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PMC:7156291 / 8159-17982 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
155 9-16 Species denotes Patient Tax:9606
161 36-44 Species denotes patients Tax:9606
162 180-188 Species denotes patients Tax:9606
163 368-376 Species denotes patients Tax:9606
164 462-470 Species denotes patients Tax:9606
165 480-489 Disease denotes pneumonia MESH:D011014
181 2056-2059 Gene denotes AST Gene:26503
182 2157-2175 Gene denotes C-reactive protein Gene:1401
183 1006-1013 Species denotes Patient Tax:9606
184 1238-1245 Species denotes patient Tax:9606
185 1019-1022 Disease denotes NCP MESH:C000657245
186 1229-1237 Disease denotes infected MESH:D007239
187 1293-1309 Disease denotes symptoms   Fever MESH:D051271
188 1322-1327 Disease denotes Cough MESH:D003371
189 1366-1373 Disease denotes Fatigue MESH:D005221
190 1408-1427 Disease denotes shortness of breath MESH:D004417
191 1440-1452 Disease denotes Pharyngalgia MESH:D010608
192 1491-1499 Disease denotes Headache MESH:D006261
193 1510-1516 Disease denotes Nausea MESH:D009325
194 1524-1532 Disease denotes vomiting MESH:D014839
195 1541-1549 Disease denotes Diarrhea MESH:D003967
197 942-949 Species denotes Patient Tax:9606
199 2277-2285 Species denotes patients Tax:9606
201 2349-2352 Gene denotes AST Gene:26503
203 2380-2385 Chemical denotes aData
206 2680-2683 Gene denotes AST Gene:26503
207 2718-2736 Gene denotes C-reactive protein Gene:1401
216 880-898 Gene denotes C-reactive protein Gene:1401
217 586-594 Species denotes Patients Tax:9606
218 666-673 Species denotes patient Tax:9606
219 859-867 Species denotes patients Tax:9606
220 924-932 Species denotes patients Tax:9606
221 657-665 Disease denotes infected MESH:D007239
222 712-717 Disease denotes Fever MESH:D005334
223 730-735 Disease denotes cough MESH:D003371
226 2908-2916 Species denotes patients Tax:9606
227 2922-2930 Disease denotes COVID-19 MESH:C000657245
229 2967-2984 Disease denotes pulmonary lesions MESH:D008171
233 3989-3997 Species denotes patients Tax:9606
234 3968-3985 Disease denotes pulmonary lesions MESH:D008171
235 4003-4011 Disease denotes COVID-19 MESH:C000657245
238 3034-3051 Disease denotes pulmonary lesions MESH:D008171
239 3181-3198 Disease denotes pulmonary lesions MESH:D008171
242 4385-4393 Species denotes patients Tax:9606
243 4399-4407 Disease denotes COVID-19 MESH:C000657245
251 5305-5313 Species denotes patients Tax:9606
252 5443-5450 Species denotes patient Tax:9606
253 5475-5482 Species denotes patient Tax:9606
254 5508-5515 Species denotes patient Tax:9606
255 5542-5549 Species denotes patient Tax:9606
256 5580-5587 Species denotes patient Tax:9606
257 5319-5327 Disease denotes COVID-19 MESH:C000657245
261 4618-4626 Species denotes patients Tax:9606
262 4720-4728 Species denotes patients Tax:9606
263 4935-4943 Species denotes patients Tax:9606
266 5630-5638 Species denotes patients Tax:9606
267 5644-5652 Disease denotes COVID-19 MESH:C000657245
272 5691-5699 Species denotes patients Tax:9606
273 5733-5741 Species denotes patients Tax:9606
274 5870-5877 Species denotes patient Tax:9606
275 5929-5937 Species denotes patients Tax:9606
278 7614-7630 Disease denotes Pleural effusion MESH:D010996
279 7667-7682 Disease denotes Lymphadenopathy MESH:D008206
282 6749-6757 Species denotes patients Tax:9606
283 6763-6771 Disease denotes COVID-19 MESH:C000657245
285 7991-7999 Species denotes patients Tax:9606
290 6072-6080 Species denotes patients Tax:9606
291 6248-6256 Species denotes patients Tax:9606
292 6402-6409 Species denotes patient Tax:9606
293 6620-6628 Species denotes patients Tax:9606
299 8040-8048 Species denotes patients Tax:9606
300 8145-8153 Species denotes patients Tax:9606
301 8250-8258 Species denotes patients Tax:9606
302 8053-8070 Disease denotes pleural effusions MESH:D010996
303 8088-8103 Disease denotes lymphadenopathy MESH:D008206
310 8429-8434 Species denotes woman Tax:9606
311 8469-8476 Species denotes patient Tax:9606
312 8454-8468 Disease denotes COVID-infected MESH:C000657245
313 8492-8497 Disease denotes fever MESH:D005334
314 8499-8504 Disease denotes cough MESH:D003371
315 8510-8523 Disease denotes low back pain MESH:D017116
320 9135-9142 Species denotes patient Tax:9606
321 9120-9134 Disease denotes COVID-infected MESH:C000657245
322 9158-9163 Disease denotes fever MESH:D005334
323 9168-9173 Disease denotes cough MESH:D003371
326 8374-8382 Species denotes patients Tax:9606
