PMC:7161517 / 10288-10773 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T55","span":{"begin":10,"end":26},"obj":"Body_part"},{"id":"T56","span":{"begin":34,"end":49},"obj":"Body_part"},{"id":"T57","span":{"begin":268,"end":287},"obj":"Body_part"},{"id":"T58","span":{"begin":307,"end":327},"obj":"Body_part"},{"id":"T59","span":{"begin":382,"end":389},"obj":"Body_part"}],"attributes":[{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma69225"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma15633"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma74636"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma74646"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T37","span":{"begin":34,"end":49},"obj":"Body_part"}],"attributes":[{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0001236"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T54","span":{"begin":278,"end":287},"obj":"Disease"}],"attributes":[{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0021156"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T107","span":{"begin":268,"end":277},"obj":"http://purl.obolibrary.org/obo/UBERON_0001353"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T123","span":{"begin":65,"end":76},"obj":"Chemical"},{"id":"T125","span":{"begin":102,"end":119},"obj":"Chemical"},{"id":"T126","span":{"begin":141,"end":146},"obj":"Chemical"},{"id":"T127","span":{"begin":176,"end":180},"obj":"Chemical"},{"id":"T129","span":{"begin":211,"end":228},"obj":"Chemical"},{"id":"T130","span":{"begin":238,"end":249},"obj":"Chemical"},{"id":"T131","span":{"begin":293,"end":295},"obj":"Chemical"},{"id":"T132","span":{"begin":320,"end":327},"obj":"Chemical"},{"id":"T133","span":{"begin":349,"end":354},"obj":"Chemical"}],"attributes":[{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A124","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_25354"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_24866"},{"id":"A128","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_26710"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_25354"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_15377"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T38","span":{"begin":65,"end":86},"obj":"http://purl.obolibrary.org/obo/GO_0035932"},{"id":"T39","span":{"begin":77,"end":86},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T40","span":{"begin":181,"end":190},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T41","span":{"begin":320,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0046879"},{"id":"T42","span":{"begin":328,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T43","span":{"begin":355,"end":364},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T44","span":{"begin":475,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T45","span":{"begin":475,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0006915"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T72","span":{"begin":0,"end":485},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T12","span":{"begin":349,"end":364},"obj":"Phenotype"},{"id":"T13","span":{"begin":453,"end":469},"obj":"Phenotype"}],"attributes":[{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0000969"},{"id":"A13","pred":"hp_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/HP_0025464"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T360","span":{"begin":10,"end":26},"obj":"UBERON:0002053"},{"id":"T361","span":{"begin":34,"end":49},"obj":"UBERON:0001236"},{"id":"T362","span":{"begin":65,"end":76},"obj":"CHEBI:27584;CHEBI:27584"},{"id":"T363","span":{"begin":102,"end":119},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T364","span":{"begin":141,"end":146},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T365","span":{"begin":176,"end":180},"obj":"CHEBI:24866;CHEBI:24866"},{"id":"T366","span":{"begin":211,"end":228},"obj":"CHEBI:25354;CHEBI:25354"},{"id":"T367","span":{"begin":229,"end":249},"obj":"CHEBI:48561;CHEBI:48561"},{"id":"T368","span":{"begin":278,"end":287},"obj":"UBERON:0002198"},{"id":"T369","span":{"begin":289,"end":295},"obj":"PR:000036009"},{"id":"T370","span":{"begin":349,"end":354},"obj":"CHEBI:15377;CHEBI:15377"},{"id":"T371","span":{"begin":382,"end":389},"obj":"UBERON:0000479"},{"id":"T372","span":{"begin":453,"end":462},"obj":"MOP:0000568"},{"id":"T373","span":{"begin":475,"end":484},"obj":"GO:0006915"},{"id":"T439","span":{"begin":31,"end":35},"obj":"G_3;PG_10;PR:000003622"},{"id":"T440","span":{"begin":36,"end":40},"obj":"PR:000036013"},{"id":"T441","span":{"begin":108,"end":113},"obj":"PR:000013883"},{"id":"T442","span":{"begin":140,"end":144},"obj":"PR:000001251"},{"id":"T443","span":{"begin":149,"end":153},"obj":"PR:000003622;G_3;PG_10"},{"id":"T444","span":{"begin":167,"end":173},"obj":"PR:000036009"},{"id":"T445","span":{"begin":185,"end":189},"obj":"PR:000001251"},{"id":"T446","span":{"begin":213,"end":217},"obj":"PR:000003622;G_3;PG_10"},{"id":"T447","span":{"begin":275,"end":280},"obj":"G_3;PG_10;PR:000003622"},{"id":"T448","span":{"begin":320,"end":326},"obj":"PR:000036009"},{"id":"T449","span":{"begin":341,"end":346},"obj":"PR:000036013"},{"id":"T450","span":{"begin":350,"end":354},"obj":"G_3;PG_10;PR:000003622"},{"id":"T451","span":{"begin":414,"end":426},"obj":"SP_10"},{"id":"T452","span":{"begin":427,"end":437},"obj":"SP_10;UBERON:0001004"},{"id":"T453","span":{"begin":438,"end":459},"obj":"SP_10"},{"id":"T454","span":{"begin":461,"end":469},"obj":"SP_10"},{"id":"T455","span":{"begin":477,"end":485},"obj":"SP_10"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}

{"project":"LitCovid-PubTator","denotations":[{"id":"478","span":{"begin":211,"end":237},"obj":"Gene"},{"id":"479","span":{"begin":289,"end":295},"obj":"Gene"},{"id":"503","span":{"begin":141,"end":146},"obj":"Chemical"},{"id":"504","span":{"begin":349,"end":354},"obj":"Chemical"},{"id":"505","span":{"begin":430,"end":441},"obj":"Disease"},{"id":"506","span":{"begin":443,"end":451},"obj":"Disease"}],"attributes":[{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"Gene:4306"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"Gene:183"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"MESH:D014867"},{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"MESH:D014867"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"MESH:D006984"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"MESH:D005355"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis."}