig/ont/fma/fma83066
T86 13823-13838 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T87 13982-13988 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T88 14088-14092 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T89 14112-14116 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T90 14421-14431 Body_part denotes myocardium http://purl.org/sig/ont/fma/fma9462
T91 14492-14504 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T92 14492-14496 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T93 14520-14526 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T94 14572-14592 Body_part denotes left coronary artery http://purl.org/sig/ont/fma/fma50040
T95 14629-14635 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T96 14677-14683 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T97 14753-14757 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T98 14839-14849 Body_part denotes myocardium http://purl.org/sig/ont/fma/fma9462
T99 14916-14922 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T100 14959-14965 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T101 15299-15309 Body_part denotes myocardium http://purl.org/sig/ont/fma/fma9462
T102 15598-15602 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T103 15607-15614 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T104 15643-15649 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T105 15731-15739 Body_part denotes collagen http://purl.org/sig/ont/fma/fma63891
T106 16043-16047 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T107 16572-16583 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T108 16787-16791 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T109 16850-16854 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T110 16974-16980 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T111 17003-17009 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T112 17056-17060 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T113 17194-17198 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T114 17734-17738 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T115 17873-17877 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T116 18244-18262 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T117 18687-18693 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T118 18751-18756 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T119 18770-18775 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T120 19033-19038 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T121 19213-19219 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T122 19272-19277 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T123 19494-19500 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T124 19620-19624 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T125 19715-19721 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T126 19742-19748 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T127 19772-19779 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T128 19826-19828 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T129 20235-20253 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T130 20418-20424 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T131 20425-20434 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T132 20607-20611 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T133 20748-20755 Body_part denotes Insulin http://purl.org/sig/ont/fma/fma83365
T134 20969-20974 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T135 21133-21139 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T136 21204-21208 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T137 21341-21345 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T138 21736-21746 Body_part denotes troponin I http://purl.org/sig/ont/fma/fma62340
T139 21736-21744 Body_part denotes troponin http://purl.org/sig/ont/fma/fma62338
T140 21759-21766 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T141 24660-24665 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T142 24727-24734 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T143 24774-24781 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T144 24842-24847 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 24912-24919 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T146 24991-24998 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T147 25011-25017 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T148 25058-25065 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T149 25272-25279 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 25308-25315 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T151 25323-25330 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T152 25440-25446 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T153 25665-25675 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T154 26164-26171 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T155 26229-26247 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T156 26294-26309 Body_part denotes early endosomes http://purl.org/sig/ont/fma/fma67463
T157 26315-26323 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T158 26428-26438 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T159 26661-26669 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T160 26691-26697 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T161 26716-26720 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T162 26716-26718 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T163 26722-26724 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T164 26728-26730 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T165 26735-26746 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T166 26806-26813 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T167 26825-26833 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T168 26850-26857 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 26861-26871 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T170 26885-26892 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T171 26989-26998 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T172 27122-27126 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T173 27191-27197 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T174 27321-27326 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T175 27336-27342 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T176 27575-27579 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T177 27725-27730 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T178 27838-27844 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T179 28308-28312 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 28360-28368 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T181 28395-28408 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T182 28395-28399 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T183 28455-28460 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T184 28554-28559 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 29436-29454 Body_part denotes Lipopolysaccharide http://purl.org/sig/ont/fma/fma82785
T186 29469-29473 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T187 29534-29538 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T188 29614-29619 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T189 29677-29681 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T190 29695-29699 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T191 29777-29795 Body_part denotes lipopolysaccharide http://purl.org/sig/ont/fma/fma82785
T192 29866-29873 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T193 29895-29899 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T194 29975-29979 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T195 31073-31078 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T196 31162-31167 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T197 31181-31186 Body_part denotes Heart http://purl.org/sig/ont/fma/fma7088
T198 31389-31395 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 1249-1273 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T7 1275-1278 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T8 1387-1392 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 1420-1425 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 1460-1463 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T11 1801-1804 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T12 2133-2136 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T13 2527-2530 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T14 2682-2685 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T15 3068-3071 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T16 3157-3165 Body_part denotes bronchus http://purl.obolibrary.org/obo/UBERON_0002185
T17 3167-3182 Body_part denotes lung parenchyma http://purl.obolibrary.org/obo/UBERON_0008946
T18 3167-3171 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 3172-3182 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T20 3184-3202 Body_part denotes heart, endothelium http://purl.obolibrary.org/obo/UBERON_0008307
T21 3184-3189 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T22 3191-3202 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T23 3213-3221 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T24 3227-3242 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T25 3233-3242 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T26 3907-3916 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T27 3925-3931 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T28 4229-4233 Body_part denotes tail http://purl.obolibrary.org/obo/UBERON_0002415
T29 6315-6321 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 7044-7048 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T31 7154-7157 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T32 7550-7565 Body_part denotes adrenal medulla http://purl.obolibrary.org/obo/UBERON_0001236
T33 8087-8090 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T34 8093-8117 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T35 8196-8199 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T36 8401-8425 Body_part denotes Renin-Angiotensin System http://purl.obolibrary.org/obo/UBERON_0018229
T37 8708-8723 Body_part denotes adrenal medulla http://purl.obolibrary.org/obo/UBERON_0001236
T38 9487-9511 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T39 9513-9516 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T40 10889-10894 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T41 12428-12443 Body_part denotes thoracic aortas http://purl.obolibrary.org/obo/UBERON_0001515
T42 12566-12572 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T43 12636-12650 Body_part denotes thoracic aorta http://purl.obolibrary.org/obo/UBERON_0001515
T44 12645-12650 Body_part denotes aorta http://purl.obolibrary.org/obo/UBERON_0000947
T45 13016-13030 Body_part denotes arterial blood http://purl.obolibrary.org/obo/UBERON_0013755
T46 13025-13030 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T47 13558-13565 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T48 13823-13838 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T49 13832-13838 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T50 14421-14431 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T51 14572-14592 Body_part denotes left coronary artery http://purl.obolibrary.org/obo/UBERON_0001626
T52 14577-14592 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T53 14586-14592 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T54 14839-14849 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T55 15299-15309 Body_part denotes myocardium http://purl.obolibrary.org/obo/UBERON_0002349
T56 16572-16583 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T57 17987-17990 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T58 18244-18262 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012
T59 18335-18338 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T60 18751-18756 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T61 18770-18775 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T62 19033-19038 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T63 19272-19277 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T64 19620-19624 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T65 20016-20019 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T66 20235-20253 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012
T67 20603-20606 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T68 21133-21139 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T69 22804-22807 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T70 23760-23763 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T71 24152-24155 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T72 27122-27126 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T73 27321-27326 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T74 27575-27579 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T75 27725-27730 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T76 27838-27844 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T77 29469-29473 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T78 29534-29538 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T79 29677-29681 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T80 29695-29699 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T81 29895-29899 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T82 29937-29940 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T83 29975-29979 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T84 30084-30087 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T85 31073-31078 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T86 31162-31167 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T87 31181-31186 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T88 31288-31291 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T89 31389-31395 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T90 31578-31581 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T91 31653-31656 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T15 10-34 Disease denotes coronavirus disease-2019 http://purl.obolibrary.org/obo/MONDO_0100096
T16 36-44 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 66-113 Disease denotes severe acute respiratory syndrome-coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T18 66-99 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T19 115-123 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T20 304-312 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T21 354-362 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 427-431 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 432-441 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 657-665 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T25 730-752 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T26 807-815 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 915-919 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T28 967-975 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T29 980-988 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 1068-1076 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 1630-1642 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T32 1686-1698 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T33 1725-1740 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311
T34 1997-2020 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T35 2283-2291 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 2294-2303 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37 2357-2365 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 2441-2445 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T39 2922-2925 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T40 4023-4028 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T41 5296-5298 Disease denotes ET http://purl.obolibrary.org/obo/MONDO_0005029
T42 5399-5401 Disease denotes ET http://purl.obolibrary.org/obo/MONDO_0005029
T43 5509-5511 Disease denotes ET http://purl.obolibrary.org/obo/MONDO_0005029
T44 5778-5781 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T45 7059-7081 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T46 7069-7081 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T47 7403-7415 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T48 7496-7499 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T49 7610-7619 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T50 8140-8162 Disease denotes Cardiovascular Disease http://purl.obolibrary.org/obo/MONDO_0004995
T51 8203-8225 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T52 8327-8350 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T53 8443-8451 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T54 8952-8961 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T55 9625-9628 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T56 9791-9824 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T57 9838-9846 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T58 9854-9862 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T59 9962-9971 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 10889-10902 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T61 12273-12276 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T62 13242-13245 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T63 13636-13639 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T64 14075-14078 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T65 14122-14143 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T66 14251-14254 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T67 14373-14376 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T68 14606-14627 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T69 14740-14743 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T70 15059-15062 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T71 15135-15156 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T72 15316-15337 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T73 15903-15906 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T74 16089-16092 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T75 16695-16698 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T76 18020-18023 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T77 18188-18223 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T78 18194-18223 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T79 18225-18229 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T80 18244-18275 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T82 18263-18275 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T83 18816-18824 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T84 19094-19098 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T85 19614-19631 Disease denotes Acute Lung Injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T87 19625-19631 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T88 19661-19665 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T89 20235-20266 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T91 20254-20266 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T92 20697-20705 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T93 20744-20783 Disease denotes Non-Insulin Dependent Diabetes Mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T94 20748-20783 Disease denotes Insulin Dependent Diabetes Mellitus http://purl.obolibrary.org/obo/MONDO_0005147
T95 20785-20790 Disease denotes NIDDM http://purl.obolibrary.org/obo/MONDO_0005148|http://purl.obolibrary.org/obo/MONDO_0007455
T97 21055-21074 Disease denotes myocardial ischemia http://purl.obolibrary.org/obo/MONDO_0024644
T98 21066-21074 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053
T99 21099-21121 Disease denotes Cardiovascular Disease http://purl.obolibrary.org/obo/MONDO_0004995
T100 21515-21523 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T101 21578-21586 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 21685-21693 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 21839-21845 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T104 22032-22074 Disease denotes ST-segment elevation myocardial infarction http://purl.obolibrary.org/obo/MONDO_0041656
T105 22053-22074 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T106 22135-22151 Disease denotes coronary disease http://purl.obolibrary.org/obo/MONDO_0005010
T107 22197-22205 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T108 22262-22268 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T109 22303-22313 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T110 22365-22371 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T111 22720-22728 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T112 22901-22904 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T113 22962-22970 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T114 22972-22984 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T115 23015-23023 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T116 23028-23035 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 23123-23131 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T118 23280-23288 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T119 23317-23325 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T120 23423-23431 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T121 23584-23592 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T122 23599-23602 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T123 23712-23720 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 23817-23839 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T125 23844-23852 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T126 23950-23958 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T127 24052-24060 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T128 24184-24192 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T129 24204-24212 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T130 24215-24223 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T131 24277-24285 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T132 24585-24593 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T133 24669-24677 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T134 24684-24692 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T135 25077-25085 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T136 25145-25153 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 25165-25212 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T138 25214-25222 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T139 25386-25391 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T140 25618-25626 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 25852-25860 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T142 25865-25873 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T143 25992-26000 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T144 26113-26122 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T145 26249-26257 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T146 26500-26508 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T147 26625-26633 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T148 27015-27023 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 27116-27133 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T151 27127-27133 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T152 27312-27334 Disease denotes advanced heart failure http://purl.obolibrary.org/obo/MONDO_0005257
T153 27321-27334 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T154 27569-27586 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T156 27580-27586 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T157 27602-27623 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T158 27725-27738 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T159 28192-28200 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T160 28430-28439 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T161 28987-28996 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T162 29050-29058 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T163 29079-29087 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 29332-29350 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T165 29341-29350 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T166 29463-29480 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T168 29474-29480 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T169 29556-29562 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T170 29700-29706 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T171 29814-29820 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T172 29855-29863 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 29951-29959 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T174 30026-30029 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T175 30116-30124 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T176 30333-30341 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T177 30665-30677 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T178 30717-30725 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T179 30752-30774 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T180 30779-30787 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T181 31073-31086 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T182 31181-31194 Disease denotes Heart Failure http://purl.obolibrary.org/obo/MONDO_0005252
T183 31437-31445 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T184 31463-31485 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T185 31552-31560 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T186 31700-31708 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T10 223-224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 254-266 http://purl.obolibrary.org/obo/OBI_0000245 denotes Organization
T12 276-278 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T13 381-382 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 451-452 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 880-884 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bats
T16 1206-1210 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T17 1226-1227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 1290-1291 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1292-1301 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T20 1387-1392 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T21 1387-1392 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T22 1420-1425 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T23 1420-1425 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T24 1949-1952 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T25 2137-2140 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T26 2149-2150 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 2191-2193 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T28 2220-2228 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T29 2392-2393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 2974-2983 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T31 3081-3082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 3099-3107 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T33 3157-3165 http://purl.obolibrary.org/obo/UBERON_0002185 denotes bronchus
T34 3167-3171 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T35 3167-3171 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T36 3184-3189 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T37 3184-3189 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T38 3184-3189 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T39 3184-3189 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T40 3191-3202 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T41 3204-3211 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T42 3204-3211 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T43 3204-3211 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T44 3227-3242 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T45 3257-3258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46 3315-3316 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 3402-3408 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T48 3433-3436 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T49 3437-3438 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 3803-3804 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T51 3805-3807 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T52 3844-3845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T53 3907-3916 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestine
T54 3907-3916 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestine
T55 3925-3931 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T56 3925-3931 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T57 3925-3931 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T58 3960-3961 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T59 4153-4154 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T60 4190-4191 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 4229-4233 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T62 4318-4319 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63 4520-4523 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T64 4524-4525 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T65 4630-4656 http://purl.obolibrary.org/obo/PR_000030035 denotes G protein coupled receptor
T66 4658-4662 http://purl.obolibrary.org/obo/PR_000030035 denotes GPCR
T67 4775-4776 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68 4799-4809 http://purl.obolibrary.org/obo/PR_000001898 denotes neprilysin
T69 4865-4866 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 5018-5025 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T71 5055-5071 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T72 5084-5095 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T73 5162-5170 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T74 5202-5218 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiac myocytes
T75 5241-5249 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T76 5253-5264 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T77 5274-5282 http://purl.obolibrary.org/obo/CL_0000187 denotes myocytes
T78 5441-5450 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T79 5514-5522 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T80 5537-5543 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T81 5661-5669 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T82 5676-5689 http://purl.obolibrary.org/obo/CL_0000746 denotes cardiomyocyte
T83 5743-5751 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T84 5814-5825 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T85 5839-5856 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T86 5935-5945 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types
T87 5970-5979 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T88 5994-6003 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T89 6045-6054 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T90 6272-6274 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T91 6288-6293 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T92 6326-6332 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T93 6347-6350 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T94 6351-6352 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 6485-6487 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T96 6616-6625 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T97 6957-6965 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T98 7044-7048 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T99 7044-7048 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T100 7108-7110 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T101 7128-7130 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T102 7600-7609 http://purl.obolibrary.org/obo/UBERON_0001353 denotes posterior
T103 7643-7651 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T104 7734-7740 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T105 8048-8058 http://purl.obolibrary.org/obo/PR_000001898 denotes neprilysin
T106 8277-8280 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T107 8942-8951 http://purl.obolibrary.org/obo/UBERON_0001353 denotes posterior
T108 9439-9440 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T109 9733-9736 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T110 10296-10301 http://purl.obolibrary.org/obo/CLO_0007836 denotes Mouse
T111 10302-10324 http://purl.obolibrary.org/obo/CL_0000581 denotes peritoneal macrophages
T112 10401-10409 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T113 10474-10479 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T114 10480-10502 http://purl.obolibrary.org/obo/CL_0000581 denotes peritoneal macrophages
T115 10826-10831 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T116 10832-10840 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T117 10889-10894 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T118 10889-10894 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T119 10889-10894 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T120 10889-10894 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T121 11014-11022 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T122 11088-11096 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T123 11222-11230 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T124 11285-11293 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T125 11392-11400 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T126 11421-11429 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T127 11620-11621 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 11713-11732 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cells
T129 11753-11762 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T130 12061-12069 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T131 12247-12254 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T132 12357-12358 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T133 12428-12443 http://purl.obolibrary.org/obo/UBERON_0001515 denotes thoracic aortas
T134 12428-12443 http://www.ebi.ac.uk/efo/EFO_0002525 denotes thoracic aortas
T135 12566-12572 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
T136 12636-12650 http://purl.obolibrary.org/obo/UBERON_0001515 denotes thoracic aorta
T137 12636-12650 http://www.ebi.ac.uk/efo/EFO_0002525 denotes thoracic aorta
T138 12840-12848 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T139 12856-12872 http://www.ebi.ac.uk/efo/EFO_0000818 denotes carotid arteries
T140 12888-12895 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T141 12961-12965 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T142 13016-13024 http://purl.obolibrary.org/obo/UBERON_0001637 denotes arterial
T143 13016-13024 http://www.ebi.ac.uk/efo/EFO_0000814 denotes arterial
T144 13025-13030 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T145 13025-13030 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T146 13181-13182 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T147 13289-13297 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T148 13366-13370 http://purl.obolibrary.org/obo/PR_000001307 denotes CD44
T149 13401-13403 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T150 13484-13492 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T151 13558-13565 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessels
T152 13692-13700 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T153 13701-13705 http://purl.obolibrary.org/obo/PR_000001307 denotes CD44
T154 13779-13781 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T155 13832-13838 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T156 13832-13838 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T157 13982-13988 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T158 14302-14310 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T159 14421-14431 http://purl.obolibrary.org/obo/UBERON_0002349 denotes myocardium
T160 14492-14496 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T161 14520-14526 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T162 14586-14592 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T163 14586-14592 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T164 14629-14635 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T165 14677-14683 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T166 14839-14849 http://purl.obolibrary.org/obo/UBERON_0002349 denotes myocardium
T167 14916-14922 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T168 14959-14965 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T169 14979-14987 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T170 15180-15181 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T171 15299-15309 http://purl.obolibrary.org/obo/UBERON_0002349 denotes myocardium
T172 15466-15468 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T173 15471-15472 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T174 15643-15649 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T175 15731-15739 http://purl.obolibrary.org/obo/CHEBI_3815 denotes collagen
T176 16572-16583 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T177 16717-16719 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T178 16787-16791 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T179 16868-16876 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T180 16974-16980 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T181 17003-17009 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T182 17246-17247 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T183 17248-17254 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T184 17509-17519 http://purl.obolibrary.org/obo/PR_000001898 denotes neprilysin
T185 17658-17664 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T186 17700-17710 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T187 17907-17908 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 17991-18000 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T189 18033-18042 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T190 18050-18060 http://purl.obolibrary.org/obo/CLO_0001658 denotes activating
T191 18123-18124 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 18244-18262 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T193 18244-18262 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T194 18401-18407 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T195 18409-18410 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T196 18479-18484 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T197 18673-18674 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T198 18687-18693 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T199 18751-18756 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T200 18751-18756 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T201 18770-18775 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T202 18770-18775 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T203 18770-18775 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T204 18770-18775 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T205 19127-19134 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T206 19213-19219 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T207 19272-19277 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T208 19415-19416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 19494-19500 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T210 19527-19528 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 19620-19624 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T212 19620-19624 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T213 19715-19721 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T214 19742-19748 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T215 20229-20234 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T216 20235-20253 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T217 20235-20253 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T218 20307-20315 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T219 20418-20424 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T220 20655-20663 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T221 20748-20755 http://purl.obolibrary.org/obo/PR_000009054 denotes Insulin
T222 20969-20974 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T223 21341-21345 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T224 21787-21788 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T225 21806-21813 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T226 22032-22034 http://purl.obolibrary.org/obo/CLO_0009141 denotes ST
T227 22032-22034 http://purl.obolibrary.org/obo/CLO_0050980 denotes ST
T228 22161-22162 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 22391-22392 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T230 23025-23027 http://purl.obolibrary.org/obo/CLO_0004265 denotes HT
T231 23215-23222 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T232 23972-23977 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T233 24022-24023 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T234 24495-24502 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T235 24638-24639 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T236 24660-24665 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T237 24761-24763 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T238 24842-24847 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T239 24881-24886 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T240 25497-25499 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T241 25504-25506 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T242 25504-25506 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T243 25516-25518 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T244 25516-25518 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T245 25526-25533 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T246 25551-25559 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T247 26082-26087 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T248 26179-26181 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T249 26182-26184 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T250 26182-26184 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T251 26195-26197 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T252 26195-26197 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T253 26238-26247 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T254 26313-26314 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 26393-26401 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T256 26634-26637 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T257 26659-26660 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 26691-26697 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T259 26716-26720 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T260 26735-26772 http://purl.obolibrary.org/obo/PR_000005932 denotes granulocyte-colony stimulating factor
T261 26774-26778 http://purl.obolibrary.org/obo/PR_000005932 denotes GCSF
T262 26781-26797 http://purl.obolibrary.org/obo/PR_000000017 denotes interferon gamma
T263 26825-26833 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T264 27077-27085 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T265 27122-27126 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T266 27122-27126 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T267 27191-27197 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T268 27232-27238 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T269 27321-27326 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T270 27321-27326 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T271 27321-27326 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T272 27321-27326 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T273 27336-27342 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T274 27348-27356 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T275 27575-27579 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T276 27575-27579 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T277 27725-27730 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T278 27725-27730 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T279 27725-27730 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T280 27725-27730 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T281 28308-28312 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T282 28395-28399 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T283 28400-28408 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T284 28455-28460 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T285 28539-28559 http://purl.obolibrary.org/obo/CL_0000228 denotes multinucleated cells
T286 28576-28581 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 28633-28638 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T288 28793-28798 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T289 29134-29142 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T290 29165-29166 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T291 29218-29223 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T292 29383-29385 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T293 29426-29434 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T294 29469-29473 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T295 29469-29473 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T296 29481-29486 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T297 29534-29538 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T298 29534-29538 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T299 29614-29619 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T300 29677-29681 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T301 29677-29681 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T302 29695-29699 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T303 29695-29699 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T304 29895-29899 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T305 29895-29899 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T306 29975-29979 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T307 29975-29979 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T308 30359-30367 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T309 30852-30853 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T310 30896-30897 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 31073-31078 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T312 31073-31078 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T313 31073-31078 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T314 31073-31078 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T315 31162-31167 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T316 31162-31167 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T317 31162-31167 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T318 31162-31167 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T319 31181-31186 http://purl.obolibrary.org/obo/UBERON_0000948 denotes Heart
T320 31181-31186 http://purl.obolibrary.org/obo/UBERON_0007100 denotes Heart
T321 31181-31186 http://purl.obolibrary.org/obo/UBERON_0015228 denotes Heart
T322 31181-31186 http://www.ebi.ac.uk/efo/EFO_0000815 denotes Heart
T323 31346-31347 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T19 839-843 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T20 1117-1128 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T21 1255-1266 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T22 1275-1278 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T23 1460-1463 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T24 1490-1504 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T27 1490-1501 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T28 1502-1504 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T29 1510-1512 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T30 1801-1804 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T31 1842-1856 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T32 1846-1856 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T33 1858-1872 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T36 1858-1869 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T37 1870-1872 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T38 1903-1920 Chemical denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T39 1930-1941 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T40 2133-2136 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T41 2310-2317 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T42 2527-2530 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T43 2633-2644 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T44 2682-2685 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T45 2743-2754 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T46 2794-2796 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T47 2805-2814 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T48 2873-2875 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T49 2911-2913 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T50 3068-3071 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T51 3108-3120 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T52 3357-3371 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T53 3361-3371 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T54 3535-3537 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T55 3580-3591 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T56 3609-3624 Chemical denotes L-phenylalanine http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997|http://purl.obolibrary.org/obo/CHEBI_58095
T59 3611-3624 Chemical denotes phenylalanine http://purl.obolibrary.org/obo/CHEBI_28044
T60 3846-3853 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T61 3874-3884 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T62 3874-3879 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T63 3880-3884 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T64 4375-4377 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T65 4467-4469 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T66 4554-4565 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T67 4632-4639 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68 4777-4781 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T70 5132-5134 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T71 5296-5298 Chemical denotes ET http://purl.obolibrary.org/obo/CHEBI_73510
T72 5393-5395 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T73 5399-5401 Chemical denotes ET http://purl.obolibrary.org/obo/CHEBI_73510
T74 5419-5429 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T75 5433-5440 Chemical denotes mitogen http://purl.obolibrary.org/obo/CHEBI_52290
T76 5451-5458 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T77 5502-5504 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T78 5509-5511 Chemical denotes ET http://purl.obolibrary.org/obo/CHEBI_73510
T79 5641-5643 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T80 5967-5969 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T81 6251-6261 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T82 6535-6537 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T83 6698-6700 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T84 6943-6945 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T86 6951-6953 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T88 6982-6989 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89 7154-7157 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T90 7194-7209 Chemical denotes Angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T91 7226-7237 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T92 7285-7287 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T93 7292-7303 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T94 7351-7361 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T95 7380-7391 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T96 7453-7455 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T97 7476-7478 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T98 7519-7530 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T100 7583-7590 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T101 7621-7632 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T102 7669-7681 Chemical denotes Endothelin-1 http://purl.obolibrary.org/obo/CHEBI_80240
T103 7691-7702 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T104 7784-7786 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T105 8026-8030 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T107 8059-8065 Chemical denotes prolyl http://purl.obolibrary.org/obo/CHEBI_26274|http://purl.obolibrary.org/obo/CHEBI_32874
T109 8081-8084 Chemical denotes PEP http://purl.obolibrary.org/obo/CHEBI_18021|http://purl.obolibrary.org/obo/CHEBI_44897
T111 8087-8090 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T112 8099-8110 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T113 8196-8199 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T114 8246-8260 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T115 8250-8260 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T116 8407-8418 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T117 8462-8473 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T118 8504-8506 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T119 8511-8522 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T120 8576-8590 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T121 8580-8590 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T122 8628-8630 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T123 8739-8750 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T125 8776-8793 Chemical denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T126 8815-8820 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T127 8850-8854 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T129 8885-8902 Chemical denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T130 8912-8923 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T131 8967-8969 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T132 8994-9001 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T133 9023-9028 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T134 9192-9203 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T135 9246-9248 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T136 9270-9272 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T137 9298-9309 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T138 9493-9504 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T139 9513-9516 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T140 9550-9552 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T141 9702-9704 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T142 9880-9887 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T143 10012-10014 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T144 10236-10240 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T145 10347-10358 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T147 10516-10559 Chemical denotes nicotinamide adenine dinucleotide phosphate http://purl.obolibrary.org/obo/CHEBI_18009|http://purl.obolibrary.org/obo/CHEBI_25523
T149 10516-10528 Chemical denotes nicotinamide http://purl.obolibrary.org/obo/CHEBI_17154
T150 10529-10536 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T151 10537-10549 Chemical denotes dinucleotide http://purl.obolibrary.org/obo/CHEBI_47885
T152 10550-10559 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T156 10568-10577 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T157 10579-10590 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T159 10687-10730 Chemical denotes nicotinamide adenine dinucleotide phosphate http://purl.obolibrary.org/obo/CHEBI_18009|http://purl.obolibrary.org/obo/CHEBI_25523
T161 10687-10699 Chemical denotes nicotinamide http://purl.obolibrary.org/obo/CHEBI_17154
T162 10700-10707 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T163 10708-10720 Chemical denotes dinucleotide http://purl.obolibrary.org/obo/CHEBI_47885
T164 10721-10730 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T168 10808-10818 Chemical denotes eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T169 10959-10973 Chemical denotes spironolactone http://purl.obolibrary.org/obo/CHEBI_9241
T170 11197-11207 Chemical denotes eplerenone http://purl.obolibrary.org/obo/CHEBI_31547
T171 11558-11560 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T172 11571-11582 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T174 11622-11665 Chemical denotes nicotinamide adenine dinucleotide phosphate http://purl.obolibrary.org/obo/CHEBI_18009|http://purl.obolibrary.org/obo/CHEBI_25523
T176 11622-11634 Chemical denotes nicotinamide http://purl.obolibrary.org/obo/CHEBI_17154
T177 11635-11642 Chemical denotes adenine http://purl.obolibrary.org/obo/CHEBI_16708
T178 11643-11655 Chemical denotes dinucleotide http://purl.obolibrary.org/obo/CHEBI_47885
T179 11656-11665 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T183 11750-11752 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T184 11850-11873 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T185 11859-11865 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T186 12129-12131 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T187 12333-12343 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T188 12472-12480 Chemical denotes atenolol http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352
T190 12485-12496 Chemical denotes hydralazine http://purl.obolibrary.org/obo/CHEBI_5775
T191 12601-12611 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T192 12757-12765 Chemical denotes atenolol http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352
T194 12769-12780 Chemical denotes hydralazine http://purl.obolibrary.org/obo/CHEBI_5775
T195 12933-12943 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T196 12970-12977 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 13118-13126 Chemical denotes atenolol http://purl.obolibrary.org/obo/CHEBI_2904|http://purl.obolibrary.org/obo/CHEBI_55352
T199 13130-13141 Chemical denotes hydralazine http://purl.obolibrary.org/obo/CHEBI_5775
T200 13204-13206 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T201 13227-13229 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T202 13311-13323 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T203 13318-13323 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T205 13433-13444 Chemical denotes telmisartan http://purl.obolibrary.org/obo/CHEBI_9434
T206 13509-13521 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T207 13516-13521 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T209 13665-13676 Chemical denotes telmisartan http://purl.obolibrary.org/obo/CHEBI_9434
T210 13931-13939 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T211 13944-13954 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T212 14640-14642 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T213 14871-14879 Chemical denotes ramipril http://purl.obolibrary.org/obo/CHEBI_8774
T214 14884-14893 Chemical denotes valsartan http://purl.obolibrary.org/obo/CHEBI_9927
T215 14937-14939 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T216 15354-15362 Chemical denotes ramipril http://purl.obolibrary.org/obo/CHEBI_8774
T217 15544-15554 Chemical denotes olmesartan http://purl.obolibrary.org/obo/CHEBI_48416
T218 15558-15569 Chemical denotes telmisartan http://purl.obolibrary.org/obo/CHEBI_9434
T219 15607-15614 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T220 15661-15663 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T221 15796-15810 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T222 15800-15810 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T223 15893-15895 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T224 15949-15951 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T225 16187-16189 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T226 16215-16229 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T227 16219-16229 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T228 16281-16295 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T229 16285-16295 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T230 16400-16414 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T231 16404-16414 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T232 16454-16456 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T233 16487-16497 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T234 16551-16561 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T235 16625-16638 Chemical denotes prostaglandin http://purl.obolibrary.org/obo/CHEBI_26333
T236 16643-16655 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T237 16650-16655 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T239 16822-16824 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T240 16936-16944 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T241 17014-17016 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T242 17089-17097 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T243 17126-17134 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T244 17139-17149 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T245 17216-17230 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T246 17220-17230 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T247 17308-17310 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T248 17487-17491 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T250 17601-17615 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T251 17605-17615 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T252 17987-17990 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T253 18017-18019 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T254 18335-18338 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T255 18485-18496 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T256 19061-19063 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T257 19234-19236 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T258 19515-19517 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T259 19573-19575 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T260 19580-19582 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T261 19726-19728 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T262 19761-19771 Chemical denotes surfactant http://purl.obolibrary.org/obo/CHEBI_35195
T263 19772-19779 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T264 19826-19828 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T266 20016-20019 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T267 20452-20465 Chemical denotes nitrotyrosine http://purl.obolibrary.org/obo/CHEBI_86267
T268 20603-20606 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T269 20731-20742 Chemical denotes candesartan http://purl.obolibrary.org/obo/CHEBI_3347
T270 20748-20755 Chemical denotes Insulin http://purl.obolibrary.org/obo/CHEBI_5931
T271 20796-20807 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T272 21759-21766 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T273 21806-21813 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T274 22032-22034 Chemical denotes ST http://purl.obolibrary.org/obo/CHEBI_141393
T275 22804-22807 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T276 22883-22896 Chemical denotes ACE inhibitor http://purl.obolibrary.org/obo/CHEBI_35457
T277 22887-22896 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T278 23067-23081 Chemical denotes Angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719
T279 23079-23081 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T280 23238-23246 Chemical denotes losartan http://purl.obolibrary.org/obo/CHEBI_6541
T281 23290-23298 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T282 23396-23404 Chemical denotes Losartan http://purl.obolibrary.org/obo/CHEBI_6541
T283 23760-23763 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T284 23764-23774 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T285 23978-23989 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T286 24152-24155 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T287 24156-24166 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T288 24339-24343 Chemical denotes beta http://purl.obolibrary.org/obo/CHEBI_10545
T289 24727-24734 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T290 24774-24781 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T291 24946-24950 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T292 24991-24998 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T293 25011-25017 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T294 25058-25065 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T295 25272-25279 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T296 25323-25330 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T297 25341-25345 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T298 25440-25446 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T299 25504-25506 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T300 25516-25518 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T301 25526-25533 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T302 25676-25686 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T303 26164-26171 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T304 26182-26184 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T305 26195-26197 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T306 26439-26449 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T307 26716-26718 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T309 26722-26724 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T311 26728-26730 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T313 26781-26816 Chemical denotes interferon gamma-induced protein 10 http://purl.obolibrary.org/obo/CHEBI_138157
T314 26781-26791 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T315 26792-26797 Chemical denotes gamma http://purl.obolibrary.org/obo/CHEBI_30212
T316 26806-26813 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T317 26850-26857 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T318 26885-26892 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T319 26895-26900 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T320 28031-28033 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T321 28096-28098 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T322 28360-28368 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T323 29167-29185 Chemical denotes physiological role http://purl.obolibrary.org/obo/CHEBI_52211
T324 29265-29279 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T325 29269-29279 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T326 29436-29454 Chemical denotes Lipopolysaccharide http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_89981
T328 29737-29751 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T329 29741-29751 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T330 29777-29795 Chemical denotes lipopolysaccharide http://purl.obolibrary.org/obo/CHEBI_16412
T331 29866-29873 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T332 29937-29940 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T333 30084-30087 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T334 30802-30816 Chemical denotes ACE inhibitors http://purl.obolibrary.org/obo/CHEBI_35457
T335 30806-30816 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T336 31288-31291 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T337 31292-31303 Chemical denotes antagonists http://purl.obolibrary.org/obo/CHEBI_48706
T338 31578-31581 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T339 31582-31592 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T340 31653-31656 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T2 1292-1309 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T3 1292-1301 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4 1326-1336 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T5 1373-1401 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T6 1373-1383 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7 1403-1414 http://purl.obolibrary.org/obo/GO_0035815 denotes natriuresis
T8 1477-1486 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T9 1686-1698 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T10 2107-2117 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11 2425-2437 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T12 2974-2991 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T13 2974-2983 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T14 4029-4037 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T15 4029-4037 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T16 4029-4037 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T17 4029-4037 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T18 4140-4149 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T19 4298-4308 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T20 5033-5043 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T21 5561-5567 http://purl.obolibrary.org/obo/GO_0004707 denotes (ERK)1
T22 5568-5572 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T23 5994-6012 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T24 5994-6003 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T25 6045-6063 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T26 6045-6054 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T27 6588-6592 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T28 6616-6625 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T29 7010-7016 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T30 7183-7193 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T31 7403-7415 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T32 7519-7540 http://purl.obolibrary.org/obo/GO_0035932 denotes aldosterone secretion
T33 7531-7540 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T34 7758-7764 http://purl.obolibrary.org/obo/GO_0004707 denotes (ERK)1
T35 7765-7769 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2
T36 8125-8135 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T37 8231-8241 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T38 8739-8760 http://purl.obolibrary.org/obo/GO_0035932 denotes aldosterone secretion
T39 8751-8760 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T40 8855-8864 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T41 8994-9011 http://purl.obolibrary.org/obo/GO_0046879 denotes hormone secretion
T42 9002-9011 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T43 9029-9038 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T44 9149-9158 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T45 9149-9158 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T46 9612-9623 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T47 9918-9937 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T48 9976-9993 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T49 9976-9993 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T50 11541-11550 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T51 11598-11611 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T52 11753-11762 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T53 11778-11793 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T54 11797-11801 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK1
T55 11850-11884 http://purl.obolibrary.org/obo/GO_1903409 denotes reactive oxygen species generation
T56 13742-13748 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T57 15868-15885 http://purl.obolibrary.org/obo/GO_0051100 denotes inhibited binding
T58 16594-16606 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T59 16677-16687 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T60 16825-16834 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T61 17275-17288 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T62 17991-18000 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T63 18033-18042 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T64 18910-18925 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T65 19804-19819 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T66 22828-22838 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T67 25392-25400 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T68 25392-25400 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T69 25392-25400 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T70 25392-25400 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T71 25481-25490 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T72 25598-25609 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T73 25698-25717 http://purl.obolibrary.org/obo/GO_0006509 denotes ectodomain cleavage
T74 26048-26059 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T75 26459-26478 http://purl.obolibrary.org/obo/GO_0006509 denotes ectodomain cleavage
T76 27063-27073 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T77 27522-27532 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T78 28344-28357 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T79 28483-28492 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T80 28526-28535 http://purl.obolibrary.org/obo/GO_0009058 denotes Formation
T81 28702-28715 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T82 28726-28741 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T83 28826-28836 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis
T84 28866-28881 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T85 28886-28896 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis
T86 29100-29115 http://purl.obolibrary.org/obo/GO_0019068 denotes virion assembly
T87 30580-30590 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T88 30665-30677 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T15 0-289 Sentence denotes The novel coronavirus disease-2019 (COVID-19) outbreak, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), originated from the Wuhan, Hubei providence in central China in December 2019 and was declared a pandemic by the World Health Organization on March 11, 2020 (1).