327 8388-8406 Disease denotes COVID-19 pneumonia MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T11 790-800 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T12 811-815 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T13 891-898 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 1386-1391 Body_part denotes Chest http://purl.org/sig/ont/fma/fma9576
T15 1465-1471 Body_part denotes Muscle http://purl.org/sig/ont/fma/fma32558
T16 1634-1650 Body_part denotes White blood cell http://purl.org/sig/ont/fma/fma62852
T17 1646-1650 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 1699-1709 Body_part denotes Lymphocyte http://purl.org/sig/ont/fma/fma62863
T19 1766-1777 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T20 1828-1840 Body_part denotes neutrophilic http://purl.org/sig/ont/fma/fma62860
T21 1841-1852 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T22 1905-1914 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T23 1957-1967 Body_part denotes Hemoglobin http://purl.org/sig/ont/fma/fma62293
T24 2168-2175 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T25 2323-2330 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T26 2559-2575 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T27 2571-2575 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T28 2583-2593 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T29 2609-2620 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T30 2630-2642 Body_part denotes neutrophilic http://purl.org/sig/ont/fma/fma62860
T31 2643-2654 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T32 2664-2673 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T33 2702-2712 Body_part denotes hemoglobin http://purl.org/sig/ont/fma/fma62293
T34 2729-2736 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T35 5283-5287 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T36 6661-6665 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T37 6725-6729 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T38 7785-7789 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T39 8514-8518 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T40 8574-8589 Body_part denotes left lower lobe http://purl.org/sig/ont/fma/fma7371
T41 8695-8700 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T42 8728-8743 Body_part denotes left lower lobe http://purl.org/sig/ont/fma/fma7371
T43 8873-8888 Body_part denotes left lower lobe http://purl.org/sig/ont/fma/fma7371
T44 9023-9038 Body_part denotes left lower lobe http://purl.org/sig/ont/fma/fma7371
T45 9260-9275 Body_part denotes left lower lobe http://purl.org/sig/ont/fma/fma7371
T46 9378-9394 Body_part denotes left lower lobes http://purl.org/sig/ont/fma/fma7371

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 1386-1391 Body_part denotes Chest http://purl.obolibrary.org/obo/UBERON_0001443
T18 1640-1645 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T19 2565-2570 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 5215-5219 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T21 5283-5287 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 5288-5292 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T23 6661-6665 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 6725-6729 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 7614-7630 Body_part denotes Pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T26 7785-7789 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T27 8053-8070 Body_part denotes pleural effusions http://purl.obolibrary.org/obo/UBERON_0000175
T28 8585-8589 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T29 8739-8743 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T30 8884-8888 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T31 9034-9038 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T32 9271-9275 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752
T33 9747-9751 Body_part denotes lobe http://purl.obolibrary.org/obo/UBERON_3010752

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T34 480-489 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T35 1541-1549 Disease denotes Diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T36 2922-2930 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T37 4003-4011 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T38 4399-4407 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T39 5319-5327 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 5644-5652 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 6763-6771 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 7667-7682 Disease denotes Lymphadenopathy http://purl.obolibrary.org/obo/MONDO_0005833
