PMC:7161517 / 10066-11799
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T55 | 232-248 | Body_part | denotes | zona glomerulosa | http://purl.org/sig/ont/fma/fma69225 |
| T56 | 256-271 | Body_part | denotes | adrenal medulla | http://purl.org/sig/ont/fma/fma15633 |
| T57 | 490-509 | Body_part | denotes | posterior pituitary | http://purl.org/sig/ont/fma/fma74636 |
| T58 | 529-549 | Body_part | denotes | antidiuretic hormone | http://purl.org/sig/ont/fma/fma74646 |
| T59 | 604-611 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T60 | 974-978 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T61 | 1428-1435 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T62 | 1486-1493 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T37 | 256-271 | Body_part | denotes | adrenal medulla | http://purl.obolibrary.org/obo/UBERON_0001236 |
| T38 | 1035-1059 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T39 | 1061-1064 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T54 | 500-509 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
| T55 | 1173-1176 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
| T56 | 1339-1372 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T57 | 1386-1394 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T58 | 1402-1410 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T59 | 1510-1519 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T107 | 490-499 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
| T108 | 987-988 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T109 | 1281-1284 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T117 | 10-21 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T118 | 52-54 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T119 | 59-70 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T120 | 124-138 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T121 | 128-138 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T122 | 176-178 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T123 | 287-298 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T125 | 324-341 | Chemical | denotes | mineralocorticoid | http://purl.obolibrary.org/obo/CHEBI_25354 |
| T126 | 363-368 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T127 | 398-402 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
| T129 | 433-450 | Chemical | denotes | mineralocorticoid | http://purl.obolibrary.org/obo/CHEBI_25354 |
| T130 | 460-471 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T131 | 515-517 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T132 | 542-549 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T133 | 571-576 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T134 | 740-751 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T135 | 794-796 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T136 | 818-820 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T137 | 846-857 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T138 | 1041-1052 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T139 | 1061-1064 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T140 | 1098-1100 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T141 | 1250-1252 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T142 | 1428-1435 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T143 | 1560-1562 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T38 | 287-308 | http://purl.obolibrary.org/obo/GO_0035932 | denotes | aldosterone secretion |
| T39 | 299-308 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T40 | 403-412 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | retention |
| T41 | 542-559 | http://purl.obolibrary.org/obo/GO_0046879 | denotes | hormone secretion |
| T42 | 550-559 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T43 | 577-586 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | retention |