T16 290-413 Sentence denotes Compared with SARS-CoV, which caused the 2002 to 2003 outbreak, SARS-CoV-2 appears to have a stronger rate of transmission.
T17 414-587 Sentence denotes Although the SARS infection exhibits a prolonged clinical course predominantly involving respiratory manifestations, the clinical course of the novel coronavirus is unclear.
T18 588-801 Sentence denotes Further clinical insights from Wuhan suggest that some patients with COVID-19 exhibit severe cardiovascular damage, and those with underlying cardiovascular disease appear to have an increased risk of death (1,2).
T19 802-870 Sentence denotes Both SARS-CoV and CoV2 belong to the beta-coronavirus phylogeny (3).
T20 871-1062 Sentence denotes Although bats may be natural reservoirs for SARS-like coronavirus (3), interspecies transfer of SARS-CoV and SARS-CoV-2 could have occurred through civets (4) and pangolins (5), respectively.
T21 1063-1217 Sentence denotes Both SARS-CoV strains have been identified to use the angiotensin-converting enzyme 2 (ACE2) receptor as the portal of entry into the affected cell (1,4).
T22 1218-1445 Sentence denotes ACE2 is a key modulator of the renin-angiotensin system (RAS), which is a signaling pathway involved in the regulation of vascular function, including the regulation of blood pressure, natriuresis, and blood volume control (6).
T23 1446-1751 Sentence denotes Normally, the RAS involves the formation of angiotensin II (Ang II) through ACE, which contributes to multiple cardiovascular physiological and pathophysiological functions, including hypertension, myocardial hypertrophy, cardiac fibrosis, inflammation, vascular remodeling, and atherosclerosis (7, 8, 9).
T24 1752-2021 Sentence denotes Because of the adverse cardiovascular effects of RAS upregulation, its inhibition through ACE inhibitors, angiotensin II receptor blockers (ARBs), and mineralocorticoid receptor antagonists (MRAs) has been critical for the management of various cardiovascular diseases.
T25 2022-2199 Sentence denotes In the last 2 decades, the identification of ACE2 and its involvement in the counter regulation of the classic RAS has offered a potentially new therapeutic target (10, 11, 12).
T26 2200-2334 Sentence denotes ACE2 exists both as membrane-bound and soluble forms, the former of which mediates SARS-CoV-2 infection via S-protein binding (13,14).
T27 2335-2490 Sentence denotes It is unclear whether SARS-CoV-2 interferes with ACE2 in a manner that contributes to the pathogenesis of SARS or the cardiovascular damage observed (1,2).
T28 2491-2631 Sentence denotes This raises the question of whether RAS inhibition in cardiovascular patients should be reassessed in the setting of this novel coronavirus.
T29 2633-2664 Sentence denotes Angiotensin-Converting Enzyme 2
T30 2665-2765 Sentence denotes Classically, the RAS involves the conversion of angiotensinogen by renin into angiotensin I (Ang I).
T31 2766-2836 Sentence denotes Ang I is metabolized to Ang II via the dipeptide carboxypeptidase ACE.
T32 2837-2937 Sentence denotes The pro-inflammatory effects of Ang II (7, 8, 9) are mediated through Ang II type I (AT1) receptors.
T33 2938-3072 Sentence denotes Recently, the ACE2 receptor and its signaling pathway were identified as an important counter regulatory mechanism to the classic RAS.
T34 3073-3248 Sentence denotes ACE2 is a type I integral membrane glycoprotein (15) expressed predominantly in the bronchus, lung parenchyma, heart, endothelium, kidneys, duodenum, and small intestine (16).
T35 3249-3377 Sentence denotes ACE2 is a monocarboxypeptidase, unlike its homolog, ACE, which is a dipeptidase; ACE2 is not antagonized by ACE inhibitors (17).
T36 3378-3499 Sentence denotes Although ACE contains 2 active catalytic domains, ACE2 has a single catalytic domain with 42% identical residues (18,19).
T37 3500-3630 Sentence denotes The major substrate of ACE2 is Ang II, which upon C-terminus cleavage, produces angiotensin 1-7 (Ang1-7) and L-phenylalanine (20).
T38 3631-3751 Sentence denotes Other substrates for ACE2 include Ang I, apelin-13, and dynorphin-13, which are catalyzed at much lower affinities (21).
T39 3752-3940 Sentence denotes The non-catalytic C-terminal domain of ACE2 shares a 48% sequence homology with collectrin, a protein involved in neutral amino acid reabsorption from the intestine and the kidney (22,23).
T40 3941-4170 Sentence denotes In the presence of a disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor (TNF)-α−converting enzyme (TACE), ACE2 exhibits ectodomain shedding (24), which results in the formation of a soluble enzyme.
T41 4171-4275 Sentence denotes ACE2 also contains a calmodulin domain on its cytoplasmic tail that influences ectodomain shedding (25).
T42 4277-4308 Sentence denotes ACE2/Ang1-7/Mas Axis Regulation
T43 4309-4385 Sentence denotes Ang I is a decapeptide that is converted into the octapeptide Ang II by ACE.
T44 4386-4512 Sentence denotes Unlike ACE, Ang I can be converted to Ang1-9 by ACE2, and, more importantly, Ang II is converted to Ang 1-7 through ACE2 (17).
T45 4513-4688 Sentence denotes Ang1-7 has a range of anti-inflammatory, antioxidant, vasodilatory, and natriuretic effects that are mediated by the G protein coupled receptor (GPCR) Mas receptor (11,26,27).
T46 4689-4903 Sentence denotes Ang1-7 may be produced directly from Ang I through the alternative pathways involving a zinc metallopeptidase neprilysin or conversion of Ang1-9 to Ang1-7 via ACE, although at a significantly lower efficiency (17).
T47 4904-5009 Sentence denotes Genetic deletion studies have established ACE2 as an essential regulator of cardiovascular function (28).
T48 5010-5270 Sentence denotes Studies focused on the regulation of ACE2 in cardiac myocytes and cardiac fibroblasts have demonstrated that although Ang II significantly reduced ACE2 activity and downregulated ACE2 mRNA in cardiac myocytes, it only reduced ACE2 activity in fibroblasts (29).
T49 5271-5357 Sentence denotes In myocytes, endothelin (ET)-1 also significantly decreased ACE2 mRNA production (29).
T50 5358-5593 Sentence denotes This reduction in ACE2 mRNA by Ang II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase 1 (MAPK1), which suggested that Ang II and ET-1 activate extracellular signal-regulated kinase (ERK)1/ERK2 to reduce ACE2 (29).
T51 5594-5805 Sentence denotes Furthermore, in vivo murine studies showed Ang II−mediated loss of membrane-bound cardiomyocyte ACE2 correlated with the upregulation of TACE/ADAM17 activity, which was prevented with AT1 receptor blockade (30).
T52 5806-5962 Sentence denotes Cardiac fibroblasts and coronary endothelial cells also express ACE2 and TACE, and this reciprocal relationship extends to these cell types as well (31,32).
T53 5963-6133 Sentence denotes Ang II activates several other signaling cascades, such as the PKC and JAK2-STAT3 signaling pathways, which results in myocardial hypertrophy and increased fibrosis (33).
T54 6134-6276 Sentence denotes The binding of Ang1-7 to the C-terminal domain also inhibits the proteolytic function of the ACE enzyme and promotes bradykinin function (34).
T55 6277-6489 Sentence denotes Studies in human vascular and cardiac tissue and plasma showed Ang1-7 has a higher affinity to ACE than Ang I, which suggests the inhibitory effects of Ang1-7 on ACE may contribute to its protective effects (35).
T56 6490-6791 Sentence denotes The treatment of ACE2 knockout mice with Ang II infusion and recombinant ACE2 (rhACE2) eliminated ERK1/2, JAK2-STAT3, and PKC signaling by rhACE2 and was at least partially responsible for attenuation of Ang II−induced myocardial hypertrophy and fibrosis and improvement in diastolic dysfunction (33).
T57 6792-7144 Sentence denotes Other studies highlighted the role of the ACE2/Ang1-7/Mas axis in modulating the expression of pro-inflammatory cytokines, such as TNF-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1, and transforming growth factor-β in cardiac and/or lung fibrosis, pulmonary hypertension, and vascular remodeling (36, 37, 38, 39, 40, 41) (Figure 1 ).
T58 7145-7193 Sentence denotes Figure 1 RAS and ACE2/Ang1-7/Mas Axis Regulation
T59 7194-7258 Sentence denotes Angiotensinogen is converted to angiotensin I (Ang I) via renin.
T60 7259-7416 Sentence denotes Ang I is converted to Ang II via angiotensin-converting enzyme (ACE), which also hydrolyzes bradykinin into its inactive metabolites, promoting inflammation.
T61 7417-7620 Sentence denotes The pro-inflammatory effects of Ang II are mediated by Ang II type I receptor (AT1), which stimulates aldosterone secretion from the adrenal medulla and antidiuretic hormone from the posterior pituitary.
T62 7621-7668 Sentence denotes Aldosterone decreases membrane ACE2 expression.
T63 7669-7779 Sentence denotes Endothelin-1 inhibits angiotensin 1-7 (Ang1-7) via extracellular signal-regulated kinase (ERK)1/ERK2 pathways.
T64 7780-7933 Sentence denotes Ang II, under favorable conditions (dashed line), can be converted to Ang1-7 via ACE2, whose counter regulatory effects are mediated by the Mas receptor.
T65 7934-8086 Sentence denotes Ang1-7 can also be formed via conversion of Ang I to an intermediate Ang1-9 or directly via zinc metallopeptidase neprilysin/prolyl endopeptidase (PEP).
T66 8087-8118 Sentence denotes RAS = renin-angiotensin system.
T67 8120-8162 Sentence denotes ACE2 Regulation and Cardiovascular Disease
T68 8163-8375 Sentence denotes Because of the importance of the RAS in cardiovascular disease, its regulation via ACE inhibitors, ARBs, and MRAs has played an essential role in the management of cardiovascular diseases (Central Illustration ).
T69 8376-8451 Sentence denotes Central Illustration The Renin-Angiotensin System Interaction With COVID-19
T70 8452-8591 Sentence denotes Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors.
T71 8592-8673 Sentence denotes The pro-inflammatory effects of Ang II are mediated through AT1R in several ways:
T72 8674-9159 Sentence denotes 1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis.
T73 9160-9265 Sentence denotes These effects are attenuated by angiotensin receptor blockers (ARBs), which block Ang II binding to AT1R.
T74 9266-9405 Sentence denotes Ang II can also be converted to angiotensin 1-7 (Ang 1-7) via ACE2, which stimulates the Mas receptor promoting anti-inflammatory benefits.
T75 9406-9518 Sentence denotes The ACE2/Ang1-7/Mas axis acts as a counter regulatory pathway to the traditional renin-angiotensin system (RAS).
T76 9519-9545 Sentence denotes AT1R and ACE2 are coupled.
T77 9546-9624 Sentence denotes Ang II binding to AT1R allows dissociation of ACE2 and subsequent degradation.
T78 9625-9727 Sentence denotes ARB prevents dissociation of ACE2 and renders it availability for unused Ang II conversion to Ang 1-7.
T79 9728-9863 Sentence denotes ACE2 has been identified as the targeted receptor for both the severe acute respiratory syndrome coronavirus (SARS-CoV) 2 and SARS-CoV.
T80 9864-9994 Sentence denotes ACE2 mediates S protein binding that stimulates viral entry into the host cytosol that results in infection and viral replication.
T81 9995-10185 Sentence denotes Diversion of Ang II towards ACE2 could competitively inhibit viral binding and also counter regulate the adverse effects caused by AT1R and improve outcomes by Mas R−based favorable effects.
T82 10186-10295 Sentence denotes Several studies have elucidated the role of these drug classes on the modulation of the ACE2/Ang1-7/Mas axis.
T83 10296-10461 Sentence denotes Mouse peritoneal macrophages treated in vitro with aldosterone, demonstrated significantly increased ACE activity as well as ACE mRNA and significantly reduced ACE2.
T84 10462-10744 Sentence denotes However, in mouse peritoneal macrophages treated with nicotinamide adenine dinucleotide phosphate oxidase inhibitor, aldosterone could not increase ACE or decrease ACE2, which suggested these effects were mediated in part by nicotinamide adenine dinucleotide phosphate oxidase (42).
T85 10745-10825 Sentence denotes These effects were also attenuated with treatment with an MRA (eplerenone) (42).
T86 10826-11064 Sentence denotes Human monocyte-derived macrophages obtained from patients with heart failure before and after 1 month of treatment with another MRA (spironolactone; 25 mg/day) showed 47% reduction in ACE activity and 53% reduction in ACE mRNA expression.
T87 11065-11163 Sentence denotes At the same time, ACE2 activity increased by 300% and ACE2 mRNA expression increased by 654% (42).
T88 11164-11314 Sentence denotes In mice treated for 2 weeks with eplerenone, cardiac ACE2 activity increased 2-fold and was paralleled by increased ACE2 activity in macrophages (42).
T89 11315-11561 Sentence denotes This study demonstrated that the MRA reduced oxidative stress, decreased ACE activity, and increased ACE2 activity and/or expression, which suggested the protective role played by increased generation of Ang 1-7 and decreased formation of Ang II.
T90 11562-11890 Sentence denotes Overall, aldosterone decreased ACE2 transcription through a nicotinamide adenine dinucleotide phosphate oxidase−mediated pathway (42), and in vascular smooth muscle cells, potentiated Ang II signaling with increased phosphorylation of ERK1/2 and c-Jun kinase, which are also dependent on reactive oxygen species generation (43).
T91 11891-12035 Sentence denotes Thus, the beneficial effects of MRAs are likely associated with reduction of oxidative stress and differential control of these angiotensinases.
T92 12036-12193 Sentence denotes MRAs appeared to promote membrane ACE2 expression and suppress the peripheral effects of Ang II; however, the effect of MRAs on soluble ACE2 remains unclear.
T93 12194-12287 Sentence denotes Similar upregulation of ACE2 was observed in studies focused on the effects of ARB treatment.
T94 12288-12551 Sentence denotes Spontaneously hypertensive rats treated with olmesartan demonstrated a 5-fold greater expression of ACE2 mRNA and increased Ang1-7 in their thoracic aortas, whereas those treated with atenolol and hydralazine exhibited no change in ACE2 expression or Ang1-7 (44).
T95 12552-12786 Sentence denotes Comparison of vessel wall dimensions showed that olmesartan selectively reduced the thoracic aorta media-to-lumen ratio, whereas vascular hypertrophy was unchanged in spontaneously hypertensive rats given atenolol or hydralazine (44).
T96 12787-12896 Sentence denotes There was no change in ACE2/Ang1-7 expression and/or activity in the carotid arteries of the treated animals.
T97 12897-13147 Sentence denotes The possibility that the effects of olmesartan on vascular ACE2 gene and protein expression were the result of reduced arterial blood pressure was ruled out because of the comparative effect observed in mice treated with atenolol or hydralazine (44).
T98 13148-13405 Sentence denotes Sprague-Dawley rats treated with a 4-week course of Ang II infusion showed Ang II upregulated AT1 receptor, downregulated AT2 receptor, ACE2 activity, endothelial nitric oxide synthase expression, as well as increased CD44 expression and hyaluronidase (45).
T99 13406-13649 Sentence denotes However, rats treated with telmisartan exhibited significantly increased ACE2 activity and endothelial nitric oxide synthase expression in intracardiac vessels and intermyocardium, as well as downregulated local expression of the AT1 receptor.
T100 13650-13783 Sentence denotes Treatment with telmisartan also inhibited membrane CD44 expression and reduced transforming growth factor−β and Smad expression (45).
T101 13784-14029 Sentence denotes Studies in normotensive rats with post-coronary artery ligation left ventricular remodeling and dysfunction exhibited partial resolution following losartan and olmesartan treatment while augmenting plasma concentrations of the angiotensins (46).
T102 14030-14316 Sentence denotes This was associated with recovery of cardiac AT1 receptor mRNA and increased ACE2 mRNA post-myocardial infarction, which implied the beneficial effects of ARBs on cardiac remodeling were accompanied by direct blockade of AT1 receptors and increased ACE2 expression and/or activity (46).
T103 14317-14539 Sentence denotes The literature offers conflicting results pertaining to ARB use and the level of ACE2 expression on the myocardium; most of the controversy arises from the difference in ACE2 cell surface expression and plasma ACE2 levels.
T104 14540-14785 Sentence denotes In the Sprague-Dawley rats with left coronary artery ligation and myocardial infarction, plasma Ang II and Ang1-7 were not elevated, but plasma ACE2 was elevated, along with enhanced cardiac ACE2 and AT1 receptor mRNA at the infarct border (47).
T105 14786-14855 Sentence denotes Receptor upregulation was not observed in the remote myocardium (47).
T106 14856-15170 Sentence denotes Treatment with ramipril and valsartan resulted in increased plasma Ang I and Ang II and suppression in plasma ACE and ACE2 activity; however, neither monotherapy nor combination therapy affected ACE2 or AT1 receptor expression, both of which remained at levels comparable to non-myocardial infarction control (47).
T107 15171-15338 Sentence denotes However, a previous study in the same murine model showed ACE and ACE2 upregulation in the border, infarct zones, and in viable myocardium after myocardial infarction.
T108 15339-15470 Sentence denotes Treatment with ramipril reduced ACE expression, whereas ACE2 remained elevated compared with the noninfarcted control subject (48).
T109 15471-15757 Sentence denotes A recent study in the same murine model demonstrated that treatment with olmesartan or telmisartan increased both cardiac ACE2 mRNA and protein expression while augmenting plasma Ang1-7/Ang II ratios, which resulted in improved cardiac function and alleviated collagen disposition (49).
T110 15758-15862 Sentence denotes These experiments suggested that both ACE inhibitors and ARBs variably upregulated ACE2 expression (49).
T111 15863-15999 Sentence denotes ARBs inhibited binding of Ang II to the AT1 receptor, which permitted circulating Ang II to be shunted to ACE2 for conversion to Ang1-7.
T112 16000-16190 Sentence denotes These studies suggest that the ACE2/Ang1-7 axis collaborates with or is regulated by the AT1 receptor and may be important in mediating the vascular and cardiac remodeling effects of Ang II.
T113 16191-16246 Sentence denotes The mechanisms by which ACE inhibitors act are complex.
T114 16247-16399 Sentence denotes Although ACE2 is not inhibited by ACE inhibitors (19), an increase in Ang1-7 suggests their clinical effects are partly mediated by the angiotensinases.
T115 16400-16498 Sentence denotes ACE inhibitors inhibit the conversion of Ang I to Ang II and inhibit the hydrolysis of bradykinin.
T116 16499-16721 Sentence denotes ACE inhibition promotes the vasodilatory effects of bradykinin, improved endothelium-dependent vasodilation through increased prostaglandin and nitric oxide production, and down regulation of the AT1 receptor (50, 51, 52).
T117 16722-16882 Sentence denotes Studies that elucidated the effect of ACE inhibition on the ACE2 gene showed that inhibition of Ang II synthesis regulated ACE2 mRNA but not ACE2 activity (53).
T118 16883-17022 Sentence denotes However, ACE inhibition alone or in combination with losartan was demonstrated to increase plasma Ang1-7 while reducing plasma Ang II (53).
T119 17023-17294 Sentence denotes Compared with the degree of ACE2 mRNA upregulation seen with post-losartan monotherapy, combination of losartan and lisinopril resulted in suppressed upregulation of ACE2 mRNA, which suggested ACE inhibitors might override a signal that regulates ACE2 transcription (53).
T120 17295-17576 Sentence denotes Although Ang II is the predominant substrate, ACE2 can also convert Ang I into Ang 1-9, which, in turn, could be converted to Ang 1-7 via ACE; Ang I can be directly converted into Ang 1-7 via zinc metallopeptidase neprilysin (17), although with less favorable kinetics at baseline.
T121 17577-17739 Sentence denotes Thus, it can be assumed ACE inhibitors disrupt the balance between catalytically active ACE and ACE2, resulting in favored activation of the ACE2/Ang1-7/Mas axis.
T122 17740-17937 Sentence denotes Overall, because of the demonstrated anti-inflammatory, antifibrotic, and antithrombotic effects associated with the ACE2/Ang1-7/Mas axis, upregulation could serve as a valuable therapeutic target.
T123 17939-17955 Sentence denotes ACE2 and Ang1-7:
T124 17956-17971 Sentence denotes Clinical Trials
T125 17972-18107 Sentence denotes ACE2 regulates RAS signaling by reducing Ang II/AT1 receptor signaling and by activating the ACE2/Ang1-7/Mas counterregulatory pathway.
T126 18108-18276 Sentence denotes Thus far, only a few pilot clinical studies have been conducted using rhACE2 in acute respiratory distress syndrome (ARDS), sepsis, and pulmonary arterial hypertension.
T127 18277-18408 Sentence denotes Multiple murine studies demonstrated rhACE2 modulates the RAS pathway, although it is unclear if these effects translate to humans.
T128 18409-18786 Sentence denotes A clinical study (Safety and Tolerability Study of APN01 [Recombinant Human Angiotensin Converting Enzyme 2]; NCT00886353) that assessed the pharmacokinetics and pharmacodynamics of soluble rhACE2 treatment in healthy volunteers with no known comorbidities showed a decrease in plasma Ang1-8 and increased Ang1-7 and Ang1-5 with no effect on blood pressure and heart rate (54).
T129 18787-18838 Sentence denotes Common side effects included diarrhea and headache.
T130 18839-18960 Sentence denotes No antibodies to rhACE2 developed, which suggested there was no elicit immune response to single or repeated dosing (54).
T131 18961-19032 Sentence denotes Further studies investigating the immunogenicity of rhACE are required.
T132 19033-19118 Sentence denotes Serum levels of ACE and Ang II are elevated in patients with ARDS and sepsis (55,56).
T133 19119-19523 Sentence denotes Studies focused on microvascular dysfunction in sepsis showed that the degree of elevation in plasma renin and Ang II were correlated with the extent of organ failure and the degree of microvascular dysfunction, especially in patients who received exogenous vasoconstrictors (56); there was also a negative correlation between re-oxygenation rates and both concentrations of plasma renin and Ang II (56).