T43 8088-8103 Disease denotes lymphadenopathy http://purl.obolibrary.org/obo/MONDO_0005833
T44 8388-8396 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T45 8397-8406 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T38 82-86 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T39 82-86 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T40 107-113 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T41 226-228 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T42 811-815 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T43 978-982 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T44 1043-1044 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 1098-1100 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T46 1110-1112 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T47 1143-1147 http://purl.obolibrary.org/obo/UBERON_0003101 denotes Male
T48 1143-1147 http://www.ebi.ac.uk/efo/EFO_0000970 denotes Male
T49 1204-1206 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T50 1386-1391 http://www.ebi.ac.uk/efo/EFO_0000965 denotes Chest
T51 1465-1471 http://purl.obolibrary.org/obo/UBERON_0001630 denotes Muscle
T52 1465-1471 http://purl.obolibrary.org/obo/UBERON_0005090 denotes Muscle
T53 1465-1471 http://www.ebi.ac.uk/efo/EFO_0000801 denotes Muscle
T54 1465-1471 http://www.ebi.ac.uk/efo/EFO_0001949 denotes Muscle
T55 1597-1604 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T56 1640-1645 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T57 1646-1650 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T58 1687-1689 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T59 1905-1914 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T60 2186-2188 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T61 2565-2570 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T62 2571-2575 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T63 2664-2673 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T64 2831-2833 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T65 3517-3518 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T66 3674-3675 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 4119-4122 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T68 4195-4197 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T69 4697-4699 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2a
T70 4887-4888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 5202-5203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 5231-5232 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T73 5283-5287 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T74 5283-5287 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T75 5535-5537 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T76 6232-6233 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T77 6294-6295 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 6386-6387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 6661-6665 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T80 6661-6665 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T81 6725-6729 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T82 6725-6729 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T83 6918-6920 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T84 7614-7630 http://purl.obolibrary.org/obo/UBERON_0000175 denotes Pleural effusion
T85 7785-7789 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T86 7785-7789 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T87 7914-7916 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T88 7932-7934 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T89 8053-8070 http://purl.obolibrary.org/obo/UBERON_0000175 denotes pleural effusions
T90 8415-8419 http://purl.obolibrary.org/obo/CLO_0001599 denotes A 54
T91 8452-8453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T92 8561-8562 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T93 8635-8638 http://purl.obolibrary.org/obo/CLO_0002755 denotes d–f
T94 8657-8658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 8695-8700 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T96 8940-8942 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T97 9083-9087 http://purl.obolibrary.org/obo/CLO_0001568 denotes A 24
