PMC:7156805 / 4685-6100
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 95 | 107-112 | Gene | denotes | NF-κB | Gene:4790 |
| 96 | 418-423 | Gene | denotes | TNF-α | Gene:7124 |
| 97 | 724-728 | Gene | denotes | IL-1 | Gene:3552 |
| 98 | 764-768 | Gene | denotes | IL-4 | Gene:3565 |
| 99 | 861-866 | Gene | denotes | IL-17 | Gene:3605 |
| 100 | 1028-1034 | Gene | denotes | IL-17a | Gene:3605 |
| 101 | 1071-1077 | Gene | denotes | IL-17a | Gene:3605 |
| 102 | 1160-1165 | Gene | denotes | IL-23 | Gene:51561 |
| 103 | 1333-1337 | Gene | denotes | PDE4 | Gene:5141 |
| 104 | 555-560 | Disease | denotes | fever | MESH:D005334 |
| 105 | 977-982 | Disease | denotes | fever | MESH:D005334 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T71 | 314-317 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T72 | 587-594 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T73 | 677-679 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T74 | 700-702 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T75 | 724-728 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T76 | 724-726 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T77 | 764-766 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T78 | 861-863 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T79 | 1028-1030 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T80 | 1071-1073 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T81 | 1115-1120 | Body_part | denotes | IL-12 | http://purl.org/sig/ont/fma/fma86579 |
| T82 | 1115-1117 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T83 | 1160-1162 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T84 | 1200-1208 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T48 | 111-112 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T33 | 107-109 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T36 | 254-263 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T37 | 264-274 | Chemical | denotes | Tacrolimus | http://purl.obolibrary.org/obo/CHEBI_61049 |
| T38 | 275-287 | Chemical | denotes | Cyclosporine | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T39 | 314-317 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T40 | 330-343 | Chemical | denotes | Mycophenolate | http://purl.obolibrary.org/obo/CHEBI_168396 |
| T41 | 365-377 | Chemical | denotes | Methotrexate | http://purl.obolibrary.org/obo/CHEBI_44185 |
| T42 | 587-594 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T43 | 595-605 | Chemical | denotes | Etanercept | http://purl.obolibrary.org/obo/CHEBI_4875 |
| T44 | 677-679 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T46 | 680-699 | Chemical | denotes | receptor modulators | http://purl.obolibrary.org/obo/CHEBI_90710 |
| T47 | 700-702 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T49 | 724-726 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T51 | 764-766 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T53 | 861-863 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T55 | 1028-1030 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T57 | 1071-1073 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T59 | 1115-1117 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T61 | 1160-1162 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T28 | 242-253 | http://purl.obolibrary.org/obo/GO_0004723 | denotes | Calcineurin |
| T29 | 242-253 | http://purl.obolibrary.org/obo/GO_0004722 | denotes | Calcineurin |
| T30 | 305-329 | http://purl.obolibrary.org/obo/GO_0008156 | denotes | Inhibits DNA replication |
| T31 | 314-329 | http://purl.obolibrary.org/obo/GO_0006260 | denotes | DNA replication |
| T32 | 677-688 | http://purl.obolibrary.org/obo/GO_0004896 | denotes | IL receptor |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T10 | 555-560 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T11 | 977-982 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T20 | 0-70 | Sentence | denotes | Drug class Mechanism of action Drug name Risk Comments/considerations∗ |
| T21 | 71-97 | Sentence | denotes | Classic immunosuppressants |
| T22 | 98-241 | Sentence | denotes | Inhibits NF-κB Corticosteroids Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure |
| T23 | 242-274 | Sentence | denotes | Calcineurin inhibitor Tacrolimus |
| T24 | 275-287 | Sentence | denotes | Cyclosporine |
| T25 | 288-351 | Sentence | denotes | Antimetabolites Inhibits DNA replication Mycophenolate mofetil |
| T26 | 352-364 | Sentence | denotes | Azathioprine |
| T27 | 365-377 | Sentence | denotes | Methotrexate |
| T28 | 378-394 | Sentence | denotes | Immunomodulators |
| T29 | 395-569 | Sentence | denotes | Monoclonal antibodies TNF-α inhibition Infliximab Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops |
| T30 | 570-605 | Sentence | denotes | Receptor fusion protein Etanercept |
| T31 | 606-641 | Sentence | denotes | Monoclonal antibodies Certolizumab |
| T32 | 642-675 | Sentence | denotes | Monoclonal antibodies Adalimumab |
| T33 | 676-729 | Sentence | denotes | IL receptor modulators IL inhibition Anakinra (IL-1) |
| T34 | 730-825 | Sentence | denotes | Monoclonal antibodies Dupilumab (IL-4) Likely low risk Continue unless severe symptoms present |
| T35 | 826-991 | Sentence | denotes | Monoclonal antibodies Brodalumab (IL-17) Likely moderate risk Continue if viral symptoms are mild, consider stopping if viral symptoms worsen or high fever develops |
| T36 | 992-1035 | Sentence | denotes | Monoclonal antibodies Secukinumab (IL-17a) |
| T37 | 1036-1078 | Sentence | denotes | Monoclonal antibodies Ixekizumab (IL-17a) |
| T38 | 1079-1124 | Sentence | denotes | Monoclonal antibodies Ustekinumab (IL-12/23) |
| T39 | 1125-1166 | Sentence | denotes | Monoclonal antibodies Guselkumab (IL-23) |
| T40 | 1167-1332 | Sentence | denotes | Monoclonal antibodies Anti-CD20 antibody Rituximab Likely concerning risk Consider stopping when viral symptoms present especially with known or potential exposure. |
| T41 | 1333-1415 | Sentence | denotes | PDE4 inhibition Apremilast Likely low risk Continue unless severe symptoms present |