T134 19524-19825 Sentence denotes In a pilot clinical trial (Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury; NCT01597635), patients with ARDS who were treated with rhACE2 exhibited decreased plasma Ang II and elevated plasma Ang 1-7 and surfactant protein-D, which is involved in innate immunity (57).
T135 19826-19988 Sentence denotes IL-6 concentrations in treated patients were also reduced, albeit statistically insignificantly, which was due to intrasubject variability and baseline imbalance.
T136 19989-20149 Sentence denotes Although rhACE2 attenuated RAS mediators, infusions of the medication did not show improvement in physiological or clinical measures of ARDs in this study (57).
T137 20150-20321 Sentence denotes An additional pilot study (NCT101884051) investigated the effects of rhACE2 in human pulmonary arterial hypertension, which is characterized by reduced ACE2 activity (58).
T138 20322-20549 Sentence denotes Treatment with rhACE2 showed improved cardiac output that coincided with maximum suppression of plasma cytokines and reduction in nitrotyrosine levels, improved peripheral vascular resistance, and improved renal perfusion (58).
T139 20550-20620 Sentence denotes Ongoing clinical studies assessing the modulation of RAS axis include:
T140 20621-20835 Sentence denotes 1) the assessment of the relative activity of ACE and ACE2 in patients with diabetes following treatment with candesartan (Non-Insulin Dependent Diabetes Mellitus [NIDDM] and Angiotensin Converting Enzyme 2 [ACE2]:
T141 20836-21154 Sentence denotes Diabetic Patients Treated With Antihypertensive Drugs; NCT00192803); and 2) the overexpression of ACE2/Ang 1-7 in cardiac progenitor cells to assess for enhancement in reparative function and the potential to attenuate myocardial ischemia−induced cardiac damage (Cardiovascular Disease Protection Tissue; NCT02348515).
T142 21155-21361 Sentence denotes It is evident that targeting the ACE2/Ang1-7/Mas axis is going to be interesting in clinical settings because of the observed cardioprotective effects in the in vivo murine and in vitro cell culture models.
T143 21362-21507 Sentence denotes However, further investigation is required to demonstrate whether these favorable experimental effects could be translated into clinical benefit.
T144 21509-21550 Sentence denotes ACE2, COVID-19, and Cardiovascular Damage
T145 21551-21626 Sentence denotes Several reports have noted COVID-19 is associated with cardiac involvement.
T146 21627-21856 Sentence denotes In cohort studies of hospitalized patients with confirmed COVID-19, several patients presented with elevated troponin I, C-reactive protein, and N-terminal pro–B-type natriuretic peptide suggestive of myocardial injury (2,59,60).
T147 21857-22157 Sentence denotes Anecdotal studies have reported patients presenting with cardiac magnetic resonance imagining−verified acute myopericarditis with systolic dysfunction masquerading as diffuse ST-segment elevation myocardial infarction with elevated cardiac markers in the absence of obstructive coronary disease (59).
T148 22158-22319 Sentence denotes In a cohort study of 139 patients with COVID-19 hospitalized in Wuhan, China, 7.2% had acute myocardial injury, 8.7% had shock, and 16.7% had an arrhythmia (61).
T149 22320-22471 Sentence denotes Of the observed patients, those with cardiac injury were found to have a high risk of death both from time of symptom onset and time of admission (60).
T150 22472-22704 Sentence denotes As more epidemiological studies emerge from China, Italy, and other affected areas, more data will be available to elucidate the clinical presentation of patients and the cardiovascular damage associated with this novel coronavirus.
T151 22705-22839 Sentence denotes With regard to COVID-19, there are currently several clinical studies investigating the effects of RAS inhibition and ACE2 regulation.
T152 22840-23158 Sentence denotes An ongoing study will assess the impact of ACE inhibitor and ARB treatment on the severity and prognosis of patients with COVID-19 (Hypertension in Patients Hospitalized With COVID-19 [HT-COVID19], NCT04318301; ACE Inhibitors, Angiotensin II Type-I Receptor Blockers and Severity of COVID-19 [CODIV-ACE], NCT04318418).
T153 23159-23476 Sentence denotes Along these lines, there are 2 recently launched trials testing the effects of losartan among patients hospitalized with COVID-19 (Losartan for Patients With COVID-19 Requiring Hospitalization; NCT04312009) and those who are ambulatory (Losartan for Patients With COVID-19 Not Requiring Hospitalization; NCT04311177).
T154 23477-23853 Sentence denotes Further studies have been launched to evaluate the effect of continuation versus replacement (Coronavirus [COVID-19] ACEi/ARB Investigation [CORONACION]; NCT04330300) or withdrawal (ACE Inhibitors or ARBs Discontinuation in Context of SARS-CoV-2 Pandemic [ACORES-2]; NCT04329195) of RAS inhibitors on the clinical outcomes in patients with cardiovascular disease and COVID-19.
T155 23854-24075 Sentence denotes There is also an ongoing pilot study assessing the effects of rhACE2 treatment in patients with COVID-19 (Recombinant Human Angiotensin-converting Enzyme 2 [rhACE2] as a Treatment for Patients With COVID-19; NCT04287686).
T156 24076-24193 Sentence denotes Currently, there is no data to support any conclusive effects of the use of RAS inhibitors in patients with COVID-19.
T157 24195-24214 Sentence denotes ACE2 and SARS-CoV-2
T158 24215-24398 Sentence denotes SARS-CoV, which emerged in the Guangdong province, China, and SARS-CoV-2, which emerged in Wuhan, China are closely related beta-coronaviruses whose affected receptor is ACE2 (1,3,4).
T159 24399-24554 Sentence denotes At this time, it is unknown if the approximate 76% sequence similarity between these strains of viruses translates into similar biological properties (14).
T160 24555-24683 Sentence denotes Recent studies have confirmed COVID-19 exploits ACE2 for entry and thus may target a similar spectrum of cells as SARS-CoV (14).
T161 24684-24743 Sentence denotes SARS-CoV-2 binds to ACE2 via its spike (S) protein (13,14).
T162 24744-24848 Sentence denotes The surface unit S1, of the S protein binds to ACE2, which facilitates viral attachment to target cells.
T163 24849-25103 Sentence denotes Following receptor binding, the virus must gain access to host cytosol, which is accomplished by acid-dependent proteolytic cleavage of the S protein by cellular serine protease TMPRSS2, which is similar to S protein priming in SARS-CoV (14) (Figure 2 ).
T164 25104-25164 Sentence denotes Figure 2 Proposed Mechanism of Entry for SARS-CoV-2 Via ACE2
T165 25165-25280 Sentence denotes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the catalytic site of ACE2 via its S protein.
T166 25281-25515 Sentence denotes To gain access to the host cytosol, the S protein undergoes acid dependent proteolytic cleavage by ACE2, tumor necrosis factor (TNF)-α, transmembrane protease serine 2 (TMPRRS2), which results in the formation of an S1 and S2 subunit.
T167 25516-25629 Sentence denotes S2 fusion peptide inserts into the membrane, which allows for clatherin-dependent endocytosis of ACE2-SARS-CoV-2.
T168 25630-25726 Sentence denotes Viral binding stimulates TNF-α and calmodulin inhibitors to promote ectodomain cleavage of ACE2.
T169 25727-25808 Sentence denotes ADAM 17 = disintegrin and metalloprotease 17; other abbreviations as in Figure 1.
T170 25809-26123 Sentence denotes Because of the sequence similarity between SARS-CoV and SARS-CoV-2, their affected receptor, and recently confirmed TMPRSS2-mediated viral entry, it is reasonable to hypothesize that SARS-CoV-2 may act similarly with respect to using host endocytosis machinery, subsequent virus propagation, and further infection.
T171 26124-26248 Sentence denotes Upon binding to ACE2, cleavage of the S protein at the S1/S2 sites and S2 allows for fusion of viral and cellular membranes.
T172 26249-26346 Sentence denotes SARS-CoV is then internalized and penetrates early endosomes in a clathrin-dependent manner (62).
T173 26347-26484 Sentence denotes Viral binding to ACE2 appears to affect TNF-α activity, which in the presence of calmodulin inhibitors promotes ectodomain cleavage (63).
T174 26485-26924 Sentence denotes In the case of SARS-CoV-2, it is possible this shedding is also mediated by TNF-α because 1 of the clinical features noted in patients with COVID-19 has been the presence of a cytokine storm with increased plasma concentrations of IL-2, IL-7, IL-10, granulocyte-colony stimulating factor (GCSF), interferon gamma-induced protein 10 (IP10), monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha (MIP1A), and TNF-α (2).
T175 26925-27024 Sentence denotes It is also possible that ACE2 shedding may be mediated by other cytokines dysregulated in COVID-19.
T176 27025-27139 Sentence denotes This shedding contributes to the down-regulation of membrane-bound ACE2 observed in severe acute lung injury (64).
T177 27140-27294 Sentence denotes Ectodomain shedding increases the concentration of plasma ACE2, which remains catalytically active, although the function of soluble ACE2 remains unclear.
T178 27295-27508 Sentence denotes In patients with advanced heart failure, plasma ACE2 activity is increased in direct proportion with worsening clinical status and reduction in ejection fraction and correlates with adverse clinical outcomes (65).
T179 27509-27950 Sentence denotes Because down-regulation of bound ACE2 is observed in severe acute lung injury (65) and after myocardial infarction (46), and concentrations of soluble ACE2 appear to correlate with clinical outcomes of patients with heart failure (30), it is possible to suggest that concentrations of soluble ACE2 may correlate to the extent of tissue damage sustained and may correlate to the degree by which systemic inflammatory pathways are upregulated.
T180 27951-28034 Sentence denotes There is some evidence to suggest soluble ACE2 is able to regulate systemic Ang II.
T181 28035-28188 Sentence denotes Clinical trials have shown rhACE2 could convert systemic Ang II to Ang 1-7 (57,58) and play some pathological, compensatory, or counter regulatory roles.
T182 28189-28525 Sentence denotes If SARS-CoV-2 does induce ACE2 ectodomain shedding, which results in the reduction of ACE2 entry sites on the infected cell, it is possible that following transcription S proteins fuse directly at the host cell membrane and directly promote infection of neighboring cells, which results in the formation of multinucleated syncytia (66).
T183 28526-28664 Sentence denotes Formation of multinucleated cells would allow the virus to spread without being detected or neutralized by virus-specific antibodies (66).
T184 28665-28842 Sentence denotes Otherwise, following replication and transcription, complete virion assembly in the Golgi would result in transportation of the virus in vesicles and release by exocytosis (66).
T185 28843-28997 Sentence denotes In the setting of full virion assembly and exocytosis, it is unclear if ACE2 ectodomain shedding would be favorable for further propagation and infection.
T186 28999-29060 Sentence denotes Medical Management in Cardiovascular Patients With SARS-CoV-2
T187 29061-29224 Sentence denotes Regardless of how SARS-CoV-2 completes virion assembly, it is clear that membrane-bound ACE2 would play a physiological role in the replication of the novel virus.
T188 29225-29435 Sentence denotes The question remains whether the use of ACE inhibitors, ARBs, and MRAs should be avoided in the setting of SARS-CoV infection because each agent (42, 43, 44, 45, 46,53) upregulates ACE2 expression and activity.
T189 29436-29707 Sentence denotes Lipopolysaccharide-induced acute lung injury mouse models exhibited decreased expression of ACE2, lung and inflammatory injury; however, this was ameliorated by the injection of cells transfected with ACE2 and resulted in the improvement of lung function and lung injury.
T190 29708-29826 Sentence denotes Treatment of these mice with ACE inhibitors and ARBs also alleviated lipopolysaccharide-induced pneumonic injury (67).
T191 29827-29941 Sentence denotes Previous studies showed the SARS-CoV S protein can exaggerate acute lung failure through dysregulation of the RAS.
T192 29942-30044 Sentence denotes However, SARS-CoV Spike–mediated lung failure could be rescued by inhibition of the AT1 receptor (67).
T193 30045-30329 Sentence denotes Again, adequate data on the effects of RAS inhibition in patients with COVID-19 is not available, and ongoing clinical and/or observations studies are being conducted (see previous mentions of NCT04318301, NCT04318418, NCT04312009, NCT04311177, NCT04287686, NCT04330300, NCT04329195).
T194 30330-30728 Sentence denotes If SARS-CoV-2 down-regulates membrane-bound ACE2 by promoting the ADAM17−mediated ectodomain shedding, resulting in increased concentrations of soluble ACE2 without compromising viral propagation, we hypothesize this would result in the overall down regulation of the ACE2/Ang1-7/Mas pathway, which would contribute to the severity of inflammation and systemic dysregulation observed in SARS-CoV-2.
T195 30729-31087 Sentence denotes Thus, in patients with cardiovascular disease and SARS-CoV-2, the use of ACE inhibitors, ARBs, or MRAs may be favorable as a method to endogenously upregulate ACE2 as a compensatory mechanism that provides anti-inflammatory, antifibrotic, and antithrombotic support as well as reduction in progression of vascular and/or cardiac remodeling and heart failure.
T196 31088-31486 Sentence denotes Several societies, including the American College of Cardiology, American Heart Association, Heart Failure Society of America (68), and European Society of Cardiology (69) have recommended continuing RAS antagonists because of the lack of conclusive data on a link between upregulation of systemic or tissue ACE2 and the increased susceptibility to COVID-19 in patients with cardiovascular disease.
T197 31487-31709 Sentence denotes Based on our review, we hypothesize cardiovascular patients with COVID-19 should remain on RAS inhibitors because of the protective effects of the ACE2 pathway until RAS blockade is proven to increase the risk of COVID-19.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 730-752 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 1630-1642 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 1725-1740 Phenotype denotes atherosclerosis http://purl.obolibrary.org/obo/HP_0002621
T6 1997-2020 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T7 4023-4028 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T8 7069-7081 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T9 8140-8162 Phenotype denotes Cardiovascular Disease http://purl.obolibrary.org/obo/HP_0001626
T10 8203-8225 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T11 8327-8350 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T12 9023-9038 Phenotype denotes water retention http://purl.obolibrary.org/obo/HP_0000969
T13 9127-9143 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T14 10889-10902 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T15 11360-11376 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T16 11968-11984 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T17 14122-14143 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T18 14606-14627 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 15135-15156 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T20 15316-15337 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T21 18194-18214 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T22 18232-18238 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T23 18244-18275 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T24 18816-18824 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T25 18829-18837 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T26 19103-19109 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T27 19167-19173 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T28 19200-19225 Phenotype denotes elevation in plasma renin http://purl.obolibrary.org/obo/HP_0000848
T29 19614-19631 Phenotype denotes Acute Lung Injury http://www.orpha.net/ORDO/Orphanet_178320
T30 20235-20266 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T31 20744-20783 Phenotype denotes Non-Insulin Dependent Diabetes Mellitus http://purl.obolibrary.org/obo/HP_0005978
T32 20785-20790 Phenotype denotes NIDDM http://purl.obolibrary.org/obo/HP_0005978
T33 21099-21121 Phenotype denotes Cardiovascular Disease http://purl.obolibrary.org/obo/HP_0001626
T34 22032-22052 Phenotype denotes ST-segment elevation http://purl.obolibrary.org/obo/HP_0012251
T35 22053-22074 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T36 22135-22151 Phenotype denotes coronary disease http://purl.obolibrary.org/obo/HP_0001677
T37 22279-22284 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T38 22303-22313 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T39 22972-22984 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T40 23817-23839 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T41 25386-25391 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T42 26661-26675 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T43 27116-27133 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T44 27321-27334 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T45 27569-27586 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T46 27602-27623 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T47 27725-27738 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T48 29463-29480 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T49 30752-30774 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T50 31073-31086 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T51 31181-31194 Phenotype denotes Heart Failure http://purl.obolibrary.org/obo/HP_0001635
T52 31463-31485 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T58 10-21 NCBITaxon:11118 denotes coronavirus
T59 36-44 SP_7 denotes COVID-19
T60 66-78 SP_7 denotes severe acute
T61 79-90 SP_7;UBERON:0001004 denotes respiratory
T62 91-113 SP_7 denotes syndrome-coronavirus-2
T63 115-125 SP_7 denotes SARS-CoV-2
T64 304-312 SP_10 denotes SARS-CoV
T65 354-364 SP_7 denotes SARS-CoV-2
T66 427-431 SP_10 denotes SARS
T67 503-514 UBERON:0001004 denotes respiratory
T68 564-575 NCBITaxon:11118 denotes coronavirus
T69 657-665 SP_7 denotes COVID-19
T70 681-695 UBERON:0004535 denotes cardiovascular
T71 730-744 UBERON:0004535 denotes cardiovascular
T72 789-794 GO:0016265 denotes death
T73 807-815 SP_10 denotes SARS-CoV
T74 844-855 NCBITaxon:11118 denotes coronavirus
T75 880-884 SP_2;NCBITaxon:8342 denotes bats
T76 915-919 SP_10 denotes SARS
T77 925-936 NCBITaxon:11118 denotes coronavirus
T78 967-975 SP_10 denotes SARS-CoV
T79 980-990 SP_7 denotes SARS-CoV-2
T80 1034-1043 SP_1 denotes pangolins
T81 1068-1076 SP_10 denotes SARS-CoV
T82 1117-1148 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T83 1150-1154 G_3;PG_10;PR:000003622 denotes ACE2
T84 1218-1222 G_3;PG_10;PR:000003622 denotes ACE2
T85 1249-1254 PR:000013883 denotes renin
T86 1326-1336 GO:0065007 denotes regulation
T87 1373-1386 GO:0008217 denotes regulation of
T88 1387-1392 GO:0008217;UBERON:0000178 denotes blood
T89 1393-1401 GO:0003095 denotes pressure
T90 1403-1414 GO:0003095 denotes natriuresis
T91 1420-1425 UBERON:0000178 denotes blood
T92 1426-1440 GO:0008217 denotes volume control
T93 1490-1504 DG_37;PR:000036009 denotes angiotensin II
T94 1506-1512 PR:000036009 denotes Ang II
T95 1557-1571 UBERON:0004535 denotes cardiovascular
T96 1644-1654 UBERON:0002349 denotes myocardial
T97 1668-1675 UBERON:0000948 denotes cardiac
T98 1775-1789 UBERON:0004535 denotes cardiovascular
T99 1846-1856 CHEBI:35222;CHEBI:35222 denotes inhibitors
T100 1858-1872 CHEBI:48432;CHEBI:48432;DG_37 denotes angiotensin II
T101 1873-1890 CHEBI:48561;CHEBI:48561 denotes receptor blockers
T102 1903-1920 CHEBI:25354;CHEBI:25354 denotes mineralocorticoid
T103 1921-1941 CHEBI:48561;CHEBI:48561 denotes receptor antagonists
T104 1997-2011 UBERON:0004535 denotes cardiovascular
T105 2067-2071 G_3;PG_10;PR:000003622 denotes ACE2
T106 2200-2204 G_3;PG_10;PR:000003622 denotes ACE2
T107 2220-2228 GO:0016020 denotes membrane
T108 2283-2287 PR:000014459;SP_7 denotes SARS
T109 2287-2293 SP_7 denotes -CoV-2
T110 2308-2317 PG_1 denotes S-protein
T111 2357-2367 SP_7 denotes SARS-CoV-2
T112 2384-2388 G_3;PG_10;PR:000003622 denotes ACE2
T113 2441-2445 SP_10 denotes SARS
T114 2453-2467 UBERON:0004535 denotes cardiovascular
T115 2545-2559 UBERON:0004535 denotes cardiovascular
T116 2619-2630 NCBITaxon:11118 denotes coronavirus
T117 2633-2655 PG_10 denotes Angiotensin-Converting
T118 2656-2664 PG_10;PR:000003622 denotes Enzyme 2
T119 2732-2737 PR:000013883 denotes renin
T120 2743-2756 PR:000036008 denotes angiotensin I
T121 2758-2763 PR:000036008 denotes Ang I
T122 2766-2769 CHEBI:37886;CHEBI:37886;PR:000036008 denotes Ang
T123 2770-2771 PR:000036008;CHEBI:16382;CHEBI:16382 denotes I
T124 2775-2786 GO:0008152 denotes metabolized
T125 2790-2793 CHEBI:37886;CHEBI:37886 denotes Ang
T126 2869-2875 PR:000036009 denotes Ang II
T127 2907-2913 PR:000036009 denotes Ang II
T128 2952-2956 G_3;PG_10;PR:000003622 denotes ACE2
T129 3073-3077 G_3;PG_10;PR:000003622 denotes ACE2
T130 3099-3107 GO:0016020 denotes membrane
T131 3108-3120 CHEBI:17089;BV_11;CHEBI:17089 denotes glycoprotein
T132 3126-3135 GO:0010467 denotes expressed
T133 3157-3165 UBERON:0002185 denotes bronchus
T134 3167-3182 UBERON:0008946 denotes lung parenchyma
T135 3184-3189 UBERON:0008307 denotes heart
T136 3191-3202 UBERON:0008307 denotes endothelium
T137 3204-3211 UBERON:0002113 denotes kidneys
T138 3213-3221 UBERON:0002114 denotes duodenum
T139 3233-3242 UBERON:0002108 denotes intestine
T140 3249-3253 G_3;PG_10;PR:000003622 denotes ACE2
T141 3292-3299 SO:0000853 denotes homolog
T142 3330-3334 G_3;PG_10;PR:000003622 denotes ACE2
T143 3361-3371 CHEBI:35222;CHEBI:35222 denotes inhibitors
T144 3419-3426 SO:0000417 denotes domains
T145 3428-3432 G_3;PG_10;PR:000003622 denotes ACE2
T146 3456-3462 SO:0000417 denotes domain
T147 3523-3527 G_3;PG_10;PR:000003622 denotes ACE2
T148 3531-3537 PR:000036009 denotes Ang II
T149 3561-3569 MOP:0000780 denotes cleavage
T150 3580-3593 PR:000036013 denotes angiotensin 1
T151 3597-3602 PR:000036013 denotes Ang1-
T152 3652-3656 G_3;PG_10;PR:000003622 denotes ACE2
T153 3665-3670 PR:000036008 denotes Ang I
T154 3672-3678 PR:000004135 denotes apelin
T155 3781-3787 SO:0000417 denotes domain
T156 3791-3795 G_3;PG_10;PR:000003622 denotes ACE2
T157 3818-3826 SO:0000853 denotes homology
T158 3832-3842 PR:000016422 denotes collectrin
T159 3907-3916 UBERON:0000160 denotes intestine
T160 3925-3931 UBERON:0002113 denotes kidney
T161 4000-4006 PR:000001279 denotes ADAM17
T162 4046-4049 PR:000000134 denotes TNF
T163 4079-4083 PR:000003622;G_3;PG_10 denotes ACE2
T164 4171-4175 G_3;PG_10;PR:000003622 denotes ACE2
T165 4192-4202 PR:000004978 denotes calmodulin
T166 4203-4209 SO:0000417 denotes domain
T167 4217-4228 GO:0005737 denotes cytoplasmic
T168 4277-4281 G_3;PG_10;PR:000003622 denotes ACE2
T169 4282-4286 PR:000036013 denotes Ang1
T170 4298-4308 GO:0065007 denotes Regulation
T171 4309-4314 PR:000036008 denotes Ang I
T172 4371-4377 PR:000036009 denotes Ang II
T173 4398-4403 PR:000036008 denotes Ang I
T174 4424-4428 PR:000036012 denotes Ang1
T175 4434-4438 PR:000003622;G_3;PG_10 denotes ACE2
T176 4463-4469 PR:000036009 denotes Ang II
T177 4486-4491 PR:000036013 denotes Ang 1
T178 4502-4506 PR:000003622;G_3;PG_10 denotes ACE2
T179 4513-4518 PR:000036013 denotes Ang1-
T180 4535-4552 CHEBI:67079;CHEBI:67079 denotes anti-inflammatory
T181 4664-4667 PR:000001563 denotes Mas
T182 4689-4695 PR:000036013 denotes Ang1-7
