PMC:7161517 / 10011-11799
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T55 | 287-303 | Body_part | denotes | zona glomerulosa | http://purl.org/sig/ont/fma/fma69225 |
| T56 | 311-326 | Body_part | denotes | adrenal medulla | http://purl.org/sig/ont/fma/fma15633 |
| T57 | 545-564 | Body_part | denotes | posterior pituitary | http://purl.org/sig/ont/fma/fma74636 |
| T58 | 584-604 | Body_part | denotes | antidiuretic hormone | http://purl.org/sig/ont/fma/fma74646 |
| T59 | 659-666 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T60 | 1029-1033 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T61 | 1483-1490 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T62 | 1541-1548 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T36 | 4-28 | Body_part | denotes | Renin-Angiotensin System | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T37 | 311-326 | Body_part | denotes | adrenal medulla | http://purl.obolibrary.org/obo/UBERON_0001236 |
| T38 | 1090-1114 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
| T39 | 1116-1119 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T53 | 46-54 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T54 | 555-564 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
| T55 | 1228-1231 | Disease | denotes | ARB | http://purl.obolibrary.org/obo/MONDO_0012733 |
| T56 | 1394-1427 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T57 | 1441-1449 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T58 | 1457-1465 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T59 | 1565-1574 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T107 | 545-554 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
| T108 | 1042-1043 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T109 | 1336-1339 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T116 | 10-21 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T117 | 65-76 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T118 | 107-109 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T119 | 114-125 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T120 | 179-193 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T121 | 183-193 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T122 | 231-233 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T123 | 342-353 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T125 | 379-396 | Chemical | denotes | mineralocorticoid | http://purl.obolibrary.org/obo/CHEBI_25354 |
| T126 | 418-423 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T127 | 453-457 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
| T129 | 488-505 | Chemical | denotes | mineralocorticoid | http://purl.obolibrary.org/obo/CHEBI_25354 |
| T130 | 515-526 | Chemical | denotes | antagonists | http://purl.obolibrary.org/obo/CHEBI_48706 |
| T131 | 570-572 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T132 | 597-604 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T133 | 626-631 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T134 | 795-806 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T135 | 849-851 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T136 | 873-875 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T137 | 901-912 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T138 | 1096-1107 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T139 | 1116-1119 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T140 | 1153-1155 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T141 | 1305-1307 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T142 | 1483-1490 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T143 | 1615-1617 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T38 | 342-363 | http://purl.obolibrary.org/obo/GO_0035932 | denotes | aldosterone secretion |
| T39 | 354-363 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T40 | 458-467 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | retention |
| T41 | 597-614 | http://purl.obolibrary.org/obo/GO_0046879 | denotes | hormone secretion |
| T42 | 605-614 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T43 | 632-641 | http://purl.obolibrary.org/obo/GO_0051235 | denotes | retention |