T98 9118-9119 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T99 9220-9223 http://purl.obolibrary.org/obo/CLO_0051456 denotes a–e
T100 9566-9568 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12 82-86 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T13 891-898 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1061-1066 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T15 1957-1967 Chemical denotes Hemoglobin http://purl.obolibrary.org/obo/CHEBI_5656
T16 2056-2059 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T17 2100-2108 Chemical denotes Creatine http://purl.obolibrary.org/obo/CHEBI_16919
T18 2168-2175 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T19 2323-2330 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T20 2349-2352 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T21 2353-2362 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T24 2680-2683 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T25 2685-2693 Chemical denotes creatine http://purl.obolibrary.org/obo/CHEBI_16919|http://purl.obolibrary.org/obo/CHEBI_57947
T27 2702-2712 Chemical denotes hemoglobin http://purl.obolibrary.org/obo/CHEBI_35143
T28 2729-2736 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T29 7814-7816 Chemical denotes SD http://purl.obolibrary.org/obo/CHEBI_74807

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T24 480-489 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T25 712-717 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T26 730-735 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T27 1304-1309 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T28 1322-1327 Phenotype denotes Cough http://purl.obolibrary.org/obo/HP_0012735
T29 1366-1373 Phenotype denotes Fatigue http://purl.obolibrary.org/obo/HP_0012378
T30 1408-1427 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T31 1440-1452 Phenotype denotes Pharyngalgia http://purl.obolibrary.org/obo/HP_0033050
T32 1491-1499 Phenotype denotes Headache http://purl.obolibrary.org/obo/HP_0002315
T33 1510-1532 Phenotype denotes Nausea and/or vomiting http://purl.obolibrary.org/obo/HP_0002017
T34 1541-1549 Phenotype denotes Diarrhea http://purl.obolibrary.org/obo/HP_0002014
T35 6953-6972 Phenotype denotes Pulmonary opacities http://purl.obolibrary.org/obo/HP_0031457
T36 7614-7630 Phenotype denotes Pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T37 7667-7682 Phenotype denotes Lymphadenopathy http://purl.obolibrary.org/obo/HP_0002716
T38 8053-8070 Phenotype denotes pleural effusions http://purl.obolibrary.org/obo/HP_0002202
T39 8088-8103 Phenotype denotes lymphadenopathy http://purl.obolibrary.org/obo/HP_0002716
T40 8397-8406 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T41 8492-8497 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T42 8499-8504 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T43 8510-8523 Phenotype denotes low back pain http://purl.obolibrary.org/obo/HP_0003419
T44 9158-9163 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T45 9168-9173 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T46 9760-9770 Phenotype denotes atoll sign http://purl.obolibrary.org/obo/HP_0032983

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T72 0-7 Sentence denotes Results
T73 9-29 Sentence denotes Patient demographics
T74 30-159 Sentence denotes Of 88 patients in the study cohort, 51 (58.0%) were male and 37 (42.0%) were female; mean age was 42.7 years (range, 4–82 years).
T75 160-255 Sentence denotes Fifty-three (60.2%) patients had 2 CTs, 24 (27.2%) had 3 CTs, and 11 (12.5%) had 4 or more CTs.
T76 256-355 Sentence denotes The mean time interval between symptom onset and baseline CT was 5.5 ± 3.5 days (range, 1–15 days).
T77 356-450 Sentence denotes Five (5.7%) patients in the study cohort were known to have been discharged from the hospital.
T78 451-523 Sentence denotes All of the patients had mild pneumonia based on the WHO definition [10].
T79 524-585 Sentence denotes The demographics of the study cohort are detailed in Table 1.
T80 586-711 Sentence denotes Patients with exposure history (recent travel to Wuhan or contact with infected patient) accounted for 85.2% of study cohort.
T81 712-785 Sentence denotes Fever (84.1%) and cough (56.8%) were the most common presenting symptoms.
T82 786-933 Sentence denotes Low lymphocyte and white cell counts were observed in 26.4% and 25.0% of patients, while high C-reactive protein was observed in 55.0% of patients.
T83 934-990 Sentence denotes Table 1 Patient demographics and laboratory test results