T183 4726-4731 PR:000036008 denotes Ang I
T184 4799-4809 PR:000001898 denotes neprilysin
T185 4827-4833 PR:000036012 denotes Ang1-9
T186 4837-4843 PR:000036013 denotes Ang1-7
T187 4904-4911 SO:0000704 denotes Genetic
T188 4946-4950 G_3;PG_10;PR:000003622 denotes ACE2
T189 4980-4994 UBERON:0004535 denotes cardiovascular
T190 5033-5043 GO:0065007 denotes regulation
T191 5047-5051 G_3;PG_10;PR:000003622 denotes ACE2
T192 5055-5062 UBERON:0000948;CL:0000746 denotes cardiac
T193 5063-5071 CL:0000746 denotes myocytes
T194 5076-5083 UBERON:0000948;CL:0002548 denotes cardiac
T195 5084-5095 CL:0002548 denotes fibroblasts
T196 5128-5134 PR:000036009 denotes Ang II
T197 5157-5161 G_3;PG_10;PR:000003622 denotes ACE2
T198 5189-5193 G_3;PG_10;PR:000003622 denotes ACE2
T199 5202-5209 UBERON:0000948;CL:0000746 denotes cardiac
T200 5210-5218 CL:0000746 denotes myocytes
T201 5236-5240 G_3;PG_10;PR:000003622 denotes ACE2
T202 5253-5264 CL:0000057 denotes fibroblasts
T203 5274-5282 CL:0000187 denotes myocytes
T204 5284-5294 UBERON:0001986 denotes endothelin
T205 5331-5335 G_3;PG_10;PR:000003622 denotes ACE2
T206 5376-5380 G_3;PG_10;PR:000003622 denotes ACE2
T207 5389-5395 PR:000036009 denotes Ang II
T208 5399-5403 PR:000006897 denotes ET-1
T209 5419-5429 CHEBI:35222;CHEBI:35222 denotes inhibitors
T210 5433-5440 CHEBI:52290;CHEBI:52290;PR:000000103 denotes mitogen
T211 5440-5467 PR:000000103 denotes -activated protein kinase 1
T212 5469-5474 PR:000000103 denotes MAPK1
T213 5498-5504 PR:000036009 denotes Ang II
T214 5509-5513 PR:000006897 denotes ET-1
T215 5523-5536 GO:0005576 denotes extracellular
T216 5544-5553 GO:0065007 denotes regulated
T217 5562-5565 PR:000007130 denotes ERK
T218 5568-5572 PR:000000103 denotes ERK2
T219 5583-5587 G_3;PG_10;PR:000003622 denotes ACE2
T220 5615-5621 NCBITaxon:39107 denotes murine
T221 5637-5643 PR:000036009 denotes Ang II
T222 5661-5669 GO:0016020 denotes membrane
T223 5676-5689 CL:0000746 denotes cardiomyocyte
T224 5690-5694 PR:000003622;G_3;PG_10 denotes ACE2
T225 5736-5742 PR:000001279 denotes ADAM17
T226 5778-5781 PR:000001251 denotes AT1
T227 5806-5813 UBERON:0000948;CL:0002548 denotes Cardiac
T228 5814-5825 CL:0002548 denotes fibroblasts
T229 5830-5838 UBERON:0005985;CL:0002364 denotes coronary
T230 5839-5850 UBERON:0001986;CL:0000115 denotes endothelial
T231 5851-5856 CL:0000115 denotes cells
T232 5862-5869 GO:0010467 denotes express
T233 5870-5874 G_3;PG_10;PR:000003622 denotes ACE2
T234 5879-5883 PR:000001279 denotes TACE
T235 5963-5969 PR:000036009 denotes Ang II
T236 6026-6029 PR:000045382 denotes PKC
T237 6034-6038 PR:000009197 denotes JAK2
T238 6039-6044 PR:000002089 denotes STAT3
T239 6082-6092 UBERON:0002349 denotes myocardial
T240 6149-6153 PR:000036013 denotes Ang1
T241 6174-6180 SO:0000417 denotes domain
T242 6199-6210 GO:0006508 denotes proteolytic
T243 6288-6293 SP_6;NCBITaxon:9606 denotes human
T244 6307-6314 UBERON:0000948 denotes cardiac
T245 6315-6321 UBERON:0000479 denotes tissue
T246 6326-6332 UBERON:0001969 denotes plasma
T247 6340-6344 PR:000036013 denotes Ang1
T248 6381-6386 PR:000036008 denotes Ang I
T249 6429-6433 PR:000036013 denotes Ang1
T250 6507-6511 G_3;PG_10;PR:000003622 denotes ACE2
T251 6521-6525 NCBITaxon:10088 denotes mice
T252 6531-6537 PR:000036009 denotes Ang II
T253 6563-6567 G_3;PG_10;PR:000003622 denotes ACE2
T254 6588-6592 PR:000000104 denotes ERK1
T255 6596-6600 PR:000009197 denotes JAK2
T256 6601-6606 PR:000002089 denotes STAT3
T257 6612-6615 PR:000045382;GO:0000187 denotes PKC
T258 6616-6625 GO:0000165 denotes signaling
T259 6694-6700 PR:000036009 denotes Ang II
T260 6709-6719 UBERON:0002349 denotes myocardial
T261 6834-6838 G_3;PG_10;PR:000003622 denotes ACE2
T262 6839-6843 PR:000036013 denotes Ang1
T263 6858-6868 GO:0065007 denotes modulating
T264 6873-6883 GO:0010467 denotes expression
T265 6923-6928 PR:000000134 denotes TNF-α
T266 6951-6955 PR:000001393 denotes IL-6
T267 6957-6965 CL:0000576;PR:000002122 denotes monocyte
T268 6966-6991 PR:000002122 denotes chemoattractant protein-1
T269 6997-7025 PR:000000046 denotes transforming growth factor-β
T270 7029-7036 UBERON:0000948 denotes cardiac
T271 7044-7048 UBERON:0002048 denotes lung
T272 7059-7068 UBERON:0002048 denotes pulmonary
T273 7162-7166 G_3;PG_10;PR:000003622 denotes ACE2
T274 7167-7171 PR:000036013 denotes Ang1
T275 7174-7177 PR:000001563 denotes Mas
T276 7183-7209 GO:0065007 denotes Regulation Angiotensinogen
T277 7226-7239 PR:000036008 denotes angiotensin I
T278 7241-7246 PR:000036008 denotes Ang I
T279 7252-7257 PR:000013883 denotes renin
T280 7259-7264 PR:000036008 denotes Ang I
T281 7281-7287 PR:000036009 denotes Ang II
T282 7340-7350 MOP:0000619 denotes hydrolyzes
T283 7351-7361 CHEBI:3165;CHEBI:3165 denotes bradykinin
T284 7380-7391 CHEBI:25212;CHEBI:25212 denotes metabolites
T285 7449-7455 PR:000036009 denotes Ang II
T286 7472-7478 PR:000036009 denotes Ang II
T287 7519-7530 CHEBI:27584;CHEBI:27584 denotes aldosterone
T288 7550-7565 UBERON:0001236 denotes adrenal medulla
T289 7610-7619 UBERON:0002198 denotes pituitary
T290 7621-7632 CHEBI:27584;CHEBI:27584 denotes Aldosterone
T291 7643-7651 GO:0016020 denotes membrane
T292 7652-7656 G_3;PG_10;PR:000003622 denotes ACE2
T293 7657-7667 GO:0010467 denotes expression
T294 7669-7679 UBERON:0001986;PR:000006897 denotes Endothelin
T295 7679-7681 PR:000006897 denotes -1
T296 7691-7704 PR:000036013 denotes angiotensin 1
T297 7708-7712 PR:000036013 denotes Ang1
T298 7720-7733 GO:0005576 denotes extracellular
T299 7741-7750 GO:0065007 denotes regulated
T300 7765-7769 PR:000000103 denotes ERK2
T301 7780-7786 PR:000036009 denotes Ang II
T302 7850-7854 PR:000036013 denotes Ang1
T303 7861-7865 PR:000003622;G_3;PG_10 denotes ACE2
T304 7934-7939 PR:000036013 denotes Ang1-
T305 7978-7983 PR:000036008 denotes Ang I
T306 8003-8009 PR:000036012 denotes Ang1-9
T307 8048-8058 PR:000001898 denotes neprilysin
T308 8093-8098 PR:000013883 denotes renin
T345 8120-8124 G_3;PG_10;PR:000003622 denotes ACE2
T346 8125-8135 GO:0065007 denotes Regulation
T347 8140-8154 UBERON:0004535 denotes Cardiovascular
T348 8203-8217 UBERON:0004535 denotes cardiovascular
T349 8231-8241 GO:0065007 denotes regulation
T350 8250-8260 CHEBI:35222;CHEBI:35222 denotes inhibitors
T351 8327-8341 UBERON:0004535 denotes cardiovascular
T352 8401-8406 PR:000013883 denotes Renin
T353 8443-8460 SP_7 denotes COVID-19 Normally
T354 8462-8475 PR:000036008 denotes angiotensin I
T355 8477-8482 PR:000036008 denotes Ang I
T356 8500-8506 PR:000036009 denotes Ang II
T357 8580-8590 CHEBI:35222;CHEBI:35222 denotes inhibitors
T358 8624-8630 PR:000036009 denotes Ang II
T359 8652-8656 PR:000001251 denotes AT1R
T360 8684-8700 UBERON:0002053 denotes zona glomerulosa
T361 8708-8723 UBERON:0001236 denotes adrenal medulla
T362 8739-8750 CHEBI:27584;CHEBI:27584 denotes aldosterone
T363 8776-8793 CHEBI:25354;CHEBI:25354 denotes mineralocorticoid
T364 8815-8820 CHEBI:15377;CHEBI:15377 denotes water
T365 8850-8854 CHEBI:24866;CHEBI:24866 denotes salt
T366 8885-8902 CHEBI:25354;CHEBI:25354 denotes mineralocorticoid
T367 8903-8923 CHEBI:48561;CHEBI:48561 denotes receptor antagonists
T368 8952-8961 UBERON:0002198 denotes pituitary
T369 8963-8969 PR:000036009 denotes Ang II
T370 9023-9028 CHEBI:15377;CHEBI:15377 denotes water
T371 9056-9063 UBERON:0000479 denotes tissues
T372 9127-9136 MOP:0000568 denotes oxidative
T373 9149-9158 GO:0006915 denotes apoptosis
T374 9242-9245 CHEBI:37886;CHEBI:37886;PR:000036009 denotes Ang
T375 9246-9248 PR:000036009 denotes II
T376 9260-9264 PR:000001251 denotes AT1R
T377 9266-9272 PR:000036009 denotes Ang II
T378 9298-9311 PR:000036013 denotes angiotensin 1
T379 9315-9320 PR:000036013 denotes Ang 1
T380 9328-9332 PR:000003622;G_3;PG_10 denotes ACE2
T381 9355-9358 PR:000001563 denotes Mas
T382 9410-9414 G_3;PG_10;PR:000003622 denotes ACE2
T383 9415-9419 PR:000036013 denotes Ang1
T384 9487-9492 PR:000013883 denotes renin
T385 9519-9523 PR:000001251 denotes AT1R
T386 9528-9532 PR:000003622;G_3;PG_10 denotes ACE2
T387 9546-9552 PR:000036009 denotes Ang II
T388 9564-9568 PR:000001251 denotes AT1R
T389 9592-9596 PR:000003622;G_3;PG_10 denotes ACE2
T390 9654-9658 G_3;PG_10;PR:000003622 denotes ACE2
T391 9698-9704 PR:000036009 denotes Ang II
T392 9719-9724 PR:000036013 denotes Ang 1
T393 9728-9732 G_3;PG_10;PR:000003622 denotes ACE2
T394 9791-9803 SP_10 denotes severe acute
T395 9804-9815 SP_10;UBERON:0001004 denotes respiratory
T396 9816-9836 SP_10 denotes syndrome coronavirus
T397 9838-9846 SP_10 denotes SARS-CoV
T398 9854-9862 SP_10 denotes SARS-CoV
T399 9864-9868 G_3;PG_10;PR:000003622 denotes ACE2
T400 9878-9887 PG_1 denotes S protein
T401 9912-9917 NCBITaxon:10239;GO:0035376 denotes viral
T402 9918-9923 GO:0035376 denotes entry
T403 9933-9945 GO:0044164 denotes host cytosol
T404 9976-9981 NCBITaxon:10239;GO:0006260 denotes viral
T405 9982-9993 GO:0006260 denotes replication
T406 10008-10014 PR:000036009 denotes Ang II
T407 10023-10027 PR:000003622;G_3;PG_10 denotes ACE2
T408 10056-10061 NCBITaxon:10239 denotes viral
T409 10126-10130 PR:000001251 denotes AT1R
T410 10155-10160 PR:000001607 denotes Mas R
T468 10236-10240 CHEBI:23888;CHEBI:23888 denotes drug
T469 10256-10266 GO:0065007 denotes modulation
T470 10274-10278 G_3;PG_10;PR:000003622 denotes ACE2
T471 10279-10283 PR:000036013 denotes Ang1
T472 10296-10301 NCBITaxon:10088 denotes Mouse
T473 10302-10312 UBERON:0001179;CL:0000581 denotes peritoneal
T474 10313-10324 CL:0000581 denotes macrophages
T475 10347-10358 CHEBI:27584;CHEBI:27584 denotes aldosterone
T476 10456-10460 G_3;PG_10;PR:000003622 denotes ACE2
T477 10474-10479 NCBITaxon:10088 denotes mouse
T478 10480-10490 UBERON:0001179;CL:0000581 denotes peritoneal
T479 10491-10502 CL:0000581 denotes macrophages
T480 10516-10528 CHEBI:17154;CHEBI:17154 denotes nicotinamide
T481 10550-10559 CHEBI:18367;CHEBI:18367 denotes phosphate
T482 10568-10577 CHEBI:35222;CHEBI:35222 denotes inhibitor
T483 10579-10590 CHEBI:27584;CHEBI:27584 denotes aldosterone
T484 10626-10630 G_3;PG_10;PR:000003622 denotes ACE2
T485 10687-10699 CHEBI:17154;CHEBI:17154 denotes nicotinamide
T486 10808-10818 CHEBI:31547;CHEBI:31547 denotes eplerenone
T487 10826-10831 SP_6;NCBITaxon:9606 denotes Human
T488 10832-10840 CL:0000576 denotes monocyte
T489 10849-10860 CL:0000235 denotes macrophages
T490 10889-10894 UBERON:0000948 denotes heart
T491 10959-10973 CHEBI:9241;CHEBI:9241 denotes spironolactone
T492 11053-11063 GO:0010467 denotes expression
T493 11083-11087 G_3;PG_10;PR:000003622 denotes ACE2
T494 11119-11123 G_3;PG_10;PR:000003622 denotes ACE2
T495 11129-11139 GO:0010467 denotes expression
T496 11167-11171 NCBITaxon:10088 denotes mice
T497 11197-11207 CHEBI:31547;CHEBI:31547 denotes eplerenone
T498 11209-11216 UBERON:0000948 denotes cardiac
T499 11217-11221 G_3;PG_10;PR:000003622 denotes ACE2
T500 11280-11284 G_3;PG_10;PR:000003622 denotes ACE2
T501 11297-11308 CL:0000235 denotes macrophages
T502 11360-11369 MOP:0000568 denotes oxidative
T503 11416-11420 G_3;PG_10;PR:000003622 denotes ACE2
T504 11437-11447 GO:0010467 denotes expression
T505 11519-11524 PR:000036013 denotes Ang 1
T506 11554-11560 PR:000036009 denotes Ang II
T507 11571-11582 CHEBI:27584;CHEBI:27584 denotes aldosterone
T508 11593-11597 G_3;PG_10;PR:000003622 denotes ACE2
T509 11622-11634 CHEBI:17154;CHEBI:17154 denotes nicotinamide
T510 11656-11665 CHEBI:18367;CHEBI:18367 denotes phosphate
T511 11704-11712 CL:0000359 denotes vascular
T512 11713-11726 CL:0000359;UBERON:0004237 denotes smooth muscle
T513 11727-11732 CL:0000359 denotes cells
T514 11746-11752 PR:000036009 denotes Ang II
T515 11797-11801 PR:000000104 denotes ERK1
T516 11810-11813 PR:000009232 denotes Jun
T517 11850-11873 CHEBI:70982;CHEBI:70982 denotes reactive oxygen species
T518 11968-11977 MOP:0000568 denotes oxidative
T519 12002-12009 GO:0065007 denotes control
T520 12061-12069 GO:0016020 denotes membrane
T521 12070-12074 G_3;PG_10;PR:000003622 denotes ACE2
T522 12075-12085 GO:0010467 denotes expression
T523 12125-12131 PR:000036009 denotes Ang II
T524 12172-12176 G_3;PG_10;PR:000003622 denotes ACE2
T525 12218-12222 G_3;PG_10;PR:000003622 denotes ACE2
T526 12315-12319 NCBITaxon:10114 denotes rats
T527 12333-12343 CHEBI:48416;CHEBI:48416 denotes olmesartan
T528 12374-12384 GO:0010467 denotes expression
T529 12388-12392 G_3;PG_10;PR:000003622 denotes ACE2
T530 12412-12416 PR:000036013 denotes Ang1
T531 12428-12443 UBERON:0001515 denotes thoracic aortas
T532 12472-12480 CHEBI:2904;CHEBI:2904 denotes atenolol
T533 12485-12496 CHEBI:5775;CHEBI:5775 denotes hydralazine
T534 12520-12524 G_3;PG_10;PR:000003622 denotes ACE2
T535 12525-12535 GO:0010467 denotes expression
T536 12539-12543 PR:000036013 denotes Ang1
T537 12566-12572 UBERON:0000055 denotes vessel
T538 12573-12577 UBERON:0000060 denotes wall
T539 12636-12650 UBERON:0001515 denotes thoracic aorta
T540 12651-12656 UBERON:0004363 denotes media
T541 12746-12750 NCBITaxon:10114 denotes rats
T542 12757-12765 CHEBI:2904;CHEBI:2904 denotes atenolol
T543 12769-12780 CHEBI:5775;CHEBI:5775 denotes hydralazine
T544 12810-12814 G_3;PG_10;PR:000003622 denotes ACE2
T545 12815-12819 PR:000036013 denotes Ang1
T546 12822-12832 GO:0010467 denotes expression
T547 12856-12872 UBERON:0005396 denotes carotid arteries
T548 12888-12895 NCBITaxon:33208 denotes animals
T549 12956-12960 G_3;PG_10;PR:000003622 denotes ACE2
T550 12961-12965 SO:0000704;GO:0010467 denotes gene
T551 12970-12977 BV_20 denotes protein
T552 12978-12988 BV_20;GO:0010467 denotes expression
T553 13016-13030 UBERON:0013755 denotes arterial blood
T554 13100-13104 NCBITaxon:10088 denotes mice
T555 13118-13126 CHEBI:2904;CHEBI:2904 denotes atenolol
T556 13130-13141 CHEBI:5775;CHEBI:5775 denotes hydralazine
T557 13163-13167 NCBITaxon:10114 denotes rats
T558 13200-13203 CHEBI:37886;CHEBI:37886;PR:000036009 denotes Ang
T559 13204-13206 PR:000036009 denotes II
T560 13223-13226 CHEBI:37886;CHEBI:37886;PR:000036009 denotes Ang
T561 13227-13229 PR:000036009 denotes II
T562 13242-13245 PR:000001251 denotes AT1
T563 13270-13273 PR:000001191 denotes AT2
T564 13284-13288 PR:000003622;G_3;PG_10 denotes ACE2
T565 13299-13310 UBERON:0001986 denotes endothelial
T566 13311-13323 CHEBI:16480;CHEBI:16480 denotes nitric oxide
T567 13333-13343 GO:0010467 denotes expression
T568 13366-13370 PR:000001307 denotes CD44
T569 13371-13381 GO:0010467 denotes expression
T570 13415-13419 NCBITaxon:10114 denotes rats
T571 13433-13444 CHEBI:9434;CHEBI:9434 denotes telmisartan
T572 13479-13483 G_3;PG_10;PR:000003622 denotes ACE2
T573 13497-13508 UBERON:0001986 denotes endothelial
T574 13509-13521 CHEBI:16480;CHEBI:16480 denotes nitric oxide
T575 13531-13541 GO:0010467 denotes expression
T576 13545-13557 UBERON:0000948 denotes intracardiac
T577 13558-13565 UBERON:0000055 denotes vessels
T578 13570-13585 UBERON:0002349 denotes intermyocardium
T579 13618-13628 GO:0010467 denotes expression
T580 13636-13639 PR:000001251 denotes AT1
T581 13665-13676 CHEBI:9434;CHEBI:9434 denotes telmisartan
T582 13692-13700 GO:0016020 denotes membrane
T583 13701-13705 PR:000001307 denotes CD44
T584 13706-13716 GO:0010467 denotes expression
T585 13729-13757 PR:000000046 denotes transforming growth factor−β
T586 13767-13777 GO:0010467 denotes expression
T587 13808-13812 NCBITaxon:10114 denotes rats
T588 13823-13838 UBERON:0001621 denotes coronary artery
T589 13848-13864 UBERON:0002084 denotes left ventricular
T590 13931-13939 CHEBI:4670;CHEBI:4670 denotes losartan
T591 13982-13988 UBERON:0001969 denotes plasma
T592 14067-14074 UBERON:0000948 denotes cardiac
T593 14075-14078 PR:000001251 denotes AT1
T594 14107-14111 PR:000003622;G_3;PG_10 denotes ACE2
T595 14122-14132 UBERON:0002349 denotes myocardial
T596 14193-14200 UBERON:0000948 denotes cardiac
T597 14251-14254 PR:000001251 denotes AT1
T598 14279-14283 PR:000003622;G_3;PG_10 denotes ACE2
T599 14284-14294 GO:0010467 denotes expression
T600 14398-14402 G_3;PG_10;PR:000003622 denotes ACE2
T601 14403-14413 GO:0010467 denotes expression
T602 14421-14431 UBERON:0002349 denotes myocardium
T603 14487-14491 G_3;PG_10;PR:000003622 denotes ACE2
T604 14497-14504 GO:0009986 denotes surface
T605 14505-14515 GO:0010467 denotes expression
T606 14520-14526 UBERON:0001969 denotes plasma
T607 14527-14531 G_3;PG_10;PR:000003622 denotes ACE2
T608 14562-14566 NCBITaxon:10114 denotes rats
T609 14572-14576 UBERON:0001652 denotes left
T610 14577-14592 UBERON:0001626 denotes coronary artery
T611 14606-14616 UBERON:0002349 denotes myocardial
T612 14629-14635 UBERON:0001969 denotes plasma
T613 14636-14642 PR:000036009 denotes Ang II
T614 14677-14683 UBERON:0001969 denotes plasma
T615 14684-14688 PR:000003622;G_3;PG_10 denotes ACE2
T616 14723-14730 UBERON:0000948 denotes cardiac
T617 14731-14735 PR:000003622;G_3;PG_10 denotes ACE2
T618 14740-14743 PR:000001251 denotes AT1
T619 14839-14849 UBERON:0002349 denotes myocardium
T620 14871-14879 CHEBI:8774;CHEBI:8774 denotes ramipril
T621 14916-14922 UBERON:0001969 denotes plasma
T622 14923-14926 CHEBI:29101;CHEBI:29101;PR:000036008 denotes Ang
T623 14927-14928 PR:000036008;CHEBI:16382;CHEBI:16382 denotes I
T624 14933-14939 PR:000036009 denotes Ang II
T625 14959-14965 UBERON:0001969 denotes plasma
T626 14974-14978 PR:000003622;G_3;PG_10 denotes ACE2
T627 15051-15055 PR:000003622;G_3;PG_10 denotes ACE2
T628 15059-15062 PR:000001251 denotes AT1
T629 15072-15082 GO:0010467 denotes expression
T630 15135-15145 UBERON:0002349 denotes myocardial
T631 15209-15215 NCBITaxon:39107 denotes murine
T632 15237-15241 G_3;PG_10;PR:000003622 denotes ACE2
T633 15299-15309 UBERON:0002349 denotes myocardium
T634 15316-15326 UBERON:0002349 denotes myocardial
T635 15354-15362 CHEBI:8774;CHEBI:8774 denotes ramipril
T636 15375-15385 GO:0010467 denotes expression
T637 15395-15399 G_3;PG_10;PR:000003622 denotes ACE2
T638 15498-15504 NCBITaxon:39107 denotes murine
T639 15544-15554 CHEBI:48416;CHEBI:48416 denotes olmesartan
T640 15558-15569 CHEBI:9434;CHEBI:9434 denotes telmisartan
T641 15585-15592 UBERON:0000948 denotes cardiac
T642 15593-15597 G_3;PG_10;PR:000003622 denotes ACE2
T643 15607-15614 BV_20 denotes protein
T644 15615-15625 BV_20;GO:0010467 denotes expression
T645 15643-15649 UBERON:0001969 denotes plasma
T646 15650-15654 PR:000036013 denotes Ang1
T647 15699-15706 UBERON:0000948 denotes cardiac
T648 15800-15810 CHEBI:35222;CHEBI:35222 denotes inhibitors
T649 15841-15845 G_3;PG_10;PR:000003622 denotes ACE2
T650 15846-15856 GO:0010467 denotes expression
T651 15889-15892 CHEBI:37886;CHEBI:37886;PR:000036009 denotes Ang
T652 15893-15895 PR:000036009 denotes II
T653 15945-15951 PR:000036009 denotes Ang II
T654 15969-15973 PR:000003622;G_3;PG_10 denotes ACE2
T655 15992-15996 PR:000036013 denotes Ang1
T656 16031-16035 G_3;PG_10;PR:000003622 denotes ACE2
T657 16036-16040 PR:000036013 denotes Ang1
T658 16072-16081 GO:0065007 denotes regulated
T659 16089-16092 PR:000001251 denotes AT1
T660 16153-16160 UBERON:0000948 denotes cardiac
T661 16183-16189 PR:000036009 denotes Ang II
T662 16219-16229 CHEBI:35222;CHEBI:35222 denotes inhibitors
T663 16256-16260 G_3;PG_10;PR:000003622 denotes ACE2
T664 16285-16295 CHEBI:35222;CHEBI:35222 denotes inhibitors
T665 16317-16321 PR:000036013 denotes Ang1
T666 16404-16414 CHEBI:35222;CHEBI:35222 denotes inhibitors
T667 16441-16444 PR:000036008 denotes Ang
T668 16445-16446 PR:000036008;CHEBI:16382;CHEBI:16382 denotes I
T669 16450-16453 CHEBI:37886;CHEBI:37886;PR:000036009 denotes Ang
T670 16454-16456 PR:000036009 denotes II
T671 16473-16483 MOP:0000619 denotes hydrolysis
T672 16487-16497 CHEBI:3165;CHEBI:3165 denotes bradykinin
T673 16551-16561 CHEBI:3165;CHEBI:3165 denotes bradykinin
T674 16572-16583 UBERON:0001986;GO:0017156 denotes endothelium
T675 16583-16593 GO:0017156 denotes -dependent
T676 16594-16606 GO:0042311 denotes vasodilation
T677 16625-16638 CHEBI:26333;CHEBI:26333 denotes prostaglandin
T678 16643-16655 CHEBI:16480;CHEBI:16480 denotes nitric oxide
T679 16695-16698 PR:000001251 denotes AT1
T680 16782-16786 G_3;PG_10;PR:000003622 denotes ACE2
T681 16787-16791 SO:0000704 denotes gene
T682 16818-16821 CHEBI:37886;CHEBI:37886;PR:000036009;GO:0034205 denotes Ang
T683 16822-16824 PR:000036009;GO:0034205 denotes II
T684 16825-16834 GO:0034205 denotes synthesis
T685 16835-16844 GO:0065007 denotes regulated
T686 16845-16849 G_3;PG_10;PR:000003622 denotes ACE2
T687 16863-16867 G_3;PG_10;PR:000003622 denotes ACE2
T688 16936-16944 CHEBI:6541;CHEBI:6541 denotes losartan
T689 16974-16980 UBERON:0001969 denotes plasma
T690 16981-16985 PR:000036013 denotes Ang1
T691 17003-17009 UBERON:0001969 denotes plasma
T692 17010-17016 PR:000036009 denotes Ang II
T693 17051-17055 G_3;PG_10;PR:000003622 denotes ACE2
T694 17089-17097 CHEBI:6541;CHEBI:6541 denotes losartan
T695 17126-17134 CHEBI:6541;CHEBI:6541 denotes losartan
T696 17139-17149 CHEBI:43755;CHEBI:43755 denotes lisinopril
T697 17189-17193 G_3;PG_10;PR:000003622 denotes ACE2
T698 17220-17230 CHEBI:35222;CHEBI:35222 denotes inhibitors
T699 17260-17269 GO:0065007 denotes regulates
T700 17270-17274 G_3;PG_10;PR:000003622 denotes ACE2
T701 17304-17310 PR:000036009 denotes Ang II
T702 17341-17345 PR:000003622;G_3;PG_10 denotes ACE2
T703 17363-17368 PR:000036008 denotes Ang I
T704 17374-17379 PR:000036012 denotes Ang 1
T705 17438-17443 PR:000036008 denotes Ang I
T706 17475-17480 PR:000036013 denotes Ang 1
T707 17509-17519 PR:000001898 denotes neprilysin
T708 17605-17615 CHEBI:35222;CHEBI:35222 denotes inhibitors
T709 17673-17677 G_3;PG_10;PR:000003622 denotes ACE2
T710 17718-17722 G_3;PG_10;PR:000003622 denotes ACE2
T711 17723-17727 PR:000036013 denotes Ang1
T712 17814-17828 GO:0007596 denotes antithrombotic
T713 17857-17861 G_3;PG_10;PR:000003622 denotes ACE2
T714 17862-17866 PR:000036013 denotes Ang1
T715 17869-17872 PR:000001563 denotes Mas
T716 17939-17943 G_3;PG_10;PR:000003622 denotes ACE2
T717 17948-17952 PR:000036013 denotes Ang1
T718 17972-17976 G_3;PG_10;PR:000003622 denotes ACE2
T719 17977-17986 GO:0065007 denotes regulates
T720 18013-18019 PR:000036009 denotes Ang II
T721 18020-18023 PR:000001251 denotes AT1
T722 18065-18069 G_3;PG_10;PR:000003622 denotes ACE2
T723 18070-18074 PR:000036013 denotes Ang1
T724 18194-18205 UBERON:0001004 denotes respiratory
T725 18244-18262 UBERON:0002012 denotes pulmonary arterial
T726 18286-18292 NCBITaxon:39107 denotes murine
T727 18321-18330 GO:0065007 denotes modulates
T728 18401-18407 NCBITaxon:9606 denotes humans
T729 18479-18484 SP_6;NCBITaxon:9606;PG_10 denotes Human
T730 18485-18516 PG_10;PR:000003622 denotes Angiotensin Converting Enzyme 2
T731 18687-18693 UBERON:0001969 denotes plasma
T732 18694-18698 PR:000004020 denotes Ang1
T733 18715-18721 PR:000036013 denotes Ang1-7
T734 18726-18730 PR:000004020 denotes Ang1
T735 18751-18756 UBERON:0000178 denotes blood
T736 18770-18775 UBERON:0000948 denotes heart
T737 18842-18852 GO:0042571 denotes antibodies
T738 18910-18916 UBERON:0002405;GO:0006955 denotes immune
T739 18917-18925 GO:0006955 denotes response
T740 18995-19009 BV_15 denotes immunogenicity
T741 19033-19038 UBERON:0001977 denotes Serum
T742 19057-19063 PR:000036009 denotes Ang II
T743 19213-19219 UBERON:0001969 denotes plasma
T744 19220-19225 PR:000013883 denotes renin
T745 19230-19236 PR:000036009 denotes Ang II
T746 19272-19277 UBERON:0000062 denotes organ
T747 19494-19500 UBERON:0001969 denotes plasma
T748 19501-19506 PR:000013883 denotes renin
T749 19511-19517 PR:000036009 denotes Ang II
T750 19620-19624 UBERON:0002048 denotes Lung
T751 19715-19721 UBERON:0001969 denotes plasma
T752 19722-19728 PR:000036009 denotes Ang II
T753 19742-19748 UBERON:0001969 denotes plasma
T754 19749-19754 PR:000036013 denotes Ang 1
T755 19761-19771 CHEBI:35195;CHEBI:35195 denotes surfactant
T756 19772-19781 PR:000006464 denotes protein-D
T757 19804-19819 GO:0045087 denotes innate immunity
T758 19826-19830 PR:000001393 denotes IL-6
T759 20229-20234 SP_6;NCBITaxon:9606 denotes human
T760 20235-20253 UBERON:0002012 denotes pulmonary arterial