| T44 | 752-761 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T45 | 752-761 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T46 | 1215-1226 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T47 | 1521-1540 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into the host |
| T48 | 1579-1596 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
| T49 | 1579-1596 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T70 | 55-194 | Sentence | denotes | Normally, angiotensin I (Ang I) is converted to Ang II via angiotensin-converting enzyme (ACE), which could be inhibited by ACE inhibitors. |
| T71 | 195-276 | Sentence | denotes | The pro-inflammatory effects of Ang II are mediated through AT1R in several ways: |
| T72 | 277-762 | Sentence | denotes | 1) in the zona glomerulosa of the adrenal medulla, it stimulates aldosterone secretion and binding to mineralocorticoid receptors to promote water reabsorption and to increase salt retention; it is inhibited by mineralocorticoid receptor antagonists (MRAs); 2) in the posterior pituitary, Ang II stimulates antidiuretic hormone secretion to promote water retention; and 3) in other tissues, it stimulates pathways responsible for hypertrophy, fibrosis, oxidative stress, and apoptosis. |
| T73 | 763-868 | Sentence | denotes | These effects are attenuated by angiotensin receptor blockers (ARBs), which block Ang II binding to AT1R. |
| T74 | 869-1008 | Sentence | denotes | Ang II can also be converted to angiotensin 1-7 (Ang 1-7) via ACE2, which stimulates the Mas receptor promoting anti-inflammatory benefits. |
| T75 | 1009-1121 | Sentence | denotes | The ACE2/Ang1-7/Mas axis acts as a counter regulatory pathway to the traditional renin-angiotensin system (RAS). |
| T76 | 1122-1148 | Sentence | denotes | AT1R and ACE2 are coupled. |
| T77 | 1149-1227 | Sentence | denotes | Ang II binding to AT1R allows dissociation of ACE2 and subsequent degradation. |
| T78 | 1228-1330 | Sentence | denotes | ARB prevents dissociation of ACE2 and renders it availability for unused Ang II conversion to Ang 1-7. |
| T79 | 1331-1466 | Sentence | denotes | ACE2 has been identified as the targeted receptor for both the severe acute respiratory syndrome coronavirus (SARS-CoV) 2 and SARS-CoV. |
| T80 | 1467-1597 | Sentence | denotes | ACE2 mediates S protein binding that stimulates viral entry into the host cytosol that results in infection and viral replication. |
| T81 | 1598-1788 | Sentence | denotes | Diversion of Ang II towards ACE2 could competitively inhibit viral binding and also counter regulate the adverse effects caused by AT1R and improve outcomes by Mas R−based favorable effects. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T12 | 626-641 | Phenotype | denotes | water retention | http://purl.obolibrary.org/obo/HP_0000969 |
| T13 | 730-746 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T352 | 4-9 | PR:000013883 | denotes | Renin |
| T353 | 46-63 | SP_7 | denotes | COVID-19 Normally |
| T354 | 65-78 | PR:000036008 | denotes | angiotensin I |
| T355 | 80-85 | PR:000036008 | denotes | Ang I |
| T356 | 103-109 | PR:000036009 | denotes | Ang II |
| T357 | 183-193 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T358 | 227-233 | PR:000036009 | denotes | Ang II |
| T359 | 255-259 | PR:000001251 | denotes | AT1R |
| T360 | 287-303 | UBERON:0002053 | denotes | zona glomerulosa |
| T361 | 311-326 | UBERON:0001236 | denotes | adrenal medulla |
| T362 | 342-353 | CHEBI:27584;CHEBI:27584 | denotes | aldosterone |
| T363 | 379-396 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
| T364 | 418-423 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T365 | 453-457 | CHEBI:24866;CHEBI:24866 | denotes | salt |
| T366 | 488-505 | CHEBI:25354;CHEBI:25354 | denotes | mineralocorticoid |
| T367 | 506-526 | CHEBI:48561;CHEBI:48561 | denotes | receptor antagonists |
| T368 | 555-564 | UBERON:0002198 | denotes | pituitary |
| T369 | 566-572 | PR:000036009 | denotes | Ang II |
| T370 | 626-631 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T371 | 659-666 | UBERON:0000479 | denotes | tissues |
