PMC:7160875 / 3857-6178
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7160875","sourcedb":"PMC","sourceid":"7160875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7160875","text":"The work of Rampp et al6 adds to the existing literature by presenting the largest case series of MEG studied for the localization of epileptogenic foci. This is a single-center retrospective observational cohort study spanning almost 30 years and reviewing 1274 MEG tests. The hypothesis was that MEG supports patient selection, contributes to the identification of the epileptogenic zone in presurgical evaluation, and impacts long-term seizure outcomes after epilepsy surgery. All recordings, source imaging, and interpretation were performed prospectively before surgery. Over the span of the study, 3 different MEG systems were used: a 37-channel radiometer system; a 2 × 37 channel axial gradiometer system or a 148-channel axial gradiometer system; and a 248-channel whole-head magnetometer. Multiple source localization methods with multiple volume conductor models (single sphere, multiple spheres, and boundary element method) and multiple inverse solutions algorithms (LORETTA/sLORETTA, minimum norms, and CLARA) were used with Curry (Compumedics; Charlotte, NC) or BESA (BESA GmbH; Grafelfing, Germany) software. Association of seizure outcome after surgery with MEG/focus hypothesis concordance, as well as MEG resection, was evaluated. Magnetoencephalography detected pathologic spikes/sharp waves in 72% of the recordings, which is similar to other observational studies. Magnetoencephalography findings were “concordant” with the presurgical consensus (derived from video-electroencephalogram, structural and functional testing) in 50% of the patients, “consistent” in 32% and “discordant” in 18%. The percentage was higher in temporal lobe epilepsy cases compared to extra-temporal lobe epilepsy cases, which is not surprising and in line with what is seen in clinical practice. Approximately 40% of the cohort went on to epilepsy surgery. Follow-up data were available at the 1- and 5-year mark for many patients, with a few even up to 20 years. Complete resections of focal MEG localizations were significantly related to Engel 1 outcome. Complete resection of an epileptogenic lesion was also related to a better outcome, compared to cases with partial or no resection. Interestingly, the association of Engel 1 outcomes with complete MEG resections was stronger in non-lesional versus lesional cases.","tracks":[{"project":"TEST0","denotations":[{"id":"32313499-23-28-4307","span":{"begin":23,"end":24},"obj":"[\"31373622\"]"}],"attributes":[{"subj":"32313499-23-28-4307","pred":"source","obj":"TEST0"}]},{"project":"0_colil","denotations":[{"id":"32313499-31373622-4307","span":{"begin":23,"end":24},"obj":"31373622"}],"attributes":[{"subj":"32313499-31373622-4307","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"32313499-31373622-28641136","span":{"begin":23,"end":24},"obj":"31373622"}],"attributes":[{"subj":"32313499-31373622-28641136","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"32313499-31373622-28641136","span":{"begin":23,"end":25},"obj":"31373622"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"32313499-31373622-28641136","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"TEST0","color":"#93bcec","default":true},{"id":"0_colil","color":"#d6ec93"},{"id":"2_test","color":"#e893ec"},{"id":"MyTest","color":"#93ecce"}]}]}}