T761 20302-20306 G_3;PG_10;PR:000003622 denotes ACE2
T762 20360-20367 UBERON:0000948 denotes cardiac
T763 20418-20424 UBERON:0001969 denotes plasma
T764 20452-20465 CHEBI:86267;CHEBI:86267 denotes nitrotyrosine
T765 20528-20533 UBERON:0002113 denotes renal
T766 20589-20599 GO:0065007 denotes modulation
T767 20675-20679 G_3;PG_10;PR:000003622 denotes ACE2
T768 20748-20755 PR:000009054 denotes Insulin
T769 20796-20827 PG_10;PR:000003622 denotes Angiotensin Converting Enzyme 2
T770 20829-20833 G_3;PG_10;PR:000003622 denotes ACE2
T771 20884-20889 CHEBI:23888;CHEBI:23888 denotes Drugs
T772 20916-20930 GO:0010467 denotes overexpression
T773 20934-20938 G_3;PG_10;PR:000003622 denotes ACE2
T774 20939-20946 PR:000036013 denotes Ang 1-7
T775 20950-20957 UBERON:0000948 denotes cardiac
T776 21055-21065 UBERON:0002349 denotes myocardial
T777 21083-21090 UBERON:0000948 denotes cardiac
T778 21099-21113 UBERON:0004535 denotes Cardiovascular
T779 21133-21139 UBERON:0000479 denotes Tissue
T780 21188-21192 G_3;PG_10;PR:000003622 denotes ACE2
T781 21193-21197 PR:000036013 denotes Ang1
T782 21321-21327 NCBITaxon:39107 denotes murine
T783 21332-21345 CL:0001034 denotes in vitro cell
T784 21509-21513 G_3;PG_10;PR:000003622 denotes ACE2
T785 21515-21523 SP_7 denotes COVID-19
T786 21529-21543 UBERON:0004535 denotes Cardiovascular
T787 21578-21586 SP_7 denotes COVID-19
T788 21606-21613 UBERON:0000948 denotes cardiac
T789 21685-21693 SP_7 denotes COVID-19
T790 21748-21766 PR:000005897 denotes C-reactive protein
T791 21828-21838 UBERON:0002349 denotes myocardial
T792 21914-21921 UBERON:0000948 denotes cardiac
T793 22053-22063 UBERON:0002349 denotes myocardial
T794 22089-22096 UBERON:0000948 denotes cardiac
T795 22135-22143 UBERON:0001621 denotes coronary
T796 22197-22205 SP_7 denotes COVID-19
T797 22251-22261 UBERON:0002349 denotes myocardial
T798 22357-22364 UBERON:0000948 denotes cardiac
T799 22406-22411 GO:0016265 denotes death
T800 22643-22657 UBERON:0004535 denotes cardiovascular
T801 22692-22703 NCBITaxon:11118 denotes coronavirus
T802 22720-22728 SP_7 denotes COVID-19
T803 22823-22827 G_3;PG_10;PR:000003622 denotes ACE2
T804 22828-22838 GO:0065007 denotes regulation
T805 22887-22896 CHEBI:35222;CHEBI:35222 denotes inhibitor
T806 22962-22970 SP_7 denotes COVID-19
T807 23015-23023 SP_7 denotes COVID-19
T808 23028-23035 SP_7 denotes COVID19
T809 23067-23081 DG_37;PR:000036009 denotes Angiotensin II
T810 23123-23131 SP_7 denotes COVID-19
T811 23238-23246 CHEBI:6541;CHEBI:6541 denotes losartan
T812 23280-23288 SP_7 denotes COVID-19
T813 23317-23325 SP_7 denotes COVID-19
T814 23384-23394 GO:0040011 denotes ambulatory
T815 23423-23431 SP_7 denotes COVID-19
T816 23571-23582 NCBITaxon:11118 denotes Coronavirus
T817 23584-23592 SP_7 denotes COVID-19
T818 23712-23722 SP_7 denotes SARS-CoV-2
T819 23764-23774 CHEBI:35222;CHEBI:35222 denotes inhibitors
T820 23817-23831 UBERON:0004535 denotes cardiovascular
T821 23844-23852 SP_7 denotes COVID-19
T822 23950-23958 SP_7 denotes COVID-19
T823 23972-23977 SP_6;NCBITaxon:9606;PG_10 denotes Human
T824 23978-24009 PG_10;PR:000003622 denotes Angiotensin-converting Enzyme 2
T825 24052-24060 SP_7 denotes COVID-19
T826 24156-24166 CHEBI:35222;CHEBI:35222 denotes inhibitors
T827 24184-24192 SP_7 denotes COVID-19
T828 24195-24199 G_3;PG_10;PR:000003622 denotes ACE2
T829 24204-24214 SP_7 denotes SARS-CoV-2
T830 24215-24223 SP_10 denotes SARS-CoV
T831 24277-24287 SP_7 denotes SARS-CoV-2
T832 24344-24357 NCBITaxon:11118 denotes coronaviruses
T833 24385-24389 G_3;PG_10;PR:000003622 denotes ACE2
T834 24495-24502 NCBITaxon:10239 denotes viruses
T835 24585-24593 SP_7 denotes COVID-19
T836 24603-24607 G_3;PG_10;PR:000003622 denotes ACE2
T837 24669-24677 SP_10 denotes SARS-CoV
T838 24684-24694 SP_7 denotes SARS-CoV-2
T839 24704-24708 G_3;PG_10;PR:000003622 denotes ACE2
T840 24748-24755 GO:0009986 denotes surface
T841 24772-24781 PG_1 denotes S protein
T842 24791-24795 G_3;PG_10;PR:000003622 denotes ACE2
T843 24815-24820 NCBITaxon:10239 denotes viral
T844 24881-24886 NCBITaxon:10239 denotes virus
T845 24907-24919 GO:0044164 denotes host cytosol
T846 24946-24950 CHEBI:37527;CHEBI:37527;GO:0010498 denotes acid
T847 24950-24960 GO:0010498 denotes -dependent
T848 24961-24972 GO:0006508 denotes proteolytic
T849 24973-24981 MOP:0000780 denotes cleavage
T850 24989-24998 PG_1 denotes S protein
T851 25027-25034 G_2;PR:000016456 denotes TMPRSS2
T852 25056-25065 PG_1 denotes S protein
T853 25077-25085 SP_10 denotes SARS-CoV
T854 25145-25155 SP_7 denotes SARS-CoV-2
T855 25160-25171 G_3;PG_10;SP_7 denotes ACE2 Severe
T856 25172-25177 SP_7 denotes acute
T857 25178-25189 SP_7;GO:0045333;UBERON:0001004 denotes respiratory
T858 25190-25212 SP_7 denotes syndrome coronavirus 2
T859 25214-25224 SP_7 denotes SARS-CoV-2
T860 25257-25261 G_3;PG_10;PR:000003622 denotes ACE2
T861 25270-25279 PG_1 denotes S protein
T862 25303-25315 GO:0044164 denotes host cytosol
T863 25321-25330 PG_1 denotes S protein
T864 25341-25345 CHEBI:37527;CHEBI:37527 denotes acid
T865 25346-25355 GO:0010498 denotes dependent
T866 25356-25367 GO:0006508 denotes proteolytic
T867 25368-25376 MOP:0000780 denotes cleavage
T868 25380-25384 G_3;PG_10;PR:000003622 denotes ACE2
T869 25409-25412 PR:000000134 denotes TNF
T870 25417-25430 GO:0016020;PG_8 denotes transmembrane
T871 25431-25448 PG_8 denotes protease serine 2
T872 25534-25541 SO:0000667 denotes inserts
T873 25551-25559 GO:0016020 denotes membrane
T874 25578-25597 GO:0017156 denotes clatherin-dependent
T875 25598-25609 GO:0006897 denotes endocytosis
T876 25613-25617 G_3;PG_10;PR:000003622 denotes ACE2
T877 25618-25628 SP_7 denotes SARS-CoV-2
T878 25655-25660 PR:000000134 denotes TNF-α
T879 25665-25675 PR:000004978 denotes calmodulin
T880 25676-25686 CHEBI:35222;CHEBI:35222 denotes inhibitors
T881 25709-25717 MOP:0000780 denotes cleavage
T882 25721-25725 PR:000003622;G_3;PG_10 denotes ACE2
T883 25727-25734 PR:000001279 denotes ADAM 17
T914 25852-25860 SP_10 denotes SARS-CoV
T915 25865-25875 SP_7 denotes SARS-CoV-2
T916 25925-25932 G_2 denotes TMPRSS2
T917 25942-25947 NCBITaxon:10239;GO:0035376 denotes viral
T918 25948-25953 GO:0035376 denotes entry
T919 25992-25996 PR:000014459;SP_7 denotes SARS
T920 25996-26002 SP_7 denotes -CoV-2
T921 26048-26059 GO:0006897 denotes endocytosis
T922 26082-26087 NCBITaxon:10239 denotes virus
T923 26140-26144 G_3;PG_10;PR:000003622 denotes ACE2
T924 26146-26154 MOP:0000780 denotes cleavage
T925 26162-26171 PG_1 denotes S protein
T926 26209-26218 GO:0061025 denotes fusion of
T927 26219-26224 GO:0019012;NCBITaxon:10239 denotes viral
T928 26229-26247 GO:0005886 denotes cellular membranes
T929 26249-26257 SP_10 denotes SARS-CoV
T930 26294-26309 GO:0005769 denotes early endosomes
T931 26364-26368 G_3;PG_10;PR:000003622 denotes ACE2
T932 26387-26392 PR:000000134 denotes TNF-α
T933 26428-26438 PR:000004978 denotes calmodulin
T934 26439-26449 CHEBI:35222;CHEBI:35222 denotes inhibitors
T935 26470-26478 MOP:0000780 denotes cleavage
T936 26500-26510 SP_7 denotes SARS-CoV-2
T937 26561-26566 PR:000000134 denotes TNF-α
T938 26625-26633 SP_7 denotes COVID-19
T939 26691-26697 UBERON:0001969 denotes plasma
T940 26716-26720 PR:000001379 denotes IL-2
T941 26722-26726 PR:000001317 denotes IL-7
T942 26728-26733 PR:000001471 denotes IL-10
T943 26735-26746 CL:0000094;PR:000005932 denotes granulocyte
T944 26746-26772 PR:000005932 denotes -colony stimulating factor
T945 26774-26778 PR:000005932 denotes GCSF
T946 26781-26797 PR:000000017 denotes interferon gamma
T947 26818-26822 PR:000006064 denotes IP10
T948 26825-26833 CL:0000576;PR:000002122 denotes monocyte
T949 26834-26859 PR:000002122 denotes chemoattractant protein 1
T950 26861-26871 CL:0000235;PR:000002123 denotes macrophage
T951 26872-26900 PR:000002123 denotes inflammatory protein 1 alpha
T952 26902-26907 PR:000002123 denotes MIP1A
T953 26914-26919 PR:000000134 denotes TNF-α
T954 26950-26954 G_3;PG_10;PR:000003622 denotes ACE2
T955 26999-27011 GO:0065007 denotes dysregulated
T956 27015-27023 SP_7 denotes COVID-19
T957 27077-27085 GO:0098589 denotes membrane
T958 27092-27096 G_3;PG_10;PR:000003622 denotes ACE2
T959 27122-27126 UBERON:0002048 denotes lung
T960 27191-27197 UBERON:0001969 denotes plasma
T961 27198-27202 G_3;PG_10;PR:000003622 denotes ACE2
T962 27273-27277 G_3;PG_10;PR:000003622 denotes ACE2
T963 27321-27326 UBERON:0000948 denotes heart
T964 27336-27342 UBERON:0001969 denotes plasma
T965 27343-27347 G_3;PG_10;PR:000003622 denotes ACE2
T966 27542-27546 G_3;PG_10;PR:000003622 denotes ACE2
T967 27575-27579 UBERON:0002048 denotes lung
T968 27602-27612 UBERON:0002349 denotes myocardial
T969 27660-27664 G_3;PG_10;PR:000003622 denotes ACE2
T970 27725-27730 UBERON:0000948 denotes heart
T971 27802-27806 G_3;PG_10;PR:000003622 denotes ACE2
T972 27838-27844 UBERON:0000479 denotes tissue
T973 27993-27997 G_3;PG_10;PR:000003622 denotes ACE2
T974 28009-28017 GO:0065007 denotes regulate
T975 28027-28033 PR:000036009 denotes Ang II
T976 28092-28098 PR:000036009 denotes Ang II
T977 28102-28107 PR:000036013 denotes Ang 1
T978 28192-28202 SP_7 denotes SARS-CoV-2
T979 28215-28219 G_3;PG_10;PR:000003622 denotes ACE2
T980 28275-28279 G_3;PG_10;PR:000003622 denotes ACE2
T981 28280-28291 SO:0000243 denotes entry sites
T982 28390-28408 GO:0033644 denotes host cell membrane
T983 28496-28510 GO:0005634 denotes multinucleated
T984 28526-28538 GO:0048468 denotes Formation of
T985 28539-28553 GO:0005634;CL:0000228 denotes multinucleated
T986 28554-28559 CL:0000228 denotes cells
T987 28576-28581 NCBITaxon:10239 denotes virus
T988 28633-28638 NCBITaxon:10239 denotes virus
T989 28648-28658 GO:0042571 denotes antibodies
T990 28686-28697 GO:0006260 denotes replication
T991 28726-28732 GO:0019012;GO:0019068 denotes virion
T992 28733-28741 GO:0019068 denotes assembly
T993 28749-28754 GO:0005794 denotes Golgi
T994 28793-28798 NCBITaxon:10239 denotes virus
T995 28802-28810 GO:0031982 denotes vesicles
T996 28826-28836 GO:0006887 denotes exocytosis
T997 28866-28881 GO:0019068 denotes virion assembly
T998 28886-28896 GO:0006887 denotes exocytosis
T999 28915-28919 G_3;PG_10;PR:000003622 denotes ACE2
T1000 29021-29035 UBERON:0004535 denotes Cardiovascular
T1001 29050-29060 SP_7 denotes SARS-CoV-2
T1002 29079-29089 SP_7 denotes SARS-CoV-2
T1003 29100-29115 GO:0019068 denotes virion assembly
T1004 29134-29142 GO:0016020 denotes membrane
T1005 29149-29153 G_3;PG_10;PR:000003622 denotes ACE2
T1006 29193-29204 GO:0006260 denotes replication
T1007 29218-29223 NCBITaxon:10239 denotes virus
T1008 29269-29279 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1009 29332-29340 SP_10 denotes SARS-CoV
T1010 29406-29410 G_3;PG_10;PR:000003622 denotes ACE2
T1011 29411-29421 GO:0010467 denotes expression
T1012 29436-29454 CHEBI:16412;CHEBI:16412 denotes Lipopolysaccharide
T1013 29469-29473 UBERON:0002048 denotes lung
T1014 29481-29486 NCBITaxon:10088 denotes mouse
T1015 29514-29524 GO:0010467 denotes expression
T1016 29528-29532 G_3;PG_10;PR:000003622 denotes ACE2
T1017 29534-29538 UBERON:0002048 denotes lung
T1018 29620-29631 GO:0009294 denotes transfected
T1019 29637-29641 G_3;PG_10;PR:000003622 denotes ACE2
T1020 29677-29681 UBERON:0002048 denotes lung
T1021 29695-29699 UBERON:0002048 denotes lung
T1022 29727-29731 NCBITaxon:10088 denotes mice
T1023 29741-29751 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1024 29777-29795 CHEBI:16412;CHEBI:16412 denotes lipopolysaccharide
T1025 29804-29813 UBERON:0006562 denotes pneumonic
T1026 29855-29863 SP_10 denotes SARS-CoV
T1027 29864-29873 PG_1 denotes S protein
T1028 29895-29899 UBERON:0002048 denotes lung
T1029 29916-29929 GO:0065007 denotes dysregulation
T1030 29951-29959 SP_10 denotes SARS-CoV
T1031 29975-29979 UBERON:0002048 denotes lung
T1032 30026-30029 PR:000001251 denotes AT1
T1033 30116-30124 SP_7 denotes COVID-19
T1034 30333-30343 SP_7 denotes SARS-CoV-2
T1035 30359-30367 GO:0016020 denotes membrane
T1036 30374-30378 G_3;PG_10;PR:000003622 denotes ACE2
T1037 30396-30402 PR:000001279 denotes ADAM17
T1038 30482-30486 G_3;PG_10;PR:000003622 denotes ACE2
T1039 30508-30513 NCBITaxon:10239 denotes viral
T1040 30598-30602 G_3;PG_10;PR:000003622 denotes ACE2
T1041 30603-30607 PR:000036013 denotes Ang1
T1042 30610-30613 PR:000001563 denotes Mas
T1043 30691-30704 GO:0065007 denotes dysregulation
T1044 30717-30727 SP_7 denotes SARS-CoV-2
T1045 30752-30766 UBERON:0004535 denotes cardiovascular
T1046 30779-30789 SP_7 denotes SARS-CoV-2
T1047 30806-30816 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1048 30888-30892 G_3;PG_10;PR:000003622 denotes ACE2
T1049 31050-31057 UBERON:0000948 denotes cardiac
T1050 31073-31078 UBERON:0000948 denotes heart
T1051 31141-31151 UBERON:0000948 denotes Cardiology
T1052 31162-31167 UBERON:0000948 denotes Heart
T1053 31181-31186 UBERON:0000948 denotes Heart
T1054 31244-31254 UBERON:0000948 denotes Cardiology
T1055 31389-31395 UBERON:0000479 denotes tissue
T1056 31396-31400 G_3;PG_10;PR:000003622 denotes ACE2
T1057 31437-31445 SP_7 denotes COVID-19
T1058 31463-31477 UBERON:0004535 denotes cardiovascular
T1059 31523-31537 UBERON:0004535 denotes cardiovascular
T1060 31552-31560 SP_7 denotes COVID-19
T1061 31582-31592 CHEBI:35222;CHEBI:35222 denotes inhibitors
T1062 31634-31638 G_3;PG_10;PR:000003622 denotes ACE2
T1063 31700-31708 SP_7 denotes COVID-19
T315 4752-4757 PR:000013883 denotes ive p
T316 4759-4764 PR:000036008 denotes hways
T317 4781-4789 PR:000036009 denotes metallo
T318 4842-4852 MOP:0000619 denotes 7 via ACE,
T48220 9790-9801 CL:0000581 denotes severe acu
T74256 21705-21710 GO:0016265 denotes tient
T20349 21939-21953 UBERON:0004535 denotes e imagining−ve
T79848 21988-21999 NCBITaxon:11118 denotes ystolic dys
T82178 22016-22024 SP_7 denotes ding as
T886 25165-25177 SP_7 denotes Severe acute
T45 21578-21586 SP_7 denotes COVID-19
T46 21606-21613 UBERON:0000948 denotes cardiac
T49 30598-30602 G_3;PG_10;PR:000003622 denotes ACE2
T50 30603-30607 PR:000036013 denotes Ang1
T51 30806-30816 CHEBI:35222;CHEBI:35222 denotes inhibitors
T56 31463-31477 UBERON:0004535 denotes cardiovascular
T42119 31552-31560 SP_7 denotes COVID-19
T45363 3036-3040 G_3;PG_10;PR:000003622 denotes lato
T60689 3050-3054 NCBITaxon:10088 denotes sm t
T27389 3060-3066 PR:000036009 denotes classi
T28823 3092-3096 G_3;PG_10;PR:000003622 denotes tegr
T40619 3117-3121 PR:000000104 denotes ein
T48796 3125-3129 PR:000009197 denotes exp
T17022 3130-3135 PR:000002089 denotes essed
T32537 3141-3144 PR:000045382;GO:0000187 denotes min
T9224 3145-3154 GO:0000165 denotes ntly in t
T33582 3223-3229 PR:000036009 denotes and sm
T84252 3238-3248 UBERON:0002349 denotes tine (16).
T53574 3363-3367 G_3;PG_10;PR:000003622 denotes hibi
T46680 3368-3372 PR:000036013 denotes ors
T39192 3386-3396 GO:0065007 denotes ACE conta
T26804 3401-3411 GO:0010467 denotes active ca
T20064 3451-3456 PR:000000134 denotes ytic
T15398 3479-3483 PR:000001393 denotes al r
T8292 3485-3493 CL:0000576;PR:000002122 denotes idues (1
T65564 3494-3519 PR:000002122 denotes ,19). The major substrate
T59008 3525-3553 PR:000000046 denotes E2 is Ang II, which upon C-t
T45631 3557-3565 UBERON:0000948 denotes nus clea
T9280 3573-3577 UBERON:0002048 denotes oduc
T93124 3588-3597 UBERON:0002048 denotes sin 1-7 (
T11843 3689-3695 G_3;PG_10;PR:000003622 denotes norphi
T96445 3696-3700 PR:000036013 denotes -13,
T35230 3703-3706 PR:000001563 denotes ich
T22891 3711-3737 GO:0065007 denotes catalyzed at much lower af
T24013 3754-3767 PR:000036008 denotes e non-catalyt
T33081 3769-3774 PR:000036008 denotes C-te
T91867 3780-3785 PR:000013883 denotes doma
T97324 3787-3792 PR:000036008 denotes of A
T69975 3809-3815 PR:000036009 denotes sequen
T54028 3868-3878 MOP:0000619 denotes utral amin
T57012 3879-3889 CHEBI:3165;CHEBI:3165 denotes acid reab
T52135 3908-3917 CHEBI:25212;CHEBI:25212 denotes ntestine
T38693 3975-3983 PR:000036009 denotes nd metal
T22665 4000-4006 PR:000036009 denotes ADAM17
T71601 4046-4057 CHEBI:27584;CHEBI:27584 denotes TNF)-α−conv
T2211 4077-4092 UBERON:0001236 denotes , ACE2 exhibits
T65489 4137-4145 UBERON:0002198 denotes he forma
T91280 4147-4158 CHEBI:27584;CHEBI:27584 denotes on of a sol
T15577 4169-4177 GO:0016020 denotes . ACE2 a
T79802 4178-4182 G_3;PG_10;PR:000003622 denotes so c
T96225 4183-4193 GO:0010467 denotes ntains a c
T26369 4195-4205 UBERON:0001986;PR:000006897 denotes modulin do
T89251 4205-4207 PR:000006897 denotes ma
T83262 4217-4230 PR:000036013 denotes cytoplasmic t
T85112 4234-4238 PR:000036013 denotes that
T54914 4246-4259 GO:0005576 denotes ces ectodomai
T85023 4267-4277 GO:0065007 denotes ng (25).
T90424 4292-4297 PR:000000103 denotes Axis
T29796 4308-4314 PR:000036009 denotes Ang I
T98730 4378-4382 PR:000036013 denotes by A
T86736 4389-4393 PR:000003622;G_3;PG_10 denotes ike
T89530 4462-4467 PR:000036013 denotes Ang
T48188 4506-4511 PR:000036008 denotes (17)
T41061 4531-4537 PR:000036012 denotes of an
T94791 4575-4585 PR:000001898 denotes tory, and
T37488 4620-4625 PR:000013883 denotes ed by
T309 4663-4667 G_3;PG_10;PR:000003622 denotes Mas
T310 4668-4672 PR:000036013 denotes rece
T311 4683-4693 GO:0065007 denotes ,27). Ang1
T312 4694-4709 CHEBI:2720;CHEBI:2720 denotes 7 may be produc
T313 4726-4739 PR:000036008 denotes Ang I through
T314 4741-4746 PR:000036008 denotes he al
T319 4853-4863 CHEBI:3165;CHEBI:3165 denotes although a
T320 4882-4891 CHEBI:25212;CHEBI:25212 denotes ower effi
T321 4949-4955 PR:000036009 denotes 2 as a
T322 4972-4978 PR:000036009 denotes ator o
T323 5018-5029 CHEBI:27584;CHEBI:27584 denotes focused on
T324 5049-5064 UBERON:0001236 denotes E2 in cardiac m
T325 5109-5117 UBERON:0002198 denotes ated tha
T326 5119-5130 CHEBI:27584;CHEBI:27584 denotes although An
T327 5141-5149 GO:0016020 denotes icantly
T328 5150-5154 G_3;PG_10;PR:000003622 denotes educ
T329 5155-5165 GO:0010467 denotes d ACE2 act
T330 5167-5177 UBERON:0001986;PR:000006897 denotes ity and do
T331 5177-5179 PR:000006897 denotes wn
T332 5189-5202 PR:000036013 denotes ACE2 mRNA in
T333 5206-5210 PR:000036013 denotes iac
T334 5218-5231 GO:0005576 denotes , it only red
T335 5239-5248 GO:0065007 denotes 2 activit
T336 5263-5267 PR:000000103 denotes s (2
T337 5278-5284 PR:000036009 denotes ytes,
T338 5348-5352 PR:000036013 denotes ion
T339 5359-5363 PR:000003622;G_3;PG_10 denotes his
T340 5432-5437 PR:000036013 denotes mito
T341 5476-5481 PR:000036008 denotes whic
T342 5501-5507 PR:000036012 denotes II an
T343 5544-5554 PR:000001898 denotes regulated
T344 5589-5594 PR:000013883 denotes 29).
T9018 5615-5620 G_3;PG_10;PR:000003622 denotes murin
T63740 5621-5631 GO:0065007 denotes studies s
T78761 5636-5650 UBERON:0004535 denotes Ang II−mediat
T29306 5699-5713 UBERON:0004535 denotes elated with th
T37860 5727-5737 GO:0065007 denotes of TACE/A
T4521 5746-5756 CHEBI:35222;CHEBI:35222 denotes ivity, whi
T92757 5823-5837 UBERON:0004535 denotes ts and coronar
T57057 5895-5900 PR:000013883 denotes ecipr
T50692 5937-5953 SP_7 denotes ll types as well
T26520 5955-5968 PR:000036008 denotes 31,32). Ang I
T11517 5970-5975 PR:000036008 denotes activ
T49885 5993-5999 PR:000036009 denotes signa
T78357 6073-6083 CHEBI:35222;CHEBI:35222 denotes sults in m
T32486 6117-6123 PR:000036009 denotes d fibr
T30438 6145-6149 PR:000001251 denotes of
T84915 6177-6193 UBERON:0002053 denotes ain also inhibit
T14662 6201-6216 UBERON:0001236 denotes oteolytic funct
T3622 6231-6242 CHEBI:27584;CHEBI:27584 denotes enzyme and
T2367 6268-6285 CHEBI:25354;CHEBI:25354 denotes on (34). Studies
T70131 6307-6312 CHEBI:15377;CHEBI:15377 denotes cardi
T22478 6342-6346 CHEBI:24866;CHEBI:24866 denotes g1-7
T53819 6377-6394 CHEBI:25354;CHEBI:25354 denotes han Ang I, which
T50077 6395-6415 CHEBI:48561;CHEBI:48561 denotes uggests the inhibito
T85097 6444-6452 UBERON:0002198 denotes ay contr
T97767 6454-6460 PR:000036009 denotes ute to
T62349 6513-6518 CHEBI:15377;CHEBI:15377 denotes nocko
T2176 6546-6553 UBERON:0000479 denotes and re
T70273 6616-6624 MOP:0000568 denotes signalin
T88849 6637-6646 GO:0006915 denotes nd was at
T55720 6730-6733 CHEBI:37886;CHEBI:37886;PR:000036009 denotes y a
T28600 6734-6736 PR:000036009 denotes d
T83802 6748-6752 PR:000001251 denotes imp
T53803 6754-6760 PR:000036009 denotes vement
T72294 6786-6799 PR:000036013 denotes (33). Other s
T20825 6803-6808 PR:000036013 denotes es hi
T14954 6816-6820 PR:000003622;G_3;PG_10 denotes d th
T39929 6842-6845 PR:000001563 denotes 1-7
T49406 6898-6902 G_3;PG_10;PR:000003622 denotes ator
T29031 6903-6907 PR:000036013 denotes cyt
T97645 6974-6979 PR:000013883 denotes racta
T54224 7006-7010 PR:000001251 denotes ing
T94906 7015-7019 PR:000003622;G_3;PG_10 denotes h fa
T80849 7033-7039 PR:000036009 denotes iac an
T57333 7051-7055 PR:000001251 denotes bros
T66538 7079-7083 PR:000003622;G_3;PG_10 denotes on,
T53794 7141-7145 G_3;PG_10;PR:000003622 denotes ).
T49835 7185-7191 PR:000036009 denotes gulati
T23691 7206-7211 PR:000036013 denotes gen i
T96566 7215-7219 G_3;PG_10;PR:000003622 denotes nver
T43762 7278-7290 SP_10 denotes to Ang II vi
T84544 7291-7301 SP_10;UBERON:0001004 denotes angiotens
T62103 7302-7322 SP_10 denotes n-converting enzyme
T45099 7324-7332 SP_10 denotes CE), whi
T96697 7340-7348 SP_10 denotes hydrolyz
T67126 7350-7354 G_3;PG_10;PR:000003622 denotes bra
T70630 7364-7373 PG_1 denotes to its in
T4074 7399-7404 NCBITaxon:10239;GO:0035376 denotes ing i
T7619 7405-7410 GO:0035376 denotes flamm
T1702 7420-7432 GO:0044164 denotes pro-inflamm
T51851 7463-7468 NCBITaxon:10239;GO:0006260 denotes iated
T38954 7469-7480 GO:0006260 denotes by Ang II t
T34720 7495-7501 PR:000036009 denotes (AT1),
T28581 7510-7515 PR:000003622;G_3;PG_10 denotes imula
T52593 7544-7549 NCBITaxon:10239 denotes m the
T53738 7615-7619 PR:000001251 denotes tary
T14088 7644-7649 PR:000001607 denotes embra
T411 7700-7705 PR:000013883 denotes in 1-
T412 7742-7750 SP_7 denotes egulated
T413 7761-7774 PR:000036008 denotes K)1/ERK2 path
T414 7776-7781 PR:000036008 denotes ys. A
T415 7923-7929 PR:000036009 denotes recep
T416 7951-7955 PR:000001251 denotes e fo
T417 7983-7999 UBERON:0002053 denotes to an intermedi
T418 8007-8022 UBERON:0001236 denotes -9 or directly
T419 8039-8050 CHEBI:27584;CHEBI:27584 denotes eptidase ne
T420 8076-8093 CHEBI:25354;CHEBI:25354 denotes ase (PEP). RAS = 
T421 8115-8121 CHEBI:15377;CHEBI:15377 denotes em. A
T422 8151-8155 CHEBI:24866;CHEBI:24866 denotes lar
T423 8186-8203 CHEBI:25354;CHEBI:25354 denotes ce of the RAS in
T424 8204-8224 CHEBI:48561;CHEBI:48561 denotes ardiovascular diseas
T425 8253-8261 UBERON:0002198 denotes ibitors,
T426 8263-8269 PR:000036009 denotes RBs, a
T427 8322-8327 CHEBI:15377;CHEBI:15377 denotes t of
T428 8355-8362 UBERON:0000479 denotes tral Il
T429 8425-8433 MOP:0000568 denotes Interac
T430 8446-8455 GO:0006915 denotes ID-19 Nor
T431 8538-8541 CHEBI:37886;CHEBI:37886;PR:000036009 denotes me
T432 8542-8544 PR:000036009 denotes AC
T433 8556-8560 PR:000001251 denotes uld
T434 8562-8568 PR:000036009 denotes inhib
T435 8594-8607 PR:000036013 denotes e pro-inflamm
T436 8611-8616 PR:000036013 denotes y eff
T437 8624-8628 PR:000003622;G_3;PG_10 denotes Ang
T438 8650-8653 PR:000001563 denotes h A
T439 8705-8709 G_3;PG_10;PR:000003622 denotes he a
T440 8710-8714 PR:000036013 denotes rena
T441 8782-8787 PR:000013883 denotes locor
T442 8814-8818 PR:000001251 denotes wat
T443 8823-8827 PR:000003622;G_3;PG_10 denotes abso
T444 8841-8847 PR:000036009 denotes increa
T445 8859-8863 PR:000001251 denotes ntio
T446 8887-8891 PR:000003622;G_3;PG_10 denotes nera
T447 8949-8954 G_3;PG_10;PR:000003622 denotes or pi
T448 8994-9000 PR:000036009 denotes hormon
T449 9015-9020 PR:000036013 denotes promo
T450 9024-9028 G_3;PG_10;PR:000003622 denotes ater
T451 9088-9100 SP_10 denotes responsible
T452 9101-9111 SP_10;UBERON:0001004 denotes or hypertr
T453 9112-9133 SP_10 denotes phy, fibrosis, oxidat
T454 9135-9143 SP_10 denotes e stress
T455 9151-9159 SP_10 denotes optosis.