| T44 | 697-706 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T45 | 697-706 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T46 | 1160-1171 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T47 | 1466-1485 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into the host |
| T48 | 1524-1541 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T49 | 1524-1541 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T70 | 0-139 | Sentence | denotes | Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors. |
| T71 | 140-221 | Sentence | denotes | The pro-inflammatory effects of Ang II are mediated through AT1R in several ways: |
| T72 | 222-707 | Sentence | denotes | 1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis. |
| T73 | 708-813 | Sentence | denotes | These effects are attenuated by angiotensin receptor blockers (ARBs), which block Ang II binding to AT1R. |
| T74 | 814-953 | Sentence | denotes | Ang II can also be converted to angiotensin 1-7 (Ang 1-7) via ACE2, which stimulates the Mas receptor promoting anti-inflammatory benefits. |
| T75 | 954-1066 | Sentence | denotes | The ACE2/Ang1-7/Mas axis acts as a counter regulatory pathway to the traditional renin-angiotensin system (RAS). |
| T76 | 1067-1093 | Sentence | denotes | AT1R and ACE2 are coupled. |
| T77 | 1094-1172 | Sentence | denotes | Ang II binding to AT1R allows dissociation of ACE2 and subsequent degradation. |
| T78 | 1173-1275 | Sentence | denotes | ARB prevents dissociation of ACE2 and renders it availability for unused Ang II conversion to Ang 1-7. |
| T79 | 1276-1411 | Sentence | denotes | ACE2 has been identified as the targeted receptor for both the severe acute respiratory syndrome coronavirus (SARS-CoV) 2 and SARS-CoV. |
| T80 | 1412-1542 | Sentence | denotes | ACE2 mediates S protein binding that stimulates viral entry into the host cytosol that results in infection and viral replication. |
| T81 | 1543-1733 | Sentence | denotes | Diversion of Ang II towards ACE2 could competitively inhibit viral binding and also counter regulate the adverse effects caused by AT1R and improve outcomes by Mas R−based favorable effects. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 571-586 | Phenotype | denotes | water retention | http://purl.obolibrary.org/obo/HP_0000969 |
| T13 | 675-691 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T354 | 10-23 | PR:000036008 | denotes | angiotensin I |
| T355 | 25-30 | PR:000036008 | denotes | Ang I |
| T356 | 48-54 | PR:000036009 | denotes | Ang II |
| T357 | 128-138 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T358 | 172-178 | PR:000036009 | denotes | Ang II |
| T359 | 200-204 | PR:000001251 | denotes | AT1R |
| T360 | 232-248 | UBERON:0002053 | denotes | zona glomerulosa |
| T361 | 256-271 | UBERON:0001236 | denotes | adrenal medulla |
| T362 | 287-298 | CHEBI:27584;CHEBI:27584 | denotes | aldosterone |
| T363 | 324-341 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
| T364 | 363-368 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T365 | 398-402 | CHEBI:24866;CHEBI:24866 | denotes | salt |
| T366 | 433-450 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
| T367 | 451-471 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
| T368 | 500-509 | UBERON:0002198 | denotes | pituitary |
| T369 | 511-517 | PR:000036009 | denotes | Ang II |
| T370 | 571-576 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T371 | 604-611 | UBERON:0000479 | denotes | tissues |
| T372 | 675-684 | MOP:0000568 | denotes | oxidative |
| T373 | 697-706 | GO:0006915 | denotes | apoptosis |
| T374 | 790-793 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | Ang |
| T375 | 794-796 | PR:000036009 | denotes | II |
| T376 | 808-812 | PR:000001251 | denotes | AT1R |
| T377 | 814-820 | PR:000036009 | denotes | Ang II |