T84 991-1031 Sentence denotes Characteristic Patient with NCP (n = 88)
T85 1032-1056 Sentence denotes Age (years)a 42.7 ± 14.5
T86 1057-1074 Sentence denotes Age group (years)
T87 1075-1089 Sentence denotes   < 15 2 (2.3)
T88 1090-1107 Sentence denotes   15–44 48 (54.5)
T89 1108-1125 Sentence denotes   45–64 28 (31.8)
T90 1126-1142 Sentence denotes   ≥ 65 10 (11.4)
T91 1143-1161 Sentence denotes Male sex 51 (58.0)
T92 1162-1178 Sentence denotes Exposure history
T93 1179-1213 Sentence denotes   Recent travel to Wuhan 45 (51.1)
T94 1214-1255 Sentence denotes   Contact with infected patient 30 (34.1)
T95 1256-1284 Sentence denotes   Unknown exposure 13 (14.8)
T96 1285-1301 Sentence denotes Initial symptoms
T97 1302-1319 Sentence denotes   Fever 74 (84.1)
T98 1320-1337 Sentence denotes   Cough 50 (56.8)
T99 1338-1363 Sentence denotes   Expectoration 19 (21.6)
T100 1364-1383 Sentence denotes   Fatigue 15 (17.0)
T101 1384-1437 Sentence denotes   Chest distress and/or shortness of breath 12 (13.6)
T102 1438-1462 Sentence denotes   Pharyngalgia 10 (11.4)
T103 1463-1488 Sentence denotes   Muscle soreness 7 (8.0)
T104 1489-1507 Sentence denotes   Headache 5 (5.7)
T105 1508-1538 Sentence denotes   Nausea and/or vomiting 0 (0)
T106 1539-1555 Sentence denotes   Diarrhea 0 (0)
T107 1556-1585 Sentence denotes   No obvious symptoms 3 (3.4)
T108 1586-1631 Sentence denotes Laboratory testing at initial hospital visitb
T109 1632-1696 Sentence denotes   White blood cell count (–, ↑, ↓) 62 (70.5), 4 (4.5), 22 (25.0)
T110 1697-1755 Sentence denotes   Lymphocyte count (–, ↑, ↓) 62 (71.3), 2 (2.3), 23 (26.4)
T111 1756-1817 Sentence denotes   Percent lymphocytes (–, ↑, ↓) 55 (62.5), 7 (8.0), 26 (29.5)
T112 1818-1894 Sentence denotes   Percent neutrophilic granulocyte (–, ↑, ↓) 59 (67.1), 17 (19.3), 12 (13.6)
T113 1895-1954 Sentence denotes   Percent monocytes (–, ↑, ↓) 59 (67.1), 26 (29.5), 3 (3.4)
T114 1955-2007 Sentence denotes   Hemoglobin (–, ↑, ↓) 68 (77.3), 8 (9.1), 12 (13.6)
T115 2008-2053 Sentence denotes   ALT (–, ↑, ↓) 70 (79.5), 16 (18.2), 2 (2.3)
T116 2054-2097 Sentence denotes   AST (–, ↑, ↓) 73 (83.0), 15 (17.0), 0 (0)
T117 2098-2154 Sentence denotes   Creatine kinase (–, ↑, ↓) 73 (84.9), 4 (4.6), 9 (10.5)
T118 2155-2213 Sentence denotes   C-reactive protein (–, ↑, ↓) 36 (45.0), 44 (55.0), 0 (0)
T119 2214-2318 Sentence denotes Unless otherwise indicated, data are reported as the number of patients, with percentages in parentheses
T120 2319-2379 Sentence denotes ALT alanine aminotransferase, AST aspartate aminotransferase
T121 2380-2432 Sentence denotes aData are reported as the mean ± standard derivation
T122 2433-2541 Sentence denotes bThe signs –, ↑, and ↓ represent within, above, and below normal ranges of laboratory results, respectively.
T123 2542-2878 Sentence denotes Normal ranges of white blood cell count, lymphocyte count, percent lymphocytes, percent neutrophilic granulocyte, percent monocytes, ALT, AST, creatine kinase, hemoglobin, and C-reactive protein were 3.5–9.5 × 109/L, 1.10–3.20 × 109/L, 20–50%, 3.0–10.0%, 40–75%, 115–150 g/L, 7–40 U/L, 13–35 U/L, 40–200 U/L, and 0–10 mg/L, respectively
T124 2880-2930 Sentence denotes Evolution of CT findings in patients with COVID-19
T125 2932-2984 Sentence denotes Evolution of CT characteristics of pulmonary lesions
T126 2985-3099 Sentence denotes Figure 1 depicts the evolution of CT features of pulmonary lesions in different time intervals from disease onset.
T127 3100-3516 Sentence denotes Significant differences were found among the time intervals in the proportion of pulmonary lesions that are (1) pure GGO (χ2 = 37.97, p = 0.01), (2) mixed attenuation (GGO and consolidation) (χ2 = 12.80, p < 0.01), (3) mixed attenuation with reticular/linear opacities (χ2 = 20.57, p < 0.01), and (4) consolidation with reticular/linear opacities (χ2 = 32.49, p < 0.01) and pure consolidation (χ2 = 10.37, p = 0.03).
T128 3517-3925 Sentence denotes A significant linear decrease in the proportions of pure GGO lesions (y = 0.55–0.08x, p < 0.01) and mixed attenuation lesions (y = 0.31–0.03x, p = 0.01) and a significant linear increase in the proportions of lesion with reticular/linear opacities (mixed attenuation + linear opacities (y = 0.08 + 0.04x, p < 0.01) and consolidation + linear opacities (y = − 0.03 + 0.04x, p < 0.01)) were observed over time.
T129 3926-4012 Sentence denotes Fig. 1 Evolution of CT characteristics of pulmonary lesions in patients with COVID-19.