| T372 | 730-739 | MOP:0000568 | denotes | oxidative |
| T373 | 752-761 | GO:0006915 | denotes | apoptosis |
| T374 | 845-848 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | Ang |
| T375 | 849-851 | PR:000036009 | denotes | II |
| T376 | 863-867 | PR:000001251 | denotes | AT1R |
| T377 | 869-875 | PR:000036009 | denotes | Ang II |
| T378 | 901-914 | PR:000036013 | denotes | angiotensin 1 |
| T379 | 918-923 | PR:000036013 | denotes | Ang 1 |
| T380 | 931-935 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T381 | 958-961 | PR:000001563 | denotes | Mas |
| T382 | 1013-1017 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T383 | 1018-1022 | PR:000036013 | denotes | Ang1 |
| T384 | 1090-1095 | PR:000013883 | denotes | renin |
| T385 | 1122-1126 | PR:000001251 | denotes | AT1R |
| T386 | 1131-1135 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T387 | 1149-1155 | PR:000036009 | denotes | Ang II |
| T388 | 1167-1171 | PR:000001251 | denotes | AT1R |
| T389 | 1195-1199 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T390 | 1257-1261 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T391 | 1301-1307 | PR:000036009 | denotes | Ang II |
| T392 | 1322-1327 | PR:000036013 | denotes | Ang 1 |
| T393 | 1331-1335 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T394 | 1394-1406 | SP_10 | denotes | severe acute |
| T395 | 1407-1418 | SP_10;UBERON:0001004 | denotes | respiratory |
| T396 | 1419-1439 | SP_10 | denotes | syndrome coronavirus |
| T397 | 1441-1449 | SP_10 | denotes | SARS-CoV |
| T398 | 1457-1465 | SP_10 | denotes | SARS-CoV |
| T399 | 1467-1471 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T400 | 1481-1490 | PG_1 | denotes | S protein |
| T401 | 1515-1520 | NCBITaxon:10239;GO:0035376 | denotes | viral |
| T402 | 1521-1526 | GO:0035376 | denotes | entry |
| T403 | 1536-1548 | GO:0044164 | denotes | host cytosol |
| T404 | 1579-1584 | NCBITaxon:10239;GO:0006260 | denotes | viral |
| T405 | 1585-1596 | GO:0006260 | denotes | replication |
| T406 | 1611-1617 | PR:000036009 | denotes | Ang II |
| T407 | 1626-1630 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T408 | 1659-1664 | NCBITaxon:10239 | denotes | viral |
| T409 | 1729-1733 | PR:000001251 | denotes | AT1R |
| T410 | 1758-1763 | PR:000001607 | denotes | Mas R |
| T48220 | 1393-1404 | CL:0000581 | denotes | severe acu |
| T429 | 28-36 | MOP:0000568 | denotes | Interac |
| T430 | 49-58 | GO:0006915 | denotes | ID-19 Nor |
| T431 | 141-144 | CHEBI:37886;CHEBI:37886;PR:000036009 | denotes | me |
| T432 | 145-147 | PR:000036009 | denotes | AC |
| T433 | 159-163 | PR:000001251 | denotes | uld |
| T434 | 165-171 | PR:000036009 | denotes | inhib |
| T435 | 197-210 | PR:000036013 | denotes | e pro-inflamm |
| T436 | 214-219 | PR:000036013 | denotes | y eff |
| T437 | 227-231 | PR:000003622;G_3;PG_10 | denotes | Ang |
| T438 | 253-256 | PR:000001563 | denotes | h A |
| T439 | 308-312 | G_3;PG_10;PR:000003622 | denotes | he a |
| T440 | 313-317 | PR:000036013 | denotes | rena |
| T441 | 385-390 | PR:000013883 | denotes | locor |
| T442 | 417-421 | PR:000001251 | denotes | wat |
| T443 | 426-430 | PR:000003622;G_3;PG_10 | denotes | abso |
| T444 | 444-450 | PR:000036009 | denotes | increa |
| T445 | 462-466 | PR:000001251 | denotes | ntio |
| T446 | 490-494 | PR:000003622;G_3;PG_10 | denotes | nera |
| T447 | 552-557 | G_3;PG_10;PR:000003622 | denotes | or pi |
| T448 | 597-603 | PR:000036009 | denotes | hormon |
| T449 | 618-623 | PR:000036013 | denotes | promo |
| T450 | 627-631 | G_3;PG_10;PR:000003622 | denotes | ater |
| T451 | 691-703 | SP_10 | denotes | responsible |
| T452 | 704-714 | SP_10;UBERON:0001004 | denotes | or hypertr |
| T453 | 715-736 | SP_10 | denotes | phy, fibrosis, oxidat |
| T454 | 738-746 | SP_10 | denotes | e stress |
| T455 | 754-762 | SP_10 | denotes | optosis. |
| T456 | 764-768 | G_3;PG_10;PR:000003622 | denotes | hese |
| T457 | 778-788 | PG_1 | denotes | re attenua |
| T458 | 812-817 | NCBITaxon:10239;GO:0035376 | denotes | tor b |
| T459 | 818-823 | GO:0035376 | denotes | ocker |
| T460 | 833-845 | GO:0044164 | denotes | which block |