| T378 | 846-859 | PR:000036013 | denotes | angiotensin 1 |
| T379 | 863-868 | PR:000036013 | denotes | Ang 1 |
| T380 | 876-880 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T381 | 903-906 | PR:000001563 | denotes | Mas |
| T382 | 958-962 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T383 | 963-967 | PR:000036013 | denotes | Ang1 |
| T384 | 1035-1040 | PR:000013883 | denotes | renin |
| T385 | 1067-1071 | PR:000001251 | denotes | AT1R |
| T386 | 1076-1080 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T387 | 1094-1100 | PR:000036009 | denotes | Ang II |
| T388 | 1112-1116 | PR:000001251 | denotes | AT1R |
| T389 | 1140-1144 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T390 | 1202-1206 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T391 | 1246-1252 | PR:000036009 | denotes | Ang II |
| T392 | 1267-1272 | PR:000036013 | denotes | Ang 1 |
| T393 | 1276-1280 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T394 | 1339-1351 | SP_10 | denotes | severe acute |
| T395 | 1352-1363 | SP_10;UBERON:0001004 | denotes | respiratory |
| T396 | 1364-1384 | SP_10 | denotes | syndrome coronavirus |
| T397 | 1386-1394 | SP_10 | denotes | SARS-CoV |
| T398 | 1402-1410 | SP_10 | denotes | SARS-CoV |
| T399 | 1412-1416 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T400 | 1426-1435 | PG_1 | denotes | S protein |
| T401 | 1460-1465 | NCBITaxon:10239;GO:0035376 | denotes | viral |
| T402 | 1466-1471 | GO:0035376 | denotes | entry |
| T403 | 1481-1493 | GO:0044164 | denotes | host cytosol |
| T404 | 1524-1529 | NCBITaxon:10239;GO:0006260 | denotes | viral |
| T405 | 1530-1541 | GO:0006260 | denotes | replication |
| T406 | 1556-1562 | PR:000036009 | denotes | Ang II |
| T407 | 1571-1575 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T408 | 1604-1609 | NCBITaxon:10239 | denotes | viral |
| T409 | 1674-1678 | PR:000001251 | denotes | AT1R |
| T410 | 1703-1708 | PR:000001607 | denotes | Mas R |
| T48220 | 1338-1349 | CL:0000581 | denotes | severe acu |
| T431 | 86-89 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | me |
| T432 | 90-92 | PR:000036009 | denotes | AC |
| T433 | 104-108 | PR:000001251 | denotes | uld |
| T434 | 110-116 | PR:000036009 | denotes | inhib |
| T435 | 142-155 | PR:000036013 | denotes | e pro-inflamm |
| T436 | 159-164 | PR:000036013 | denotes | y eff |
| T437 | 172-176 | PR:000003622;G_3;PG_10 | denotes | Ang |
| T438 | 198-201 | PR:000001563 | denotes | h A |
| T439 | 253-257 | G_3;PG_10;PR:000003622 | denotes | he a |
| T440 | 258-262 | PR:000036013 | denotes | rena |
| T441 | 330-335 | PR:000013883 | denotes | locor |
| T442 | 362-366 | PR:000001251 | denotes | wat |
| T443 | 371-375 | PR:000003622;G_3;PG_10 | denotes | abso |
| T444 | 389-395 | PR:000036009 | denotes | increa |
| T445 | 407-411 | PR:000001251 | denotes | ntio |
| T446 | 435-439 | PR:000003622;G_3;PG_10 | denotes | nera |
| T447 | 497-502 | G_3;PG_10;PR:000003622 | denotes | or pi |
| T448 | 542-548 | PR:000036009 | denotes | hormon |
| T449 | 563-568 | PR:000036013 | denotes | promo |
| T450 | 572-576 | G_3;PG_10;PR:000003622 | denotes | ater |
| T451 | 636-648 | SP_10 | denotes | responsible |
| T452 | 649-659 | SP_10;UBERON:0001004 | denotes | or hypertr |
| T453 | 660-681 | SP_10 | denotes | phy, fibrosis, oxidat |
| T454 | 683-691 | SP_10 | denotes | e stress |
| T455 | 699-707 | SP_10 | denotes | optosis. |
| T456 | 709-713 | G_3;PG_10;PR:000003622 | denotes | hese |
| T457 | 723-733 | PG_1 | denotes | re attenua |
| T458 | 757-762 | NCBITaxon:10239;GO:0035376 | denotes | tor b |
| T459 | 763-768 | GO:0035376 | denotes | ocker |
| T460 | 778-790 | GO:0044164 | denotes | which block |
| T461 | 821-826 | NCBITaxon:10239;GO:0006260 | denotes | can a |
| T462 | 827-838 | GO:0006260 | denotes | so be conve |
| T463 | 853-859 | PR:000036009 | denotes | nsin 1 |