T456 9161-9165 G_3;PG_10;PR:000003622 denotes hese
T457 9175-9185 PG_1 denotes re attenua
T458 9209-9214 NCBITaxon:10239;GO:0035376 denotes tor b
T459 9215-9220 GO:0035376 denotes ocker
T460 9230-9242 GO:0044164 denotes which block
T461 9273-9278 NCBITaxon:10239;GO:0006260 denotes can a
T462 9279-9290 GO:0006260 denotes so be conve
T463 9305-9311 PR:000036009 denotes nsin 1
T464 9320-9324 PR:000003622;G_3;PG_10 denotes -7)
T465 9354-9359 NCBITaxon:10239 denotes Mas
T466 9424-9429 PR:000001251 denotes s axi
T467 9454-9459 PR:000001607 denotes atory
T89708 9535-9539 CHEBI:23888;CHEBI:23888 denotes e co
T16250 9555-9565 GO:0065007 denotes nding to A
T24993 9573-9577 G_3;PG_10;PR:000003622 denotes ws d
T40191 9578-9582 PR:000036013 denotes ssoc
T14894 9594-9599 NCBITaxon:10088 denotes E2 an
T95497 9600-9610 UBERON:0001179;CL:0000581 denotes subsequen
T5844 9611-9622 CL:0000581 denotes degradatio
T3127 9645-9656 CHEBI:27584;CHEBI:27584 denotes ation of AC
T32730 9755-9759 G_3;PG_10;PR:000003622 denotes the
T99955 9773-9778 NCBITaxon:10088 denotes ptor
T27470 9779-9789 UBERON:0001179;CL:0000581 denotes or both th
T26688 9816-9828 CHEBI:17154;CHEBI:17154 denotes syndrome cor
T64863 9849-9858 CHEBI:18367;CHEBI:18367 denotes and SARS
T51748 9866-9875 CHEBI:35222;CHEBI:35222 denotes E2 mediat
T79147 9877-9888 CHEBI:27584;CHEBI:27584 denotes S protein
T23025 9925-9929 G_3;PG_10;PR:000003622 denotes nto
T84481 9986-9998 CHEBI:17154;CHEBI:17154 denotes ication. Div
T4704 10104-10114 CHEBI:31547;CHEBI:31547 denotes rse effect
T67581 10122-10127 SP_6;NCBITaxon:9606 denotes by A
T67016 10128-10136 CL:0000576 denotes 1R and i
T80087 10145-10156 CL:0000235 denotes tcomes by M
T18992 10185-10190 UBERON:0000948 denotes Seve
T31322 10255-10268 CHEBI:9241;CHEBI:9241 denotes modulation o
T65607 10349-10359 GO:0010467 denotes dosterone,
T63851 10379-10383 G_3;PG_10;PR:000003622 denotes ican
T37523 10415-10419 G_3;PG_10;PR:000003622 denotes ll a
T52917 10425-10435 GO:0010467 denotes mRNA and s
T20330 10463-10467 NCBITaxon:10088 denotes owev
T67854 10493-10503 CHEBI:31547;CHEBI:31547 denotes crophages
T68420 10505-10512 UBERON:0000948 denotes eated w
T17389 10513-10517 G_3;PG_10;PR:000003622 denotes th n
T21485 10578-10582 G_3;PG_10;PR:000003622 denotes ald
T43223 10595-10606 CL:0000235 denotes d not incre
T52621 10658-10666 MOP:0000568 denotes cts were
T13234 10714-10718 G_3;PG_10;PR:000003622 denotes eoti
T67008 10736-10746 GO:0010467 denotes se (42). T
T6775 10819-10824 PR:000036013 denotes (42)
T76816 10854-10860 PR:000036009 denotes phages
T82259 10871-10882 CHEBI:27584;CHEBI:27584 denotes rom patient
T28961 10893-10897 G_3;PG_10;PR:000003622 denotes t fa
T21763 10922-10934 CHEBI:17154;CHEBI:17154 denotes month of tre
T7075 10955-10965 CHEBI:18367;CHEBI:18367 denotes RA (spiron
T6242 11003-11011 CL:0000359 denotes ion in A
T57466 11012-11024 CL:0000359;UBERON:0004237 denotes E activity a
T21141 11025-11030 CL:0000359 denotes d 53%
T12094 11044-11050 PR:000036009 denotes ACE mR
T22669 11095-11099 PR:000000104 denotes y in
T30163 11108-11111 PR:000009232 denotes y 3
T73442 11148-11171 CHEBI:70982;CHEBI:70982 denotes d by 654% (42). In mice
T49074 11266-11274 MOP:0000568 denotes by incr
T27310 11299-11306 GO:0065007 denotes crophag
T72608 11358-11367 GO:0016020 denotes d oxidati
T87411 11368-11372 G_3;PG_10;PR:000003622 denotes e st
T69430 11373-11383 GO:0010467 denotes ess, decre
T7887 11423-11429 PR:000036009 denotes tivity
T82843 11470-11474 G_3;PG_10;PR:000003622 denotes rote
T64927 11516-11520 G_3;PG_10;PR:000003622 denotes of A
T2864 11613-11617 NCBITaxon:10114 denotes hrou
T75186 11631-11641 CHEBI:48416;CHEBI:48416 denotes ide adenin
T41759 11674-11684 GO:0010467 denotes mediated p
T99248 11688-11692 G_3;PG_10;PR:000003622 denotes ay (
T90139 11712-11716 PR:000036013 denotes smo
T20676 11729-11744 UBERON:0001515 denotes lls, potentiate
T14808 11773-11781 CHEBI:2904;CHEBI:2904 denotes ased pho
T53336 11786-11797 CHEBI:5775;CHEBI:5775 denotes ylation of
T75817 11821-11825 G_3;PG_10;PR:000003622 denotes whi
T33850 11826-11836 GO:0010467 denotes h are also
T31286 11840-11844 PR:000036013 denotes ende
T46627 11867-11873 UBERON:0000055 denotes pecies
T86512 11874-11878 UBERON:0000060 denotes gene
T9294 11937-11951 UBERON:0001515 denotes y associated w
T66808 11952-11957 UBERON:0004363 denotes th re
T37862 12048-12052 NCBITaxon:10114 denotes d to
T72848 12059-12067 CHEBI:2904;CHEBI:2904 denotes e membra
T28474 12071-12082 CHEBI:5775;CHEBI:5775 denotes CE2 express
T95172 12112-12116 G_3;PG_10;PR:000003622 denotes l ef
T54342 12117-12121 PR:000036013 denotes ects
T8468 12124-12134 GO:0010467 denotes Ang II; h
T76399 12158-12174 UBERON:0005396 denotes As on soluble AC
T76616 12190-12197 NCBITaxon:33208 denotes ar. Sim
T23650 12258-12262 G_3;PG_10;PR:000003622 denotes the
T20063 12263-12267 SO:0000704;GO:0010467 denotes ffec
T90002 12272-12279 BV_20 denotes ARB tr
T2173 12280-12290 BV_20;GO:0010467 denotes atment. Sp
T84173 12318-12332 UBERON:0013755 denotes s treated with
T25744 12402-12406 NCBITaxon:10088 denotes incr
T59010 12420-12428 CHEBI:2904;CHEBI:2904 denotes n their
T47013 12432-12443 CHEBI:5775;CHEBI:5775 denotes acic aortas
T34872 12465-12469 NCBITaxon:10114 denotes d wi
T53714 12502-12505 CHEBI:37886;CHEBI:37886;PR:000036009 denotes ite
T14892 12506-12508 PR:000036009 denotes n
T88568 12525-12528 CHEBI:37886;CHEBI:37886;PR:000036009 denotes exp
T25496 12529-12531 PR:000036009 denotes es
T6560 12544-12547 PR:000001251 denotes 7 (
T62928 12572-12575 PR:000001191 denotes wa
T35232 12586-12590 PR:000003622;G_3;PG_10 denotes ns s
T26354 12601-12612 UBERON:0001986 denotes olmesartan
T89670 12613-12624 CHEBI:16480;CHEBI:16480 denotes electively
T84189 12634-12644 GO:0010467 denotes e thoracic
T10845 12667-12671 PR:000001307 denotes atio
T1909 12672-12682 GO:0010467 denotes whereas v
T89580 12716-12720 NCBITaxon:10114 denotes in s
T30307 12734-12745 CHEBI:9434;CHEBI:9434 denotes ypertensive
T38415 12780-12784 G_3;PG_10;PR:000003622 denotes (44
T98868 12798-12809 UBERON:0001986 denotes o change in
T64155 12810-12821 CHEBI:16480;CHEBI:16480 denotes ACE2/Ang1-7
T75423 12831-12841 GO:0010467 denotes n and/or a
T30401 12845-12857 UBERON:0000948 denotes ity in the c
T13751 12858-12865 UBERON:0000055 denotes rotid a
T36514 12870-12885 UBERON:0002349 denotes es of the treat
T22953 12918-12928 GO:0010467 denotes the effect
T33050 12936-12939 PR:000001251 denotes esa
T74336 12965-12976 CHEBI:9434;CHEBI:9434 denotes and protei
T29878 12992-13000 GO:0016020 denotes e the re
T86770 13001-13005 PR:000001307 denotes ult
T46947 13006-13016 GO:0010467 denotes f reduced
T78149 13029-13057 PR:000000046 denotes d pressure was ruled out bec
T7543 13067-13077 GO:0010467 denotes e comparat
T19226 13108-13112 NCBITaxon:10114 denotes ated
T6758 13123-13138 UBERON:0001621 denotes lol or hydralaz
T95747 13148-13164 UBERON:0002084 denotes Sprague-Dawley r
T8675 13231-13239 CHEBI:4670;CHEBI:4670 denotes pregulat
T91170 13282-13288 UBERON:0001969 denotes , ACE2
T42939 13368-13375 UBERON:0000948 denotes 44 expr
T89507 13376-13379 PR:000001251 denotes ssi
T67399 13408-13412 PR:000003622;G_3;PG_10 denotes weve
T50252 13423-13433 UBERON:0002349 denotes ated with
T80802 13494-13501 UBERON:0000948 denotes nd endo
T66318 13553-13556 PR:000001251 denotes dia
T59358 13581-13585 PR:000003622;G_3;PG_10 denotes dium
T3857 13586-13596 GO:0010467 denotes as well a
T15004 13700-13704 G_3;PG_10;PR:000003622 denotes CD4
T55429 13705-13715 GO:0010467 denotes expressio
T56789 13723-13733 UBERON:0002349 denotes duced tran
T22016 13789-13793 G_3;PG_10;PR:000003622 denotes es i
T73746 13799-13806 GO:0009986 denotes otensiv
T3793 13807-13817 GO:0010467 denotes rats with
T94556 13822-13828 UBERON:0001969 denotes -coron
T7532 13829-13833 G_3;PG_10;PR:000003622 denotes ry a
T59750 13864-13868 NCBITaxon:10114 denotes rem
T68812 13874-13878 UBERON:0001652 denotes g an
T80708 13879-13894 UBERON:0001626 denotes dysfunction ex
T19064 13908-13918 UBERON:0002349 denotes l resoluti
T68086 13931-13937 UBERON:0001969 denotes losart
T9555 13938-13944 PR:000036009 denotes n and
T46842 13979-13985 UBERON:0001969 denotes ng pla
T63923 13986-13990 PR:000003622;G_3;PG_10 denotes ma c
T57073 14025-14032 UBERON:0000948 denotes 46). Th
T11029 14033-14037 PR:000003622;G_3;PG_10 denotes s wa
T22615 14042-14045 PR:000001251 denotes oci
T54648 14141-14151 UBERON:0002349 denotes on, which
T39259 14173-14181 CHEBI:8774;CHEBI:8774 denotes effects
T49629 14218-14224 UBERON:0001969 denotes ccompa
T84997 14225-14228 CHEBI:29101;CHEBI:29101;PR:000036008 denotes ied
T62274 14229-14230 PR:000036008;CHEBI:16382;CHEBI:16382 denotes b
T49616 14235-14241 PR:000036009 denotes ect bl
T93686 14261-14267 UBERON:0001969 denotes ors an
T73758 14276-14280 PR:000003622;G_3;PG_10 denotes ed A
T15813 14353-14357 PR:000003622;G_3;PG_10 denotes sult
T48553 14361-14364 PR:000001251 denotes rta
T52193 14374-14384 GO:0010467 denotes RB use and
T47893 14437-14447 UBERON:0002349 denotes of the co
T5376 14511-14516 NCBITaxon:39107 denotes sion
T50240 14538-14542 G_3;PG_10;PR:000003622 denotes . In
T48024 14600-14610 UBERON:0002349 denotes n and myoc
T2031 14617-14627 UBERON:0002349 denotes infarction
T75536 14655-14663 CHEBI:8774;CHEBI:8774 denotes ere not
T21825 14676-14686 GO:0010467 denotes plasma AC
T49779 14696-14700 G_3;PG_10;PR:000003622 denotes vate
T30668 14799-14804 NCBITaxon:39107 denotes gulat
T69554 14844-14854 CHEBI:48416;CHEBI:48416 denotes rdium (47)
T74716 14858-14869 CHEBI:9434;CHEBI:9434 denotes eatment wit
T88764 14885-14892 UBERON:0000948 denotes alsarta
T80829 14893-14897 G_3;PG_10;PR:000003622 denotes res
T65771 14907-14914 BV_20 denotes ncrease
T58470 14915-14925 BV_20;GO:0010467 denotes plasma An
T72678 14943-14949 UBERON:0001969 denotes suppr
T79500 14950-14954 PR:000036013 denotes ssio
T87382 14999-15006 UBERON:0000948 denotes either
T91462 15100-15110 CHEBI:35222;CHEBI:35222 denotes mained at
T59581 15141-15145 G_3;PG_10;PR:000003622 denotes dial
T32923 15146-15156 GO:0010467 denotes infarction
T89116 15189-15192 CHEBI:37886;CHEBI:37886;PR:000036009 denotes s s
T52084 15193-15195 PR:000036009 denotes ud
T59745 15246-15252 PR:000036009 denotes gulati
T42872 15270-15274 PR:000003622;G_3;PG_10 denotes infa
T18348 15293-15297 PR:000036013 denotes iabl
T25440 15332-15336 G_3;PG_10;PR:000003622 denotes ctio
T42655 15337-15341 PR:000036013 denotes . Tr
T1503 15372-15381 GO:0065007 denotes CE expres
T18131 15389-15392 PR:000001251 denotes ere
T33157 15453-15460 UBERON:0000948 denotes rol sub
T63784 15483-15489 PR:000036009 denotes dy in
T32447 15520-15530 CHEBI:35222;CHEBI:35222 denotes ted that t
T28230 15557-15561 G_3;PG_10;PR:000003622 denotes tel
T56486 15586-15596 CHEBI:35222;CHEBI:35222 denotes ardiac ACE
T60150 15618-15622 PR:000036013 denotes ress
T27622 15705-15715 CHEBI:35222;CHEBI:35222 denotes c function
T45254 15742-15745 PR:000036008 denotes spo
T68302 15746-15747 PR:000036008;CHEBI:16382;CHEBI:16382 denotes i
T53701 15751-15754 CHEBI:37886;CHEBI:37886;PR:000036009 denotes (4
T10363 15755-15757 PR:000036009 denotes ).
T56333 15774-15784 MOP:0000619 denotes s suggeste
T27917 15788-15798 CHEBI:3165;CHEBI:3165 denotes at both AC
T15920 15852-15862 CHEBI:3165;CHEBI:3165 denotes sion (49).
T33386 15873-15884 UBERON:0001986;GO:0017156 denotes ited bindin
T67450 15884-15894 GO:0017156 denotes g of Ang I
T25824 15895-15907 GO:0042311 denotes to the AT1
T87208 15926-15939 CHEBI:26333;CHEBI:26333 denotes mitted circul
T9658 15944-15955 CHEBI:16480;CHEBI:16480 denotes Ang II to
T36835 15995-15998 PR:000001251 denotes 1-7
T72048 16083-16087 G_3;PG_10;PR:000003622 denotes y th
T5759 16088-16092 SO:0000704 denotes AT1
T63904 16119-16122 CHEBI:37886;CHEBI:37886;PR:000036009;GO:0034205 denotes ant
T97196 16123-16125 PR:000036009;GO:0034205 denotes in
T84140 16126-16135 GO:0034205 denotes mediating
T65944 16136-16145 GO:0065007 denotes the vascu
T2616 16146-16150 G_3;PG_10;PR:000003622 denotes ar a
T8775 16164-16168 G_3;PG_10;PR:000003622 denotes odel
T7666 16237-16245 CHEBI:6541;CHEBI:6541 denotes complex
T40696 16275-16281 UBERON:0001969 denotes ed by
T51121 16282-16286 PR:000036013 denotes CE i
T58974 16304-16310 UBERON:0001969 denotes incre
T80784 16311-16317 PR:000036009 denotes se in
T33334 16352-16356 G_3;PG_10;PR:000003622 denotes cts
T83597 16390-16398 CHEBI:6541;CHEBI:6541 denotes nsinases
T62347 16427-16435 CHEBI:6541;CHEBI:6541 denotes conversi
T16234 16440-16450 CHEBI:43755;CHEBI:43755 denotes Ang I to
T90761 16490-16494 G_3;PG_10;PR:000003622 denotes dyki
T25248 16521-16531 CHEBI:35222;CHEBI:35222 denotes s the vaso
T50049 16561-16570 GO:0065007 denotes , improve
T45483 16571-16575 G_3;PG_10;PR:000003622 denotes end
T32689 16605-16611 PR:000036009 denotes n thro
T27991 16642-16646 PR:000003622;G_3;PG_10 denotes nit
T22569 16665-16670 PR:000036008 denotes n, an
T41693 16676-16681 PR:000036012 denotes regu
T9119 16740-16745 PR:000036008 denotes dated
T90264 16777-16782 PR:000036013 denotes the
T46244 16809-16819 PR:000001898 denotes ition of A
T39670 16905-16915 CHEBI:35222;CHEBI:35222 denotes n alone or
T35970 16973-16977 G_3;PG_10;PR:000003622 denotes pla
T45388 17018-17022 G_3;PG_10;PR:000003622 denotes 53).
T37721 17023-17027 PR:000036013 denotes Comp
T77914 17113-17127 GO:0007596 denotes mbination of l
T92396 17156-17160 G_3;PG_10;PR:000003622 denotes ed i
T36791 17161-17165 PR:000036013 denotes sup
T91226 17168-17171 PR:000001563 denotes sse
T41455 17236-17240 G_3;PG_10;PR:000003622 denotes ove
T47287 17245-17249 PR:000036013 denotes a s
T94041 17269-17273 G_3;PG_10;PR:000003622 denotes ACE
T46256 17274-17283 GO:0065007 denotes transcri
T27522 17310-17316 PR:000036009 denotes is th
T18328 17317-17320 PR:000001251 denotes pr
T97445 17362-17366 G_3;PG_10;PR:000003622 denotes Ang
T95349 17367-17371 PR:000036013 denotes I in
T57032 17490-17502 UBERON:0001004 denotes c metallopep
T84387 17539-17557 UBERON:0002012 denotes less favorable ki
T17302 17580-17585 NCBITaxon:39107 denotes s, it
T83070 17614-17623 GO:0065007 denotes s disrupt
T26990 17694-17700 NCBITaxon:9606 denotes vored
T44915 17773-17778 SP_6;NCBITaxon:9606;PG_10 denotes ted a
T17920 17779-17810 PG_10;PR:000003622 denotes ti-inflammatory, antifibrotic,
T73021 17983-17989 UBERON:0001969 denotes tes RA
T61927 17990-17994 PR:000004020 denotes sig
T23026 18011-18017 PR:000036013 denotes g Ang
T71840 18022-18026 PR:000004020 denotes 1 re
T22204 18047-18052 UBERON:0000178 denotes by ac
T26814 18066-18071 UBERON:0000948 denotes CE2/A
T94557 18139-18149 GO:0042571 denotes ical studi
T30861 18208-18213 UBERON:0002405;GO:0006955 denotes stres
T57602 18214-18222 GO:0006955 denotes syndrom
T94938 18296-18309 BV_15 denotes dies demonstr
T33007 18333-18338 UBERON:0001977 denotes e RAS
T38801 18357-18363 PR:000036009 denotes it is
T28701 18509-18515 UBERON:0001969 denotes nzyme
T71861 18516-18521 PR:000013883 denotes ]; NC
T50650 18526-18532 PR:000036009 denotes 6353)
T8408 18568-18573 UBERON:0000062 denotes nd ph
T29635 18790-18796 UBERON:0001969 denotes mon si
T18517 18797-18802 PR:000013883 denotes e eff
T27148 18807-18813 PR:000036009 denotes includ
T7152 18916-18920 UBERON:0002048 denotes res
T95849 19012-19018 UBERON:0001969 denotes rhACE
T33072 19019-19025 PR:000036009 denotes are re
T92303 19039-19045 UBERON:0001969 denotes levels
T37164 19046-19051 PR:000036013 denotes of AC
T45720 19058-19068 CHEBI:35195;CHEBI:35195 denotes ng II are
T33861 19069-19078 PR:000006464 denotes levated i
T25070 19101-19117 GO:0045087 denotes d sepsis (55,56)
T51504 19124-19128 PR:000001393 denotes es f
T11222 19527-19533 SP_6;NCBITaxon:9606 denotes a pilo
T89438 19534-19552 UBERON:0002012 denotes clinical trial (S
T79951 19601-19605 G_3;PG_10;PR:000003622 denotes atie
T75956 19659-19666 UBERON:0000948 denotes h ARDS
T51050 19715-19721 UBERON:0001969 denotes plasma
T89508 19749-19762 CHEBI:86267;CHEBI:86267 denotes Ang 1-7 and s
T57885 19826-19831 UBERON:0002113 denotes IL-6
T40937 19887-19897 GO:0065007 denotes beit stati
T51775 19972-19976 G_3;PG_10;PR:000003622 denotes elin
T24590 20046-20053 PR:000009054 denotes e medic
T6576 20094-20125 PG_10;PR:000003622 denotes ogical or clinical measures of
T15507 20127-20131 G_3;PG_10;PR:000003622 denotes Ds i
T89094 20183-20188 CHEBI:23888;CHEBI:23888 denotes 88405
T42418 20215-20229 GO:0010467 denotes of rhACE2 in
T33738 20233-20237 G_3;PG_10;PR:000003622 denotes n pu
T80753 20238-20245 PR:000036013 denotes monary
T25938 20249-20256 UBERON:0000948 denotes rial hy
T79570 20353-20363 UBERON:0002349 denotes proved car
T17295 20381-20388 UBERON:0000948 denotes oincide
T7913 20397-20413 UBERON:0004535 denotes ximum suppressio
T31024 20433-20439 UBERON:0000479 denotes s and
T80939 20488-20492 G_3;PG_10;PR:000003622 denotes hera
T64668 20493-20497 PR:000036013 denotes vas
T83220 20621-20626 NCBITaxon:39107 denotes 1) th
T99627 20631-20644 CL:0001034 denotes essment of th
T57790 20807-20811 G_3;PG_10;PR:000003622 denotes Con
T74175 20813-20821 SP_7 denotes rting En
T41191 20827-20841 UBERON:0004535 denotes [ACE2]: Diabe
T25778 20876-20884 SP_7 denotes tensive
T84221 20904-20911 UBERON:0000948 denotes and 2)
T89571 20982-20990 SP_7 denotes ss for e
T85711 21045-21064 PR:000005897 denotes attenuate myocardia
T57094 21126-21136 UBERON:0002349 denotes ection Tis
T15258 21213-21220 UBERON:0000948 denotes oing to
T1531 21353-21363 UBERON:0002349 denotes models. H
T97341 21389-21396 UBERON:0000948 denotes ion is
T2733 21435-21443 UBERON:0001621 denotes avorable
T89171 21497-21505 SP_7 denotes l benefi
T31987 21549-21559 UBERON:0002349 denotes e Several
T2470 21656-21663 UBERON:0000948 denotes ized pa
T26035 22119-22123 G_3;PG_10;PR:000003622 denotes of
T10049 22124-22134 GO:0065007 denotes bstructive
T65218 22183-22192 CHEBI:35222;CHEBI:35222 denotes patients
T55523 22261-22269 SP_7 denotes injury,
T53933 22313-22321 SP_7 denotes (61). O
T49807 22326-22333 SP_7 denotes observ
T79663 22365-22379 DG_37;PR:000036009 denotes injury were fo
T15361 22421-22429 SP_7 denotes time of
T52890 22539-22547 CHEBI:6541;CHEBI:6541 denotes affecte
T87551 22580-22588 SP_7 denotes ble to e
T34732 22617-22625 SP_7 denotes ation of
T23219 22683-22693 GO:0040011 denotes is novel c
T76836 22722-22730 SP_7 denotes VID-19,
T3029 22868-22879 NCBITaxon:11118 denotes the impact
T36086 22881-22889 SP_7 denotes f ACE in
T82622 23009-23019 SP_7 denotes With COVI
T40928 23061-23071 CHEBI:35222;CHEBI:35222 denotes tors, Angi
T14768 23114-23128 UBERON:0004535 denotes erity of COVID
T50691 23141-23149 SP_7 denotes E], NCT0
T93421 23246-23254 SP_7 denotes among p
T67192 23269-23274 SP_6;NCBITaxon:9606;PG_10 denotes lized
T67994 23275-23306 PG_10;PR:000003622 denotes with COVID-19 (Losartan for Pat
T78338 23350-23358 SP_7 denotes n; NCT04
T89352 23455-23465 CHEBI:35222;CHEBI:35222 denotes zation; NC
T71976 23483-23491 SP_7 denotes r studie
T44016 23493-23497 G_3;PG_10;PR:000003622 denotes have
T47722 23502-23512 SP_7 denotes launched
T88225 23513-23521 SP_10 denotes o evalua
T20549 23574-23584 SP_7 denotes onavirus [
T74305 23636-23649 NCBITaxon:11118 denotes 330300) or wi
T20522 23677-23681 G_3;PG_10;PR:000003622 denotes ARBs
T10417 23787-23794 NCBITaxon:10239 denotes cal out
T82275 23877-23886 SP_7 denotes g pilot s
T54073 23896-23900 G_3;PG_10;PR:000003622 denotes sing
T59849 23962-23970 SP_10 denotes combinan
T87907 23977-23987 SP_7 denotes Angiotens
T87618 23997-24001 G_3;PG_10;PR:000003622 denotes ing
T56047 24040-24047 GO:0009986 denotes tients
T52387 24064-24073 PG_1 denotes T04287686
T22150 24083-24087 G_3;PG_10;PR:000003622 denotes ly,
T49602 24107-24112 NCBITaxon:10239 denotes suppo
T68685 24173-24178 NCBITaxon:10239 denotes ients
T34678 24199-24211 GO:0044164 denotes and SARS-Co
T52783 24238-24242 CHEBI:37527;CHEBI:37527;GO:0010498 denotes in
T54873 24242-24252 GO:0010498 denotes the Guangd
T95293 24253-24264 GO:0006508 denotes ng province
T11073 24265-24275 MOP:0000780 denotes China, an
T13099 24283-24292 PG_1 denotes oV-2, whi
T14929 24323-24330 G_2;PR:000016456 denotes closely
T20618 24355-24364 PG_1 denotes es whose
T16546 24376-24384 SP_10 denotes eptor is
T5011 24443-24453 SP_7 denotes te 76% seq
T84770 24458-24468 G_3;PG_10;SP_7 denotes similarit
T39079 24469-24474 SP_7 denotes betw
T5967 24475-24485 SP_7;GO:0045333;UBERON:0001004 denotes en these s
T3924 24486-24508 SP_7 denotes rains of viruses trans
T64738 24510-24520 SP_7 denotes tes into s
T67752 24553-24557 G_3;PG_10;PR:000003622 denotes . Re
T95513 24566-24575 PG_1 denotes ies have
T26459 24599-24611 GO:0044164 denotes its ACE2 for
T52219 24617-24626 PG_1 denotes and thus
T32797 24637-24641 CHEBI:37527;CHEBI:37527 denotes a s
T12112 24642-24651 GO:0010498 denotes milar spe
T50709 24652-24663 GO:0006508 denotes trum of cel
T9467 24664-24672 MOP:0000780 denotes s as SAR
T2172 24676-24680 G_3;PG_10;PR:000003622 denotes V (1
T77069 24705-24708 PR:000000134 denotes CE2
T33950 24713-24727 GO:0016020;PG_8 denotes its spike (S)
T23220 24728-24745 PG_8 denotes rotein (13,14). T
T70156 24831-24838 SO:0000667 denotes to tar
T48199 24848-24856 GO:0016020 denotes Followi
T83469 24875-24895 GO:0017156 denotes , the virus must gai
T19170 24896-24907 GO:0006897 denotes access to
T94560 24911-24915 G_3;PG_10;PR:000003622 denotes cyt
T70254 24916-24926 SP_7 denotes sol, which
T31520 24952-24957 PR:000000134 denotes epend
T5382 24962-24972 PR:000004978 denotes roteolytic
T22066 24973-24983 CHEBI:35222;CHEBI:35222 denotes cleavage o
T40974 25006-25014 MOP:0000780 denotes ular ser
T9335 25018-25022 PR:000003622;G_3;PG_10 denotes prot
T76096 25024-25031 PR:000001279 denotes se TMPR
T884 25145-25155 SP_7 denotes SARS-CoV-2
T885 25160-25164 G_3;PG_10;PR:000003622 denotes ACE2
T887 25178-25189 SP_7;UBERON:0001004;GO:0045333 denotes respiratory
T888 25190-25212 SP_7 denotes syndrome coronavirus 2
T889 25214-25224 SP_7 denotes SARS-CoV-2
T890 25257-25261 G_3;PG_10;PR:000003622 denotes ACE2
T891 25270-25279 PG_1 denotes S protein
T892 25303-25315 GO:0044164 denotes host cytosol
T893 25321-25330 PG_1 denotes S protein
T894 25341-25345 CHEBI:37527;CHEBI:37527 denotes acid
T895 25346-25355 GO:0010498 denotes dependent
T896 25356-25367 GO:0006508 denotes proteolytic
T897 25368-25376 MOP:0000780 denotes cleavage
T898 25380-25384 G_3;PG_10;PR:000003622 denotes ACE2
T899 25409-25412 PR:000000134 denotes TNF
T900 25417-25430 GO:0016020;PG_8 denotes transmembrane
T901 25431-25448 PG_8 denotes protease serine 2
T902 25534-25541 SO:0000667 denotes inserts
T903 25551-25559 GO:0016020 denotes membrane
T904 25578-25597 GO:0017156 denotes clatherin-dependent
T905 25598-25609 GO:0006897 denotes endocytosis
T906 25613-25617 G_3;PG_10;PR:000003622 denotes ACE2
T907 25618-25628 SP_7 denotes SARS-CoV-2
T908 25655-25660 PR:000000134 denotes TNF-α
T909 25665-25675 PR:000004978 denotes calmodulin
T910 25676-25686 CHEBI:35222;CHEBI:35222 denotes inhibitors
T911 25709-25717 MOP:0000780 denotes cleavage
T912 25721-25725 PR:000003622;G_3;PG_10 denotes ACE2