T130 4013-4260 Sentence denotes The time intervals after disease onset (days) were divided into 5 groups, i.e., days 0–3 (lesion number = 114), days 4–7 (lesion number = 241), days 8–10 (lesion number = 189), days 11–14 (lesion number = 178), and days 15–21 (lesion number = 95).
T131 4261-4348 Sentence denotes GGO, ground glass opacities; mixed attenuation = ground glass opacities + consolidation
T132 4350-4407 Sentence denotes Evolution of lobar distribution in patients with COVID-19
T133 4408-4586 Sentence denotes No statistically significant difference was found in the lobar distribution of pulmonary findings over different time intervals from symptom onset, but some trends were observed.
T134 4587-4701 Sentence denotes For example, the proportion of patients with fewer than 3 lobes affected decreased in the first 10 days (Fig. 2a).
T135 4702-4812 Sentence denotes The proportion of patients with three or more affected lobes was higher in all of the time intervals analyzed.
T136 4813-5027 Sentence denotes Bilateral involvement was more prevalent than unilateral involvement with a trend toward an increase in the proportion of patients with bilateral CT abnormalities in the first 2 weeks after disease onset (Fig. 2b).
T137 5028-5154 Sentence denotes Lower lobes have higher rates of involvement than the others, but the differences are not statistically significant (Fig. 2c).
T138 5155-5363 Sentence denotes Fig. 2 Evolution of lobar distribution of the (a) number of lobe affected, (b) unilateral and bilateral lobes affected, and (c) lung lobe affected in patients with COVID-19 within 21 days after disease onset.
T139 5364-5600 Sentence denotes The time after disease onset (day) is categorized as 5 groups, i.e., days 0–3 (patient number = 37), days 4–7 (patient number = 69), days 8–10 (patient number = 53), days 11–14 (patient number = 49), and days 15–21 (patient number = 25)
T140 5602-5652 Sentence denotes Evolution of CT findings in patients with COVID-19
T141 5653-5714 Sentence denotes The initial CTs of 4 out of 88 (4.5%) patients were negative.
T142 5715-5838 Sentence denotes Two of these four patients had their baseline CT during days 1–3, one during days 4–7, and one during days 8–10 of disease.
T143 5839-5965 Sentence denotes Subsequently, CT images of one patient remained negative even during days 8–10, and other patients developed CT abnormalities.
T144 5966-6231 Sentence denotes There were significant differences between the time interval groups after disease onset in proportions of patients with both GGO and consolidation (χ2 = 22.2, p < 0.01) and the combination of GGO, consolidation, and linear opacities (χ2 = 21.5, p < 0.01) (Table 2).
T145 6232-6561 Sentence denotes A proportion of patients with GGO and consolidation presented a decreasing trend during the 21 days after disease onset (y = 0.48–0.09x, p < 0.01), while a proportion of patient with all three findings including ground glass opacities, consolidation, and linear opacities presented an increasing trend (y = 0.12–0.11x, p < 0.01).
T146 6562-6681 Sentence denotes No significant difference was found in the proportions of patients with other CT findings or total lung severity score.