| T461 | 876-881 | NCBITaxon:10239;GO:0006260 | denotes | can a |
| T462 | 882-893 | GO:0006260 | denotes | so be conve |
| T463 | 908-914 | PR:000036009 | denotes | nsin 1 |
| T464 | 923-927 | PR:000003622;G_3;PG_10 | denotes | -7) |
| T465 | 957-962 | NCBITaxon:10239 | denotes | Mas |
| T466 | 1027-1032 | PR:000001251 | denotes | s axi |
| T467 | 1057-1062 | PR:000001607 | denotes | atory |
| T89708 | 1138-1142 | CHEBI:23888;CHEBI:23888 | denotes | e co |
| T16250 | 1158-1168 | GO:0065007 | denotes | nding to A |
| T24993 | 1176-1180 | G_3;PG_10;PR:000003622 | denotes | ws d |
| T40191 | 1181-1185 | PR:000036013 | denotes | ssoc |
| T14894 | 1197-1202 | NCBITaxon:10088 | denotes | E2 an |
| T95497 | 1203-1213 | UBERON:0001179;CL:0000581 | denotes | subsequen |
| T5844 | 1214-1225 | CL:0000581 | denotes | degradatio |
| T3127 | 1248-1259 | CHEBI:27584;CHEBI:27584 | denotes | ation of AC |
| T32730 | 1358-1362 | G_3;PG_10;PR:000003622 | denotes | the |
| T99955 | 1376-1381 | NCBITaxon:10088 | denotes | ptor |
| T27470 | 1382-1392 | UBERON:0001179;CL:0000581 | denotes | or both th |
| T26688 | 1419-1431 | CHEBI:17154;CHEBI:17154 | denotes | syndrome cor |
| T64863 | 1452-1461 | CHEBI:18367;CHEBI:18367 | denotes | and SARS |
| T51748 | 1469-1478 | CHEBI:35222;CHEBI:35222 | denotes | E2 mediat |
| T79147 | 1480-1491 | CHEBI:27584;CHEBI:27584 | denotes | S protein |
| T23025 | 1528-1532 | G_3;PG_10;PR:000003622 | denotes | nto |
| T84481 | 1589-1601 | CHEBI:17154;CHEBI:17154 | denotes | ication. Div |
| T4704 | 1707-1717 | CHEBI:31547;CHEBI:31547 | denotes | rse effect |
| T67581 | 1725-1730 | SP_6;NCBITaxon:9606 | denotes | by A |
| T67016 | 1731-1739 | CL:0000576 | denotes | 1R and i |
| T80087 | 1748-1759 | CL:0000235 | denotes | tcomes by M |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 431 | 46-54 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 470 | 65-78 | Gene | denotes | angiotensin I | Gene:183 |
| 471 | 80-85 | Gene | denotes | Ang I | Gene:183 |
| 472 | 103-109 | Gene | denotes | Ang II | Gene:183 |
| 473 | 114-143 | Gene | denotes | angiotensin-converting enzyme | Gene:1636 |
| 474 | 145-148 | Gene | denotes | ACE | Gene:1636 |
| 475 | 179-182 | Gene | denotes | ACE | Gene:1636 |
| 476 | 227-233 | Gene | denotes | Ang II | Gene:183 |
| 477 | 255-259 | Gene | denotes | AT1R | Gene:185 |
| 478 | 488-514 | Gene | denotes | mineralocorticoid receptor | Gene:4306 |
| 479 | 566-572 | Gene | denotes | Ang II | Gene:183 |
| 480 | 845-851 | Gene | denotes | Ang II | Gene:183 |
| 481 | 863-867 | Gene | denotes | AT1R | Gene:185 |
| 482 | 869-875 | Gene | denotes | Ang II | Gene:183 |
| 483 | 918-925 | Gene | denotes | Ang 1-7 | Gene:284 |
| 484 | 931-935 | Gene | denotes | ACE2 | Gene:59272 |
| 485 | 1013-1017 | Gene | denotes | ACE2 | Gene:59272 |
| 486 | 1018-1024 | Gene | denotes | Ang1-7 | Gene:284 |
| 487 | 1122-1126 | Gene | denotes | AT1R | Gene:185 |
| 488 | 1131-1135 | Gene | denotes | ACE2 | Gene:59272 |
| 489 | 1149-1155 | Gene | denotes | Ang II | Gene:183 |
| 490 | 1167-1171 | Gene | denotes | AT1R | Gene:185 |
| 491 | 1195-1199 | Gene | denotes | ACE2 | Gene:59272 |
| 492 | 1257-1261 | Gene | denotes | ACE2 | Gene:59272 |
| 493 | 1322-1329 | Gene | denotes | Ang 1-7 | Gene:284 |
| 494 | 1331-1335 | Gene | denotes | ACE2 | Gene:59272 |
| 495 | 1467-1471 | Gene | denotes | ACE2 | Gene:59272 |
| 496 | 1626-1630 | Gene | denotes | ACE2 | Gene:59272 |
| 497 | 1729-1733 | Gene | denotes | AT1R | Gene:185 |
| 498 | 1301-1307 | Gene | denotes | Ang II | Gene:183 |
| 499 | 1611-1614 | Gene | denotes | Ang | Gene:283 |
| 500 | 1394-1439 | Species | denotes | severe acute respiratory syndrome coronavirus | Tax:694009 |
| 501 | 1441-1452 | Species | denotes | SARS-CoV) 2 | Tax:2697049 |
| 502 | 1457-1465 | Species | denotes | SARS-CoV | Tax:694009 |
| 503 | 418-423 | Chemical | denotes | water | MESH:D014867 |
| 504 | 626-631 | Chemical | denotes | water | MESH:D014867 |
| 505 | 707-718 | Disease | denotes | hypertrophy | MESH:D006984 |
| 506 | 720-728 | Disease | denotes | fibrosis | MESH:D005355 |
| 507 | 1565-1574 | Disease | denotes | infection | MESH:D007239 |