T913 25727-25734 PR:000001279 denotes ADAM 17
T21951 25852-25860 SP_10 denotes SARS-CoV
T35191 25865-25875 SP_7 denotes SARS-CoV-2
T98859 25925-25932 G_2 denotes TMPRSS2
T23879 25942-25947 NCBITaxon:10239;GO:0035376 denotes viral
T41028 25948-25953 GO:0035376 denotes entry
T79311 25992-25996 PR:000014459;SP_7 denotes SARS
T99975 25996-26002 SP_7 denotes -CoV-2
T30836 26048-26059 GO:0006897 denotes endocytosis
T41639 26082-26087 NCBITaxon:10239 denotes virus
T74403 26140-26144 G_3;PG_10;PR:000003622 denotes ACE2
T70404 26146-26154 MOP:0000780 denotes cleavage
T16501 26162-26171 PG_1 denotes S protein
T28844 26209-26218 GO:0061025 denotes fusion of
T72200 26219-26224 GO:0019012;NCBITaxon:10239 denotes viral
T23585 26229-26247 GO:0005886 denotes cellular membranes
T25830 26249-26257 SP_10 denotes SARS-CoV
T50948 26294-26309 GO:0005769 denotes early endosomes
T53216 26364-26368 G_3;PG_10;PR:000003622 denotes ACE2
T17762 26387-26392 PR:000000134 denotes TNF-α
T36976 26428-26438 PR:000004978 denotes calmodulin
T22481 26439-26449 CHEBI:35222;CHEBI:35222 denotes inhibitors
T67587 26470-26478 MOP:0000780 denotes cleavage
T81337 26500-26510 SP_7 denotes SARS-CoV-2
T64884 26561-26566 PR:000000134 denotes TNF-α
T14890 26625-26633 SP_7 denotes COVID-19
T78453 26691-26697 UBERON:0001969 denotes plasma
T19233 26716-26720 PR:000001379 denotes IL-2
T94987 26722-26726 PR:000001317 denotes IL-7
T67055 26728-26733 PR:000001471 denotes IL-10
T59312 26735-26746 CL:0000094;PR:000005932 denotes granulocyte
T9881 26746-26772 PR:000005932 denotes -colony stimulating factor
T51530 26774-26778 PR:000005932 denotes GCSF
T83137 26781-26797 PR:000000017 denotes interferon gamma
T54488 26818-26822 PR:000006064 denotes IP10
T81532 26825-26833 CL:0000576;PR:000002122 denotes monocyte
T25729 26834-26859 PR:000002122 denotes chemoattractant protein 1
T34939 26861-26871 CL:0000235;PR:000002123 denotes macrophage
T7552 26872-26900 PR:000002123 denotes inflammatory protein 1 alpha
T1328 26902-26907 PR:000002123 denotes MIP1A
T95282 26914-26919 PR:000000134 denotes TNF-α
T43558 26950-26954 G_3;PG_10;PR:000003622 denotes ACE2
T63317 26999-27011 GO:0065007 denotes dysregulated
T57932 27015-27023 SP_7 denotes COVID-19
T29873 27077-27085 GO:0098589 denotes membrane
T95515 27092-27096 G_3;PG_10;PR:000003622 denotes ACE2
T3701 27122-27126 UBERON:0002048 denotes lung
T59078 27191-27197 UBERON:0001969 denotes plasma
T11403 27198-27202 G_3;PG_10;PR:000003622 denotes ACE2
T99062 27273-27277 G_3;PG_10;PR:000003622 denotes ACE2
T51252 27321-27326 UBERON:0000948 denotes heart
T92926 27336-27342 UBERON:0001969 denotes plasma
T37668 27343-27347 G_3;PG_10;PR:000003622 denotes ACE2
T47121 27542-27546 G_3;PG_10;PR:000003622 denotes ACE2
T29313 27575-27579 UBERON:0002048 denotes lung
T84153 27602-27612 UBERON:0002349 denotes myocardial
T19874 27660-27664 G_3;PG_10;PR:000003622 denotes ACE2
T8611 27725-27730 UBERON:0000948 denotes heart
T29252 27802-27806 G_3;PG_10;PR:000003622 denotes ACE2
T4915 27838-27844 UBERON:0000479 denotes tissue
T16322 27993-27997 G_3;PG_10;PR:000003622 denotes ACE2
T66472 28009-28017 GO:0065007 denotes regulate
T77188 28027-28033 PR:000036009 denotes Ang II
T35804 28092-28098 PR:000036009 denotes Ang II
T98162 28102-28107 PR:000036013 denotes Ang 1
T28163 28192-28202 SP_7 denotes SARS-CoV-2
T43635 28215-28219 G_3;PG_10;PR:000003622 denotes ACE2
T8828 28275-28279 G_3;PG_10;PR:000003622 denotes ACE2
T1098 28280-28291 SO:0000243 denotes entry sites
T6321 28390-28408 GO:0033644 denotes host cell membrane
T55209 28496-28510 GO:0005634 denotes multinucleated
T36761 28526-28538 GO:0048468 denotes Formation of
T98942 28539-28553 GO:0005634;CL:0000228 denotes multinucleated
T72211 28554-28559 CL:0000228 denotes cells
T30799 28576-28581 NCBITaxon:10239 denotes virus
T11178 28633-28638 NCBITaxon:10239 denotes virus
T64611 28648-28658 GO:0042571 denotes antibodies
T23970 28686-28697 GO:0006260 denotes replication
T77931 28726-28732 GO:0019012;GO:0019068 denotes virion
T3886 28733-28741 GO:0019068 denotes assembly
T94309 28749-28754 GO:0005794 denotes Golgi
T20019 28793-28798 NCBITaxon:10239 denotes virus
T27779 28802-28810 GO:0031982 denotes vesicles
T75315 28826-28836 GO:0006887 denotes exocytosis
T94094 28866-28881 GO:0019068 denotes virion assembly
T55582 28886-28896 GO:0006887 denotes exocytosis
T20788 28915-28919 G_3;PG_10;PR:000003622 denotes ACE2
T94149 29021-29035 UBERON:0004535 denotes Cardiovascular
T11413 29050-29060 SP_7 denotes SARS-CoV-2
T96807 29079-29089 SP_7 denotes SARS-CoV-2
T29852 29100-29115 GO:0019068 denotes virion assembly
T92838 29134-29142 GO:0016020 denotes membrane
T55000 29149-29153 G_3;PG_10;PR:000003622 denotes ACE2
T37615 29193-29204 GO:0006260 denotes replication
T3663 29218-29223 NCBITaxon:10239 denotes virus
T77253 29269-29279 CHEBI:35222;CHEBI:35222 denotes inhibitors
T68013 29332-29340 SP_10 denotes SARS-CoV
T90735 29406-29410 G_3;PG_10;PR:000003622 denotes ACE2
T99855 29411-29421 GO:0010467 denotes expression
T45949 29436-29454 CHEBI:16412;CHEBI:16412 denotes Lipopolysaccharide
T26573 29469-29473 UBERON:0002048 denotes lung
T67408 29481-29486 NCBITaxon:10088 denotes mouse
T64221 29514-29524 GO:0010467 denotes expression
T339 29528-29532 G_3;PG_10;PR:000003622 denotes ACE2
T57577 29534-29538 UBERON:0002048 denotes lung
T30771 29620-29631 GO:0009294 denotes transfected
T2102 29637-29641 G_3;PG_10;PR:000003622 denotes ACE2
T26427 29677-29681 UBERON:0002048 denotes lung
T88548 29695-29699 UBERON:0002048 denotes lung
T40701 29727-29731 NCBITaxon:10088 denotes mice
T25934 29741-29751 CHEBI:35222;CHEBI:35222 denotes inhibitors
T13796 29777-29795 CHEBI:16412;CHEBI:16412 denotes lipopolysaccharide
T57031 29804-29813 UBERON:0006562 denotes pneumonic
T56145 29855-29863 SP_10 denotes SARS-CoV
T3099 29864-29873 PG_1 denotes S protein
T33336 29895-29899 UBERON:0002048 denotes lung
T48754 29916-29929 GO:0065007 denotes dysregulation
T39370 29951-29959 SP_10 denotes SARS-CoV
T41763 29975-29979 UBERON:0002048 denotes lung
T35901 30026-30029 PR:000001251 denotes AT1
T86863 30116-30124 SP_7 denotes COVID-19
T90528 30333-30343 SP_7 denotes SARS-CoV-2
T82967 30359-30367 GO:0016020 denotes membrane
T4860 30374-30378 G_3;PG_10;PR:000003622 denotes ACE2
T49764 30396-30402 PR:000001279 denotes ADAM17
T57158 30482-30486 G_3;PG_10;PR:000003622 denotes ACE2
T51582 30508-30513 NCBITaxon:10239 denotes viral
T18657 30598-30602 G_3;PG_10;PR:000003622 denotes ACE2
T56429 30603-30607 PR:000036013 denotes Ang1
T24733 30610-30613 PR:000001563 denotes Mas
T40354 30691-30704 GO:0065007 denotes dysregulation
T61569 30717-30727 SP_7 denotes SARS-CoV-2
T7547 30752-30766 UBERON:0004535 denotes cardiovascular
T55968 30779-30789 SP_7 denotes SARS-CoV-2
T80913 30806-30816 CHEBI:35222;CHEBI:35222 denotes inhibitors
T91618 30888-30892 G_3;PG_10;PR:000003622 denotes ACE2
T66182 31050-31057 UBERON:0000948 denotes cardiac
T49783 31073-31078 UBERON:0000948 denotes heart
T17759 31141-31151 UBERON:0000948 denotes Cardiology
T7351 31162-31167 UBERON:0000948 denotes Heart
T73963 31181-31186 UBERON:0000948 denotes Heart
T87034 31244-31254 UBERON:0000948 denotes Cardiology
T40873 31389-31395 UBERON:0000479 denotes tissue
T70153 31396-31400 G_3;PG_10;PR:000003622 denotes ACE2
T30590 31437-31445 SP_7 denotes COVID-19
T5335 31463-31477 UBERON:0004535 denotes cardiovascular
T24575 31523-31537 UBERON:0004535 denotes cardiovascular
T78530 31552-31560 SP_7 denotes COVID-19
T40154 31582-31592 CHEBI:35222;CHEBI:35222 denotes inhibitors
T60460 31634-31638 G_3;PG_10;PR:000003622 denotes ACE2
T33728 31700-31708 SP_7 denotes COVID-19

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
107 1117-1148 Gene denotes angiotensin-converting enzyme 2 Gene:59272
108 1150-1154 Gene denotes ACE2 Gene:59272
109 1218-1222 Gene denotes ACE2 Gene:59272
110 1506-1512 Gene denotes Ang II Gene:183
111 1522-1525 Gene denotes ACE Gene:1636
112 1842-1845 Gene denotes ACE Gene:1636
113 1903-1929 Gene denotes mineralocorticoid receptor Gene:4306
114 2067-2071 Gene denotes ACE2 Gene:59272
115 2200-2204 Gene denotes ACE2 Gene:59272
116 2384-2388 Gene denotes ACE2 Gene:59272
117 1490-1504 Gene denotes angiotensin II Gene:183
118 2308-2309 Gene denotes S Gene:43740568
119 66-113 Species denotes severe acute respiratory syndrome-coronavirus-2 Tax:2697049
120 115-125 Species denotes SARS-CoV-2 Tax:2697049
121 304-312 Species denotes SARS-CoV Tax:694009
122 354-364 Species denotes SARS-CoV-2 Tax:2697049
123 558-575 Species denotes novel coronavirus Tax:2697049
124 643-651 Species denotes patients Tax:9606
125 807-815 Species denotes SARS-CoV Tax:694009
126 820-824 Species denotes CoV2 Tax:2697049
127 839-855 Species denotes beta-coronavirus Tax:694002
128 915-936 Species denotes SARS-like coronavirus Tax:694009
129 967-975 Species denotes SARS-CoV Tax:694009
130 980-990 Species denotes SARS-CoV-2 Tax:2697049
131 1068-1076 Species denotes SARS-CoV Tax:694009
132 2357-2367 Species denotes SARS-CoV-2 Tax:2697049
133 2560-2568 Species denotes patients Tax:9606
134 2613-2630 Species denotes novel coronavirus Tax:2697049
135 4-34 Disease denotes novel coronavirus disease-2019 MESH:C000657245
136 36-44 Disease denotes COVID-19 MESH:C000657245
137 432-441 Disease denotes infection MESH:D007239
138 657-665 Disease denotes COVID-19 MESH:C000657245
139 681-702 Disease denotes cardiovascular damage MESH:D002318
140 730-752 Disease denotes cardiovascular disease MESH:D002318
141 789-794 Disease denotes death MESH:D003643
142 1630-1642 Disease denotes hypertension MESH:D006973
143 1644-1666 Disease denotes myocardial hypertrophy MESH:D006332
144 1668-1684 Disease denotes cardiac fibrosis MESH:D005355
145 1686-1698 Disease denotes inflammation MESH:D007249
146 1725-1740 Disease denotes atherosclerosis MESH:D050197
147 1997-2020 Disease denotes cardiovascular diseases MESH:D002318
148 2283-2303 Disease denotes SARS-CoV-2 infection MESH:C000657245
149 2453-2474 Disease denotes cardiovascular damage MESH:D002318
151 2633-2662 Gene denotes Angiotensin-Converting Enzyme Gene:1636
161 2732-2737 Gene denotes renin Gene:5972
162 2743-2756 Gene denotes angiotensin I Gene:183
163 2758-2763 Gene denotes Ang I Gene:183
164 2869-2875 Gene denotes Ang II Gene:183
165 2952-2956 Gene denotes ACE2 Gene:59272
166 2766-2771 Gene denotes Ang I Gene:183
167 2713-2728 Gene denotes angiotensinogen Gene:183
168 2832-2835 Gene denotes ACE Gene:1636
169 2790-2793 Gene denotes Ang Gene:283
191 3073-3077 Gene denotes ACE2 Gene:59272
192 3249-3253 Gene denotes ACE2 Gene:59272
193 3301-3304 Gene denotes ACE Gene:1636
194 3330-3334 Gene denotes ACE2 Gene:59272
195 3357-3360 Gene denotes ACE Gene:1636
196 3428-3432 Gene denotes ACE2 Gene:59272
197 3523-3527 Gene denotes ACE2 Gene:59272
198 3531-3537 Gene denotes Ang II Gene:183
199 3597-3603 Gene denotes Ang1-7 Gene:284
200 3652-3656 Gene denotes ACE2 Gene:59272
201 3665-3670 Gene denotes Ang I Gene:183
202 3791-3795 Gene denotes ACE2 Gene:59272
203 3832-3842 Gene denotes collectrin Gene:57393
204 4000-4006 Gene denotes ADAM17 Gene:6868
205 4023-4070 Gene denotes tumor necrosis factor (TNF)-α−converting enzyme Gene:6868
206 4072-4076 Gene denotes TACE Gene:6868
207 4079-4083 Gene denotes ACE2 Gene:59272
208 4171-4175 Gene denotes ACE2 Gene:59272
209 3387-3390 Gene denotes ACE Gene:1636
210 4192-4202 Gene denotes calmodulin Gene:801
211 3609-3624 Chemical denotes L-phenylalanine MESH:D010649
214 4277-4281 Gene denotes ACE2 Gene:59272
215 4282-4288 Gene denotes Ang1-7 Gene:284
218 7162-7166 Gene denotes ACE2 Gene:59272
219 7167-7173 Gene denotes Ang1-7 Gene:284
247 7194-7209 Gene denotes Angiotensinogen Gene:183
248 7226-7239 Gene denotes angiotensin I Gene:183
249 7241-7246 Gene denotes Ang I Gene:183
250 7259-7264 Gene denotes Ang I Gene:183
251 7281-7287 Gene denotes Ang II Gene:183
252 7292-7321 Gene denotes angiotensin-converting enzyme Gene:1636
253 7323-7326 Gene denotes ACE Gene:1636
254 7351-7361 Gene denotes bradykinin Gene:3827
255 7449-7455 Gene denotes Ang II Gene:183
256 7652-7656 Gene denotes ACE2 Gene:59272
257 7669-7681 Gene denotes Endothelin-1 Gene:1906
258 7708-7714 Gene denotes Ang1-7 Gene:284
259 7720-7764 Gene denotes extracellular signal-regulated kinase (ERK)1 Gene:5594
260 7765-7769 Gene denotes ERK2 Gene:5594
261 7780-7786 Gene denotes Ang II Gene:183
262 7850-7856 Gene denotes Ang1-7 Gene:284
263 7861-7865 Gene denotes ACE2 Gene:59272
264 7934-7940 Gene denotes Ang1-7 Gene:284
265 8003-8009 Gene denotes Ang1-9 Gene:284
266 8048-8058 Gene denotes neprilysin Gene:4311
267 8059-8079 Gene denotes prolyl endopeptidase Gene:5550
268 8081-8084 Gene denotes PEP Gene:5550
269 7978-7983 Gene denotes Ang I Gene:183
270 7252-7257 Gene denotes renin Gene:5972
271 7519-7530 Chemical denotes aldosterone MESH:D000450
272 7621-7632 Chemical denotes Aldosterone MESH:D000450
273 7403-7415 Disease denotes inflammation MESH:D007249
350 4309-4314 Gene denotes Ang I Gene:183
351 4371-4377 Gene denotes Ang II Gene:183
352 4381-4384 Gene denotes ACE Gene:1636
353 4393-4396 Gene denotes ACE Gene:1636
354 4398-4403 Gene denotes Ang I Gene:183
355 4424-4430 Gene denotes Ang1-9 Gene:284
356 4434-4438 Gene denotes ACE2 Gene:59272
357 4463-4469 Gene denotes Ang II Gene:183
358 4486-4493 Gene denotes Ang 1-7 Gene:284
359 4502-4506 Gene denotes ACE2 Gene:59272
360 4513-4519 Gene denotes Ang1-7 Gene:284
361 4630-4656 Gene denotes G protein coupled receptor Gene:1909
362 4658-4662 Gene denotes GPCR Gene:1909
363 4689-4695 Gene denotes Ang1-7 Gene:284
364 4799-4809 Gene denotes neprilysin Gene:4311
365 4827-4833 Gene denotes Ang1-9 Gene:284
366 4837-4843 Gene denotes Ang1-7 Gene:284
367 4848-4851 Gene denotes ACE Gene:1636
368 4946-4950 Gene denotes ACE2 Gene:59272
369 5047-5051 Gene denotes ACE2 Gene:59272
370 5128-5134 Gene denotes Ang II Gene:183
371 5157-5161 Gene denotes ACE2 Gene:59272
372 5189-5193 Gene denotes ACE2 Gene:59272
373 5236-5240 Gene denotes ACE2 Gene:59272
374 5331-5335 Gene denotes ACE2 Gene:59272
375 5376-5380 Gene denotes ACE2 Gene:59272
376 5389-5395 Gene denotes Ang II Gene:183
377 5433-5467 Gene denotes mitogen-activated protein kinase 1 Gene:5594
378 5469-5474 Gene denotes MAPK1 Gene:5594
379 5498-5504 Gene denotes Ang II Gene:183
380 5523-5567 Gene denotes extracellular signal-regulated kinase (ERK)1 Gene:5594
381 5568-5572 Gene denotes ERK2 Gene:5594
382 5583-5587 Gene denotes ACE2 Gene:59272
383 5690-5694 Gene denotes ACE2 Gene:70008
384 5731-5735 Gene denotes TACE Gene:11491
385 5736-5742 Gene denotes ADAM17 Gene:11491
386 5870-5874 Gene denotes ACE2 Gene:70008
387 5879-5883 Gene denotes TACE Gene:11491
388 5963-5969 Gene denotes Ang II Gene:11606
389 6034-6038 Gene denotes JAK2 Gene:16452
390 6039-6044 Gene denotes STAT3 Gene:20848
391 6149-6155 Gene denotes Ang1-7 Gene:11727
392 6227-6230 Gene denotes ACE Gene:11421
393 6251-6261 Gene denotes bradykinin Gene:3827
394 6340-6346 Gene denotes Ang1-7 Gene:284
395 6372-6375 Gene denotes ACE Gene:1636
396 6381-6386 Gene denotes Ang I Gene:183
397 6429-6435 Gene denotes Ang1-7 Gene:284
398 6439-6442 Gene denotes ACE Gene:1636
399 6507-6511 Gene denotes ACE2 Gene:70008
400 6531-6537 Gene denotes Ang II Gene:11606
401 6563-6567 Gene denotes ACE2 Gene:70008
402 6588-6594 Gene denotes ERK1/2 Gene:26417
403 6596-6600 Gene denotes JAK2 Gene:16452
404 6601-6606 Gene denotes STAT3 Gene:20848
405 6694-6700 Gene denotes Ang II Gene:11606
406 6834-6838 Gene denotes ACE2 Gene:70008
407 6839-6845 Gene denotes Ang1-7 Gene:11727
408 6923-6928 Gene denotes TNF-α Gene:7124
409 6930-6949 Gene denotes interleukin (IL)-1β Gene:3552
410 6951-6955 Gene denotes IL-6 Gene:3569
411 6957-6991 Gene denotes monocyte chemoattractant protein-1 Gene:6347
412 6997-7025 Gene denotes transforming growth factor-β Gene:7124
413 4726-4731 Gene denotes Ang I Gene:183
414 5637-5640 Gene denotes Ang Gene:11727
415 5615-5621 Species denotes murine Tax:10090
416 6288-6293 Species denotes human Tax:9606
417 6521-6525 Species denotes mice Tax:10090
418 6629-6635 Chemical denotes rhACE2
419 6082-6104 Disease denotes myocardial hypertrophy MESH:D006332
420 6119-6127 Disease denotes fibrosis MESH:D005355
421 6709-6731 Disease denotes myocardial hypertrophy MESH:D006332
422 6736-6744 Disease denotes fibrosis MESH:D005355
423 6764-6785 Disease denotes diastolic dysfunction MESH:D007022
424 7049-7057 Disease denotes fibrosis MESH:D005355
425 7059-7081 Disease denotes pulmonary hypertension MESH:D006976
428 8120-8124 Gene denotes ACE2 Gene:59272
429 8140-8162 Disease denotes Cardiovascular Disease MESH:D002318
431 8443-8451 Disease denotes COVID-19 MESH:C000657245
470 8462-8475 Gene denotes angiotensin I Gene:183
471 8477-8482 Gene denotes Ang I Gene:183
472 8500-8506 Gene denotes Ang II Gene:183
473 8511-8540 Gene denotes angiotensin-converting enzyme Gene:1636
474 8542-8545 Gene denotes ACE Gene:1636
475 8576-8579 Gene denotes ACE Gene:1636
476 8624-8630 Gene denotes Ang II Gene:183
477 8652-8656 Gene denotes AT1R Gene:185
478 8885-8911 Gene denotes mineralocorticoid receptor Gene:4306
479 8963-8969 Gene denotes Ang II Gene:183
480 9242-9248 Gene denotes Ang II Gene:183
481 9260-9264 Gene denotes AT1R Gene:185
482 9266-9272 Gene denotes Ang II Gene:183
483 9315-9322 Gene denotes Ang 1-7 Gene:284
484 9328-9332 Gene denotes ACE2 Gene:59272
485 9410-9414 Gene denotes ACE2 Gene:59272
486 9415-9421 Gene denotes Ang1-7 Gene:284
487 9519-9523 Gene denotes AT1R Gene:185
488 9528-9532 Gene denotes ACE2 Gene:59272
489 9546-9552 Gene denotes Ang II Gene:183
490 9564-9568 Gene denotes AT1R Gene:185
491 9592-9596 Gene denotes ACE2 Gene:59272
492 9654-9658 Gene denotes ACE2 Gene:59272
493 9719-9726 Gene denotes Ang 1-7 Gene:284
494 9728-9732 Gene denotes ACE2 Gene:59272
495 9864-9868 Gene denotes ACE2 Gene:59272
496 10023-10027 Gene denotes ACE2 Gene:59272
497 10126-10130 Gene denotes AT1R Gene:185
498 9698-9704 Gene denotes Ang II Gene:183
499 10008-10011 Gene denotes Ang Gene:283
500 9791-9836 Species denotes severe acute respiratory syndrome coronavirus Tax:694009
501 9838-9849 Species denotes SARS-CoV) 2 Tax:2697049
502 9854-9862 Species denotes SARS-CoV Tax:694009
503 8815-8820 Chemical denotes water MESH:D014867
504 9023-9028 Chemical denotes water MESH:D014867
505 9104-9115 Disease denotes hypertrophy MESH:D006984
506 9117-9125 Disease denotes fibrosis MESH:D005355
507 9962-9971 Disease denotes infection MESH:D007239
511 8246-8249 Gene denotes ACE Gene:1636
512 8203-8225 Disease denotes cardiovascular disease MESH:D002318
513 8327-8350 Disease denotes cardiovascular diseases MESH:D002318
552 10274-10278 Gene denotes ACE2 Gene:59272
553 10279-10285 Gene denotes Ang1-7 Gene:284
554 10397-10400 Gene denotes ACE Gene:11421
555 10421-10424 Gene denotes ACE Gene:11421
556 10456-10460 Gene denotes ACE2 Gene:70008
557 10610-10613 Gene denotes ACE Gene:11421
558 10626-10630 Gene denotes ACE2 Gene:70008
559 11044-11047 Gene denotes ACE Gene:1636
560 11083-11087 Gene denotes ACE2 Gene:59272
561 11119-11123 Gene denotes ACE2 Gene:59272
562 11217-11221 Gene denotes ACE2 Gene:70008
563 11280-11284 Gene denotes ACE2 Gene:70008
564 11388-11391 Gene denotes ACE Gene:11421
565 11416-11420 Gene denotes ACE2 Gene:70008
566 11519-11526 Gene denotes Ang 1-7 Gene:284
567 11554-11560 Gene denotes Ang II Gene:183
568 11593-11597 Gene denotes ACE2 Gene:70008
569 11746-11752 Gene denotes Ang II Gene:183
570 11797-11803 Gene denotes ERK1/2 Gene:5595
571 12070-12074 Gene denotes ACE2 Gene:70008
572 12125-12131 Gene denotes Ang II Gene:183
573 12172-12176 Gene denotes ACE2 Gene:70008
574 11010-11013 Gene denotes ACE Gene:1636
575 10296-10301 Species denotes Mouse Tax:10090
576 10474-10479 Species denotes mouse Tax:10090
577 10826-10831 Species denotes Human Tax:9606
578 10875-10883 Species denotes patients Tax:9606
579 11167-11171 Species denotes mice Tax:10090
580 10347-10358 Chemical denotes aldosterone MESH:D000450
581 10516-10549 Chemical denotes nicotinamide adenine dinucleotide MESH:D009243
582 10579-10590 Chemical denotes aldosterone MESH:D000450
583 10808-10818 Chemical denotes eplerenone MESH:D000077545
584 10959-10973 Chemical denotes spironolactone MESH:D013148
585 11197-11207 Chemical denotes eplerenone MESH:D000077545
586 11571-11582 Chemical denotes aldosterone MESH:D000450
587 11622-11655 Chemical denotes nicotinamide adenine dinucleotide MESH:D009243
588 11859-11865 Chemical denotes oxygen MESH:D010100
589 10889-10902 Disease denotes heart failure MESH:D006333
613 12218-12222 Gene denotes ACE2 Gene:59272
614 12388-12392 Gene denotes ACE2 Gene:302668
615 12412-12418 Gene denotes Ang1-7 Gene:305843
616 12520-12524 Gene denotes ACE2 Gene:302668
617 12539-12545 Gene denotes Ang1-7 Gene:305843
618 12810-12814 Gene denotes ACE2 Gene:302668
619 12815-12821 Gene denotes Ang1-7 Gene:305843
620 12956-12960 Gene denotes ACE2 Gene:70008
621 12315-12319 Species denotes rats Tax:10116
622 12746-12750 Species denotes rats Tax:10116
623 13100-13104 Species denotes mice Tax:10090
624 12333-12343 Chemical denotes olmesartan MESH:C437965
625 12472-12480 Chemical denotes atenolol MESH:D001262
626 12485-12496 Chemical denotes hydralazine MESH:D006830
627 12601-12611 Chemical denotes olmesartan MESH:C437965
628 12757-12765 Chemical denotes atenolol MESH:D001262
629 12769-12780 Chemical denotes hydralazine MESH:D006830
630 12933-12943 Chemical denotes olmesartan MESH:C437965
631 13118-13126 Chemical denotes atenolol MESH:D001262
632 13130-13141 Chemical denotes hydralazine MESH:D006830
633 12302-12314 Disease denotes hypertensive MESH:D006973
634 12681-12701 Disease denotes vascular hypertrophy MESH:D006984
635 12733-12745 Disease denotes hypertensive MESH:D006973
695 13200-13206 Gene denotes Ang II Gene:183
696 13284-13288 Gene denotes ACE2 Gene:59272
697 13299-13332 Gene denotes endothelial nitric oxide synthase Gene:4846
698 13479-13483 Gene denotes ACE2 Gene:302668
699 13497-13530 Gene denotes endothelial nitric oxide synthase Gene:4846
700 13729-13757 Gene denotes transforming growth factor−β Gene:7124
701 14107-14111 Gene denotes ACE2 Gene:302668
702 14279-14283 Gene denotes ACE2 Gene:302668
703 14398-14402 Gene denotes ACE2 Gene:302668
704 14487-14491 Gene denotes ACE2 Gene:302668
705 14527-14531 Gene denotes ACE2 Gene:302668
706 14636-14642 Gene denotes Ang II Gene:24179
707 14647-14653 Gene denotes Ang1-7 Gene:305843
708 14684-14688 Gene denotes ACE2 Gene:302668
709 14731-14735 Gene denotes ACE2 Gene:302668
710 14966-14969 Gene denotes ACE Gene:24310
711 14974-14978 Gene denotes ACE2 Gene:302668
712 15051-15055 Gene denotes ACE2 Gene:302668
713 15229-15232 Gene denotes ACE Gene:11421
714 15237-15241 Gene denotes ACE2 Gene:70008
715 15371-15374 Gene denotes ACE Gene:11421
716 15395-15399 Gene denotes ACE2 Gene:70008
717 15593-15597 Gene denotes ACE2 Gene:70008
718 15650-15656 Gene denotes Ang1-7 Gene:11727
719 15657-15663 Gene denotes Ang II Gene:11606
720 15796-15799 Gene denotes ACE Gene:11421
721 15841-15845 Gene denotes ACE2 Gene:70008
722 15889-15895 Gene denotes Ang II Gene:11606