T147 6682-6806 Sentence denotes Table 2 Evolution of CT findings and total lung severity scores of patients with COVID-19 within 21 days after disease onset
T148 6807-6857 Sentence denotes Characteristic Time after disease onset χ2 p value
T149 6858-6952 Sentence denotes Days 0–3 (n = 37) Days 4–7 (n = 69) Days 8–10 (n = 53) Days 11–14 (n = 49) Days 15–21 (n = 25)
T150 6953-6972 Sentence denotes Pulmonary opacities
T151 6973-7036 Sentence denotes   GGO only 8 (21.6) 13 (18.8) 7 (13.2) 4 (8.2) 1 (4.0) 6.6 0.16
T152 7037-7118 Sentence denotes   GGO and consolidation 12 (32.4) 26 (37.7) 8 (15.1) 5 (10.1) 1 (4.0) 22.2 < 0.01
T153 7119-7195 Sentence denotes   GGO and linear opacities 2 (5.4) 2 (2.9) 4 (7.5) 2 (4.1) 2 (8.0) 1.87 0.76
T154 7196-7266 Sentence denotes   Consolidation only 1 (2.8) 6 (8.7) 3 (5.7) 4 (8.2) 1 (4.0) 1.98 0.74
T155 7267-7351 Sentence denotes   Consolidation and linear opacities 0 (0) 2 (2.9) 4 (7.5) 4 (8.2) 3 (12.0) 6.0 0.19
T156 7352-7456 Sentence denotes   GGO, consolidation, and linear opacities 12 (32.4) 19 (27.5) 25 (47.2) 30 (61.2) 17 (68.0) 21.5 < 0.01
T157 7457-7519 Sentence denotes   Negative CT 2 (5.4) 1 (1.5) 2 (3.8) 0 (0.0) 0 (0.0) 4.3 0.36
T158 7520-7534 Sentence denotes Other findings
T159 7535-7611 Sentence denotes   Discrete pulmonary nodules 4 (10.8) 4 (5.8) 3 (5.7) 1 (2.0) 0 (0) 4.8 0.36
T160 7612-7664 Sentence denotes   Pleural effusion 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) – –
T161 7665-7716 Sentence denotes   Lymphadenopathy 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) – –
T162 7717-7778 Sentence denotes   Cavitation 3 (8.1) 3 (4.3) 1 (1.9) 2 (4.1) 1 (4.0) 2.1 0.72
T163 7779-7804 Sentence denotes Total lung severity score
T164 7805-7873 Sentence denotes   Mean ± SD 3.9 ± 2.7 4.8 ± 2.9 4.9 ± 2.8 5.3 ± 3.3 5.2 ± 2.8 – 0.29
T165 7874-7939 Sentence denotes   Median (range) 4 (0–10) 5 (0–12) 5 (0–11) 5 (1–13) 5 (1–11) – –
T166 7940-7978 Sentence denotes Numbers in parentheses are percentages
T167 7979-8027 Sentence denotes n number of patients, GGO ground glass opacities
T168 8028-8132 Sentence denotes None of the patients had pleural effusions or intrathoracic lymphadenopathy during the follow-up period.
T169 8133-8316 Sentence denotes Some of the patients had cavitation on CT, but these are thought to represent pre-existing conditions as none of the patients in the study cohort developed cavitation on follow-up CT.
T170 8317-8407 Sentence denotes Figures 3 and 4 show the evolution of CT findings of two patients with COVID-19 pneumonia.
T171 8408-8603 Sentence denotes Fig. 3 A 54-year-old woman with exposure to a COVID-infected patient presented with fever, cough, and low back pain for 2 days and remains hospitalized. a–c CT shows left lower lobe GGO on day 2.
T172 8604-8701 Sentence denotes The total severity score is 1. d–f CT on day 7 shows a significant increase in GGO in both lungs.
T173 8702-8749 Sentence denotes The severity score of the left lower lobe is 2.
T174 8750-8846 Sentence denotes The total severity score is 5. g–i CT on day 9 shows bilateral GGO and subpleural consolidation.
T175 8847-8894 Sentence denotes The severity score of the left lower lobe is 3.
T176 8895-8996 Sentence denotes The total severity score is 9. j–l CT on day 11 shows diffuse GGO and linear opacities (thick arrow).
T177 8997-9044 Sentence denotes The severity score of the left lower lobe is 4.
T178 9045-9075 Sentence denotes The total severity score is 12
T179 9076-9299 Sentence denotes Fig. 4 A 24-year-old man with exposure to a COVID-infected patient presented with fever and cough for 1 day and remains hospitalized currently. a–e CT scan shows GGO in the subpleural left lower lobe on day 1 (thick arrow).
T180 9300-9409 Sentence denotes The overall total severity score is 1. f–j CT on day 4 shows enlarging GGO in left lower lobes (thick arrow).
T181 9410-9510 Sentence denotes The overall total severity score is 3. k–o CT on day 8 shows increased GGO in bilateral lower lobes.
T182 9511-9643 Sentence denotes The total severity score was 5. p–t CT obtained on day 11 shows bilateral ground glass opacities and linear opacities (thick arrow).
T183 9644-9785 Sentence denotes The overall total severity score was 7. u–y CT obtained on day 15 shows improvement of bilateral lower lobe GGO and atoll sign (thick arrow).
T184 9786-9823 Sentence denotes The overall total severity score is 5