| T464 | 868-872 | PR:000003622;G_3;PG_10 | denotes | -7) |
| T465 | 902-907 | NCBITaxon:10239 | denotes | Mas |
| T466 | 972-977 | PR:000001251 | denotes | s axi |
| T467 | 1002-1007 | PR:000001607 | denotes | atory |
| T89708 | 1083-1087 | CHEBI:23888;CHEBI:23888 | denotes | e co |
| T16250 | 1103-1113 | GO:0065007 | denotes | nding to A |
| T24993 | 1121-1125 | G_3;PG_10;PR:000003622 | denotes | ws d |
| T40191 | 1126-1130 | PR:000036013 | denotes | ssoc |
| T14894 | 1142-1147 | NCBITaxon:10088 | denotes | E2 an |
| T95497 | 1148-1158 | UBERON:0001179;CL:0000581 | denotes | subsequen |
| T5844 | 1159-1170 | CL:0000581 | denotes | degradatio |
| T3127 | 1193-1204 | CHEBI:27584;CHEBI:27584 | denotes | ation of AC |
| T32730 | 1303-1307 | G_3;PG_10;PR:000003622 | denotes | the |
| T99955 | 1321-1326 | NCBITaxon:10088 | denotes | ptor |
| T27470 | 1327-1337 | UBERON:0001179;CL:0000581 | denotes | or both th |
| T26688 | 1364-1376 | CHEBI:17154;CHEBI:17154 | denotes | syndrome cor |
| T64863 | 1397-1406 | CHEBI:18367;CHEBI:18367 | denotes | and SARS |
| T51748 | 1414-1423 | CHEBI:35222;CHEBI:35222 | denotes | E2 mediat |
| T79147 | 1425-1436 | CHEBI:27584;CHEBI:27584 | denotes | S protein |
| T23025 | 1473-1477 | G_3;PG_10;PR:000003622 | denotes | nto |
| T84481 | 1534-1546 | CHEBI:17154;CHEBI:17154 | denotes | ication. Div |
| T4704 | 1652-1662 | CHEBI:31547;CHEBI:31547 | denotes | rse effect |
| T67581 | 1670-1675 | SP_6;NCBITaxon:9606 | denotes | by A |
| T67016 | 1676-1684 | CL:0000576 | denotes | 1R and i |
| T80087 | 1693-1704 | CL:0000235 | denotes | tcomes by M |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 470 | 10-23 | Gene | denotes | angiotensin I | Gene:183 |
| 471 | 25-30 | Gene | denotes | Ang I | Gene:183 |
| 472 | 48-54 | Gene | denotes | Ang II | Gene:183 |
| 473 | 59-88 | Gene | denotes | angiotensin-converting enzyme | Gene:1636 |
| 474 | 90-93 | Gene | denotes | ACE | Gene:1636 |
| 475 | 124-127 | Gene | denotes | ACE | Gene:1636 |
| 476 | 172-178 | Gene | denotes | Ang II | Gene:183 |
| 477 | 200-204 | Gene | denotes | AT1R | Gene:185 |
| 478 | 433-459 | Gene | denotes | mineralocorticoid receptor | Gene:4306 |
| 479 | 511-517 | Gene | denotes | Ang II | Gene:183 |
| 480 | 790-796 | Gene | denotes | Ang II | Gene:183 |
| 481 | 808-812 | Gene | denotes | AT1R | Gene:185 |
| 482 | 814-820 | Gene | denotes | Ang II | Gene:183 |
| 483 | 863-870 | Gene | denotes | Ang 1-7 | Gene:284 |
| 484 | 876-880 | Gene | denotes | ACE2 | Gene:59272 |
| 485 | 958-962 | Gene | denotes | ACE2 | Gene:59272 |
| 486 | 963-969 | Gene | denotes | Ang1-7 | Gene:284 |
| 487 | 1067-1071 | Gene | denotes | AT1R | Gene:185 |
| 488 | 1076-1080 | Gene | denotes | ACE2 | Gene:59272 |
| 489 | 1094-1100 | Gene | denotes | Ang II | Gene:183 |
| 490 | 1112-1116 | Gene | denotes | AT1R | Gene:185 |
| 491 | 1140-1144 | Gene | denotes | ACE2 | Gene:59272 |
| 492 | 1202-1206 | Gene | denotes | ACE2 | Gene:59272 |
| 493 | 1267-1274 | Gene | denotes | Ang 1-7 | Gene:284 |
| 494 | 1276-1280 | Gene | denotes | ACE2 | Gene:59272 |
| 495 | 1412-1416 | Gene | denotes | ACE2 | Gene:59272 |
| 496 | 1571-1575 | Gene | denotes | ACE2 | Gene:59272 |
| 497 | 1674-1678 | Gene | denotes | AT1R | Gene:185 |
| 498 | 1246-1252 | Gene | denotes | Ang II | Gene:183 |
| 499 | 1556-1559 | Gene | denotes | Ang | Gene:283 |
| 500 | 1339-1384 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
| 501 | 1386-1397 | Species | denotes | SARS-CoV) 2 | Tax:2697049 |
| 502 | 1402-1410 | Species | denotes | SARS-CoV | Tax:694009 |
| 503 | 363-368 | Chemical | denotes | water | MESH:D014867 |
| 504 | 571-576 | Chemical | denotes | water | MESH:D014867 |
| 505 | 652-663 | Disease | denotes | hypertrophy | MESH:D006984 |
| 506 | 665-673 | Disease | denotes | fibrosis | MESH:D005355 |
| 507 | 1510-1519 | Disease | denotes | infection | MESH:D007239 |