723 15945-15951 Gene denotes Ang II Gene:11606
724 15969-15973 Gene denotes ACE2 Gene:70008
725 15992-15998 Gene denotes Ang1-7 Gene:11727
726 16031-16035 Gene denotes ACE2 Gene:70008
727 16036-16042 Gene denotes Ang1-7 Gene:11727
728 16183-16189 Gene denotes Ang II Gene:11606
729 14923-14926 Gene denotes Ang Gene:283
730 13223-13226 Gene denotes Ang Gene:283
731 13148-13167 Species denotes Sprague-Dawley rats Tax:10116
732 13415-13419 Species denotes rats Tax:10116
733 13808-13812 Species denotes rats Tax:10116
734 14547-14566 Species denotes Sprague-Dawley rats Tax:10116
735 15209-15215 Species denotes murine Tax:10090
736 15498-15504 Species denotes murine Tax:10090
737 14933-14936 Gene denotes Ang Gene:283
738 13433-13444 Chemical denotes telmisartan MESH:D000077333
739 13665-13676 Chemical denotes telmisartan MESH:D000077333
740 13931-13939 Chemical denotes losartan MESH:D019808
741 13944-13954 Chemical denotes olmesartan MESH:C437965
742 14871-14879 Chemical denotes ramipril MESH:D017257
743 14884-14893 Chemical denotes valsartan MESH:D000068756
744 15354-15362 Chemical denotes ramipril MESH:D017257
745 15544-15554 Chemical denotes olmesartan MESH:C437965
746 15558-15569 Chemical denotes telmisartan MESH:D000077333
747 13853-13891 Disease denotes ventricular remodeling and dysfunction MESH:D020257
748 14122-14143 Disease denotes myocardial infarction MESH:D009203
749 14606-14627 Disease denotes myocardial infarction MESH:D009203
750 14765-14772 Disease denotes infarct MESH:D007238
751 15135-15156 Disease denotes myocardial infarction MESH:D009203
752 15270-15283 Disease denotes infarct zones MESH:D007238
753 15316-15337 Disease denotes myocardial infarction MESH:D009203
796 16215-16218 Gene denotes ACE Gene:1636
797 16256-16260 Gene denotes ACE2 Gene:59272
798 16281-16284 Gene denotes ACE Gene:1636
799 16317-16323 Gene denotes Ang1-7 Gene:284
800 16400-16403 Gene denotes ACE Gene:1636
801 16487-16497 Gene denotes bradykinin Gene:3827
802 16499-16502 Gene denotes ACE Gene:1636
803 16551-16561 Gene denotes bradykinin Gene:3827
804 16760-16763 Gene denotes ACE Gene:1636
805 16782-16786 Gene denotes ACE2 Gene:59272
806 16818-16824 Gene denotes Ang II Gene:183
807 16845-16849 Gene denotes ACE2 Gene:59272
808 16863-16867 Gene denotes ACE2 Gene:59272
809 16892-16895 Gene denotes ACE Gene:1636
810 16981-16987 Gene denotes Ang1-7 Gene:284
811 17010-17016 Gene denotes Ang II Gene:183
812 17051-17055 Gene denotes ACE2 Gene:59272
813 17189-17193 Gene denotes ACE2 Gene:59272
814 17216-17219 Gene denotes ACE Gene:1636
815 17270-17274 Gene denotes ACE2 Gene:59272
816 17304-17310 Gene denotes Ang II Gene:183
817 17341-17345 Gene denotes ACE2 Gene:59272
818 17374-17381 Gene denotes Ang 1-9 Gene:284
819 17421-17428 Gene denotes Ang 1-7 Gene:284
820 17433-17436 Gene denotes ACE Gene:1636
821 17438-17443 Gene denotes Ang I Gene:183
822 17475-17482 Gene denotes Ang 1-7 Gene:284
823 17509-17519 Gene denotes neprilysin Gene:4311
824 17601-17604 Gene denotes ACE Gene:1636
825 17665-17668 Gene denotes ACE Gene:1636
826 17673-17677 Gene denotes ACE2 Gene:59272
827 17718-17722 Gene denotes ACE2 Gene:59272
828 17723-17729 Gene denotes Ang1-7 Gene:284
829 16450-16456 Gene denotes Ang II Gene:183
830 17363-17368 Gene denotes Ang I Gene:183
831 16441-16446 Gene denotes Ang I Gene:183
832 16625-16638 Chemical denotes prostaglandin MESH:D011453
833 16643-16655 Chemical denotes nitric oxide MESH:D009569
834 16936-16944 Chemical denotes losartan MESH:D019808
835 17089-17097 Chemical denotes losartan MESH:D019808
836 17126-17134 Chemical denotes losartan MESH:D019808
837 17139-17149 Chemical denotes lisinopril MESH:D017706
840 17857-17861 Gene denotes ACE2 Gene:59272
841 17862-17868 Gene denotes Ang1-7 Gene:284
844 17939-17943 Gene denotes ACE2 Gene:59272
845 17948-17954 Gene denotes Ang1-7 Gene:284
855 17972-17976 Gene denotes ACE2 Gene:59272
856 18013-18019 Gene denotes Ang II Gene:183
857 18065-18069 Gene denotes ACE2 Gene:59272
858 18070-18076 Gene denotes Ang1-7 Gene:284
859 18178-18184 Chemical denotes rhACE2
860 18188-18223 Disease denotes acute respiratory distress syndrome MESH:D012128
861 18225-18229 Disease denotes ARDS MESH:D012128
862 18232-18238 Disease denotes sepsis MESH:D018805
863 18244-18275 Disease denotes pulmonary arterial hypertension MESH:D000081029
877 18485-18516 Gene denotes Angiotensin Converting Enzyme 2 Gene:59272
878 18694-18700 Gene denotes Ang1-8 Gene:284
879 18715-18721 Gene denotes Ang1-7 Gene:284
880 18726-18730 Gene denotes Ang1 Gene:284
881 18286-18292 Species denotes murine Tax:10090
882 18401-18407 Species denotes humans Tax:9606
883 18479-18484 Species denotes Human Tax:9606
884 18314-18320 Chemical denotes rhACE2
885 18599-18605 Chemical denotes rhACE2
886 18856-18862 Chemical denotes rhACE2
887 19013-19018 Chemical denotes rhACE
888 18816-18824 Disease denotes diarrhea MESH:D003967
889 18829-18837 Disease denotes headache MESH:D006261
917 19049-19052 Gene denotes ACE Gene:1636
918 19057-19063 Gene denotes Ang II Gene:183
919 19220-19225 Gene denotes renin Gene:5972
920 19230-19236 Gene denotes Ang II Gene:183
921 19511-19517 Gene denotes Ang II Gene:183
922 19722-19728 Gene denotes Ang II Gene:183
923 19749-19756 Gene denotes Ang 1-7 Gene:284
924 19826-19830 Gene denotes IL-6 Gene:3569
925 19501-19506 Gene denotes renin Gene:5972
926 19080-19088 Species denotes patients Tax:9606
927 19345-19353 Species denotes patients Tax:9606
928 19600-19608 Species denotes Patients Tax:9606
929 19647-19655 Species denotes patients Tax:9606
930 19857-19865 Species denotes patients Tax:9606
931 19586-19596 Chemical denotes GSK2586881
932 19688-19694 Chemical denotes rhACE2
933 19998-20004 Chemical denotes rhACE2
934 19094-19098 Disease denotes ARDS MESH:D012128
935 19103-19109 Disease denotes sepsis MESH:D018805
936 19138-19163 Disease denotes microvascular dysfunction MESH:D017566
937 19167-19173 Disease denotes sepsis MESH:D018805
938 19272-19285 Disease denotes organ failure MESH:D009102
939 19304-19329 Disease denotes microvascular dysfunction MESH:D017566
940 19580-19582 Disease denotes PD MESH:D010300
941 19614-19631 Disease denotes Acute Lung Injury MESH:D055371
942 19661-19665 Disease denotes ARDS MESH:D012128
943 20125-20129 Disease denotes ARDs
950 20302-20306 Gene denotes ACE2 Gene:59272
951 20229-20234 Species denotes human Tax:9606
952 20219-20225 Chemical denotes rhACE2
953 20337-20343 Chemical denotes rhACE2
954 20452-20465 Chemical denotes nitrotyrosine MESH:C002744
955 20235-20266 Disease denotes pulmonary arterial hypertension MESH:D000081029
974 20667-20670 Gene denotes ACE Gene:1636
975 20675-20679 Gene denotes ACE2 Gene:59272
976 20796-20827 Gene denotes Angiotensin Converting Enzyme 2 Gene:59272
977 20829-20833 Gene denotes ACE2 Gene:59272
978 20934-20938 Gene denotes ACE2 Gene:59272
979 20939-20946 Gene denotes Ang 1-7 Gene:284
980 21188-21192 Gene denotes ACE2 Gene:70008
981 21193-21199 Gene denotes Ang1-7 Gene:11727
982 20683-20691 Species denotes patients Tax:9606
983 20845-20853 Species denotes Patients Tax:9606
984 21321-21327 Species denotes murine Tax:10090
985 20697-20705 Disease denotes diabetes MESH:D003920
986 20744-20783 Disease denotes Non-Insulin Dependent Diabetes Mellitus MESH:D003924
987 20785-20790 Disease denotes NIDDM MESH:D003924
988 20836-20844 Disease denotes Diabetic MESH:D003920
989 21055-21074 Disease denotes myocardial ischemia MESH:D003324
990 21083-21097 Disease denotes cardiac damage MESH:D006331
991 21099-21121 Disease denotes Cardiovascular Disease MESH:D002318
995 21509-21513 Gene denotes ACE2 Gene:59272
996 21515-21523 Disease denotes COVID-19 MESH:C000657245
997 21529-21550 Disease denotes Cardiovascular Damage MESH:D002318
1021 21748-21766 Gene denotes C-reactive protein Gene:1401
1022 21661-21669 Species denotes patients Tax:9606
1023 21703-21711 Species denotes patients Tax:9606
1024 21889-21897 Species denotes patients Tax:9606
1025 22183-22191 Species denotes patients Tax:9606
1026 22336-22344 Species denotes patients Tax:9606
1027 22626-22634 Species denotes patients Tax:9606
1028 22686-22703 Species denotes novel coronavirus Tax:2697049
1029 21578-21586 Disease denotes COVID-19 MESH:C000657245
1030 21606-21625 Disease denotes cardiac involvement MESH:D006331
1031 21685-21693 Disease denotes COVID-19 MESH:C000657245
1032 21828-21845 Disease denotes myocardial injury MESH:D009202
1033 21960-21981 Disease denotes acute myopericarditis MESH:D059787
1034 21987-22007 Disease denotes systolic dysfunction MESH:D006331
1035 22053-22074 Disease denotes myocardial infarction MESH:D009203
1036 22112-22151 Disease denotes absence of obstructive coronary disease MESH:D003324
1037 22197-22205 Disease denotes COVID-19 MESH:C000657245
1038 22251-22268 Disease denotes myocardial injury MESH:D009202
1039 22279-22284 Disease denotes shock MESH:D012769
1040 22303-22313 Disease denotes arrhythmia MESH:D001145
1041 22357-22371 Disease denotes cardiac injury MESH:D006331
1042 22406-22411 Disease denotes death MESH:D003643
1043 22643-22664 Disease denotes cardiovascular damage MESH:D002318
1083 22823-22827 Gene denotes ACE2 Gene:59272
1084 22883-22886 Gene denotes ACE Gene:1636
1085 23051-23054 Gene denotes ACE Gene:1636
1086 23067-23081 Gene denotes Angiotensin II Gene:183
1087 23139-23142 Gene denotes ACE Gene:1636
1088 23978-24009 Gene denotes Angiotensin-converting Enzyme 2 Gene:59272
1089 23659-23662 Gene denotes ACE Gene:1636
1090 22948-22956 Species denotes patients Tax:9606
1091 22988-22996 Species denotes Patients Tax:9606
1092 23253-23261 Species denotes patients Tax:9606
1093 23303-23311 Species denotes Patients Tax:9606
1094 23409-23417 Species denotes Patients Tax:9606
1095 23571-23582 Species denotes Coronavirus Tax:11118
1096 23712-23722 Species denotes SARS-CoV-2 Tax:2697049
1097 23803-23811 Species denotes patients Tax:9606
1098 23936-23944 Species denotes patients Tax:9606
1099 23972-23977 Species denotes Human Tax:9606
1100 24038-24046 Species denotes Patients Tax:9606
1101 24170-24178 Species denotes patients Tax:9606
1102 23238-23246 Chemical denotes losartan MESH:D019808
1103 23290-23298 Chemical denotes Losartan MESH:D019808
1104 23396-23404 Chemical denotes Losartan MESH:D019808
1105 23916-23922 Chemical denotes rhACE2
1106 24011-24017 Chemical denotes rhACE2
1107 22720-22728 Disease denotes COVID-19 MESH:C000657245
1108 22962-22970 Disease denotes COVID-19 MESH:C000657245
1109 22972-22984 Disease denotes Hypertension MESH:D006973
1110 23015-23023 Disease denotes COVID-19 MESH:C000657245
1111 23025-23035 Disease denotes HT-COVID19 MESH:C000657245
1112 23123-23131 Disease denotes COVID-19 MESH:C000657245
1113 23280-23288 Disease denotes COVID-19 MESH:C000657245
1114 23317-23325 Disease denotes COVID-19 MESH:C000657245
1115 23423-23431 Disease denotes COVID-19 MESH:C000657245
1116 23584-23592 Disease denotes COVID-19 MESH:C000657245
1117 23817-23839 Disease denotes cardiovascular disease MESH:D002318
1118 23844-23852 Disease denotes COVID-19 MESH:C000657245
1119 23950-23958 Disease denotes COVID-19 MESH:C000657245
1120 24052-24060 Disease denotes COVID-19 MESH:C000657245
1121 24184-24192 Disease denotes COVID-19 MESH:C000657245
1123 24195-24199 Gene denotes ACE2 Gene:59272
1125 25145-25155 Species denotes SARS-CoV-2 Tax:2697049
1141 25257-25261 Gene denotes ACE2 Gene:59272
1142 25380-25384 Gene denotes ACE2 Gene:59272
1143 25386-25415 Gene denotes tumor necrosis factor (TNF)-α Gene:7124
1144 25417-25448 Gene denotes transmembrane protease serine 2 Gene:7113
1145 25613-25617 Gene denotes ACE2 Gene:59272
1146 25655-25660 Gene denotes TNF-α Gene:7124
1147 25665-25675 Gene denotes calmodulin Gene:801
1148 25721-25725 Gene denotes ACE2 Gene:59272
1149 25727-25734 Gene denotes ADAM 17 Gene:6868
1150 25321-25322 Gene denotes S Gene:43740568
1151 25270-25271 Gene denotes S Gene:43740568
1152 25165-25212 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
1153 25214-25224 Species denotes SARS-CoV-2 Tax:2697049
1154 25618-25628 Species denotes SARS-CoV-2 Tax:2697049
1155 25578-25587 Chemical denotes clatherin
1170 24385-24389 Gene denotes ACE2 Gene:59272
1171 24603-24607 Gene denotes ACE2 Gene:59272
1172 24704-24708 Gene denotes ACE2 Gene:59272
1173 24791-24795 Gene denotes ACE2 Gene:59272
1174 25027-25034 Gene denotes TMPRSS2 Gene:7113
1175 24772-24773 Gene denotes S Gene:43740568
1176 24215-24223 Species denotes SARS-CoV Tax:694009
1177 24277-24287 Species denotes SARS-CoV-2 Tax:2697049
1178 24339-24357 Species denotes beta-coronaviruses Tax:694002
1179 24669-24677 Species denotes SARS-CoV Tax:694009
1180 24684-24694 Species denotes SARS-CoV-2 Tax:2697049
1181 25077-25085 Species denotes SARS-CoV Tax:694009
1182 25011-25017 Chemical denotes serine MESH:D012694
1183 24585-24593 Disease denotes COVID-19 MESH:C000657245
1229 25925-25932 Gene denotes TMPRSS2 Gene:7113
1230 26140-26144 Gene denotes ACE2 Gene:59272
1231 26364-26368 Gene denotes ACE2 Gene:59272
1232 26387-26392 Gene denotes TNF-α Gene:7124
1233 26561-26566 Gene denotes TNF-α Gene:7124
1234 26716-26720 Gene denotes IL-2 Gene:3558
1235 26722-26726 Gene denotes IL-7 Gene:3574
1236 26728-26733 Gene denotes IL-10 Gene:3586
1237 26735-26772 Gene denotes granulocyte-colony stimulating factor Gene:1440
1238 26774-26778 Gene denotes GCSF Gene:1440
1239 26818-26822 Gene denotes IP10 Gene:3627
1240 26825-26859 Gene denotes monocyte chemoattractant protein 1 Gene:6347
1241 26861-26900 Gene denotes macrophage inflammatory protein 1 alpha Gene:6348
1242 26902-26907 Gene denotes MIP1A Gene:6348
1243 26914-26919 Gene denotes TNF-α Gene:7124
1244 26950-26954 Gene denotes ACE2 Gene:59272
1245 27092-27096 Gene denotes ACE2 Gene:59272
1246 27198-27202 Gene denotes ACE2 Gene:59272
1247 27273-27277 Gene denotes ACE2 Gene:59272
1248 27343-27347 Gene denotes ACE2 Gene:59272
1249 27542-27546 Gene denotes ACE2 Gene:59272
1250 27660-27664 Gene denotes ACE2 Gene:59272
1251 27802-27806 Gene denotes ACE2 Gene:59272
1252 27993-27997 Gene denotes ACE2 Gene:59272
1253 28027-28033 Gene denotes Ang II Gene:183
1254 28102-28109 Gene denotes Ang 1-7 Gene:284
1255 26428-26438 Gene denotes calmodulin Gene:801
1256 25852-25860 Species denotes SARS-CoV Tax:694009
1257 25865-25875 Species denotes SARS-CoV-2 Tax:2697049
1258 25992-26002 Species denotes SARS-CoV-2 Tax:2697049
1259 26249-26257 Species denotes SARS-CoV Tax:694009
1260 26500-26510 Species denotes SARS-CoV-2 Tax:2697049
1261 26611-26619 Species denotes patients Tax:9606
1262 27298-27306 Species denotes patients Tax:9606
1263 27711-27719 Species denotes patients Tax:9606
1264 28092-28095 Gene denotes Ang Gene:283
1265 28062-28068 Chemical denotes rhACE2
1266 26113-26122 Disease denotes infection MESH:D007239
1267 26625-26633 Disease denotes COVID-19 MESH:C000657245
1268 27015-27023 Disease denotes COVID-19 MESH:C000657245
1269 27122-27133 Disease denotes lung injury MESH:D055370
1270 27321-27334 Disease denotes heart failure MESH:D006333
1271 27575-27586 Disease denotes lung injury MESH:D055370
1272 27602-27623 Disease denotes myocardial infarction MESH:D009203
1273 27725-27738 Disease denotes heart failure MESH:D006333
1281 28215-28219 Gene denotes ACE2 Gene:59272
1282 28275-28279 Gene denotes ACE2 Gene:59272
1283 28915-28919 Gene denotes ACE2 Gene:59272
1284 28192-28202 Species denotes SARS-CoV-2 Tax:2697049
1285 28299-28307 Disease denotes infected MESH:D007239
1286 28430-28439 Disease denotes infection MESH:D007239
1287 28987-28996 Disease denotes infection MESH:D007239
1289 29036-29044 Species denotes Patients Tax:9606
1295 29149-29153 Gene denotes ACE2 Gene:59272
1296 29265-29268 Gene denotes ACE Gene:1636
1297 29406-29410 Gene denotes ACE2 Gene:59272
1298 29079-29089 Species denotes SARS-CoV-2 Tax:2697049
1299 29332-29350 Disease denotes SARS-CoV infection MESH:C000657245
1316 29528-29532 Gene denotes ACE2 Gene:70008
1317 29637-29641 Gene denotes ACE2 Gene:70008
1318 29737-29740 Gene denotes ACE Gene:11421
1319 29481-29486 Species denotes mouse Tax:10090
1320 29727-29731 Species denotes mice Tax:10090
1321 29855-29863 Species denotes SARS-CoV Tax:694009
1322 29951-29959 Species denotes SARS-CoV Tax:694009
1323 30102-30110 Species denotes patients Tax:9606
1324 29436-29454 Chemical denotes Lipopolysaccharide MESH:D008070
1325 29777-29795 Chemical denotes lipopolysaccharide MESH:D008070
1326 29463-29480 Disease denotes acute lung injury MESH:D055371
1327 29695-29706 Disease denotes lung injury MESH:D055370
1328 29804-29820 Disease denotes pneumonic injury MESH:D011014
1329 29895-29907 Disease denotes lung failure MESH:D012131
1330 29975-29987 Disease denotes lung failure MESH:D012131
1331 30116-30124 Disease denotes COVID-19 MESH:C000657245
1354 30374-30378 Gene denotes ACE2 Gene:59272
1355 30396-30402 Gene denotes ADAM17 Gene:6868
1356 30482-30486 Gene denotes ACE2 Gene:59272
1357 30598-30602 Gene denotes ACE2 Gene:59272
1358 30603-30609 Gene denotes Ang1-7 Gene:284
1359 30802-30805 Gene denotes ACE Gene:1636
1360 30888-30892 Gene denotes ACE2 Gene:59272
1361 31396-31400 Gene denotes ACE2 Gene:59272
1362 31634-31638 Gene denotes ACE2 Gene:59272
1363 30333-30343 Species denotes SARS-CoV-2 Tax:2697049
1364 30717-30727 Species denotes SARS-CoV-2 Tax:2697049
1365 30738-30746 Species denotes patients Tax:9606
1366 30779-30789 Species denotes SARS-CoV-2 Tax:2697049
1367 31449-31457 Species denotes patients Tax:9606
1368 31538-31546 Species denotes patients Tax:9606
1369 30665-30677 Disease denotes inflammation MESH:D007249
1370 30752-30774 Disease denotes cardiovascular disease MESH:D002318
1371 31073-31086 Disease denotes heart failure MESH:D006333
1372 31437-31445 Disease denotes COVID-19 MESH:C000657245
1373 31463-31485 Disease denotes cardiovascular disease MESH:D002318
1374 31552-31560 Disease denotes COVID-19 MESH:C000657245
1375 31700-31708 Disease denotes COVID-19 MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32305401-29217510-55252919 2877-2878 29217510 denotes 7
32305401-10773230-55252920 2880-2881 10773230 denotes 8
32305401-8307637-55252921 2883-2884 8307637 denotes 9
32305401-24309898-55252922 3244-3246 24309898 denotes 16
32305401-15283675-55252923 3373-3375 15283675 denotes 17
32305401-1649623-55252924 3492-3494 1649623 denotes 18
32305401-2849100-55252925 3495-3497 2849100 denotes 19
32305401-11931993-55252926 3626-3628 11931993 denotes 20
32305401-11815627-55252927 3747-3749 11815627 denotes 21
32305401-18424768-55252928 3936-3938 18424768 denotes 23
32305401-15983030-55252929 4114-4116 15983030 denotes 24
32305401-18070603-55252930 4271-4273 18070603 denotes 25
32305401-15283675-55252931 4508-4510 15283675 denotes 17
32305401-20102883-55252932 4681-4683 20102883 denotes 26
32305401-15283675-55252933 4899-4901 15283675 denotes 17
32305401-12075344-55252934 5005-5007 12075344 denotes 28
32305401-24332999-55252935 5801-5803 24332999 denotes 30
32305401-1828192-55252936 5955-5957 1828192 denotes 31
32305401-20679547-55252937 6129-6131 20679547 denotes 33
32305401-18417117-55252938 6485-6487 18417117 denotes 35
32305401-20679547-55252939 6787-6789 20679547 denotes 33
32305401-16024575-55252940 7108-7110 16024575 denotes 36
32305401-19715669-55252941 7112-7114 19715669 denotes 37
32305401-17098828-55252942 7116-7118 17098828 denotes 38
32305401-21952934-55252943 7120-7122 21952934 denotes 39
32305401-19246717-55252944 7124-7126 19246717 denotes 40
32305401-19564552-55252945 7128-7130 19564552 denotes 41
32305401-16179584-55252946 10740-10742 16179584 denotes 42
32305401-16179584-55252947 10821-10823 16179584 denotes 42
32305401-16179584-55252948 11159-11161 16179584 denotes 42
32305401-16179584-55252949 11310-11312 16179584 denotes 42
32305401-16179584-55252950 11692-11694 16179584 denotes 42
32305401-15159288-55252951 11886-11888 15159288 denotes 43
32305401-15833808-55252952 12547-12549 15833808 denotes 44
32305401-15833808-55252953 12782-12784 15833808 denotes 44
32305401-15833808-55252954 13143-13145 15833808 denotes 44
32305401-27085217-55252955 13401-13403 27085217 denotes 45
32305401-27085217-55252956 13779-13781 27085217 denotes 45
32305401-15007027-55252957 14025-14027 15007027 denotes 46
32305401-15007027-55252958 14312-14314 15007027 denotes 46
32305401-22715807-55252959 14781-14783 22715807 denotes 47
32305401-22715807-55252960 14851-14853 22715807 denotes 47
32305401-22715807-55252961 15166-15168 22715807 denotes 47
32305401-28656296-55252962 15753-15755 28656296 denotes 49
32305401-28656296-55252963 15858-15860 28656296 denotes 49
32305401-2849100-55252964 16297-16299 2849100 denotes 19
32305401-10892668-55252965 16709-16711 10892668 denotes 50
32305401-8793704-55252966 16713-16715 8793704 denotes 51
32305401-9461243-55252967 16878-16880 9461243 denotes 53
32305401-9461243-55252968 17018-17020 9461243 denotes 53
32305401-9461243-55252969 17290-17292 9461243 denotes 53
32305401-15283675-55252970 17521-17523 15283675 denotes 17
32305401-23681967-55252971 18782-18784 23681967 denotes 54
32305401-23681967-55252972 18956-18958 23681967 denotes 54
32305401-10823385-55252973 19111-19113 10823385 denotes 55
32305401-20175923-55252974 19114-19116 20175923 denotes 56
32305401-20175923-55252975 19395-19397 20175923 denotes 56
32305401-20175923-55252976 19519-19521 20175923 denotes 56
32305401-28877748-55252977 19821-19823 28877748 denotes 57
32305401-28877748-55252978 20145-20147 28877748 denotes 57
32305401-29903860-55252979 20317-20319 29903860 denotes 58
32305401-29903860-55252980 20545-20547 29903860 denotes 58
32305401-31986264-55252981 21847-21848 31986264 denotes 2
32305401-32015507-55252982 24391-24392 32015507 denotes 1
32305401-30426315-55252983 24393-24394 30426315 denotes 3
32305401-16339739-55252984 24395-24396 16339739 denotes 4
32305401-16007097-55252985 24736-24738 16007097 denotes 13
32305401-17522231-55252986 26342-26344 17522231 denotes 62
32305401-18490652-55252987 26480-26482 18490652 denotes 63
32305401-31986264-55252988 26921-26922 31986264 denotes 2
32305401-16001071-55252989 27135-27137 16001071 denotes 64
32305401-18718423-55252990 27504-27506 18718423 denotes 65
32305401-18718423-55252991 27588-27590 18718423 denotes 65
32305401-15007027-55252992 27625-27627 15007027 denotes 46
32305401-24332999-55252993 27740-27742 24332999 denotes 30
32305401-28877748-55252994 28111-28113 28877748 denotes 57
32305401-29903860-55252995 28114-28116 29903860 denotes 58
32305401-25720466-55252996 28521-28523 25720466 denotes 66
32305401-25720466-55252997 28660-28662 25720466 denotes 66
32305401-25720466-55252998 28838-28840 25720466 denotes 66
32305401-16179584-55252999 29371-29373 16179584 denotes 42
32305401-15159288-55253000 29375-29377 15159288 denotes 43
32305401-15833808-55253001 29379-29381 15833808 denotes 44
32305401-27085217-55253002 29383-29385 27085217 denotes 45
32305401-15007027-55253003 29387-29389 15007027 denotes 46
32305401-9461243-55253004 29390-29392 9461243 denotes 53
32305401-31805278-55253005 29822-29824 31805278 denotes 67
32305401-31805278-55253006 30040-30042 31805278 denotes 67