PMC:7156805 / 3733-4172 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"81","span":{"begin":157,"end":173},"obj":"Disease"},{"id":"82","span":{"begin":277,"end":286},"obj":"Disease"},{"id":"83","span":{"begin":414,"end":419},"obj":"Disease"}],"attributes":[{"id":"A81","pred":"tao:has_database_id","subj":"81","obj":"MESH:D001102"},{"id":"A82","pred":"tao:has_database_id","subj":"82","obj":"MESH:D007239"},{"id":"A83","pred":"tao:has_database_id","subj":"83","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T66","span":{"begin":40,"end":48},"obj":"Body_part"},{"id":"T67","span":{"begin":203,"end":212},"obj":"Body_part"},{"id":"T68","span":{"begin":251,"end":256},"obj":"Body_part"},{"id":"T69","span":{"begin":367,"end":375},"obj":"Body_part"}],"attributes":[{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T15","span":{"begin":157,"end":173},"obj":"Disease"},{"id":"T16","span":{"begin":277,"end":286},"obj":"Disease"}],"attributes":[{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T45","span":{"begin":78,"end":81},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T46","span":{"begin":251,"end":256},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T47","span":{"begin":364,"end":365},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T26","span":{"begin":157,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":367,"end":381},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}

{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":0,"end":174},"obj":"Sentence"},{"id":"T14","span":{"begin":175,"end":287},"obj":"Sentence"},{"id":"T15","span":{"begin":288,"end":439},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Broad immunosuppression across multiple cytokine axes with immunosuppressants has the potential to increase susceptibility, persistence, and reactivation of viral infections. Immunosuppressants decrease cytokines that recruit and differentiate immune cells needed to clear the infection. In addition, inflammatory mediators can become hyperactivated, resulting in a “cytokine storm,” which is the primary cause of death in severe disease.3"}